LV10100A - Purine nucleoside phosphorylase inhibitors and their uptake - Google Patents
Purine nucleoside phosphorylase inhibitors and their uptakeInfo
- Publication number
- LV10100A LV10100A LV930342A LV930342A LV10100A LV 10100 A LV10100 A LV 10100A LV 930342 A LV930342 A LV 930342A LV 930342 A LV930342 A LV 930342A LV 10100 A LV10100 A LV 10100A
- Authority
- LV
- Latvia
- Prior art keywords
- uptake
- purine nucleoside
- nucleoside phosphorylase
- phosphorylase inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/35—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/40—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/429,099 US5008265A (en) | 1989-10-31 | 1989-10-31 | 2-amino-7-(alicyclomethyl)-3H,5H,-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same |
US07/429,097 US5008270A (en) | 1989-10-31 | 1989-10-31 | 2-amino-7-(heterocyclomethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same |
US07/429,098 US4985434A (en) | 1989-10-31 | 1989-10-31 | 7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical uses and compositions containing the same |
US07/429,100 US4985433A (en) | 1989-10-31 | 1989-10-31 | 2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same |
US44279889A | 1989-11-29 | 1989-11-29 | |
PCT/US1990/005756 WO1991006548A1 (en) | 1989-10-31 | 1990-10-12 | Inhibitors of purine nucleoside phosphorylase |
Publications (2)
Publication Number | Publication Date |
---|---|
LV10100A true LV10100A (en) | 1994-05-10 |
LV10100B LV10100B (en) | 1995-08-20 |
Family
ID=27541578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-93-342A LV10100B (en) | 1989-10-31 | 1993-05-14 | Inhibitors of purine nucleoside phosphorylase |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0500653A4 (en) |
JP (1) | JP2866478B2 (en) |
AU (1) | AU654264B2 (en) |
CA (1) | CA2072123C (en) |
FI (1) | FI103972B1 (en) |
HU (1) | HUT61765A (en) |
LV (1) | LV10100B (en) |
NO (1) | NO301423B1 (en) |
WO (1) | WO1991006548A1 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5726311A (en) * | 1989-11-29 | 1998-03-10 | Biocryst Pharmaceuticals, Inc. | 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo 3,2-d!pyrimidine and pharmaceutical uses and compositions containing the same |
US5236926A (en) * | 1992-02-03 | 1993-08-17 | Warner-Lambert Company | 9-substituted-8-halo or -8-hydroxy-9-deazaguanines as inhibitors or PNP for pharmaceutical compositions |
JPH07507062A (en) * | 1992-04-21 | 1995-08-03 | バイオクリスト・ファーマシューティカルズ・インコーポレイテッド | 7-Disubstituted-methyl-4-oxo-3H,5H-pyrrolo[3,2-d]pyrimidine and pharmaceutical uses and compositions containing the same |
AU695032B2 (en) * | 1994-10-05 | 1998-08-06 | Darwin Discovery Limited | Purine and guanine compounds as inhibitors of PNP |
GB9520364D0 (en) * | 1995-10-05 | 1995-12-06 | Chiroscience Ltd | Compouundds |
GB9520363D0 (en) * | 1995-10-05 | 1995-12-06 | Chiroscience Ltd | Compounds |
AU8210798A (en) * | 1997-05-29 | 1998-12-30 | Novartis Ag | 2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydro-pyrrolo (3,2-d)pyrimidin-4-ones |
US6174888B1 (en) | 1998-05-28 | 2001-01-16 | Novartis Ag | 2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydropyrrolo[3,2-D]pyrimidin-4-ones |
JP4496586B2 (en) * | 2000-01-24 | 2010-07-07 | 日産化学工業株式会社 | Process for producing quinolylacrylonitrile and its intermediate |
ATE505474T1 (en) * | 2002-08-21 | 2011-04-15 | Einstein Coll Med | INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES |
NZ523970A (en) * | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
EP2225226B1 (en) | 2007-12-26 | 2016-08-17 | Critical Outcome Technologies, Inc. | Compounds and their use in a method for treatment of cancer |
EP2318406B1 (en) | 2008-07-17 | 2016-01-27 | Critical Outcome Technologies, Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
EP3235818A3 (en) | 2010-04-01 | 2018-03-14 | Critical Outcome Technologies, Inc. | Compounds for the treatment of hiv |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5988484A (en) * | 1982-11-09 | 1984-05-22 | Takeda Chem Ind Ltd | Novel 7-deazapurine derivative |
CA1293727C (en) * | 1986-08-26 | 1991-12-31 | Catherine Rose Kostlan | 9-deazaguanines |
US4921858A (en) * | 1986-10-24 | 1990-05-01 | Warner-Lambert Company | 7-deazaguanines as immunomodulators |
CA1294960C (en) * | 1986-10-24 | 1992-01-28 | Thomas C. Malone | 7-deazaguanines as immunomodulators |
DE3726044A1 (en) * | 1987-02-11 | 1988-08-25 | Bayer Ag | ACARICIDES ON THE BASIS OF AZOMETHINE DERIVATIVES AND AZOMETHINE OF 2,3-DIAMINOMALEAINSAURENITRILE |
US4927830A (en) * | 1988-04-08 | 1990-05-22 | The Regents Of The University Of Michigan | Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents |
WO1990010631A1 (en) * | 1989-02-27 | 1990-09-20 | Biocryst | 9-substituted-8-unsubstituted-9-deazaguanines |
US4985433A (en) * | 1989-10-31 | 1991-01-15 | Biocryst, Inc. | 2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same |
US4985434A (en) * | 1989-10-31 | 1991-01-15 | Biocryst, Inc. | 7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical uses and compositions containing the same |
-
1990
- 1990-10-12 WO PCT/US1990/005756 patent/WO1991006548A1/en not_active Application Discontinuation
- 1990-10-12 AU AU67125/90A patent/AU654264B2/en not_active Ceased
- 1990-10-12 EP EP90916628A patent/EP0500653A4/en not_active Withdrawn
- 1990-10-12 JP JP2515550A patent/JP2866478B2/en not_active Expired - Lifetime
- 1990-10-12 HU HU9201450A patent/HUT61765A/en unknown
- 1990-10-12 CA CA002072123A patent/CA2072123C/en not_active Expired - Fee Related
-
1992
- 1992-04-28 FI FI921900A patent/FI103972B1/en active
- 1992-04-29 NO NO921679A patent/NO301423B1/en not_active IP Right Cessation
-
1993
- 1993-05-14 LV LVP-93-342A patent/LV10100B/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO921679D0 (en) | 1992-04-29 |
FI103972B (en) | 1999-10-29 |
HU9201450D0 (en) | 1992-09-28 |
JP2866478B2 (en) | 1999-03-08 |
FI921900A0 (en) | 1992-04-28 |
NO921679L (en) | 1992-06-17 |
EP0500653A4 (en) | 1995-08-23 |
FI103972B1 (en) | 1999-10-29 |
HUT61765A (en) | 1993-03-01 |
FI921900A (en) | 1992-04-28 |
AU6712590A (en) | 1991-05-31 |
CA2072123C (en) | 2001-06-12 |
NO301423B1 (en) | 1997-10-27 |
AU654264B2 (en) | 1994-11-03 |
CA2072123A1 (en) | 1991-05-01 |
EP0500653A1 (en) | 1992-09-02 |
JPH05504551A (en) | 1993-07-15 |
LV10100B (en) | 1995-08-20 |
WO1991006548A1 (en) | 1991-05-16 |
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