LTIP959A - An antivirally active pharmaceutical oil-in-water emulsion containing 9-£(2-hydroxy-ethoxy)methyl|guanine (acyclovir) or a salt or ester thereof - Google Patents
An antivirally active pharmaceutical oil-in-water emulsion containing 9-£(2-hydroxy-ethoxy)methyl|guanine (acyclovir) or a salt or ester thereofInfo
- Publication number
- LTIP959A LTIP959A LTIP959A LTIP959A LTIP959A LT IP959 A LTIP959 A LT IP959A LT IP959 A LTIP959 A LT IP959A LT IP959 A LTIP959 A LT IP959A LT IP959 A LTIP959 A LT IP959A
- Authority
- LT
- Lithuania
- Prior art keywords
- acyclovir
- ester
- salt
- guanine
- methyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
An antivirally active pharmaceutical oil-in-water emulsion containing 9-[(2-hydroxyethoxy)methyl]guanine (acyclovir) or a salt or ester thereof as an active ingredient in the continuous aqueous phase, said phase in addition to said active ingredient and the dispersed oil phase containing a water miscible organic solvent, wherein a polyhydric alcohol may form a constituent. The emulsion comprises from 1 % to 10 % w/w of acyclovir or a salt or ester thereof, from 20 % to 50 % w/w of organic solvent comprising from 5 % to 50 % w/w glycerol formal and from 0 % to 29 % w/w of a polyhydric alcohol, and from 20 % to 40 % w/w water, said percentages being based on the total weight of the formulation. As a polyhydric alcohol propylene glycol may be used, and the emulsion may be available as a cream, wherein the oil phase comprises white vaseline, liquid paraffin (paraffin oil), glycerol monostearate, and stearic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK111392A DK169121B1 (en) | 1992-09-09 | 1992-09-09 | Antivirally active pharmaceutical oil-in-water emulsion containing 9 - [(2-hydroxyethoxy) methyl] guanine (acyclovir) or a salt or ester thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP959A true LTIP959A (en) | 1994-05-15 |
| LT3056B LT3056B (en) | 1994-10-25 |
Family
ID=8101156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP959A LT3056B (en) | 1992-09-09 | 1993-09-09 | An antivirally active pharmaceutical oil-in-water emulsion containing 9-£(2-hydroxy-ethoxy)methyl|guanine (acyclovir) or a salt or ester thereof |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0662819B1 (en) |
| JP (1) | JPH08501089A (en) |
| AT (1) | ATE137113T1 (en) |
| AU (1) | AU4945393A (en) |
| BG (1) | BG62032B1 (en) |
| BR (1) | BR9307024A (en) |
| CA (1) | CA2142493A1 (en) |
| CZ (1) | CZ284007B6 (en) |
| DE (1) | DE69302396T2 (en) |
| DK (1) | DK169121B1 (en) |
| EE (1) | EE03088B1 (en) |
| ES (1) | ES2086235T3 (en) |
| FI (1) | FI112777B (en) |
| GR (1) | GR3019984T3 (en) |
| HR (1) | HRP931160B1 (en) |
| HU (1) | HUT72606A (en) |
| LT (1) | LT3056B (en) |
| LV (1) | LV10912B (en) |
| NO (1) | NO308234B1 (en) |
| PL (1) | PL172663B1 (en) |
| RO (1) | RO113306B1 (en) |
| RU (1) | RU2128503C1 (en) |
| SI (1) | SI9300469A (en) |
| SK (1) | SK280119B6 (en) |
| UA (1) | UA41897C2 (en) |
| WO (1) | WO1994005258A1 (en) |
| ZA (1) | ZA936661B (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4416674C2 (en) * | 1994-05-11 | 1997-01-30 | Rentschler Arzneimittel | Topical preparation containing acyclovir |
| ZA96525B (en) * | 1995-02-06 | 1996-08-06 | Astra Ab | Novel pharmaceutical compositions |
| US6440980B1 (en) * | 1996-09-17 | 2002-08-27 | Avanir Pharmaceuticals | Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs |
| FR2753626B1 (en) * | 1996-09-20 | 1998-11-06 | Centre International De Rech Dermatologiques Galderma Cird Galderma | NOVEL TOPICAL COMPOSITIONS IN THE FORM OF A FLUID O / W EMULSION WITH A HIGH PRO-PENETRATING GLYCOL CONTENT |
| AU2004202929B2 (en) * | 1999-09-22 | 2006-11-23 | B. Ron Johnson | Systems for agitated delivery of anti-infective compositions to treat disordered tissue such as cold sores |
| WO2005067941A1 (en) * | 2004-01-08 | 2005-07-28 | Universidad De Concepcion | Topical aciclovir formulation |
| EP1737429B1 (en) * | 2004-04-19 | 2013-07-17 | Strategic Science & Technologies, LLC | Transdermal delivery of beneficial substances effected by a high ionic strength environment |
| US20050257718A1 (en) * | 2004-05-22 | 2005-11-24 | Engelhard Corporation | Natural Pearl in Butylene Glycol |
| US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
| WO2008006085A2 (en) * | 2006-07-07 | 2008-01-10 | University Of Washington | Compositions and methods for predicting inhibitors of protein targets |
| CN102481275B (en) | 2009-06-24 | 2014-07-23 | 战略科学技术有限公司 | Topical compositions containing ibuprofen |
| US11684624B2 (en) | 2009-06-24 | 2023-06-27 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| US12138268B2 (en) | 2009-06-24 | 2024-11-12 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| US9463158B2 (en) | 2009-06-24 | 2016-10-11 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| US9125911B2 (en) | 2013-03-14 | 2015-09-08 | Quadex Pharmaceuticals, Llc | Combined systemic and topical treatment of disordered tissues |
| US9463180B2 (en) | 2013-03-14 | 2016-10-11 | Quadex Pharmaceuticals, Llc | Treatment of molluscum contagiosum |
| US9549930B2 (en) | 2013-03-14 | 2017-01-24 | Quadex Pharmaceuticals, Llc | Combined systemic and topical treatment of disordered and/or prodromal stage tissue |
| FR3023718B1 (en) * | 2014-07-16 | 2018-10-12 | Pierre Fabre Medicament | PHARMACEUTICAL AND / OR COSMETIC COMPOSITIONS DECONTAMINATED BY HIGH PRESSURE |
| GB201819418D0 (en) | 2018-11-29 | 2019-01-16 | Daniel Calladine Ltd | Anti-viral compositions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1523865A (en) | 1974-09-02 | 1978-09-06 | Wellcome Found | Purine compunds and salts thereof |
| GB2080106B (en) * | 1980-07-18 | 1984-03-07 | Weelcome Foundation Ltd | Acyclovin preparations |
-
1992
- 1992-09-09 DK DK111392A patent/DK169121B1/en not_active IP Right Cessation
-
1993
- 1993-09-07 HR HR1113/92A patent/HRP931160B1/en not_active IP Right Cessation
- 1993-09-09 PL PL93307860A patent/PL172663B1/en unknown
- 1993-09-09 UA UA95038210A patent/UA41897C2/en unknown
- 1993-09-09 AU AU49453/93A patent/AU4945393A/en not_active Abandoned
- 1993-09-09 LT LTIP959A patent/LT3056B/en not_active IP Right Cessation
- 1993-09-09 DE DE69302396T patent/DE69302396T2/en not_active Expired - Fee Related
- 1993-09-09 EP EP93919042A patent/EP0662819B1/en not_active Expired - Lifetime
- 1993-09-09 RO RO95-00478A patent/RO113306B1/en unknown
- 1993-09-09 ZA ZA936661A patent/ZA936661B/en unknown
- 1993-09-09 BR BR9307024A patent/BR9307024A/en not_active Application Discontinuation
- 1993-09-09 AT AT93919042T patent/ATE137113T1/en not_active IP Right Cessation
- 1993-09-09 CZ CZ95599A patent/CZ284007B6/en unknown
- 1993-09-09 WO PCT/DK1993/000288 patent/WO1994005258A1/en not_active Ceased
- 1993-09-09 RU RU95110930A patent/RU2128503C1/en active
- 1993-09-09 SK SK291-95A patent/SK280119B6/en unknown
- 1993-09-09 CA CA002142493A patent/CA2142493A1/en not_active Abandoned
- 1993-09-09 SI SI9300469A patent/SI9300469A/en unknown
- 1993-09-09 JP JP6506765A patent/JPH08501089A/en active Pending
- 1993-09-09 ES ES93919042T patent/ES2086235T3/en not_active Expired - Lifetime
- 1993-09-09 HU HU9500702A patent/HUT72606A/en unknown
-
1994
- 1994-08-09 EE EE9400083A patent/EE03088B1/en unknown
-
1995
- 1995-03-08 FI FI951086A patent/FI112777B/en active
- 1995-03-08 NO NO950895A patent/NO308234B1/en not_active IP Right Cessation
- 1995-03-08 BG BG99484A patent/BG62032B1/en unknown
- 1995-04-07 LV LVP-95-90A patent/LV10912B/en unknown
-
1996
- 1996-05-20 GR GR960401359T patent/GR3019984T3/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LTIP959A (en) | An antivirally active pharmaceutical oil-in-water emulsion containing 9-£(2-hydroxy-ethoxy)methyl|guanine (acyclovir) or a salt or ester thereof | |
| US4963555A (en) | Formulations of heterocyclic compounds | |
| IE811617L (en) | Topical formulations of 9-(2-hydroxyethoxymethyl) guanine | |
| FR2706298B1 (en) | Cosmetic or dermatological composition in the form of a stable oil-in-water emulsion containing at least one vegetable oil consisting of at least 40% of linoleic acid triglycerides. | |
| AU643975B2 (en) | Pharmaceutical formulation | |
| EP0593562B1 (en) | Topical composition containing penciclovir | |
| CA2022632A1 (en) | Pharmaceutical formulation | |
| HK1012242B (en) | Topical composition containing penciclovir |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9A | Lapsed patents |
Effective date: 19990909 |