LU504397B1 - Resolution system and resolution method for chiral drugs - Google Patents

Resolution system and resolution method for chiral drugs Download PDF

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Publication number
LU504397B1
LU504397B1 LU504397A LU504397A LU504397B1 LU 504397 B1 LU504397 B1 LU 504397B1 LU 504397 A LU504397 A LU 504397A LU 504397 A LU504397 A LU 504397A LU 504397 B1 LU504397 B1 LU 504397B1
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LU
Luxembourg
Prior art keywords
pores
chiral
organic material
base
pore structure
Prior art date
Application number
LU504397A
Other languages
English (en)
Inventor
Ligang Zheng
Xing Sun
Jiye Fan
Yong Zhang
Bingzhu Zhang
Original Assignee
Hebei Chemical and Pharmaceutical Vocational and Technical College
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Publication date
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Application granted granted Critical
Publication of LU504397B1 publication Critical patent/LU504397B1/de

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3833—Chiral chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28011—Other properties, e.g. density, crush strength
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/28085—Pore diameter being more than 50 nm, i.e. macropores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28088—Pore-size distribution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Claims (10)

  1. ANSPRUCHE LU504397
    1. Auftrennungsverfahren für chirale Arzneimittel, dadurch gekennzeichnet, dass das Verfahren ein organisches Material mit einer mehrstufigen Porenstruktur verwendet, um eine Adsorplionsaufidsung an den aufzutrennenden chiralen Arzneimitteln durchzuführen.
    2. Auftrennungsverfahren für chirale Arzneimittel nach Anspruch 1, dadurch gekennzeichnet, dass die Porenstruktur des organischen Materials mit der kontinuierlichen Porenstruktur miteinander verbundene Grundporen umfasst und der Bereich, in dem die Grundporen miteinander verbunden sind, mit Sekundärporen versehen ist, deren Durchmesser kleiner als der der Grundporen ist.
    3. Organisches Material zur chiralen Trennung, dadurch gekennzeichnet, dass es ein organisches Material mit einer mehrstufigen kontinuierlichen Porenstruktur ist.
    4. Organisches Material für die chirale Trennung nach Anspruch 3, dadurch gekennzeichnet, dass die Porenstruktur miteinander verbundene Basisporen umfasst und der Bereich, in dem die Basisporen miteinander verbunden sind, mit zweistufigen Poren mit kleineren Porendurchmessern als die Basisporen versehen ist.
    5. Organisches Material zur chiralen Trennung nach Anspruch 4, dadurch gekennzeichnet, dass der Durchmesser der Grundporen zwischen 0,5 um und 200 um liegt.
    8. Organisches Material für die chirale Trennung nach Anspruch 4, dadurch gekennzeichnet, dass der Durchmesser der Grundporen zwischen 10 um und 100 um liegt.
    7. Organisches Material für die chirale Trennung nach Anspruch 4, dadurch gekennzeichnet, dass der Durchmesser der Sekundärporen zwischen 0,05 um und 50 um liegt. 8 Organisches Material für die chirale Trennung nach Anspruch 4, dadurch gekennzeichnet, dass der Durchmesser der Sekundärporen zwischen 0,5 um und 10 um liegt.
    9. Verfahren zur sekundären Modifikation eines porôsen organischen Materials, wobei das porôse organische Material eine mehrstufige kontinulerliche Porenstruktur mit miteinander verbundenen Grundporen aufweist, wobei die zweistufigen Poren in einem Bereich, in dem die Grundporen miteinander verbunden sind, eine kleinere Porengröße als die Grundporen aufweisen, dadurch gekennzeichnet, dass chirale aktive Gruppen gleichmäßig in diese kontinuierliche Porenstruktur in einem chemischen Infiltrationsmodus eingeführt werden.
    10. Verfahren zur sekundären Modifikation eines porösen organischen Materials nach LU504397 Anspruch 9, dadurch gekennzeichnet, dass ein Teil der aktiven Gruppen nach dem gleichmäßigen Einbringen der aktiven Gruppen einer sekundären Inaktivierungsbehandlung unterzogen wird.
LU504397A 2023-05-05 2023-06-01 Resolution system and resolution method for chiral drugs LU504397B1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310496550.6A CN116492718A (zh) 2023-05-05 2023-05-05 一种手性药物的拆分系统和方法

Publications (1)

Publication Number Publication Date
LU504397B1 true LU504397B1 (de) 2023-12-01

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ID=87328144

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LU504397A LU504397B1 (de) 2023-05-05 2023-06-01 Resolution system and resolution method for chiral drugs

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CN (1) CN116492718A (de)
LU (1) LU504397B1 (de)

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Publication number Publication date
CN116492718A (zh) 2023-07-28

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Effective date: 20231201