LTIP878A - Process for preparation of phenyl alkylamines - Google Patents

Process for preparation of phenyl alkylamines

Info

Publication number
LTIP878A
LTIP878A LTIP878A LTIP878A LTIP878A LT IP878 A LTIP878 A LT IP878A LT IP878 A LTIP878 A LT IP878A LT IP878 A LTIP878 A LT IP878A LT IP878 A LTIP878 A LT IP878A
Authority
LT
Lithuania
Prior art keywords
phenyl
cycloalkyl
straight
branched chain
chain alkyl
Prior art date
Application number
LTIP878A
Inventor
Jozsef Knoll
Antal Simay
Eva Szinnyei
Eva Somfai
Zoltan Torok
Karoly Mozsolits
Janos Bergmann
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of LTIP878A publication Critical patent/LTIP878A/en
Publication of LT3530B publication Critical patent/LT3530B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • External Artificial Organs (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method of treating a learning deficiency is disclosed wherein a patient in need of stimulating learning ability is treated with a therapeutically effective amount of a compound of the Formula (I) <IMAGE> (I) wherein R1 is C1 to C8 straight or branched chain alkyl, C7 to C10 phenylalkyl, phenyl, or C3 to C8 cycloalkyl; and R2 is C1 to C8 straight or branched chain alkyl, unsubstituted or substituted by halogen, hydroxy, C1 to C4 alkoxy or by 1 or 2 phenyl groups; or is C3 to C8 cycloalkyl; with the proviso that R1 and R2 together contain at least 3 carbon atoms; or a pharmaceutically acceptable salt thereof.
LTIP878A 1986-09-25 1993-08-19 Process for preparation of phenyl alkylamines LT3530B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU864101A HU207280B (en) 1986-09-25 1986-09-25 Process for producing new phenyl-alkyl-amines and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
LTIP878A true LTIP878A (en) 1995-03-27
LT3530B LT3530B (en) 1995-11-27

Family

ID=10966901

Family Applications (2)

Application Number Title Priority Date Filing Date
LTIP878A LT3530B (en) 1986-09-25 1993-08-19 Process for preparation of phenyl alkylamines
LTIP879A LT3531B (en) 1986-09-25 1993-08-19 Process for preparation of phenyl alkylamines

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTIP879A LT3531B (en) 1986-09-25 1993-08-19 Process for preparation of phenyl alkylamines

Country Status (21)

Country Link
US (1) US5075338A (en)
EP (1) EP0284621B1 (en)
KR (1) KR880701545A (en)
AT (1) ATE117204T1 (en)
CS (1) CS277418B6 (en)
DD (1) DD262226A5 (en)
DE (1) DE3751006T2 (en)
DK (1) DK282488A (en)
ES (1) ES2007411A6 (en)
FI (1) FI882474A0 (en)
GE (1) GEP19960656B (en)
HU (1) HU207280B (en)
IL (1) IL83905A (en)
LT (2) LT3530B (en)
LV (2) LV10709B (en)
PL (1) PL151642B1 (en)
PT (1) PT85799B (en)
RU (1) RU2007384C1 (en)
SU (1) SU1746882A3 (en)
UA (3) UA11100A (en)
WO (1) WO1988002254A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430044A (en) * 1987-02-06 1995-07-04 Fisons Corporation Arylalkyl-amines and -amides having anticonvulsant and neuroprotective properties
EP0356035B1 (en) * 1988-08-12 1996-03-13 Astra Aktiebolag Arylkalkyl-amines and -amides having anticonvulsant and neuroprotective properties
HUT58270A (en) * 1989-06-02 1992-02-28 Wyeth John & Brother Ltd Process for producing amine derivatives and pharmaceutical compositions containing them
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
HUT63579A (en) * 1991-12-20 1993-09-28 Chinoin Gyogyszer Es Vegyeszet Process for producing double-phase pharmaceutical compositions suitable for treating diseases occurring during neurodegenerative processes
CN1147459C (en) 1994-10-21 2004-04-28 Nps药物有限公司 Calcium Receptor Active Compounds
US6033682A (en) 1995-01-13 2000-03-07 Somerset Pharmaceuticals, Inc. S(+) desmethylselegiline and its use in therapeutic methods and pharmaceutical compositions
US6319954B1 (en) 1995-01-13 2001-11-20 Somerset Pharmaceuticals, Inc. S-(+)-desmethylselegiline and its use in the therapeutic methods and pharmaceutical compositions
US6348208B1 (en) 1995-01-13 2002-02-19 Somerset Pharmaceuticals, Inc. Methods and pharmaceutical compositions employing desmethylselegiline
US6299901B1 (en) 1995-01-13 2001-10-09 Somerset Pharmaceuticals, Inc. Methods and pharmaceutical compositions employing desmethylselegiline
JPH11506744A (en) * 1995-06-07 1999-06-15 ノウブン ファーマシューティカルズ インク． Transdermal compositions containing low molecular weight drugs that are liquid at room temperature
US6316022B1 (en) 1995-06-07 2001-11-13 Noven Pharmaceuticals, Inc. Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
ATE430123T1 (en) 1996-05-01 2009-05-15 Nps Pharma Inc INORGANIC COMPOUNDS ACTIVE ON THE ION RECEPTOR
CA2267315C (en) * 1997-08-07 2008-01-08 Fujimoto Co., Ltd. Ethylamine derivatives
JP4499208B2 (en) * 1998-10-29 2010-07-07 株式会社フジモト・コーポレーション Novel optically active aminopentane derivatives
US20030232890A1 (en) * 2000-11-01 2003-12-18 Sention, Inc. Methods for treating an impairment in memory consolidation
US7619005B2 (en) * 2000-11-01 2009-11-17 Cognition Pharmaceuticals Llc Methods for treating cognitive impairment in humans with Multiple Sclerosis
WO2005000203A2 (en) 2001-10-31 2005-01-06 Sention, Inc. Methods for treating cognitive impairment and improving cognition
JP2004534724A (en) * 2000-11-01 2004-11-18 センション，インコーポレイテッド Methods and compositions for regulating memory consolidation
US20030119884A1 (en) * 2000-11-01 2003-06-26 Epstein Mel H. Methods and compositions for regulating memory consolidation
US20070117869A1 (en) * 2000-11-01 2007-05-24 Cognition Pharmaceuticals Llc Methods for treating coginitive impairment and improving cognition
US20050059743A1 (en) * 2000-11-01 2005-03-17 Sention, Inc. Methods for treating mild cognitive impairment and alzheimer's disease
EP1383497B1 (en) * 2001-05-02 2008-10-15 Blanchette Rockefeller Neurosciences Institute Carbonic anhydrase activators for enhancing learning and memory
EP1935414A3 (en) * 2001-05-02 2010-08-18 Blanchette Rockefeller Neurosciences Institute Carbonic anhydrase activators for enhancig learning and memory
TW201207390A (en) * 2004-05-18 2012-02-16 Brni Neurosciences Inst Method for screening agent for antidepressant activity
AU2010236404B2 (en) 2009-04-15 2016-11-03 Research Triangle Institute Monoamine reuptake inhibitors
JP6875279B2 (en) 2014-12-05 2021-05-19 ゼンメルワイス ユニバーシティ Preventive or therapeutic agents for cancer or its metastasis

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US485926A (en) 1892-11-08 Field
DE767263C (en) * 1937-10-03 1952-03-31 Theodor H Temmler Process for the preparation of ª-aralkylamines
DE893341C (en) * 1950-08-23 1953-10-15 Troponwerke Dinklage & Co Process for preparing N-aralkyl-ª-phenyl-isopropylamines
US2797242A (en) * 1953-08-11 1957-06-25 Parke Davis & Co Substituted alpha-benzylphenethylamines and methods for producing the same
DE227447C (en) 1955-03-23 1910-10-21
DE1210873B (en) * 1959-03-18 1966-02-17 Hoffmann La Roche Process for the preparation of haloalkylamines
US3044932A (en) * 1960-02-24 1962-07-17 Upjohn Co Appetite suppressant drugs
DE1133395B (en) * 1960-11-12 1962-07-19 Hoechst Ag Process for the production of phenylalkylamines with cardiovascular effects
DE1227447B (en) * 1962-03-30 1966-10-27 Chinoin Gyogyszer Es Vegyeszet Process for the preparation of phenylisopropylamines
GB1031425A (en) * 1962-03-30 1966-06-02 Chinoin Gyogyszer Es Vegyeszet New aralkylamines and their preparation
FR1478311A (en) * 1963-10-18 1967-04-28 Koninklijke Pharma Fab Nv Process for the preparation of amino alkanes and resulting products
GB1218135A (en) * 1967-07-28 1971-01-06 Abbott Lab Substituted phenethylamine derivatives
DE2143204C3 (en) * 1971-08-28 1979-09-27 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt N-fluoroalkyl-phenylisopropylamine derivatives and their salts, processes for their preparation and pharmaceuticals based on them
US4025624A (en) * 1975-11-18 1977-05-24 A. H. Robins Company, Incorporated Phenylalkylamines and phenylalkylureas in combinations to suppress gastric bleeding in aspirin therapy
US4404222A (en) * 1980-08-25 1983-09-13 American Cyanamid Company Phenylethanolamine derivatives and acid addition salts thereof for enhancing the growth rate of meat-producing animals and improving the efficiency of feed utilization thereby
DD145599A1 (en) * 1979-08-23 1980-12-24 Roswitha Toepfer MEANS FOR REGULATING PLANT GROWTH

Also Published As

Publication number Publication date
ES2007411A6 (en) 1989-06-16
FI882474A7 (en) 1988-05-25
PL267913A1 (en) 1989-03-06
DE3751006D1 (en) 1995-03-02
LTIP879A (en) 1995-03-27
US5075338A (en) 1991-12-24
LT3530B (en) 1995-11-27
DD262226A5 (en) 1988-11-23
KR880701545A (en) 1988-11-03
FI882474A0 (en) 1988-05-25
PL151642B1 (en) 1990-09-28
IL83905A (en) 1993-07-08
ATE117204T1 (en) 1995-02-15
GEP19960656B (en) 1996-12-24
PT85799A (en) 1987-10-01
HU207280B (en) 1993-03-29
DK282488D0 (en) 1988-05-24
EP0284621B1 (en) 1995-01-18
LT3531B (en) 1995-11-27
UA11100A (en) 1996-12-25
PT85799B (en) 1990-08-31
LV10709A (en) 1995-06-20
RU2007384C1 (en) 1994-02-15
DE3751006T2 (en) 1995-05-24
LV10709B (en) 1995-12-20
DK282488A (en) 1988-05-24
EP0284621A1 (en) 1988-10-05
SU1746882A3 (en) 1992-07-07
UA19808A (en) 1997-12-25
HUT45962A (en) 1988-09-28
UA19171A (en) 1997-12-25
CS689887A3 (en) 1992-08-12
WO1988002254A1 (en) 1988-04-07
CS277418B6 (en) 1993-03-17
LV10860B (en) 1996-04-20
LV10860A (en) 1995-10-20

Similar Documents

Publication Publication Date Title
LTIP879A (en) Process for preparation of phenyl alkylamines
KR860004850A (en) Method for preparing 1α-hydroxy vitamin D₃ derivative
HUT35629A (en) Preparations of plant growth controlling effect and containing 1-methyl-amino-cylopropane-1-carboxylic acid-derivatives as agent and process for the production of the agents
ES2166381T3 (en) TREATMENT OF HYPERPROLIFERATIVE VASCULAR DISEASES.
NZ216907A (en) Treatment of mycoplasmotic and bacterial infections in fowl
EP0311068A3 (en) Polyamine derivatives as antineoplastic agents
ES539123A0 (en) A COMPOUND OF 3-INDOLCARBOXAMIDE
MY104521A (en) Treatment of depression.
GR3001955T3 (en) N-phenethylaminoalkyl-benzamide anti-arrhythmia agents
PT76196B (en) PROCESS FOR THE PREPARATION OF IMIDAZOLIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HUT49283A (en) Process for production of medical compositions applicable for treatment of peptical ulcer
ES8507469A1 (en) Compositions for treating glaucoma.
PL285062A1 (en) Method of obtaining novel 2-hydroxy-3-phenoxypropylamine derivatives
SE8701887D0 (en) NOUVEAUX DERIVES DE L&#39;ACIDE 4-PHENYL 4-OXO 2-BUTENOIQUE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION COMME MEDICAMENTS AND LES COMPOSITIONS LES RENFERMANT
EP0239500A3 (en) 1-styrene-sulfonyl-2-oxo-5-hydroxy-pyrrolidine derivatives, their intermediates, process for their preparation, compositions containing them and their use as medicines
EP1103255A4 (en) Method of rearing and feeds
EP0447812A3 (en) Use of a dihydropyridine to improve the inner ear blood circulation
ZA886916B (en) Novel compound of choline,a process for its preparation and therapeutic composition containing it
DE3667380D1 (en) M-CYANPHENETHANOLAMINE AS ANOTHER GROWTH SUPPORT AND ANTILIPOGENIC AGENT.

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 19970819