LU101133B1 - Method for diagnosing symptomatic malaria - Google Patents
Method for diagnosing symptomatic malaria Download PDFInfo
- Publication number
- LU101133B1 LU101133B1 LU101133A LU101133A LU101133B1 LU 101133 B1 LU101133 B1 LU 101133B1 LU 101133 A LU101133 A LU 101133A LU 101133 A LU101133 A LU 101133A LU 101133 B1 LU101133 B1 LU 101133B1
- Authority
- LU
- Luxembourg
- Prior art keywords
- malaria
- subject
- concentration
- reference value
- symptomatic
- Prior art date
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Claims (15)
1. Verfahren zur Diagnose, ob ein Subjekt an symptomatischer Malaria oder einer bakteriellen Infektion der Blutbahn leidet, bei dem man: a) eine Kôrperflüssigkeitsprobe von dem Subjekt, bei dem vermutet wird, dass es entweder an symptomatischer Malaria oder einer bakteriellen Infektion der Blut- bahn leidet; b) die Konzentration des C2-Proteins in der Kôrper- flüssigkeitsprobe von dem Subjekt bestimmt; C) die in Schritt (b) erhaltene Konzentration mit min- destens einem Referenzwert vergleicht; wobei der Vergleich der in Schritt (b) erhaltenen Konzent- ration mit dem mindestens einen Referenzwert zeigt, ob das Subjekt an symptomatischer Malaria oder einer bakteriellen Infektion der Blutbahn leidet.
2. Verfahren nach Anspruch 1, wobei das Verfahren den Ver- gleich der in Schritt (b) erhaltenen Konzentration mit ei- nem einzelnen Referenzwert umfasst.
3. Verfahren nach Anspruch 2, bei dem (i) das Subjekt an einer bakteriellen Infektion der Blut- bahn leidet, wenn die in Schritt (b) erhaltene Kon- zentration den Referenzwert überschreitet; und (ii) das Subjekt an symptomatischer Malaria leidet, wenn die in Schritt (b) erhaltene Konzentration geringer ist als der Referenzwert.
J Le
- 2 - LU101133
4. Verfahren nach einem der Ansprüche 1 bis 3, wobei das Sub- jekt eine Malaria-Parasitämie aufweist.
5. Verfahren nach einem der Ansprüche 1 bis 4, wobei das Ver- fahren Schritte umfasst, bei denen man: a) eine Serumprobe aus dem Subjekt, bei dem vermutet wird, dass es entweder an symptomatischer Malaria oder einer bakteriellen Infektion der Blutbahn lei- det, gewinnt; b) die Konzentration des C2-Proteins in der Serumprobe von dem Subjekt bestimmt; wobei das Subjekt an symptomatischer Malaria leidet, wenn die in Schritt (b) bestimmte Konzentration unter 480 ng/ml liegt, vorzugsweise unter 450 ng/ml oder 400 ng/ml, und wobei das Subjekt an einer bakteriellen Infektion der Blutbahn leidet, wenn die in Schritt (b) bestimmte Kon- zentration {ber 490 ng/ml liegt, vorzugsweise über 500 ng/ml oder über 550 ng/ml.
6. Verfahren zur Diagnose einer symptomatischen Malaria in einem Subjekt, wobei das Verfahren Schritte umfasst, bei denen man: a) eine Malaria-Parasitämie in einer Kôrperflüssigkeits- probe von dem Subjekt bestimmt; b) die Konzentration des C2-Proteins in einer Kôäôrper- flüssigkeitsprobe von dem Subjekt bestimmt; C) die in Schritt (b) erhaltene Konzentration mit min- destens einem Referenzwert vergleicht;
- 3 = LU101133 wobei eine Malaria-Parasitämie in Kombination mit einer C2-Konzentration unterhalb des Referenzwerts zeigt, dass das Subjekt an symptomatischer Malaria leidet.
7. Verfahren nach Anspruch 6, wobei das Verfahren den Ver- gleich der in Schritt (b) erhaltenen Konzentration mit ei- nem einzelnen Referenzwert umfasst.
8. Verfahren nach einem der Ansprüche 6 bis 7, wobei das Ver- fahren Schritte umfasst, bei denen man: a) eine Malaria-Parasitämie in einer Korperfliissigkeits- probe von dem Subjekt bestimmt; b) die Konzentration des C2-Proteins in einer Korper- flüssigkeitsprobe von dem Subjekt bestimmt; wobei Malaria-Parasitämie in Kombination mit einer C2- Konzentration von weniger als 480 ng/ml anzeigt, dass das Subjekt an symptomatischer Malaria leidet.
9. Verfahren nach einem der Ansprüche 1 bis 8, wobei die C2- Konzentration durch einen immundiagnostischen Assay, vor- zugsweise einen enzymgebundenen Immunosorbent-Assay (ELI- SA) bestimmt wird.
10. Verfahren nach einem der Ansprüche 1 bis 9, wobei das C2 menschliches C2 ist, welches die Sequenz gemäß SEQ ID NO:1 oder ein Fragment davon umfasst.
11. Verfahren nach einem der Ansprüche 1 bis 10, wobei die Ma- laria durch Plasmodium falciparum, Plasmodium ovale, Plas- modium vivax, Plasmodium malariae oder Plasmodium knowlesi verursacht wird.
SS
—- 4 - LU101133
12. Verfahren nach einem der Ansprüche 2 bis 3 und 7, wobei der Referenzwert ungefähr 482,63 ng/ml beträgt.
13. Verfahren nach einem der Ansprüche 4 bis 5, wobei der ers- te Referenzwert, der indikativ für symptomatische Malaria ist, einer C2-Konzentration im Blutplasma oder im Blutse- rum von <482,63 ng/ml entspricht.
14. Verfahren nach einem der Ansprüche 4 bis 5, wobei der zweite Referenzwert, der indikativ für eine bakterielle Infektion der Blutbahn ist, einer C2-Konzentration im Blutplasma oder im Blutserum von >482,63 ng/ml entspricht.
15. Kit zur Durchführung des Verfahrens nach einem der Ansprü- che 1 bis 14, umfassend: (a) Mittel zur Bestimmung, ob ein Subjekt von Malaria be- troffen ist; (b) Mittel zur Bestimmung der C2-Konzentration; und (c) optional Puffer und Verdünnungsmittel.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU101133A LU101133B1 (en) | 2019-02-20 | 2019-02-20 | Method for diagnosing symptomatic malaria |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU101133A LU101133B1 (en) | 2019-02-20 | 2019-02-20 | Method for diagnosing symptomatic malaria |
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| LU101133B1 true LU101133B1 (en) | 2020-08-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| LU101133A LU101133B1 (en) | 2019-02-20 | 2019-02-20 | Method for diagnosing symptomatic malaria |
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| LU (1) | LU101133B1 (de) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150111776A1 (en) * | 2013-09-23 | 2015-04-23 | Assaypro, Llc | Immunoassays using over-labeled fluorescent probes |
| WO2018096129A1 (en) * | 2016-11-25 | 2018-05-31 | Universitätsklinikum Hamburg-Eppendorf | Method for diagnosing different forms of malaria |
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- 2019-02-20 LU LU101133A patent/LU101133B1/en active IP Right Grant
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150111776A1 (en) * | 2013-09-23 | 2015-04-23 | Assaypro, Llc | Immunoassays using over-labeled fluorescent probes |
| WO2018096129A1 (en) * | 2016-11-25 | 2018-05-31 | Universitätsklinikum Hamburg-Eppendorf | Method for diagnosing different forms of malaria |
Non-Patent Citations (2)
| Title |
|---|
| GELFAND E W ET AL: "Inherited deficiency of properdin and C2 in a patient with recurrent bacteremia", AMERICAN JOURNAL OF MEDICINE, EXCERPTA MEDICA, INC, UNITED STATES, vol. 82, no. 3, 23 March 1987 (1987-03-23), pages 671 - 675, XP026850104, ISSN: 0002-9343, [retrieved on 19870323] * |
| KARLEE L. SILVER ET AL: "Complement driven innate immune response to malaria: fuelling severe malarial diseases : Complement in malaria", CELLULAR MICROBIOLOGY, vol. 12, no. 8, 25 June 2010 (2010-06-25), GB, pages 1036 - 1045, XP055599422, ISSN: 1462-5814, DOI: 10.1111/j.1462-5822.2010.01492.x * |
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