LTIP600A - Novel steroids with pregnane skeleton,pharmaceutical compositions containing them and process for preparing thereof - Google Patents
Novel steroids with pregnane skeleton,pharmaceutical compositions containing them and process for preparing thereofInfo
- Publication number
- LTIP600A LTIP600A LTIP600A LTIP600A LTIP600A LT IP600 A LTIP600 A LT IP600A LT IP600 A LTIP600 A LT IP600A LT IP600 A LTIP600 A LT IP600A LT IP600 A LTIP600 A LT IP600A
- Authority
- LT
- Lithuania
- Prior art keywords
- amino group
- secondary amino
- alkyl
- compounds
- group
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- JWMFYGXQPXQEEM-WZBAXQLOSA-N pregnane group Chemical group [C@@H]12CC[C@H](CC)[C@@]1(C)CC[C@H]1[C@H]2CCC2CCCC[C@]12C JWMFYGXQPXQEEM-WZBAXQLOSA-N 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006546 (C4-C10) cycloalkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003859 lipid peroxidation Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 238000005502 peroxidation Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Šis išradimas priskiriamas naujiems, terapiškai aktyviems 21-aminosteroidams, kurių formulė@@@@@@@@@turintiems pregnano skeletą, kurioje@du iš X Y ir Z yra azoto atomai, o trečias yra metino grupė;@R1 ir R2 yra, nepriklausomai vienas nuo kito, priminė aminogrupė, kaip pakaitalą turinti šakotos grandinės C4-8-alkilo, -alkenilo arba -alkinilo grupes, arba C4-10-cikloalkilo grupę, į kurią įeina 1-3 žiedai, kuriuose gali būti C1-3-alkilo grupė(s); arba@R1 ir R2 kartu sudaro spiro-heterociklinę antrinę aminogrupę, turinčią daugiausia 10 anglies atomų ir kurioje gali būti mažiausiai vienas deguonies atomas, kaip papildomas heteroatomas; arba@vienas iš R1 ir R2 yra nepakeista heterociklinė antrinė aminogrupė, turinti nuo 4 iki 7 anglies atomų, o kitas yra aukščiau minėta pirminė aminogrupė, aukščiau minėta spiroheterociklinė antrinė aminogrupė, arba heterociklinė antrinė aminogrupė, turinti 4-7 C-atomus, su C1-4-alkilo(ų) pakaitais; ir n yra 1 arba 2,@ir jų adityvinėms druskoms, bei farmacinei kompozicijai, į kurią įeina šie junginiai.@Be to, išradimas priskiariamas ir aukščiau minėtų junginių gavimo būdui.@Junginiai, kurių formulė (I), pasižymi antioksidantiniu, ypač lipidų peroksidinimą inhibuojančiu efektu, ir todėl jie gali būti naudingi, gydant patologines lipidų peroksidinimo pasekmes, atsiradusias žinduolių, tame tarpe ir žmogaus, organizmuose.The present invention relates to novel therapeutically active 21-aminosteroids having the formula @@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@ @@@ as a substitute, an amino group substituted with a branched C4-8 alkyl, alkenyl or alkynyl group, or a C4-10 cycloalkyl group containing 1-3 rings which may contain a C1-3 alkyl group (s); or @ R 1 and R 2 together form a spiro-heterocyclic secondary amino group having up to 10 carbon atoms and which may contain at least one oxygen atom as an additional heteroatom; or one of R 1 and R 2 is an unsubstituted heterocyclic secondary amino group having from 4 to 7 carbon atoms, and the other is the above-mentioned primary amino group, the above-mentioned spiroheterocyclic secondary amino group, or a heterocyclic secondary amino group having from 4 to 7 C atoms with Cl -4-alkyl (s) substituted; and n is 1 or 2, @ and their addition salts, and the pharmaceutical composition comprising these compounds. In addition, the invention is also contemplated for the preparation of the above compounds. Compounds of formula (I) are antioxidant, especially lipid. peroxidation inhibitory effect, and therefore may be useful in treating the pathological effects of lipid peroxidation in mammalian, including human, organisms.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9201904A HU9201904D0 (en) | 1992-06-09 | 1992-06-09 | Laboratorial sem-automatic disclosing appartus operating with microwaves, equipped with teflone dividing and destructor holding devices, int two varieties one with controlled supercooling, another with energy dissipating unit |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LTIP600A true LTIP600A (en) | 1994-04-25 |
| LT3071B LT3071B (en) | 1994-11-25 |
Family
ID=10982015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTIP600A LT3071B (en) | 1992-06-09 | 1993-06-02 | Novel steroids with pregnane skeleton,pharmaceutical compositions containing them and process for preparing thereof |
Country Status (3)
| Country | Link |
|---|---|
| HU (1) | HU9201904D0 (en) |
| LT (1) | LT3071B (en) |
| LV (1) | LV10282B (en) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1296544A (en) | 1960-08-17 | 1962-06-22 | Roussel Uclaf | New 9alpha-fluorinated corticosteroids and their preparation process |
| CA1310009C (en) | 1984-03-28 | 1992-11-10 | John Mark Braughler | Ester prodrugs of steroids |
| WO1987001706A2 (en) | 1985-09-12 | 1987-03-26 | The Upjohn Company | C20 through c26 amino steroids |
| AU7580187A (en) | 1986-06-23 | 1988-01-12 | Upjohn Company, The | Androstane-type and cortical aminoesters |
| FR2644788B1 (en) | 1989-03-22 | 1995-02-03 | Roussel Uclaf | NOVEL 3-CETO STEROIDS COMPRISING AN AMINO-SUBSTITUTED 17-CHAIN, THEIR PREPARATION METHOD AND THE INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| FR2644787B1 (en) | 1989-03-22 | 1995-02-03 | Roussel Uclaf | NOVEL AMINOSUBSTITUTED STEROIDS 21, THEIR PREPARATION PROCESS AND THE INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
1992
- 1992-06-09 HU HU9201904A patent/HU9201904D0/en unknown
-
1993
- 1993-06-02 LT LTIP600A patent/LT3071B/en not_active IP Right Cessation
- 1993-06-08 LV LVP-93-493A patent/LV10282B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LV10282A (en) | 1994-10-20 |
| LT3071B (en) | 1994-11-25 |
| HU9201904D0 (en) | 1992-09-28 |
| LV10282B (en) | 1995-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9A | Lapsed patents |
Effective date: 19960602 |