LU602198B1 - Implantable wireless monitor for measuring portal vein blood pressure - Google Patents

Implantable wireless monitor for measuring portal vein blood pressure

Info

Publication number
LU602198B1
LU602198B1 LU602198A LU602198A LU602198B1 LU 602198 B1 LU602198 B1 LU 602198B1 LU 602198 A LU602198 A LU 602198A LU 602198 A LU602198 A LU 602198A LU 602198 B1 LU602198 B1 LU 602198B1
Authority
LU
Luxembourg
Prior art keywords
portal vein
pressure
signal
blood pressure
conditioning circuitry
Prior art date
Application number
LU602198A
Other languages
French (fr)
Inventor
Xing Chen
Original Assignee
Univ Beihang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Beihang filed Critical Univ Beihang
Application granted granted Critical
Publication of LU602198B1 publication Critical patent/LU602198B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • A61B5/02152—Measuring pressure in heart or blood vessels by means inserted into the body specially adapted for venous pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6876—Blood vessel

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Physiology (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

The present application provides an implantable wireless monitor for measuring portal vein blood pressure, including a pressure sensing element, a signal conditioning circuitry and a wireless transceiver. The pressure sensing element is implanted in a portal vein of a patient and connected to the signal conditioning circuitry; the signal conditioning circuitry is implanted in subcutaneous tissue of the patient and wirelessly connected to the wireless transceiver, and the signal conditioning circuitry is used for processing the pressure signal in the portal vein to generate pressure data in the portal vein; and the wireless transceiver is used for displaying the pressure data in the portal vein in real time to monitor the portal vein blood pressure of the patient in real time. In the present application, the portal vein pressure can be monitored in real time with continuity and accuracy.

Description

DESCRIPTION
IMPLANTABLE WIRELESS MONITOR FOR MEASURING PORTAL VEIN
BLOOD PRESSURE
TECHNICAL FIELD
The present application relates to the field of blood pressure monitoring, and in particular to an implantable wireless monitor for measuring portal vein blood pressure.
BACKGROUND
Portal hypertension is a clinical syndrome of increased blood pressure in the portal system caused by many factors, which is commonly seen in patients with cirrhosis.
Traditional portal vein blood pressure monitoring techniques, including percutaneous transhepatic puncture and hepatic vein pressure gradient measurement, are limited by their invasive nature, lack of real-time continuous monitoring, operator dependency, and high complication risks, significantly constraining their clinical applicability.
SUMMARY
An objective of the present application is to provide an implantable wireless monitor for measuring portal vein blood pressure, which enable a real-time, continuous and accurate monitoring paradigm for evaluating cirrhosis.
In order to achieve the above objective, the present application provides the following solutions.
The present application provides an implantable wireless monitor for measuring portal vein blood pressure, including a pressure sensing element, a signal conditioning circuitry, and a wireless transceiver,
the pressure sensing element is implanted inside a portal vein of a patient and connected to the signal conditioning circuitry, and the pressure sensing element is used for measuring blood pressure in the portal vein which is processed by signal conditioning circuitry in real time; the signal conditioning circuitry is implanted in subcutaneous tissue of the patient and wirelessiy communicated to the wireless transceiver outside of patient body, the signal conditioning circuitry is used for processing the pressure signal in the portal vein to obtain blood pressure data in the portal vein, and wirelessly sending the processed data to the wireless transceiver; and the wireless transceiver is used for transmitting and receiving data signals to monitor the portal vein blood pressure of the patient in real time.
Alternatively, the pressure sensing element includes a hemispherical head, a groove, and a pressure sensor chip; and the groove is fixed to the hemispherical head, and the pressure sensor chip is positioned in the groove.
Alternatively, the material of the hemispherical head is biocompatible silicone.
Alternatively, the groove is a metallic U-shaped groove.
Alternatively, the pressure sensor chip is connected to a metal below the groove through epoxy.
Alternatively, the pressure sensor chip is a piezoresistive sensor with a half-bridge circuit.
Alternatively, the implantable wireless monitor for measuring portal vein blood pressure further includes an insulated flexible lead, and the pressure sensing element is connected to the signal conditioning circuitry through the insulated flexible lead.
Alternatively, the signal conditioning circuitry is on a flexible printed circuit board.
Alternatively, the signal conditioning circuitry includes a power supply circuit and a signal amplification circuit, a filter circuit, an analog-to-digital conversion circuit and a wireless transmission circuit operatively connected in sequence, and the power supply circuit is connected to the signal amplification circuit, the filter circuit, the analog-to-digital conversion circuit and the wireless transmission circuit;
the signal amplification circuit is further connected to the pressure sensing element to receive the blood pressure signal in the portal vein and amplify the pressure signal in the portal vein to obtain an amplified signal; the filter circuit is used for filtering the amplified signal to obtain a filtered signal; the analog-to-digital conversion circuit is used for converting the filtered signal into digital signals to obtain the digitalized portal vein blood pressure data; and the wireless transmission circuit is communicated with the wireless transceiver to send the pressure data in the portal vein outside.
Alternatively, the wireless transceiver receives and displays portal vein blood pressure in waveform format.
According to specific examples provided by the present application, the present application discloses the following technical effects.
According to the implantable wireless monitor for measuring portal vein blood pressure provided by the present application, by implanting the pressure sensing element in the portal vein of the patient, and the blood pressure change of the portal vein can be monitored accurately in real time; the signal conditioning circuitry is implanted in the subcutaneous tissue of the patient, which will not disrupt the normal blood flow; and the blood pressure data in the portal vein is sent to the wireless transceiver outside of patients in a wireless manner, which makes the data collection and monitoring noninvasive, alleviating patient discomfort while reducing workload of healthcare providers; and displays the pressure data in the portal vein in real time through the wireless transceiver, thus realizing real-time, continuous and accurate monitoring of the portal vein blood pressure.
BRIEF DESCRIPTION OF THE DRAWINGS
To explain the technical solutions of examples in the present application or in the related art more clearly, the accompanying drawings required in the description of the examples or the related art are introduced briefly below. Obviously, the accompanying drawings in the following description are only some examples of the present application, and other accompanying drawings can be obtained according to these accompanying drawings without creative efforts for those ordinary skilled in the art.
FIG. 1 is a schematic diagram of an overall structure of an implantable wireless monitor for measuring portal vein blood pressure according to an example of the present application.
FIG. 2 is a schematic diagram of a connection between a pressure sensing element and a signal conditioning circuitry according to an example of the present application.
FIG. 3 is a schematic diagram of the pressure sensing element according to an example of the present application.
FIG. 4 is a schematic diagram of an implantable wireless monitor for measuring portal vein blood pressure according to an example of the present application.
Reference numerals and denotations thereof: 1-pressure sensing element, 2-signal conditioning circuitry, 3-wireless transceiver, 4- hemispherical head, 5-groove, 6-pressure sensor chip, 7-insulated flexible lead, 8-sensor protection adhesive, 9-power supply circuit, 10-signal amplification circuit, 11-filter circuit, 12-analog-to-digital conversion circuit, and 13-wireless transmission circuit.
DETAILED DESCRIPTION
Technical solutions in the examples of the present application will be described clearly and completely in the following with reference to the attached drawings in the examples of the present application. Obviously, all the described examples are only some, rather than all examples of the present application. Based on the examples in the present application, all other examples obtained by those ordinary skilled in the art without creative efforts belong to the protection scope of the present application.
In the present application, combined microchip and wireless transmission technology, real-time, continuous and accurate monitoring of portal vein pressure is realized by implantation, which overcoming the limitations of traditional methods.
In order to make the above objectives, features and advantages of the present application more apparent and easily understood, the present application will be described in further detail below with reference to the accompanying drawings and detailed description.
In an exemplary example, as shown in FIGS. 1 and 2, an implantable wireless monitor for measuring portal vein blood pressure is provided, including a pressure sensing element 1, a signal conditioning circuitry 2 and a wireless transceiver 3.
The pressure sensing element 1 is implanted in a portal vein of a patient and connected to the signal conditioning circuitry 2, and the pressure sensing element 1 is used for detecting pressure in the portal vein in real time and sending a pressure signal in the portal vein to the signal conditioning circuitry 2 in real time.
After puncturing a right branch of a hepatic portal vein, the pressure sensing element 1 travels along the blood vessel until it reaches the main portal vein, and performs pressure measurement in reverse blood flow.
Preferably, as shown in FIGS. 1-3, the pressure sensing element 1 includes a hemispherical head 4, a groove 5, and a pressure sensor chip 6. The groove 5 is fixed to the hemispherical head 4. The pressure sensor chip 6 is positioned in the groove 5.
The hemispherical head 4 is used for reducing the resistance of puncture into the hepatic portal vein, and the hemispherical head 4 can reduce stress concentration by dispersing stress within the vessel, thereby protecting the vascular system.
In a specific example, the material of the hemispherical head 4 is a biocompatible silicone. The groove 5 is a metallic U-shaped groove. The metallic U-shaped groove is used for placing the pressure sensor chip 6 and the sensor protection adhesive 8. The pressure sensor chip 6 is connected to a metal below the groove 5 through a sensor protection adhesive 8. The sensor protection adhesive 8 has biocompatibility, does not cause the functional decline of cells and tissues, does not cause inflammation, carcinogenesis and tissue rejection, does not cause the formation of thrombus, and does not affect the normal flow of blood in veins. The sensor protection adhesive 8 is used for protecting and firmly bonding the pressure sensor chip 6, and reducing the relative movement of the pressure sensor chip 6 with respect to the hemispherical head 4.
The pressure sensor chip 6 is a piezoresistive sensor configured in a half-bridge circuit. The chip is fabricated based on the piezoresistive effect of silicon material. For a silicon chip with a thin etched diaphragm, the diaphragm will bend under the action of pressure, which will lead to the change of resistance. The pressure sensing chip has stable operation and compact size.
Further, the implantable wireless monitor for measuring portal vein blood pressure further includes an insulated flexible lead 7. The pressure sensing element 1 is connected to the signal conditioning circuitry 2 through the insulated flexible lead 7.
The signal conditioning circuitry 2 is implanted in subcutaneous tissue of the patient and wirelessly communicated to the wireless transceiver 3, the signal conditioning circuitry 2 is used for processing the pressure signal in the portal vein to generate pressure data in the portal vein, and wirelessly transmitting the pressure data in the portal vein to the wireless transceiver 3.
In a specific example, the signal conditioning circuitry 2 is fabricated on a flexible printed circuit board (PCB), which is implanted into the subcutaneous tissue of the chest and transmits signals to the wireless transceiver 3 via Bluetooth. The signal conditioning circuitry 2 is only implanted in the subcutaneous tissue of the chest, and the normal blood flow will not be affected.
As shown in FIG. 4, the signal conditioning circuitry 2 includes a power supply circuit 9 and a signal amplification circuit 10, a filter circuit 11, an analog-to-digital conversion circuit 12, and a wireless transmission circuit 13 operatively connected in sequence. The power supply circuit 9 is connected to the signal amplification circuit 10, the filter circuit 11, the analog-to-digital conversion circuit 12, and the wireless transmission circuit 13.
The power supply circuit 9 uses a lithium battery to supply power to the signal amplification circuit 10, the filter circuit 11, the analog-to-digital conversion circuit 12, and the wireless transmission circuit 13.
The signal amplification circuit 10 is further connected to the pressure sensing element 1 to receive the pressure signal in the portal vein and amplify the pressure signal in the portal vein to obtain an amplified signal.
The filter circuit 11 is used for filtering the amplified signal to obtain a filtered signal.
The analog-to-digital conversion circuit 12 is used for converting the filtered signal into a digital signal to obtain the pressure data in the portal vein.
The wireless transmission circuit 13 is also connected to the wireless transceiver 3 to transmit pressure data in the portal vein to the wireless transceiver 3.
The wireless transceiver 3 is used for displaying the pressure data in the portal vein in real time for real-time monitoring the portal vein blood pressure of the patient in real time.
Specifically, the wireless transceiver 3 displays the pressure data in the portal vein in waveform format. That is, the wireless transceiver 3 receives the portal vein pressure data sent by the Bluetooth module via a serial interface and realizes the real-time waveform display of the pressure signal.
Further, the wireless transceiver 3 is further used for determining if the blood pressure in the portal vein exceeds a predetermined threshold in real time according to the pressure data in the portal vein, and generating an alarm when the blood pressure in the portal vein exceeds the standard, thereby intervening in time.
In summary, the operation of the implantable wireless monitor for measuring portal vein blood pressure is as follows. The pressure sensor chip 6 detects the pressure in the portal vein in real time, and transmits the pressure signal to the signal conditioning circuitry 2 through the insulated flexible lead 7. The signal conditioning circuitry 2 performs compensation, amplification, filtering and analog-to-digital conversion on the pressure signal. The processed digital signal is transmitted to the wireless transceiver 3 through the wireless module, and the pressure change is displayed in real time.
According to the implantable wireless monitor for measuring portal vein blood pressure provided by the present application, portal vein blood pressure is monitored during surgery and can also be monitored in real time during daily life.
In the present application, the micro pressure sensor chip implanted in the portal vein of the patient can monitor the pressure change of the portal vein in real time and reflect the patient's condition change in time. The pressure sensor chip 6 is precisely calibrated, with high sensitivity and small temperature drift and humidity drift, which ensures the accuracy of measurement data. The pressure sensor chip 6 transmits the pressure signal to the signal conditioning circuitry 2. After the signal processing, the pressure signal is transmitted wirelessly through Bluetooth to the wireless transceiver 3 for real-time display and record. The wireless transmission function makes the data collection and monitoring more convenient, reducing the pain of patients and the workload of medical staff. The wireless transceiver 3 can not only display continuous blood pressure data, but also send out an alarm when the blood pressure exceeds the standard, which is convenient for timely intervention.
It is to be noted that the user information (including but not limited to user equipment information, user personal information, etc.) and data (including but not limited to analyzed data, stored data, displayed data, etc.) involved in this application are information and data authorized by the user or fully authorized by all parties, and the collection, use and processing of relevant data need to comply with relevant regulations.
The technical features of the above examples can be combined in various ways, and for the sake of conciseness, all possible combinations of the technical features in the above examples are not described. However, as long as there is no contradiction between the combinations of these technical features, they shall be considered to be within the scope of this specification.
Herein, specific embodiments are used to explain the principles and embodiments of the present application, and the description of the above examples is only for helping to understand the methods and core ideas of the present application. Meanwhile, those skilled in the art may change the specific embodiments and the scope of application according to the ideas of the present application. In summary, the contents of the present specification are not to be construed as limiting the present application.

Claims (10)

1. An implantable wireless monitor for measuring portal vein blood pressure, comprising a pressure sensing element, a signal conditioning circuitry and a wireless transceiver, wherein the pressure sensing element is implanted in a portal vein of a patient and connected to the signal conditioning circuitry, and the pressure sensing element is used for detecting pressure in the portal vein in real time and sending a pressure signal in the portal vein to the signal conditioning circuitry in real time; the signal conditioning circuitry is implanted in subcutaneous tissue of the patient and wirelessly connected to the wireless transceiver, the signal conditioning circuitry is used for processing the pressure signal in the portal vein to generate pressure data in the portal vein, and wirelessly transmitting the pressure data in the portal vein to the wireless transceiver; and the wireless transceiver is used for displaying the pressure data in the portal vein in real time for real-time monitoring the portal vein blood pressure of the patient in real time.
2. The implantable wireless monitor for measuring portal vein blood pressure according to claim 1, wherein the pressure sensing element comprises a hemispherical head, a groove, and a pressure sensor chip; and the groove is fixed to the hemispherical head, and the pressure sensor chip is housed within the groove.
3. The implantable wireless monitor for measuring portal vein blood pressure according to claim 2, wherein the material of the hemispherical head is a biocompatible silicone.
4. The implantable wireless monitor for measuring portal vein blood pressure according to claim 2, wherein the groove is a metallic U-shaped groove.
5. The implantable wireless monitor for measuring portal vein blood pressure according to claim 4, wherein the pressure sensor chip is connected to a metal below the groove using a sensor protection adhesive.
6. The implantable wireless monitor for measuring portal vein blood pressure according to claim 2, wherein the pressure sensor chip is a piezoresistive sensor configured in a half-bridge circuit.
7. The implantable wireless monitor for measuring portal vein blood pressure according to claim 1, further comprising an insulated flexible lead, wherein the pressure sensing element is connected to the signal conditioning circuitry through the insulated flexible lead.
8. The implantable wireless monitor for measuring portal vein blood pressure according to claim 1, wherein the signal conditioning circuitry is a flexible circuit board.
9. The implantable wireless monitor for measuring portal vein blood pressure according to claim 1, wherein the signal conditioning circuitry comprises a power supply circuit and a signal amplification circuit, a filter circuit, an analog-to-digital conversion circuit and a wireless transmission circuit operatively connected in sequence, and the power supply circuit is connected to the signal amplification circuit, the filter circuit, the analog-to-digital conversion circuit and the wireless transmission circuit; the signal amplification circuit is further connected to the pressure sensing element to receive the pressure signal in the portal vein and amplify the pressure signal in the portal vein to obtain an amplified signal; the filter circuit is used for filtering the amplified signal to obtain a filtered signal; the analog-to-digital conversion circuit is used for converting the filtered signal into a digital signal to obtain the pressure data in the portal vein; and the wireless transmission circuit is in communication with the wireless transceiver to send the pressure data in the portal vein to the wireless transceiver.
10. The implantable wireless monitor for measuring portal vein blood pressure according to claim 1, wherein the wireless transceiver displays the pressure data in the portal vein in waveform format.
LU602198A 2024-10-21 2025-06-24 Implantable wireless monitor for measuring portal vein blood pressure LU602198B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202411464127.9A CN119344695A (en) 2024-10-21 2024-10-21 An implantable wireless monitor for monitoring portal blood pressure

Publications (1)

Publication Number Publication Date
LU602198B1 true LU602198B1 (en) 2025-12-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
LU602198A LU602198B1 (en) 2024-10-21 2025-06-24 Implantable wireless monitor for measuring portal vein blood pressure

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Country Link
CN (1) CN119344695A (en)
LU (1) LU602198B1 (en)

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Publication number Publication date
CN119344695A (en) 2025-01-24

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Effective date: 20251224