LV10197B - Analgestic and inflammation - suppressing medicament - Google Patents

Analgestic and inflammation - suppressing medicament Download PDF

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Publication number
LV10197B
LV10197B LVP-93-937A LV930937A LV10197B LV 10197 B LV10197 B LV 10197B LV 930937 A LV930937 A LV 930937A LV 10197 B LV10197 B LV 10197B
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populus tremula
inflammation
solidago virgaurea
fraxinus excelsior
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LVP-93-937A
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LV10197A (en
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Samuel N Okpanyi
Michaela Arens-Corell
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Steigerwald Arzneimittelwerk
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Publication of LV10197B publication Critical patent/LV10197B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/76—Salicaceae (Willow family), e.g. poplar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The use is described of the medicament with analgesic and inflammation-suppressing action based on plants and containing populus tremula, solidago virgaurea and fraxinus excelsior as the sole active vehicle as a basic therapeutic.

Description

LV 10197 TEPAnEBTUHECKM/l ΠΡΕΠΑΡΑΤEN 10197 TEPAnEBTUHECKM / l ΠΡΕΠΑΡΑΤ

OnMcaHueOnMcaHue

HacToamee M3o6peieHne othochtch κ πρμμθηθημιο 6oneyTonaK)inero m npoTMBOBocnaamenbHoro npenapaTa b KanecTBe οοηοβηογο TepaneBTMMecKoro npenapaTa. B Tepannn BocnannTenbHbix ρθβμοτοπογμμθοκμχ saSoneBaHuii, b HaCTHOCTM, peBMaTOMflHblX apTpMTOB, MCnonb3yiOTflBa pa3nMMHblX MeAHLļMHČKHX npnHLļnna. npnHunn coctomt b tom, hto yMeHbUja»OT 6onb m BocnanmenbHbie CMMnTOMbi b cycTaBax. flna 3tom qenn ncnonb3yioT pa3nnMHbie Knaccbi οοθαιίηθημμ, HanpMMep, npoM3BOflHbie cajimļiinoBOM KucnoTbi, npon3BOflHbie yKCyCHOii H ΠρΟΠΜΟΗΟΒΟΜ KMCnOTbl, ΜΠΜ OKCMKaMU. OČUļMM flna ΗΜΧ Η33Β3ΗΜΘΜ aBnaeTca "HecTeponflHbie npoTMBOpeBMaTMMecKue npenapaībi” /ΗΟΠΡΠ/. Mx aKTMBHOCTb 0146ΗΙ4ΒΒ10Τ ΠΟ MX fleilCTBMK) B CaMMX CyCTaBaX. B03fleiiCTBMH nponennioTca 6biCTpo /ot HecKonbKnx nācos no HecxonbKMX cyroic/. flo3y nofl6npatoT b 3aBticMM0CTM ot cmyaiļnn. Μ3μθηθημη b τθηθημθ BocnannTenbHoro peBMaTMHecKoro 3a6oneBaHna He «BnaioTca pe3ynbTaT0M fleiicTBna 3thx MeAMKaMeHTOB.HacToamee M3o6peieHne othochtch κ πρμμθηθημιο 6oneyTonaK) inero m npoTMBOBocnaamenbHoro npenapTa b KanecTBe οοηοβηογο TepaneBTMMecKoro npenapaTa. B Tepannn BocnannTenbHbix ρθβμοτοπογμμθοκμχ saSoneBaHuii, b HaCTHOCTM, peBMaTOMflHblX apTpMTOB, MCnonb3yiOTflBa pa3nMMHblX MeAHLMMHČKHX npnHLLnna. npnHunn coctomt b tom, hto yMeHbUja »OT 6onb m BocnanmenbHbie CMMnTOMbi b cycTaBax. flna 3tom qenn ncnonb3yioT pa3nnMHbie Knaccbi οοθαιίηθημμ, HanpMMep, npoM3BOflHbie cayimlineBOM KucnoTbi, npon3BOflHbie yKCyCHOii H ΠρΟΠΜΟΗΟΒΟΜ KMCnOTbl, ΜΠΜ OKCMKaMU. Č ļMMM flna na Η33Β3Η aBnaeTca " HecTeponflHbie npoTMBOpeBMaTMMecKue npenapius' / ΗΟΠΡΠ /. Mx aKTMBHOCTb 0146ΗΙ4ΒΒ10Τ ΠΟ MX fleilCTBMK) B CaMMX CyCTaBaX. B03fleiiCTBMH nponennioTca 6biCTpo / ot HecKonbKnx came from HecxonbKMX cyroic /. flo3y nofl6npatoT b 3aBticMM0CTM ot cmyaiļnn. Μ3μθηθημη b τθηθημθ BocnannTenbHoro peBMaTMHecKoro 3a6oneBaHna He «BnaioTca pe3ynbTaT0M fleiicTBna 3thx MeAMKaMeHTOB.

MefluunHCKuii npenapat Ha hhcto pacTnienbHoii ochobb, onncaHHbiii b 2 3aflBKe B014C WO 87/02248 Taiotce oSnapaeT ΘφφθκτβΜΗ HecieponpHbix npoTMBopeBMaTMMecKMx npenapairoB /ΗΟΠΡΓΊ/, ho o6napaeT bmcokom TonepaHTHOCTbK).MefluunHCHiPhenPHaHhcto pacTnienbHoii ochobb, HHbiii b 2 3aflBKe B014C WO 87/02248 Taiotce oSnapaeT ΘφφθκτβΜΗ HecieponpHbix npoTMBopeBMaTMMecKMx npenapairoB / ho, ho o6napaeT bmcokom TonepaHTHOCTbK).

HapBfly C OnUCaHHoil aKTMBHOCTblO, Μ3ΒΘ0ΤΗΜ μ μητθηομβηο npeonaraJOTca HOBbie npenapaTbi, KOTOpbie čnaroTBopHO βπμβιοτ Ha očmee ' ΤΘΜΘΗΗΘ ΗΘΜ3ΠΘΜΜΜΜΧ ΧρΟΗΗΜβΟΚΜΧ 3a6oneBaHMM /ΤΆΚ Ha3blBaeMbie "ΜΟΑίιφΜΜΜργιοιίίΘθ 3a6oneBaHMe neKapcTBeHHbie npenapaTbi”/. Ohh 0Ka3biBaioT βπμβηηθ na 6onb vi BocnaneHMH TonbKo b pe3ynbTaTe p/iHTenbHoro πρμμθηθηηβ /b τθμθημθ MecaueB/ npn coxpaHeHMH R03 m conpoBO>KAaiOTCB μηογο-HMCneHHblMM no604HblMM peHCTBMHMH /y ΠρΜΜΘρΗΟ TpeTM naUMeHTOB πρηχορμτόη npeKpauļaTb Taxoii xypc πθηθημβ/. I4x aKTHBHocTb nepBOHawajibHO npoBB/iaeTca b yny4iueHMH ομμπτομοβ χροημμθοκογο BocnaneHMH. 3το, b HacTHocTH, xapaiaepHO pna noKa3aienefi McnbuaHua Ha oca>KfleHne apuTpoumoB, κοτοροθ b o6meM cnyMae ncnonb3yK)T b κβηθοτβθ npouepypbi pna aHann3a BoenanMTenbHoro 3a6oneBaHHH. flpyrne McnbīTaHHH, b npMHpwne, He flaiOT HOBblX ηρΟΒΒΠΘΗΜΜ, HanpHMep, MCnblTaHMe Ha C-aKTHBHblii ΠρΟΤβΗΗ /ΟΑΠΑ flonrocpOHHOM penbīo TaKoro πθμθηιλβ ββπηθτοη yMeHbiueHMe μπμ ποπηοθ μοκπιοηθημθ pa3pytueHHH cyciaBOB b pe3ynbTaie peBMaTMMecKoro BocnaneHHa. Ta«aa Tepanna M3BecTHa b HacToamee BpeMa πορ η3Μμθηοβ3ημθμ "ochobhoh TepanMH”.HapBfly C OnUCaHHoil aKTMBHOCTblO, Μ3ΒΘ0ΤΗΜ μ μητθηομβηο npeonaraJOTca Hobbs npenapaTbi, KOTOpbie čnaroTBopHO βπμβιοτ Ha očmee 'ΤΘΜΘΗΗΘ ΗΘΜ3ΠΘΜΜΜΜΧ ΧρΟΗΗΜβΟΚΜΧ 3a6oneBaHMM / ΤΆΚ Ha3blBaeMbie " ΜΟΑίιφΜΜΜργιοιίίΘθ 3a6oneBaHMe neKapcTBeHHbie npenapaTbi "/. Ohh 0Ka3biBaioT βπμβηηθ na 6onb vi BocnaneHMH TonbKo b pe3ynbTaTe p / iHTenbHoro πρμμθηθηηβ / b τθμθημθ MecaueB / npn coxpaHeHMH R03 m conpoBO > KAaiOTCB μηογο-HMCneHHblMM no604HblMM peHCTBMHMH / y ΠρΜΜΘρΗΟ TpeTM naUMeHTOB πρηχορμτόη npeKpauļaTb Taxoii xypc πθηθημβ /. I4x aKTHBHocTb nepBOHawajibHO npoBB / iaeTca b yny4iueHMH ομμπτομοβ χροημμθοκογο BocnaneHMH. 3το, b HacTHocTH, xapaiaepHO pna noKa3aienefi McnbuaHua Ha oca > KfleHne HelpToPoB, κοτοροθ b o6meM cnyMae ncnonb3yK) T b κβηθοτβθ npouepypbi pna aHann3a BoenanMTenbHoro 3a6oneBaHHH. flpyrne McnbīTaHHH, b npMHpwne, He FLAIS HOBblX ηρΟΒΒΠΘΗΜΜ, e.g. MCnblTaHMe Ha C-aKTHBHblii ΠρΟΤβΗΗ / ΟΑΠΑ flonrocpOHHOM penbīo Takor πθμθηιλβ ββπηθτοη yMeHbiueHMe μπμ ποπηοθ μοκπιοηθημθ pa3pytueHHH cyciaBOB b pe3ynbTaie peBMaTMMecKoro BocnaneHHa. He «aa Tepanna M3BecTHa b HacToamee BpeMa πορ η3Μμθηοβ3ημθμ " ochobhoh TepanMH.

Bbhry MacTbix η βρβμβηβμη 6one3HeHHbix no6o4Hbix ΘφφβκτοΒ ημθιοτοα TmaTenbHo pa3pa6oTaHHbie npaBMna pna πθηθημβ h ncnonb30BaHM3 οοηοβημχ TepaneBTMMCKnx npnēMOB. HanpHMep, mojkho npMBecTM pe3ynbTaTbi 20-HepenbHoro ρβομηογο "χοποοτογο” McenepoBaHHa μ3ΜΘΗθημβ b HcnbuaHHH Ha occDKpeHMe apMTpoMMTOB /Bapp flacP. m pp., Arthritis and Rhcumatism τ.26, T11, 1983, CTp.1303-1315/.Bbhry MacTbix η βρβμβηβμη 6one3HeHHbix no6o4Hbix ΘφφβκτοΒ ημθιοτοα TmaTenbHo pa3pa6oTaHHbie npaBMna pna πθηθημβ h ncnonb30BaHM3 οοηοβημχ TepaneBTMMCKnx npnMOB. HanpHMep, mojkho npMBecTM pe3ynbTaTbi 20-HepenbHoro ρβομηογο " χοποοτογο ”McenepoBaHHa μ3ΜΘΗθημβ b HcnbuaHHH Ha occDKpeHMe apMTpoMMTOB / Bapp flacP. mp., Arthritis and Rhcumatism τ.26, T11, 1983, CTp.1303-1315 /.

MepHKaMeHT P03 nepep Tepannen P03 cnycTa 20 Hepenb rinaueOo 65 51 ΑγρΟΗΟφΗΗ 63 22 TnoManaiNa 30n0TMCTbIH 58 33 rpe POS = CKOpocTb ocaxpeHna sphtpouhtob b μμη/μβο, TonbKo pna nepBoro saca.MepHKaMeHT P03 nepep Tepann P03 cnycTa 20 Hepenb rinOo 65 51 ΑγρΟΗΟφΗΗ 63 22 TnoManaiNa 30n0TMCTbIH 58 33 rpe POS = CKOpocTb ocaxpeHna sphtpouhtob b μμη / μβο, TonbK pna notBoro saca.

HeojKMpaHHbiM o6pa30M 6bino ycTaHOBneHo b pe3ynbTaie HccnepoeaHMa 3 LV 10197 b pa3riMHHbix nccneflOBaienbCKMx ueHTpax, hto ocHOBHbix TepaneBTMHecKMx ΘφφΘΚΤΟΒ flOCTMraKDT TaiOKe npM MCn0nb30BaHMM MeflMLļMHCKOrO npenapaia, πρθρπωκΘΗΗΟΓΟ b 3aflBKe WO 87/02248. 3tot MeflMKaMeHT, o6naflaK)Lunii 6oneyTormiomw\/i μ προτΜΒΟ- BOcnanmenbHbiM οθμοτβμθμ, Ha pacTMTenbHotf οοηοβθ, OTnuMaeica conep>KaHMeM Populus tremula, Solidago Virgaurea v\ Fraxinus exce!sior bHeojKMpaHHbiM o6pa30M 6bino ycTaHOBneHo b pe3ynbTaie HccnepoeaHMa 3 EN 10197 b pa3riMHHbix nccneflOBaienbCKMx ueHTpax, whereby to ocHOBHbix TepaneBTMHecKMx ΘφφΘΚΤΟΒ flOCTMraKDT TaiOKe NPM MCn0nb30BaHMM MeflMLļMHCKOrO npenapaia, πρθρπωκΘΗΗΟΓΟ b 3aflBKe WO 87/02248. 3tot MeflMKaMeHT, o6naflaK) Lunii 6oneyTormiomw / i μ προτΜΒΟ- BOcnanmenbHbiM οθμοτβμθμ, Ha pacTMTenbHotf οοηοβθ, OTnuMaeica conep > KaHMM Populus tremula, Solidago Virgaurea v

KanecTBe eflMHCTBeHHbix HOCMTeneii aKTMBHOCTM. B npeflnoHTmenbHOM BapnaHTe npenapaT, HBnaioiuMiicfl πρββΜβτοΜKanecTBe eflMHCTBeHHbix HOCMTenei aKTMBHOCTM. B npeflnoHTmenbHOM BapnaHTe npenapaT, HBnaioiuMiicfl πρββΜβτοΜ

HacToamero Μ3θ6ρβτβΗΜΑ, copepaorr 50-70 o6i»ēMHbix % Populus tremula,10-30 ο6ι.θμημχ % Solidago Virgaurea m 10-30 ο6τ>§μημχ % FraXinus excelsior. B ocočeHHO npennoMTmenbHOM BapnaHTe HaoToamero M3o6peieHna κομπο3μι4μη copepJKUT npuMepHO 60 o6i»ēMHbix % Populus tremula, 20 o6-bēMHbix % Solidago Virgaurea m 20 o6tēMHbix % Fraxinus excelsior.HacToamero Μ3θ6ρβτβΗΜΑ, copepaorr 50-70 o6i »EHHix% Populus tremula, 10-30 ο6ι.θμημχ% Solidago Virgaurea m 10-30 ο6τ > §μημχ% FraXinus excelsior. B ocočeHHO npennoMTmenbHOM BapnaHTe HaoToamero M3o6peieHna κομπο3μι4μη copepJKUT npuMepHO 60 o6iMHbix% Populus tremula, 20o6-beHHix% Solidago Virgaurea m 20 oTeMHbix% Fraxinus excelsior.

HaKOHeu, b οοοτβθτοτβμμ c HacToamnM μ3ο6ρθτθημθμ b κομποηθητθHaKOHeu, b οοοτβθτοτβμμ c HacToamnM μ3ο6ρθτθημθμ b κομποηθητθ

Populus tremula Kopa n nncTba conepttaTca b οοοτηοιιιθημμ 1:2.Populus tremula Kopa n nncTba conepttaTca b οοοτηοιιιθημμ 1: 2.

HacToamee M3odpeTeHne ocHOBaHO Ha Heo>KMflaHHOM οτκρΗΤΜΜ, 3aKmoMaiomeMCfl b tom, hto stot MeflmļMHCKMii npenapaT mojkho ncnonb30BaTbHacToamee M3odpeTeHne ocHOBaHO Ha Heo KMflaHHOM οτκρΗΤΜΜ, 3aKmoMaiomeMCfl b tom, hto stot MeflmlMHCKMii npenapaT mojkho ncnonb30BaTb

He TonbKO ρπίΐ ΗβΜβρπβΗΗΟΓΟ πβΗβΗΜΗ ρβΒΜ3ΤΜΗβοκΜΧ 3a6oneBaHWii, ΗΟ, Β čonbmeii CTeneHH, TaiOKe b KanecTBe ochobhoto TepaneBTMHecKoro areHTa. B KanecTBe npmviepa οοηοβηογο TepaneBTunecKoro αθμοτβμλHe TonbKO ρπίΐ ΗβΜβρπβΗΗΟΓΟ πβΗβΗΜΗ ρβΒΜ3ΤΜΗβοκΜΧ 3a6oneBaHWii, ΗΟ, on čonbmeii CTeneHH, TaiOKe b KanecTBe ochobhoto TepaneBTMHecKoro areHTa. B KanecTBe npmviepa οοηοβηογο TepaneBTunecKoro αθμοτβμλ

MeflMUMHCKoro npenapaTa, HB/iaiomerocH πρθαμθτομ HaoToamero Μ3ο6ρβτβΗΜΛ,MeflMUMHCKoro npenapaTa, HB / iaiomerocH πρθαμθτομ HaoToamero Μ3ο6ρβτβΗΜΛ,

Hn>Ke BOcnpon3BepeHbi pe3y/ibTaTbi MccneflOBaHMii β ρθβμ3τοπογμηθοκομ OTfleneHMM rocnMTana, b nacTHOc™, β φορΜθ P03-3HaHeHMii pna npenapaTa, oniicaHHoro b 3aaBKe WO 87/02248. Mo>kho BMfleTb ηβηοθ οημχθημθ stmx 3ΗΒΗβΗΜΜ. C yBepeHHOCTblO MO)KHO CKa3aTb, HTO 6narOJļapfl ΠρΜΜβΗβΗΜΚ) npenapaTa, onncaHHoro b 3aaBxe WO 87/02248, BocnanMTenbHaa aKTMBHOCTb peBMaTonorviHecKMX 3a6oneBaHnii, BbipaaceHHaa b TepMMHax C-aKTMBHoro * npoTeMHa, ηβηο οημχοθτοη. HeKOTopbie pe3ynbTaTbi npnBefleHbi ημ>κθ β βμαθ Ta6nnubi: P03-3HaHeHMaHn > Ke BOcnpon3BepeHbi pe3y / ibTaTbi MccneflOBaHMii β ρθβμ3τοπογμηθοκομ OTfleneHMM rocnMTana, b nacTHOc? Mo > body BMfleTb ηβηοθ οημχθημθ stmx 3ΗΒΗβΗΜΜ. C yBepeHHOCTblO MO) KOH CKa3aTb, HTO 6narOJļapfl ΠρΜΜβΗβΗΜΚ) technology ', onncaHHoro b 3aaBxe WO 87/02248, BocnanMTenbHaa aKTMBHOCTb peBMaTonorviHecKMX 3a6oneBaHnii, BbipaaceHHaa b TepMMHax C-aKTMBHoro * npoTeMHa, ηβηο οημχοθτοη. HeKOTopbie pe3ynbTaTbi npnBefleHbi ημ > κθ β βμαθ Ta6nnubi: P03-3HaHeHMa

BpeMeHHOM MHTepBan CpeflHee 3HaHeHMe ±CT. ΟΤΚΠΟΗΘΗΜβ riepen WO 87/02248 46,2 32,1 CnycTa 3 Mecaua 37,4 30,9 CnycTH 6 MecapeB 32,9 26,4 CnycTa 9 Mecauee 29,4 21,8 CnycTa 12 MecaueB 27,9 21,3 4 Ηθο6χοαμμο MMeTb BBMpy, hto b stom cnynae naMneHTbi b o6enx rpynnax, ynacTByiomMx b nccnenoBaHnax, pono/iHMTenbHO nopBeprariMCb flnMTenbHOM ocHOBHoii TepanMM, KOTopaa 6bina Hanaia 3anonro po Hanana MCPblTaHMM. 3ī0 ΗΜΗβΓΟ ΗΘ ΜΘΗΑΘΤ, TaK KaK ΟΉφΜΤΜβ 6binO HeOJKMpaHHblM. 3φφβκπ>ι 6binn pe3ynbTaT0M βο3ρθμοτβμη npenapaTa Ha pacTMTenbHoii οοηοβθ b cooTBeTCTBMM c WO 87/02248, cnepoBaTenbHO, ohm npeBbiiuaiOT y*e flOcmrHyTbie ΘφφθκτΜ. B stom cnynae rpynny npenapaTOB Ha pacTMTenbHoii οοηοβθ, npeflnox<eHHbix b WO 87/02248, HaHMHanM c 6onee He6naronpMHTHbix θηθηθημμ, ΗΘΜ rpynny nnapeOo. ļipu ΘΤΜΧ yCnOBMHX B MCnblTaHMM Ha ΟΟΘΧΡβΗΜβ SpMTpOLļMTOB ΟΗΜΧβΗΜβ Ha 31 % flBrmeTca 3HanMTenbHbiM θφφβκτοΜ.BpeMeHHOM MHTepBan CpeflHee 3HaHeHMe + CT. ΟΤΚΠΟΗΘΗΜβ tire WO 87/02248 46,2 32,1 CnycTa 3 Mecaua 37,4 30,9 CnycTH 6 MecapeB 32,9 26,4 CnycTa 9 Mecauee 29,4 21,8 CnycTa 12 MecaueB 27,9 21,3 4 Ηθο6χοαμμο MMeTb BBMpy, hto b stom cnynae naMneHTb b o6enx rpynnax, ynacTByiomMx b nccnenoBaHnax, pono / iHMTenbHO nyBeprariMCb flnMTenbHOM ocHOBHoii TepanMM, KOTopaa 6bina Hanaia 3anonro po Hanana MCPblTaHMM. 3i0 ΗΜΗβΓΟ ΗΘ ΜΘΗΑΘΤ, TaK KaK ΟΉφΜΤΜβ 6binO HeOJKMpaHHblM. 3φφβκπ > ι 6binn pe3ynbTaT0M βο3ρθμοτβμη npenapaTa ha pacTMTenbHoii οοηοβθ b cooTBeTCTBMM c WO 87/02248, cnepoBaTenbHO, ohm npeBbiiuaiOT y * e flOcmrHyTbie ΘφφθκτΜ. B stom cnynae rpynny npenapTOB If pacTMTenbHoii οοηοβθ, npeflnox < eHHbix b WO 87/02248, HaHMHanM c 6onee He6naronpMHTHbix θηθηθημμ, ΗΘΜ rpynny nnapeOo. ipu yCnOBMHX B MCnblTaHMM If ΟΟΘΧΡβΗΜβ SpMTpOLLMTOB ΟΗΜΧβΗΜβ Ha 31% flBrmeTca 3HanMTenbHbiM θφφβκτοΜ.

Bo BpeMH MccnepoBaHMn Ha 5 naqneHTax, CTpapafomMx peBMaTMHecKMM apTpmoM, KOTopbie yxe nopBepranMCb πθηθημιο, OKa3anocb, mo b pe3ynbiaTe flononHmenbHoro πρμμθηθημβ npenapaTa Ha pacTHTenboii οοηοβθ no 3anBKe BOMC WO 87/02248, μ3μθηθημ« b HanpaBneHMM yMeHbiueHMn, T.e. b TepaneBTMHecKOM HanpaBneHHH, μμθιοτ μθοτο pnn μοχορημχ 3HaneHMM b τρδχ M3 πβτμ cnywaeB b μοπμτθημμ Ha oca^KpeHMM apMTpopMTOB m b HeTbipēx M3 πατμ CnynaeB C C-aKTMBHbIM ΠρΟΤβΜΗΟΜ B ΤΘΗΘΗΜΘ neTbipēx Hepenb. 3τοτ θφφθκτ nenne tca ypMBMTenbHbiM no HecKonbKMM npMHMHaM: 1. flo3bi, ncnonb3yeMbie b stom cnynae, ηθ onpepennnM oTHocmenbHO ocHOBHoii TepaneBTMHecKOM 3κτμβηοοτμ. Ohm cooTBeTCTByioT CKopee Bcero A03aM OTHOCMTenbHO CMMnTOMaTMnecKOM TepanMM. 2. 05HapyxeHHbie θφφβκτΜ ββπβιοτοα pononHMTenbHbiMM ΘφφβκτβΜΜ b yxe ocymecTBnaeMOM ochobhom TepanMM. Ebino 6bi θτμηθοκμ HeonpaBpaHHbiM 0TKa3biBaTbcn οτ μ3βθοτηομ 3φφβκτΜΒΗ0Μ TepanMM cepbē3H0 OonbHbiM. Ebino coBepuieHHO Heo>KMpaHHbiM, hto panbHeMiuee yBennMeHne b ochobhom TepaneBTMHecKOM θκτμβηοοτμ μμθθτ μθοτο ceepx θτομ TpapMpMOHHofi TepanMM. 3. ΗβοβχορΜΜΟ MMeTb b BMpy, hto npenapaT Ha pacTMTenbHoii οοηοβθ no 3anBKe WO 87/02248 ropa3po 6onee TonepaHTeH, ηθμ ppyrMe προτΜΒΟ-peBMaTMHCKMe npenapaTbi. OTCiopa cnepyeT, hto ΜΜββτοη B03M0>KH0CTbBo BpeMH MccnepoBaHMn H 5 naqneHTax, CTpapafomMx peBMaTMHecKMM apTpmoM, KOTopbie yxe nopBepranMCb πθηθημιο, OKa3anocb mo b pe3ynbiaTe flononHmenbHoro πρμμθηθημβ technology 'H pacTHTenboii οοηοβθ of 3anBKe BOMCA WO 87/02248, μ3μθηθημ "b HanpaBneHMM yMeHbiueHMn, T.e. b TepaneBTMHecKOM HanpaBneHHH, μμθιοτ μθοτο pnn μοχορημχ 3HaneHMM b τρδχ M3 πβτμ cnywaeB μμπμτθημμ Ha oca ^ KpeHMM apMTpopMTOB m b HeTbippex M3 πατμ Cnynae C C-aKTMBHbIM ΠρΟΤβΜΗΟΜ B ΤΘΗΘΗΜΘ neTbipx Hepenb. 3τοτ θφφθκτ nenne tca ypMBMTenbHbiM from HecKonbKMM npMHMHaM: 1. flo3bi, ncnonb3yeMbie b stom cnynae, ηθ onpepennnM oTHocmenbHO ocHOBHoii TepaneBTMHecKOM 3κτμβηοοτμ. Ohm cooTBeTCTByioT CKopee Bcero A03aM OTHOCMTenbHO CMMnTOMaTMnecKOM TepanMM. 2. 05HapyxeHHbie θφφβκτΜ ββπβιοτοα pononHMTenbHbiMM ΘφφβκτβΜΜ b yxe ocymecTBnaeMOM ochobhom TepanMM. Ebino 6bi θτμηθοκμ HeonpaBpaHHbiM 0TKa3biBaTbcn οτ μ3βθοτηομ 3φφβκτΜΒΗ0Μ TepanMM in oven 3H0 OonbHbiM. Ebino coBepuieHHO Heo KMpaHHbiM, hto panbHeMiue yBennMeHne b ochobhom TepaneBTMHecKOM θκτμβηοοτμ μμθθτ μθοτο ceepx θτομ TpapMpMOHHofi TepanMM. 3. ΗβοβχορΜΜΟ MMeTb b BMpy, hto npenapaT Ha pacTMTenbHoii οοηοβθ no 3anBKe WO 87/02248 ropa3po 6onee TonepaHTeH, ηθμ ppyrMe προτΜΒΟ-peBMaTMHCKMe npenapaTbi. OTCiopa cnepyeT, hto ΜΜββτοη B03M0 > KH0CTb

3.1. pocTMrHyTb 6onee 3HaHMTenbHbix ΘφφβκτοΒ npM noMomM 6onee BblCOKMX Π03 M 3.2. yBenMHMTb μχ 3φφβκτΜΒΗοση> npM πομοιμμ pononHMTenbHoro Mcnonb30BaHMn npenapaTa no 3anBKe BOMC WO 87/02248, b ροποπΗβΗΜβ κ TpapMLļMOHHOM TepanMM. 5 LV 10197 ΦΟΡΜΥΠΑ M30EPETEHHfl 1. Πρμμθηθημθ npenapaTa Ha pacTmenbHoii οοηοβθ, copep^ainero b KanecTBe aKTiiBHoro Hanana cneflyK)mne κομποηθητβι:3.1. pocTMrHyTb 6onee 3HaHMTenbHbix ΘφφβκτοΒ npM noMomM 6onee BblCOKMX Π03 M 3.2. yBenMHMTb μχ 3φφβκτΜΒΗοση > npM πομοιμμ pononHMTenbHoro Mcnonb30BaHMn nppaAn 3anBKe BOMC WO 87/02248, b ροποπΗβΗΜβ κ TpapMLMOHHOM TepanMM. 5 EN 10197 30 M30EPETEHHfl 1. Πρμμθηθημθ npenapaTa If pacTmenbHoii οοηοβθ, copep ^ ainero b KanecTBe aKTiiBHoro Hanana cneflyK) mne κομποηθητβι:

Populus tremula Solidago Virgaurea Fraxinus ExceIsior b KanecTBe οοηοβηογο TepaneBTunecKoro npenapaTa. 2. Πρμμθηθημθ no π.1 npenapaTa, copep>Kamero 50-70 o6.% Populus tremula 10-30 o6.% Solidago Virgaurea 10-30 o6.% Fraxinus Excelsior 3. ΠρίΊΜβΗβΗΜβ no π.1 npenapaTa, copepacamero 60 o6.% Populus tremula 20 o6.% Solidago Virgaurea 20 o6.% Fraxinus Excelsior 4. ΠρΜΜβΗβΗΜβ no n.1 npenapaTa, β κοτοροΜ κομποηθητ Populus tremula conep>KMT Kopy m nncTbH β cooTHomeHMM 1:2. 6 ΡΕΦΕΡΑΤPopulus tremula Solidago Virgaurea Fraxinus ExceIsior b KanecTBe οοηοβηογο TepaneBTunecKoro npenapaTa. 2. Πρμμθηθημθ no π.1 npenapaTa, copep > Chamber 50-70 o6%% Populus tremula 10-30 o6% Solidago Virgaurea 10-30 o6% Fraxinus Excelsior 3. ΠρίΊΜβΗβΗΜβ no π.1 npenapaTa, copepacamero 60 o6% Populus tremula 20 o6% Solidago Virgaurea 20% Fraxinus Excelsior 4. ΠρΜΜβΗβΗΜβ no n.1 npenapaTa, β κοτοροΜ κομποηθητ Populus tremula conep > KMT Kopy m nncTbH β cooTHomeHMM 1: 2. 6 ΡΕΦΕΡΑΤ

npeflnaraeTCfl πρΜΜβΗΛπ» npenapaT, o6nanaiomMii 6oneyTonaiomeii m npoTMBOBOcnanuTenbHoii aKTMBHOCTbK), Ha pacTMTenbHoii οοηοβθ, conepaoinMMnpeflnaraeTCfl πρΜΜβΗΛπ »npenapaT, o6nanaiomMii 6oneyTonsome m npoTMBOBOcnanuTenbHoii aKTMBHOCTbK), Ha pacTMTenbHoii οοηοβθ, conepaoinMM

Populus tremula Solidago Virgaurea Fraxinus Excelsior b KanecTBe θαμηοτβθηηογο οοηοβηογο TepaneBTMMecKoro npenapaia.Populus tremula Solidago Virgaurea Fraxinus Excelsior b KanecTBe θαμηοτβθηηογο οοηοβηογο TepaneBTMMecKoro npenapaia.

Claims (4)

LV 10197 IZGUDROJUMA FORMULA 1. Augu valsts preparāta izmantošana, kurš kā aktīvās vielas satur sekojošus komponentus: Populus tremula Solidago virgaurea Fraxinus excelsior par terapeitiskā preparāta pamatu.Use of a herbal preparation which, as active ingredients, contains the following components: Populus tremula Solidago virgaurea Fraxinus excelsior as the basis for a therapeutic preparation. 2. Preparāta izmantošana, saskaņā ar 1. punktu, kas atšķiras ar to, ka satur 50-70 tilp.% Populus tremula 10-30 tilp.% Solidago virgaurea 10-30 tilp.% Fraxinus excelsiorUse of the preparation according to claim 1, comprising 50-70% by volume of Populus tremula 10-30% by volume Solidago virgaurea 10-30% by volume Fraxinus excelsior 3. Preparāta izmantošana, saskaņā ar 1. punktu, kas atšķiras ar to, ka satur 60 tilp.% Populus tremula 20 tilp.% Solidago virgaurea 20 tilp.% Fraxinus excelsior3. Use of the preparation according to claim 1, comprising 60% by volume of Populus tremula 20% by volume Solidago virgaurea 20% by volume Fraxinus excelsior 4. Preparāta izmantošana, saskaņā ar 1. punktu, kas atšķiras ar to, ka komponents Populus tremula satur mizu un lapas attiecībUse of the preparation according to claim 1, characterized in that the component Populus tremula contains bark and leaf ratio
LVP-93-937A 1989-07-11 1993-06-30 Analgestic and inflammation - suppressing medicament LV10197B (en)

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EP89112639A EP0407634B1 (en) 1989-07-11 1989-07-11 Analgetic and antiinflammatory medicine
PCT/EP1990/001114 WO1991000735A1 (en) 1989-07-11 1990-07-09 Analgesic and inflammation-suppressing medicament

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LV10197B true LV10197B (en) 1995-04-20

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ATE91898T1 (en) 1993-08-15
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CA2035443A1 (en) 1991-01-12
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HU212264B (en) 1996-04-29
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EP0407634A1 (en) 1991-01-16
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EP0407634B1 (en) 1993-07-28
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