LU500738B1

LU500738B1 - Graphene or Cellulose Hydrogel with Rapid Heat Dissipation and Fever Cooling Patch

Info

Publication number: LU500738B1
Application number: LU500738A
Authority: LU
Inventors: Huiying Gao; Lujia Luo; Lijing Shen; Ranju Meng; Man Zheng; Ting Zhang
Original assignee: Jiaxing vocational technical college
Priority date: 2021-10-15
Filing date: 2021-10-15
Publication date: 2022-04-15

Abstract

The invention discloses a graphene/cellulose hydrogel with rapid heat dissipation and a cooling patch, and the preparation method is as follows: S1, preparing graphene oxide powder; S2, preparing cellulose solution; S3, preparing 5-10% gelatin solution, adding graphene oxide powder in S1 into gelatin solution, and carrying out ultrasonic treatment at 40-50?at 200-400w for 10-60 min; S4, preparing a two-component crosslinking curing agent; S5, gradually dripping the gelatin solution in S3 and the two-component crosslinking curing agent in S4 into the cellulose solution in S2, keeping the cellulose solution in an ice-water bath and stirring for 40-60 min at 200-500 r/min; and S6, after the solution is solidified, washing the surface with distilled water to remove excessive crosslinking curing agent, and naturally drying in the shade. By arranging graphene in the hydrogel, the heat conduction capability can be greatly increased and the heat dissipation is rapid.

Description

DESCRIPTION Graphene or Cellulose Hydrogel with Rapid Heat Dissipation and Fever Cooling Patch

TECHNICAL FIELD The invention relates to the technical field of medical polymer materials, particularly to a graphene/cellulose hydrogel with rapid heat dissipation and a cooling patch thereof.

BACKGROUND Fever is a common and frequent disease in children. If it 1s not treated in time, when the body temperature exceeds 41°C, the protein in the body will decompose, thus causing different degrees of brain damage. The existing medicines for reducing temperature and fever are mostly oral medicines, and have side effects, which are not conducive to children’s use. Physical cooling is simple, reliable and has few side effects. It is one of the effective measures to reduce fever and prevent convulsions and avoid sequelae in children, and has been advocated by pediatric experts in recent years. Antipyretic patch (cooling patch) is a popular external patch recently, which belongs to physical cooling products and has the advantages of rapid antipyretic, good cooling effect, safety and non- toxicity. At present, the antipyretic principle of most antipyretic stickers in the market is to take out the excessive heat in the body through vaporization of water in hydrogel, so as to achieve the effect of lowering body temperature. However, due to poor air permeability and water fixation of polymer skeleton in gel, the evaporation rate of water from this antipyretic patch is slow, the antipyretic effect is not ideal, and the antipyretic efficiency is low.

SUMMARY The present invention aims at solving one of the technical problems in related technologies to at least a certain extent. Therefore, it is an object of the present invention to provide a graphene/cellulose hydrogel with rapid heat dissipation and its cooling patch. By arranging graphene in the hydrogel, the heat conduction capability can be greatly increased and the heat dissipation is rapid. At the same time, the efficiency of the heat conduction paste can be better indicated by adding a temperature change indicator. The technical scheme of the present invention is as follows:

a graphene/cellulose hydrogel with rapid heat dissipation, characterized by the following preparation method: S1, preparing graphene oxide powder; S2, preparing cellulose solution; S3, preparing 5-10% gelatin solution, adding graphene oxide powder in S1 into the gelatin solution, and performing ultrasonic treatment at 200-400w at 20-30°C for 10-60 min; S4, preparing a two-component crosslinking curing agent; S5, gradually dripping the gelatin solution in S3 and the two-component crosslinking curing agent in S4 into the cellulose solution in S2, keeping the cellulose solution in an ice-water bath and stirring for 40-60 min at 200-500 r/min.

S6, after the solution is solidified, washing the surface with distilled water to remove excessive crosslinking curing agent, and naturally drying in the shade.

Furthermore, graphene oxide is prepared by Hummer method in step S1. Furthermore, the preparation method of cellulose solution in step S2 is as follows: preparation of cellulose solution: precooling the mixed solution of 7 wt% sodium hydroxide solution and 12wt% % urea at 0-5°C, then putting the waste cotton products into the mixture solution, stirring uniformly, freezing at -12-20°C for 3-5h, and stirring uniformly.

Furthermore, the volume ratio of gelatin solution to cellulose solution in step S3 is (1- 3):10. Furthermore, the mass volume ratio of graphene oxide to gelatin solution in step S3 is (0.01-5):100 g/ml.

Furthermore, the gelatin solution in the step S3 is further added with a color-developing agent of 0.1%-0.5% of the mass of the gelatin solution.

Furthermore, the color-developing agent is a commercially available microencapsulated 39°C temperature-dependent pigment.

Furtheremore, the two-component crosslinking curing agent in step S4 comprises a component A and a component B, and the components and configuration methods are as follows: component A: preparing 1%-5% glutaraldehyde solution;

component B: preparing 1%-5% (w/v) MBA solution; the volume ratio of component A to component B is (1-5):1. A cooling patch prepared by using the graphene/cellulose hydrogel rapid heat dissipation comprises a non-woven fabric layer, a hydrogel layer and an anti-sticking layer, wherein the hydrogel is coated on the non-woven fabric layer, and the anti-sticking layer is a PET film. The beneficial effects of the present invention:

1. By setting a two-component cross-linking agent and adding gelatin to the cellulose solution for cross-linking, since both glutaraldehyde and MBA can react with the active hydroxyl and carboxyl groups in the system, graphene and gelatin, cellulose molecules form a relatively uniform network system to avoid graphene agglomeration;

2. the reaction preparation conditions are mild and suitable for large-scale production;

3. the use of microcapsule temperature change pigment can better indicate whether the cooling patch is invalid.

DESCRIPTION OF THE INVENTION The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Embodiment 1 The graphene/cellulose hydrogel with rapid heat dissipation is prepared as follows: S1, preparing graphene oxide powder by using Hummer method, S2, preparing cellulose solution: precooling the mixed solution of 7 wt% sodium hydroxide solution and 12wt% % urea at 0-5°C, then putting the waste cotton products into the mixture solution, stirring uniformly, freezing at -12-20°C for 3-5h, and stirring uniformly. S3, preparing 10% gelatin solution, with the volume ratio of gelatin solution to cellulose solution of 1:10; adding graphene oxide powder in S1 into the gelatin solution, with the mass volume ratio of graphene oxide to gelatin solution of 0.05:100 g/ml; further adding a color-developing agent of 0.1% of the mass of the gelatin solution into the gelatin solution and the color-developing agent is commercially available microencapsulated

39°C temperature-dependent pigment; performing ultrasonic treatment at 400 w at 20°C for 15 min; S4, preparing a two-component crosslinking curing agent; Comprising the component A and the component B, and the components and configuration methods are as follows: component A: preparing 1.5% glutaraldehyde solution; component B: preparing 5% (w/v) MBA(N,N- methylene bisacrylamide) solution; the volume ratio of component A to component B is 2:1; S5, gradually dripping the gelatin solution in S3 and the two-component crosslinking curing agent in S4 into the cellulose solution in S2, keeping the cellulose solution in an ice-water bath and stirring for 60 min at 200 r/min; and S6, after the solution is solidified, washing the surface with distilled water to remove excessive crosslinking curing agent, and naturally drying in the shade.

A cooling patch prepared by using above graphene/cellulose hydrogel rapid heat dissipation comprises the non-woven fabric layer, the hydrogel layer and the anti-sticking layer, wherein the hydrogel is coated on the non-woven fabric layer, and the anti-sticking layer is a PET film.

Embodiment 2 The graphene/cellulose hydrogel with rapid heat dissipation is prepared as follows: S1, preparing graphene oxide powder by using Hummer method, S2, preparing cellulose solution: precooling the mixed solution of 7 wt% sodium hydroxide solution and 12 wt%% urea at 0-5°C, then putting the waste cotton products into the mixture solution, stirring uniformly, freezing at -12-20°C for 3-5h, and stirring uniformly.

S3, preparing 6% gelatin solution, with the volume ratio of gelatin solution to cellulose solution of 2:10; adding graphene oxide powder in S1 into the gelatin solution, with the mass volume ratio of graphene oxide to gelatin solution of 4:100 g/ml; further adding a color-developing agent of 0.5% of the mass of the gelatin solution into the gelatin solution and the color-developing agent is commercially available microencapsulated 39°C temperature-dependent pigment; performing ultrasonic treatment at 200 w at 40°C for 40 min;

S4, preparing a two-component crosslinking curing agent; Comprising the component A and the component B, and the components and configuration methods are as follows: component A: preparing 3% glutaraldehyde solution; component B: preparing 1% (w/v) MBA solution; the volume ratio of component A to component B is 5:1; S5, gradually dripping the gelatin solution in S3 and the two-component crosslinking curing agent in S4 into the cellulose solution in S2, keeping the cellulose solution in an ice-water bath and stirring for 40 min at 500 r/min; and S6, after the solution is solidified, washing the surface with distilled water to remove excessive crosslinking curing agent, and naturally drying in the shade.

Embodiment 3 The graphene/cellulose hydrogel with rapid heat dissipation is prepared as follows: S1, preparing graphene oxide powder by using Hummer method, S2, preparing cellulose solution: precooling the mixed solution of 7 wt% sodium hydroxide solution and 12wt% % urea at 0-5°C, then putting the waste cotton products into the mixture solution, stirring uniformly, freezing at -12-20°C for 3-5h, and stirring uniformly.

S3, preparing 8% gelatin solution, with the volume ratio of gelatin solution to cellulose solution of 3:10; adding graphene oxide powder in S1 into the gelatin solution, with the mass volume ratio of graphene oxide to gelatin solution of 1:100 g/ml; further adding a color-developing agent of 0.3% of the mass of the gelatin solution into the gelatin solution and the color-developing agent is commercially available microencapsulated 39°C temperature-dependent pigment; performing ultrasonic treatment at 300 w at 50°C for 30 min; S4, preparing a two-component crosslinking curing agent;

Comprising the component A and the component B, and the components and configuration methods are as follows: component A: preparing 2% glutaraldehyde solution; component B: preparing 2% (w/v) MBA solution; the volume ratio of component A to component B is 3:1; S5, gradually dripping the gelatin solution in S3 and the two-component crosslinking curing agent in S4 into the cellulose solution in S2, keeping the cellulose solution in an ice-water bath and stirring for 50 min at 300 r/min; and S6, after the solution is solidified, washing the surface with distilled water to remove excessive crosslinking curing agent, and naturally drying in the shade.

The above is only a preferred embodiment of the present invention, but the protection scope of the present invention is not limited to this.

Any equivalent substitution or change made by any person familiar with the technical field according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention shall be covered within the protection scope of the present invention.

Claims

1. A graphene/cellulose hydrogel with rapid heat dissipation, characterized by the following preparation method: sl, preparing graphene oxide powder; s2, preparing cellulose solution: s3, preparing 5-10% gelatin solution, adding graphene oxide powder in sl into gelatin solution, and carrying out ultrasonic treatment at 40-50°Cat 200-400w for 10-60 min; s4, preparing a two-component crosslinking curing agent; s5, gradually dripping the gelatin solution in s3 and the two-component crosslinking curing agent in s4 into the cellulose solution in s2, keeping the cellulose solution in an ice-water bath and stirring for 40-60 min at 200-500 r/min; and s6, after the solution is solidified, washing the surface with distilled water to remove excessive crosslinking curing agent, and naturally drying in the shade.

2. The graphene/cellulose hydrogel with rapid heat dissipation according to claim 1, characterized in that graphene oxide is prepared by Hummer method in step s1.

3. The graphene/cellulose hydrogel with rapid heat dissipation according to claim 1, characterized in that the preparation method of cellulose solution in step s2 is as follows: preparation of cellulose solution: precooling the mixed solution of 7 wt% sodium hydroxide solution and 12wt% % urea at 0-5°C, then putting the waste cotton products into the mixture solution, stirring uniformly, freezing at -12-20°C for 3-5 h, and stirring uniformly.

4. The graphene/cellulose hydrogel with rapid heat dissipation according to claim 1, wherein the volume ratio of gelatin solution to cellulose solution in step s3 1s (1-3):10.

5. The graphene/cellulose hydrogel with rapid heat dissipation according to claim 1, wherein the mass volume ratio of graphene oxide to gelatin solution in step s3 is (0.01- 5):100 g/ml.

6. The graphene/cellulose hydrogel with rapid heat dissipation according to claim 1, wherein the gelatin solution in the step s3 is further added with a color-developing agent of 0.1%-0.5% of the mass of the gelatin solution.

7. The graphene/cellulose hydrogel with rapid heat dissipation according to claim 6, wherein the color-developing agent is a commercially available microencapsulated 39°C temperature-dependent pigment.

8. The graphene/cellulose hydrogel with rapid heat dissipation according to claim 1, characterized in that the two-component crosslinking curing agent in step s4 comprises a component A and a component B, and the components and configuration methods are as follows: component A: preparing 1%-5% glutaraldehyde solution; component B: preparing 1%-5% (w/v) MBA solution; the volume ratio of component A to component B is (1-5):1.

9. A cooling patch prepared by using the graphene/cellulose hydrogel rapid heat dissipation according to claim 1, which is characterized by comprising a non-woven fabric layer, a hydrogel layer and an anti-sticking layer, wherein the hydrogel is coated on the non-woven fabric layer, and the anti-sticking layer is a PET film.