LT2555775T - Combination compositions of adenosine a1 agonists and carbonic anhydrase inhibitors for reducing intraocular pressure - Google Patents

Combination compositions of adenosine a1 agonists and carbonic anhydrase inhibitors for reducing intraocular pressure

Info

Publication number
LT2555775T
LT2555775T LTEP11757063.0T LT11757063T LT2555775T LT 2555775 T LT2555775 T LT 2555775T LT 11757063 T LT11757063 T LT 11757063T LT 2555775 T LT2555775 T LT 2555775T
Authority
LT
Lithuania
Prior art keywords
adenosine
agonists
intraocular pressure
carbonic anhydrase
anhydrase inhibitors
Prior art date
Application number
LTEP11757063.0T
Other languages
Lithuanian (lt)
Inventor
Norman N. Kim
William K. Mcvicar
Thomas G. Mccauley
Original Assignee
Inotek Pharmaceuticals Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inotek Pharmaceuticals Corporation filed Critical Inotek Pharmaceuticals Corporation
Publication of LT2555775T publication Critical patent/LT2555775T/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
LTEP11757063.0T 2010-03-19 2011-03-18 Combination compositions of adenosine a1 agonists and carbonic anhydrase inhibitors for reducing intraocular pressure LT2555775T (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31572110P 2010-03-19 2010-03-19
PCT/US2011/029010 WO2011116290A1 (en) 2010-03-19 2011-03-18 Combination compositions of adenosine a1 agonists and carbonic anhydrase inhibitors for reducing intraocular pressure

Publications (1)

Publication Number Publication Date
LT2555775T true LT2555775T (en) 2017-04-25

Family

ID=44649619

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP11757063.0T LT2555775T (en) 2010-03-19 2011-03-18 Combination compositions of adenosine a1 agonists and carbonic anhydrase inhibitors for reducing intraocular pressure

Country Status (17)

Country Link
US (1) US8440639B2 (en)
EP (1) EP2555775B1 (en)
JP (1) JP2013522322A (en)
CN (1) CN102933220A (en)
CY (1) CY1118495T1 (en)
DK (1) DK2555775T3 (en)
ES (1) ES2613254T3 (en)
HR (1) HRP20170008T1 (en)
HU (1) HUE031529T2 (en)
LT (1) LT2555775T (en)
ME (1) ME02593B (en)
PL (1) PL2555775T3 (en)
PT (1) PT2555775T (en)
RS (1) RS55617B1 (en)
SI (1) SI2555775T1 (en)
SM (1) SMT201700019B (en)
WO (1) WO2011116290A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2424546E (en) * 2009-05-01 2015-12-23 Inotek Pharmaceuticals Corp Method of reducing intraocular pressure in humans
EP2523669B1 (en) * 2010-01-11 2016-12-07 Inotek Pharmaceuticals Corporation Combination, kit and method of reducing intraocular pressure
SG184221A1 (en) * 2010-03-26 2012-10-30 Inotek Pharmaceuticals Corp Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
HUE035750T2 (en) * 2012-01-26 2018-05-28 Inotek Pharmaceuticals Corp Anhydrous polymorphs of (2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) } methyl nitrate and processes of preparation thereof
US9522160B2 (en) 2013-03-15 2016-12-20 Inotek Pharmaceuticals Corporation Ophthalmic formulations
JP2018501219A (en) * 2014-12-03 2018-01-18 イノテック ファーマシューティカルズ コーポレイション How to prevent, reduce or treat macular degeneration

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7423144B2 (en) * 2004-05-26 2008-09-09 Inotek Pharmaceuticals Corporation Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof
CN101010085B (en) 2004-05-26 2012-12-26 伊诺泰克制药公司 Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
CN101321460A (en) * 2005-11-30 2008-12-10 伊诺泰克制药公司 Purine derivatives and methods of use thereof
PT2424546E (en) * 2009-05-01 2015-12-23 Inotek Pharmaceuticals Corp Method of reducing intraocular pressure in humans

Also Published As

Publication number Publication date
EP2555775B1 (en) 2016-12-07
SI2555775T1 (en) 2017-05-31
RS55617B1 (en) 2017-06-30
US8440639B2 (en) 2013-05-14
JP2013522322A (en) 2013-06-13
HRP20170008T1 (en) 2017-03-10
PL2555775T3 (en) 2017-08-31
EP2555775A4 (en) 2013-08-28
ME02593B (en) 2017-06-20
US20110245193A1 (en) 2011-10-06
CN102933220A (en) 2013-02-13
DK2555775T3 (en) 2017-02-06
WO2011116290A1 (en) 2011-09-22
HUE031529T2 (en) 2017-07-28
PT2555775T (en) 2017-02-01
SMT201700019B (en) 2017-03-08
EP2555775A1 (en) 2013-02-13
CY1118495T1 (en) 2017-07-12
ES2613254T3 (en) 2017-05-23

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