LU500694B1 - Method for preparing deapioplatycodin d and use thereof - Google Patents

Method for preparing deapioplatycodin d and use thereof

Info

Publication number
LU500694B1
LU500694B1 LU500694A LU500694A LU500694B1 LU 500694 B1 LU500694 B1 LU 500694B1 LU 500694 A LU500694 A LU 500694A LU 500694 A LU500694 A LU 500694A LU 500694 B1 LU500694 B1 LU 500694B1
Authority
LU
Luxembourg
Prior art keywords
deapioplatycodin
platycodin
strains
preparing
present disclosure
Prior art date
Application number
LU500694A
Inventor
Fushun Cui
Cunhui Huang
hushan Cui
Hongjie Piao
Qing Jin
Guanhao Li
Original Assignee
Univ Yanbian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yanbian filed Critical Univ Yanbian
Priority to LU500694A priority Critical patent/LU500694B1/en
Application granted granted Critical
Publication of LU500694B1 publication Critical patent/LU500694B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/165—Yeast isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/84—Pichia

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present disclosure provides a method for preparing deapioplatycodin D, where the deapioplatycodin D is prepared using two or more strains including a Pichia kudriavzevii strain and a Bacillus velezensis strain. In the present disclosure, two strains with different transformation mechanisms are used to transform platycodin by mixed fermentation, which effectively improves the yield of deapioplatycodin D. A biotransformation of the platycodon is conducted by the fermentation characteristics of the strains. Therefore, not only safe and environmentally-friendly production of the platycodin can be realized, but also Platycodon grandiflorum resources can be fully used to convert the platycodin with low biological activity contained in the Platycodon grandiflorum into saponins with high biological activity, thereby turning waste into wealth.
LU500694A 2021-09-27 2021-09-27 Method for preparing deapioplatycodin d and use thereof LU500694B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
LU500694A LU500694B1 (en) 2021-09-27 2021-09-27 Method for preparing deapioplatycodin d and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU500694A LU500694B1 (en) 2021-09-27 2021-09-27 Method for preparing deapioplatycodin d and use thereof

Publications (1)

Publication Number Publication Date
LU500694B1 true LU500694B1 (en) 2022-03-28

Family

ID=80855728

Family Applications (1)

Application Number Title Priority Date Filing Date
LU500694A LU500694B1 (en) 2021-09-27 2021-09-27 Method for preparing deapioplatycodin d and use thereof

Country Status (1)

Country Link
LU (1) LU500694B1 (en)

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Effective date: 20220328