LU504397B1 - Resolution system and resolution method for chiral drugs - Google Patents

Resolution system and resolution method for chiral drugs Download PDF

Info

Publication number
LU504397B1
LU504397B1 LU504397A LU504397A LU504397B1 LU 504397 B1 LU504397 B1 LU 504397B1 LU 504397 A LU504397 A LU 504397A LU 504397 A LU504397 A LU 504397A LU 504397 B1 LU504397 B1 LU 504397B1
Authority
LU
Luxembourg
Prior art keywords
pores
chiral
organic material
base
pore structure
Prior art date
Application number
LU504397A
Other languages
English (en)
Inventor
Ligang Zheng
Xing Sun
Jiye Fan
Yong Zhang
Bingzhu Zhang
Original Assignee
Hebei Chemical and Pharmaceutical Vocational and Technical College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hebei Chemical and Pharmaceutical Vocational and Technical College filed Critical Hebei Chemical and Pharmaceutical Vocational and Technical College
Application granted granted Critical
Publication of LU504397B1 publication Critical patent/LU504397B1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3833—Chiral chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28011—Other properties, e.g. density, crush strength
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/28085—Pore diameter being more than 50 nm, i.e. macropores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28088—Pore-size distribution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Claims (10)

  1. ANSPRUCHE LU504397
    1. Auftrennungsverfahren für chirale Arzneimittel, dadurch gekennzeichnet, dass das Verfahren ein organisches Material mit einer mehrstufigen Porenstruktur verwendet, um eine Adsorplionsaufidsung an den aufzutrennenden chiralen Arzneimitteln durchzuführen.
    2. Auftrennungsverfahren für chirale Arzneimittel nach Anspruch 1, dadurch gekennzeichnet, dass die Porenstruktur des organischen Materials mit der kontinuierlichen Porenstruktur miteinander verbundene Grundporen umfasst und der Bereich, in dem die Grundporen miteinander verbunden sind, mit Sekundärporen versehen ist, deren Durchmesser kleiner als der der Grundporen ist.
    3. Organisches Material zur chiralen Trennung, dadurch gekennzeichnet, dass es ein organisches Material mit einer mehrstufigen kontinuierlichen Porenstruktur ist.
    4. Organisches Material für die chirale Trennung nach Anspruch 3, dadurch gekennzeichnet, dass die Porenstruktur miteinander verbundene Basisporen umfasst und der Bereich, in dem die Basisporen miteinander verbunden sind, mit zweistufigen Poren mit kleineren Porendurchmessern als die Basisporen versehen ist.
    5. Organisches Material zur chiralen Trennung nach Anspruch 4, dadurch gekennzeichnet, dass der Durchmesser der Grundporen zwischen 0,5 um und 200 um liegt.
    8. Organisches Material für die chirale Trennung nach Anspruch 4, dadurch gekennzeichnet, dass der Durchmesser der Grundporen zwischen 10 um und 100 um liegt.
    7. Organisches Material für die chirale Trennung nach Anspruch 4, dadurch gekennzeichnet, dass der Durchmesser der Sekundärporen zwischen 0,05 um und 50 um liegt. 8 Organisches Material für die chirale Trennung nach Anspruch 4, dadurch gekennzeichnet, dass der Durchmesser der Sekundärporen zwischen 0,5 um und 10 um liegt.
    9. Verfahren zur sekundären Modifikation eines porôsen organischen Materials, wobei das porôse organische Material eine mehrstufige kontinulerliche Porenstruktur mit miteinander verbundenen Grundporen aufweist, wobei die zweistufigen Poren in einem Bereich, in dem die Grundporen miteinander verbunden sind, eine kleinere Porengröße als die Grundporen aufweisen, dadurch gekennzeichnet, dass chirale aktive Gruppen gleichmäßig in diese kontinuierliche Porenstruktur in einem chemischen Infiltrationsmodus eingeführt werden.
    10. Verfahren zur sekundären Modifikation eines porösen organischen Materials nach LU504397 Anspruch 9, dadurch gekennzeichnet, dass ein Teil der aktiven Gruppen nach dem gleichmäßigen Einbringen der aktiven Gruppen einer sekundären Inaktivierungsbehandlung unterzogen wird.
LU504397A 2023-05-05 2023-06-01 Resolution system and resolution method for chiral drugs LU504397B1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310496550.6A CN116492718A (zh) 2023-05-05 2023-05-05 一种手性药物的拆分系统和方法

Publications (1)

Publication Number Publication Date
LU504397B1 true LU504397B1 (de) 2023-12-01

Family

ID=87328144

Family Applications (1)

Application Number Title Priority Date Filing Date
LU504397A LU504397B1 (de) 2023-05-05 2023-06-01 Resolution system and resolution method for chiral drugs

Country Status (2)

Country Link
CN (1) CN116492718A (de)
LU (1) LU504397B1 (de)

Also Published As

Publication number Publication date
CN116492718A (zh) 2023-07-28

Similar Documents

Publication Publication Date Title
US4202775A (en) Adsorbent for adsorbing organic compounds adsorbed on proteins
Rutkowska et al. Application of molecularly imprinted polymers in analytical chiral separations and analysis
Arvidsson et al. Chromatography of microbial cells using continuous supermacroporous affinity and ion-exchange columns
EP2088160A1 (de) Supermakroporöse polymermikrokugel und herstellungsverfahren dafür
CN102630240B (zh) 三维多孔结构
CN1205239C (zh) 聚合物吸附剂及其制备方法
JP6733900B2 (ja) 分離用担体、分離用担体の製造方法、カラム、及び、液体クロマトグラフィー用装置又は固相抽出用装置
CN101747473B (zh) 表面功能化的分子印迹聚合物微球及其制备方法
JP2008500172A (ja) マクロ孔質イオン交換樹脂
CN100562530C (zh) 一种超大孔聚合物微球的制备方法及其产品
JPH02238032A (ja) 多孔性重合体ビーズおよびその製造法
Vlakh et al. Molecular imprinting: A tool of modern chemistry for the preparation of highly selective monolithic sorbents
WO1992007640A1 (en) Polysaccharide-based porous sheets
CN110327894A (zh) 一种高吸附量的血液净化高分子微球及其制备方法
Lai et al. Highly efficient chiral separation of amlodipine enantiomers via triple recognition hollow fiber membrane extraction
US9028694B2 (en) Non-particulate organic porous material having optical resolution capability and method for manufacturing same
Haginaka et al. Uniformly sized molecularly imprinted polymers for d-chlorpheniramine: Influence of a porogen on their morphology and enantioselectivity
CN104761748A (zh) 双模板分子印迹固相萃取膜的制备方法及所制膜的应用
CN116492718A (zh) 一种手性药物的拆分系统和方法
JPH0579377B2 (de)
Guo et al. Graphene oxide-based a network porous poly (trially isocyanurate-co-methacrylate) monolithic column for HPLC separation of aromatic molecular and lipopeptide antibiotics
Zhao et al. Preparation of halloysite nanotube-based monolithic column for small molecules and protein analysis
Shach‐Caplan et al. Modification of porous suspension‐PVC particles by stabilizer‐free aqueous dispersion polymerization of absorbed acrylate monomers
JP4944350B2 (ja) 方法
CN104014322A (zh) 一种粒径窄分散的聚合物微球固定相填料及其制备方法

Legal Events

Date Code Title Description
FG Patent granted

Effective date: 20231201