LV11786B - Inhalator - Google Patents

Abstract

The form of implantable drug is provided for long-lasted biologically active albumen, peptide or polypeptide inlet. This drug form is produced as a pressed partially covered combination with deepening. The combination has from 1 to 3 turns. Each turn contains (% of the common combination weight):20-80 of active substance,10-75 fat, wax or its mixture,0-20 buffer substance,salt or its mixture,and 0-25 carbohydrates.The deepening is not covered and serves as a canal for active substance outlet.<IMAGE>

Description

LV 11786 MHrajisrrop

OnMCaHMe Μ3θ6ρθΤβΗΜ5Ι H3o6peTeHne οτηοομτοα κ oānacm 3ApaBooxpaHeHMn, b ηθοτηοοτμ- κ w nynbMaHonornn nenečHbiM cpepcTBaM, CBn3aHHbiM c ββθαθημθμ nei &lt; apcTBeHHbix βθιμθοτβ npn MHrannMmi, μ μοχθτ 6biTb ncnonb30BaHO Tak &gt; xe flnii προΒβΑβΗΜη πθηθ6ηοτρθημροβοηηογο AbixaHnn, noBbimatomero aiļanTaLļMOHHbie bo3moxhoctm opraHM3Ma. Μ3βθοτθη nHranaTop from naTeHTy EP 0507913 (1995r), b κοτοροΜ B03flyiuHaii cMecb coBMeiuaeTcn c πθιοροτβθηηημμ βθιμθοτβθμμ μ pacnbineTcn. Μ3ΒθοτβΗ TaioKe MHrannTop of naieHTy Ηποημμ 4-314457 (κπ.Α61Μ16 / 00) b κοτοροΜ B03flymHaa mixture of očoramaeTcn KucnopopoM, Ι43βθοτθη Taxxe MHrannTop of naTeHTy TflP 55757 (κη. A61M15 / 00) coAepxamnK pe3epByap PNA χμακοοτμ, noABOAflmyK) Tpy6 "yc ΒοροΗκοίί , xaMepy pa36pbi3rMBaHMn.

Hančonee 6πμ3κμμ k 3anBneHHOMy ycTpoMCTBy ηΒπηβτοη MHrannTop no a.c. SU 1790417 (κη. A61M15 / 02), BiobasHHbiii KanecTBe npoTOTE m npeflCTaBnnjomnM co6om HapyxHbiii cocyn, β κοτοροΜ KoaKcnanbHo pacnonoxeHa aapo3onbHan KaMepa c οτβθροτμαμμ.

HeflOdaTKOM npoTOTuna ηΒπηβτοη HaKonneHne BpeflHbix οτχοαοβ AbixaTenbHoro npoiļecca, Further preferably, MMKpoopraHM3MOB μ Μοκροτ, b HHranflMHOHHOM ΧΜΑΚΟΟΤΜ, ΗβΧΟΑΑΙΑΜΟΑ B a3p030HbH0ii M MHranflLļMOHHOM KaMepax, m Ha BHyTpeHHMx οτβΗκβχ caMoii aapo3onbHOM KaMepbi, hto npn BflbixaHMn M3 3tom xe aapo3onbHOM KaMepbi, 3aC0peHH0ii MHKpOOpraHM3MaMM M MOKpOTaMM, ΟΗΜΧββΤ 3φφβΚΤΜΒΗ00ΤΒ ΜΗΓ3Πηί4ΜΜ. Lļenb Μ3θ6ρβΤβΗΜΑ - nOBblllJeHMe ΘφφβΚΤΜΒΗΟΟΤΜ Β03ΑβΜ0ΤΒΜη HHrannunoHHoii CMEC Ha AbixaTenbHbiii TpaKT nauMem-a, ycTpaHeHne OTpHLiaTenbHO AeMCTByioLuero 3φφβκτ3 HaKonneHMn BpeAHbix οτχοαοβ, Hanpmviep, MHKpoopraHH3MOB μ Μοκροτ, b MHrannLļMOHHOM χμακοοτμ h Ha CTeH &lt; ax aspo3onbHOM KaMepbi. npeAnaraeMbiki HHranmop noKa3aH Ha φΜΓ. 1, rpe: 1 - poTOBan BCTaBKa, 2 - BbiAbixaeMan coeAMHMTenbHan TpyāKa, 3 - BAbixaeMan coeAUHmenbHan Tpy6Ka, 4 n 5 - peryanpyeMbie οτΒβροτΜη, 6 - KnanaH no BbiAbixaHmo, 8 h 9 - perynnpyeMbie OTBepcTMn, 10 - aspoaonbHan KaMepa of BAbixaHHfo 11 - aspoaonbHan KaMepa of BbiAbixaHMK) 12 - OHmiļaiOLHHM cocyA of BbiAbixaHmo 13 - MHrannuMOHHbiii cocyA of BAbixaHwo 14 - eMKoeTb απβ CMeujMBaHiin 15 - HHranmtHOHHan xnAKOCTb 16 - OHmuaioman χμακοοτμ YKa3aHHan rape and AOCTHraeTcn τθμ, hto b npennaraeMOM MHrannTope (Φμγ.1) MMeKDTcn ABA OTAenbHbix cocyAa 12 m 13 μ αβθ OTAenbHbie a3p030nt &gt; Hbie KaMepbl 10 m 11 Kaxpafl H3 KOTOpblX ΟΟΟΤΒβΤΟΤΒβΗΗΟ BCTaBnaeTcn b cocypbi 12 m 13 npuneivi οημιαθιοιιιμμ cocyp 12 c a3po3onbHoii KaMepoii 11 BHyTpbi npeflHa3HaHeH PNN BbipbixaHMa B03pyiuH0ū CMEC, ee οημι ^ θημη h o6e33apaxMBaHMa, a MHrannpMOHHbiM cocyp 13 c a3po3onbHoii KaMepoii 10 BHyTpn npepHa3Ha4eH pna BpbixaHMn B03AyiUH0Ū CMecu, nOAMeiUMBaHMfl ΟΒβΧβίί KAMA Hapy &Gt; KHOrO B03Ayxa B ΟΟΟΤΒβΤΟΤΒΜΜ C 3aAaHHOM npOrpaMMOii M HaCbimeHMfl B03pyUJH0M CMecu neKapcTBeHHbiM BemecTBOM. B npepnaraeMOM MHranaTope b cocyAax 12 m 13 μμθιοτοα perynnpoBOMHbie οτΒβροτΜη 8 m 9 nepeoe M3 κοτορωχ npeAHa3HaHeH0 PNA perynnpoBKM οοπροτΜΒπβΗΜη BbiAbixaeMOMy B03Ayxy, a Βτοροβ PNA perynnpoBKM nocTynneHna 3apaHee 3aAaHHoro nporpaMMoii MHranaunu cooTHOiiļeHna BbiAbixaeMoro B03Ayxa m pononHMTenbHoii noppun CBexero B03Ayxa, nocTynaK) uļero nepe3 perynnpoBOHHbie OTBepCTMH 4 n 5 HapyxHofi θμκοοτμ 14, b κοτοροϋ pacnonoxeHbi cocyAbi 12 m 13. ΚροΜΘ τογο, κ Kaxpoii H3 ποαβοαλιαμχ Tpy6oK 2 n 3 MHransrrop, COeAMHatOmHX pOTOByK &gt; BCT3BKy 1 C a3p030nbH0M ΚΘΜβρΟΜ 11 of BblAblXaHM (0 MC a3p030nbH0ii KaMepoii 10 ΠΟ BblAblXaHMIO, ΟΟΟΤΒΘΤΟΤΒβΗΗΟ pacnono &gt; KeHbi KnanaHbi 6 m 7 KnanaH 7 πο3Βθπηβτ 3βτομ3τμηθοκμ HanpaBnaTb B03pywHyio mixture of M3 potobom βοτθβκμ 1 b a3p03onbHyio &lt; aMepy 11 of BbipbixaHMio, a ppyroii KnanaH 6 πο3Βθπηβτ HanpaenaTb B03AywHyto mixture of H3 a3po3onbHoii KaMepbi 10 of βαηχθημιο b poTOByio BdaBKy 1 flbixaHne nepe3 pa3AenbHbie aapo3onHbie cocyAbi 10 m 11 πο3Βοηηβτ nocToaHHO oHMīpaTb OTpa6oTaHHyio B03pyujHyK) A mixture, Bbixopamyio M3 nerKnx nauHeHTa, οτ BpepHbix οτχοαοβ pbixaHMH, e.g. MHKp00praHM3M0B H Mokpo, m 06e33apaXMBaTb B03AyiUHyiO CMecb B onmyMomm cocype 12 from BbiAbixaHHK &gt;. flanee OHMīpeHHaa B03pyujHafl mixture of BbixoAHT sepe3 perynnpoBOHHbie οτΒβροτΜη 8 OHMīpaioinero cocypa 12 h, CMemMBaacb c pononHMTenbHoii nopuMeū hapy &gt; Khor B03Ayxa, nocTynnBLuero nepe3 perynnpoBOHHbie οτΒβροτΜη 4m5 HapyxHOū θμκοοτμ 14, nocTynaeT b MHranauMOHHbiii cocyA 13 Προχορη nepe3 MHrannuMOHHyio &gt; KMAKOCTb 15 HaxoAaiAyK) ca b μηγβπλαμοηηομ cocepe 13 m nepe3 OTBepcTMa b a3p030nH0ū KaMepe 10 B03pyLUHaa mixture of HacbiuļaeTca neKapcTBeHHbiMM BeujecTBaM m, pacTBopeHHbiMM b MHranauMOHHoii xmrkoctm 15 flanee B03pywHan mixture of, oāorameHHaa neKapcTBeHHbiMM BemecTBaMM, nonapaeT b Camye a3po3onbHyio into chamber 10, RPE npeBpamaeTca b B03AyuiHO-KanenbHyio mixture of m sepe3 KnanaH 6 no Tpy6Ke 3 nOt 3 PoTOByio BCTaBKy 1 nocTynaeT b πθγοηηημ TpaKT nauMeHTa. 3το πο3Βθπηβτ 3HaMMTenbH0 ynywujMTb after ycTpoUtCtBa m o3AopoBMTb npopepypy nessHMa m TpeHMHra, hto yBenMHMBaeT 3φφβκτΜΒΗ00 ^ yorpoiicTBa.

Ha φΜΓ.1 noKa3aHa cxeMa MHranaTopa, pacnonoxeHMe cocyAOB 12 m 13, aapo3onbHbix KaMep 10 m 11, KnanaHOB 6 m 7, Tpy6oK 2 m 3, perynMpoB04Hbix OTBepCTMfi 4, 5, 8 m 9, a TaKxe θμκοοτμ 14, oxBaTbiBaiomeM cocyAbi. H3 paccMOTpeHMa cxeMbi If φΜΓ.1 bmaho, hto BHyTpM θμκοοτμ 14 ycTaHOBneHbi pBa cocypa 12 m 13; a b KaxpoM cocype ycTaHOBneHa cooTBeTCTByiomaa a3po3onbHaa KaMepa 10 m 11 opHa M3 KOTopbix npepHa3HaHeHa PNA BbipbixaHMa B03pyLUHOū ομθομ m οημιρθημη B03pyujHOM CMecM, a ppyraa npepHa3HaHeHa prm BbipbixaHMn m MHranapMM. LV 11786

TatoKe b coeflHHMTenbHbix Tpy6xax 2 n 3 ycTaHOBneHbi προτηΒοηοπο &gt; κΗθ HanpaBneHHbie KnanaHbi 6 n 7 KOTopbie nop B03pencTBneM BbipbixaeMon n BflblXaeMOli B03AyilJH0H ΟΜβΟη OTKpbIBatOTCfl H 3aKpblBaKDTCfl B takt AbixaTenbHOMy npoLļeccy. PoTOBaa BCTaBKa 1 MHrarmTop coepnHeHa c AbixaTenbHbiMM Tpy6xaMH 2 n 3. HocoByio BCTaB &lt; y. npennoKeHHbiii MHrannTop paraTeT cneAyioinHM oapa30M. Πρη Bbifloxe nauneHTa OTpaāoTaHHan B03AywH0-KanenbHan A mixture, copepjKaman yrneKMCnblM RA3, MMKp00praHH3Mbl H MOKpOTbl, Ηβρβ3 poTOByio BCTaBKy 1 n Hepe3 coeflHHMTenbHyK) Tpy6xy 1 c KnanaHOM 7 nonapaeT b a3po3onbHyio xaMepy 11 npepHa3HaHeHHyio PNN BbipbixaeMon CMecn. Προχορπ nepe3 OHnmaK) MYK) jKnpKOCTb 16 η οτΒβροτηπ aepo3onbHon KaMepbi 11 B03pywH0-KanenbHaa mixture of, copepaoīpan ymeKncnoTy, MMKpoopraHH3Mbi n MOKpoTbi, OHumaeTCfi n pane BbixoAHT n3 onnipatomero cocyAa 12 nepe3 perynnpyeMoe οτβθροτμθ 8 Ποοπθ θτογο yrneKncnoTHan mixture of nepe3 OTBepCTne 8 nonaAaei b pna eMKocTb cMeiiīnBaHnn 14 B θμκοοτμ yrneKncnoTa CMeuiHBaeTcn c nopunen οβθ &gt; κθγο B03Ayxa, nocTynaiomero Ηβρβ3 perynnpyeMbie οτΒβροτηπ 4 n 5 Β θμκοοτμ 14 προηοχορητ CMemuBaHue yrneKncnoTbi H3 onninaioiiļero cocyAa 12 m CBexero B03Ayxa, nociynMBiiiero nepe3 οτΒβροτηπ 4 m 5 Ποοπθ ομθιιιμβθημπ B03pyiuH0-yrneKMcnoTHOii ομθομ β οπρθαθπθηηομ nponopunn, 3pagesHee 3pcsHHon perynMp0B04HblMM ΟΤΒθρΟΤΜΠΜΜ 4, 5 M 8, CMeCb Ηθρθ3 ΟΤΒθρ n 9 nocTynaeT bnHrannHHbin cocyA 13 m KaMepbi 10 nocTynaeT b Camye a3po3onbHyio xaMepy 10 Ποπθβ b aep03onbHyio xaMepy μ nponpn nepe3 MHrannuMOHHyK) &gt; KMAKOCTb 15 B03pyujHafl ymeKMcnoTHan mixture of oSorauļaeTcn neKapcTBeHHbiMM βθιαθοτββμμ, η3χοαπιμμμμοπ b χηρκοοτη 15 μ ποα αθμοτβμθμ HacTynMBiuero pa3pnxeHMn β a3po3onbHoii KaMepe β pe3ynbTaie Bpoxa nauneHTa pacnbīnneTcn μ of coepnHnTenbHon Tpy6xe 3, προηρπ Ηβρθ3 «nanaH 6 m poTOByio BdaBKy 1, nonaAaeT β πθγκμθ nauMeHTa ea ΠρΟΒΘΑβΗΜΠ ΠΘΗθδΗΟΓΟ ΜΠΜ ΤρβΗΜρΟΒΟΗΗΟΓΟ CeaHCa. ΠΟΟΠΘ 3Τ0Γ0 11ΜΚΠ AblXaHMH ΠΟΒΤΟΡΠΘΤΟΠ. &Lt; DopMyna Μ3θ6ρΘΤΘΗΜΠ 1 HHranaTop, copepaoinnn cocyA 12 c οτβθροτμθμ 8 ρππ BbixoAa B03Ayxa, KoaKCManbHo ycTaHOBneHHyio BHyTpn ηθγο a3po3onbHyio into chamber 11, COeAHHeHHytO C pOTOBOH BCTaBKOH 1 ΟΤΠΜΗΘΙΟΙΑΜΜΟΗ ΤΘΜ, HTO, c LļenbtO nOBbILUeHMH 3φφΘΚΤΜΒΗ00ΤΜ Β03ΑΘΜ0ΤΒΜΠ ΗΗΓβΠ ^ ΗΟΗΗΗΧ ΒΘΙΑΘΟΤΒ Ha AbixaTenbHbiM TpaKT nauneHTa , ycTpaHeHna 3φφβκτ3 HaKannnBaHna BpeAHblX ΟΤΧΟΑΟΒ TMna MHKpOOpraHH3MOB Μ Μοκροτ B MHranBUMOHHOM jkmakoctm nb aapo3onbHOM KaMepe, a TaioKe yBennHeHnn aAanTaunoHHbix B03M0 &gt; KH0CTeM opraHH3Ma nauneHTa, nHranaTop ηΜββτ PBE oTpenbHbie aapo3onbHbie "aiviepbi 10 n 11 n nea cocflypa 12 m 13 oamh m3 KOTopbix OHmuaioiuMii, a npyroii - MHrannLiHOHHbiii, npuneM oflHa hub cocypoB -aapo3onbHaa KaMepa 11 m on the crown cocyn 12 - npeflHa3HaHeHa pnn TaKTa BbiflbixaHHf, a npyra hub cocypoB - a3po3onbHan KaMepa 10 m ixaHnsi m HacbiLueHMii B03flyiuH0fi CMEC neKapcTBeHHbiMM BemecTBaMi / i, B paCTBOpeHHblMU HHranflLļMOHHOM &gt; KMflKOCTM 15 2 MHranflTop of n.1, OTJiiiHaiomwiicsi τθμ, hto b coepnHMTenbHbix TpyčKax 2 n 3 serve napbi cocypoB (a3po3onbHan KaMepa - OHmpaiomi'M cocyp) ycTaHOBneHbi KnanaHbi 6 m 7, npuneM KnanaH 7 nponycKaeT B03flyujHyK) CMecb M3 ροτοΒοίί BCTaBKM 1 b a3po3onbHyto KaMepy 11, a KnanaH 6 nponycKaei B03flyuiHyK) CMecb M3 a3po3onbHoii KaMepbi 10 b pOTOByK 1. 3. MHrannTop from n.1 nmi 2, hto kax &lt; no nio6oMy npeflbipymeMy nyHKTy, OTJiMHatoiiMMCH τθμ, hto pbixaTenbHbie Tpy6KM 2 m 3, coennHmomne ροτοΒΟίο BCTaBKy 1 h aapo3onbHbie KaMepbi 10 m 11, βνποπηθην anacTHHHbiM H.

PeppepaT ripeflnaraeMbiii MHrannTOp (φΜΓ.1) πο3βοπηθτ npoBOflMTb πβπβΗΜβ AbixaTenbHoro Tpaicra namieHTa, Tao &lt; e TpeHnpoBKy flbixaTenbHOii CMCTeMbi c uenbK) noBbiiueHMn aflanTHaHHix B03MO &gt; KH0CTeii opraHM3Ma. MHrannTop μμθθτ pee OTpenbHbie aapo3onbHbie KaMepbi m pea OTflenbHbix cocypa, opmh M3 κοτορωχ npeflHa3HaHeH PNN οημιρθημ * B03flyiuHoii CMEC, nocTynaiouļeii M3 πθγοηηογο Tpaicra nauMeHTa Nocni Taicra Bbipoxa, a flpyroii cocyn npenHa3HaneH ρπη HacbimeHMn οηιιιιιθηηομ B03flyLUHoii CMEC neKapcTBeHHbiMM BemecTBaMii m pacnbmeHMn nx b OTpenbHoii aapo3onbHoii KaMepe, hto 3HaHMTenbHo yBennHMBaeT 300eKTMBHOCTb ycTpoiicTBa.

Claims (4)

1. An inhaler comprising a vessel 12 with an air outlet, a coaxially mounted aerosol chamber 11 connected to a mouthpiece 1, characterized in that, in order to increase the efficacy of the inhaled substances on the patient's respiratory tract, Prevent harmful remnants, microorganisms and sputum, accumulation in inhalation solution and aerosol chamber, and increase patient's adaptability and adaptability, the inhaler has two separate aerosol chambers 10 and 11 and two vessels 12 and 13, one of which is a purification vessel, but the second one is an inhalation vessel, one pair of containers - aerosol chamber 11 and a cleaning vessel 12 - intended for the exhalation tactile, and the other a pair of vessels - an aerosol chamber 10 and an inhalation vessel 13 - for saturating the inhalation tact and the air mixture with the medicated substances dissolved. inhalation solution 15. 2. An inhaler according to claim 1, characterized in that valves 6 and 7 are mounted in the connecting tubes of each pair of aerosol dispensers (aerosol chamber - purification vessel), wherein the valve 7 releases the air mixture from the oral insert 1 to the aerosol chamber 11 and the valve 6 placing the air mixture from the aerosol chamber 10 onto the mouthpiece 1. An inhaler according to claim 1 or 2, characterized in that each of the vessels 12 and 13 with the aerosol chambers 10 and 11, as well as the container 14, which covers the dishes 12 and 13 and is intended for mixing air and carbon dioxide, is adjustable openings 4, 5, 8 and 9. An inhaler according to any one of the preceding claims, characterized in that the breathing tubes 2 and 3 connecting the oral insert 1 and the aerosol cans 10 and 11 are elastic.