LT2012098A - Onkologinės patologijos sąlygotų audinių skysčių fotodinaminė diagnostika - Google Patents

Onkologinės patologijos sąlygotų audinių skysčių fotodinaminė diagnostika

Info

Publication number
LT2012098A
LT2012098A LT2012098A LT2012098A LT2012098A LT 2012098 A LT2012098 A LT 2012098A LT 2012098 A LT2012098 A LT 2012098A LT 2012098 A LT2012098 A LT 2012098A LT 2012098 A LT2012098 A LT 2012098A
Authority
LT
Lithuania
Prior art keywords
tissue
oncological
tissue fluids
fluid
radiance
Prior art date
Application number
LT2012098A
Other languages
English (en)
Other versions
LT6038B (lt
Inventor
Laima PLĖŠNIENĖ
Albinas Plėšnys
Rimantas Vaišnoras
Original Assignee
I. Į. Lazerių Ir Bangų Medicinos Mokslinė Klinika
Lietuvos Edukologijos Universitetas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I. Į. Lazerių Ir Bangų Medicinos Mokslinė Klinika, Lietuvos Edukologijos Universitetas filed Critical I. Į. Lazerių Ir Bangų Medicinos Mokslinė Klinika
Priority to LT2012098A priority Critical patent/LT6038B/lt
Priority to EP13189606.0A priority patent/EP2722059B1/en
Publication of LT2012098A publication Critical patent/LT2012098A/lt
Publication of LT6038B publication Critical patent/LT6038B/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Išradimas yra susijęs su biomedicina ir yra skirtas onkologinės patologijos sąlygotų audinių skysčio diagnostikai. Navikinis procesas dažnai sąlygoja audinių skysčio išsiskyrimą ir kaupimąsi įvairiose kūno ertmėse, dažniau pleuros bei pilvaplėvės ertmėse. Pacientų, kuriems kaupiasi navikinio proceso sukelti audinių skysčiai, gydymas iš esmės skiriasi nuo kitų susirgimų sąlygoto audinių skysčių kaupimosi atvejų, Todėl klinicistams labai svarbi maligninių pleurito ascito bei kitų navikinės patologijos sąlygotų audinių skysčių teisinga ir savalaikė diagnostika. Šis išradimas pateikia diagnostikos sistemą, apimančią audiniuose susikaupusio skysčio atitinkamo tūrio punktavimą, kai tiriamam pacientui prieš minėtą audinių skysčio punktavimą gydymo ir (arba) diagnozės nustatymo tikslu yra įvesta fotosensibilizatoriaus arba jo pirmtako, taip pat tuo, kad surinktas punktatas apšviečiamas tam tikro bangos ilgio ( violetine) šviesa, o tiriamo skysčio švytėjimo spalva ir intensyvumas vertinami vizualiai arba spektrofotometriniais metodais. Išradime naudojami hematoporfirino dariniai, tokie, kaip fotofrinas, fotohemas, fotosanas, kurie apšviečiami 400-405 nm bangos ilgio šviesa; tiriamo skysčio avietinis švytėjimas vertinamas vizualiai arba spektrofotometro pagalba.
LT2012098A 2012-10-22 2012-10-22 Onkologinės patologijos sąlygotų audinių skysčių fotodinaminė diagnostika LT6038B (lt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
LT2012098A LT6038B (lt) 2012-10-22 2012-10-22 Onkologinės patologijos sąlygotų audinių skysčių fotodinaminė diagnostika
EP13189606.0A EP2722059B1 (en) 2012-10-22 2013-10-22 Photodynamic diagnostics of tissue fluids caused by oncological pathology

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LT2012098A LT6038B (lt) 2012-10-22 2012-10-22 Onkologinės patologijos sąlygotų audinių skysčių fotodinaminė diagnostika

Publications (2)

Publication Number Publication Date
LT2012098A true LT2012098A (lt) 2014-04-25
LT6038B LT6038B (lt) 2014-06-25

Family

ID=49596051

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2012098A LT6038B (lt) 2012-10-22 2012-10-22 Onkologinės patologijos sąlygotų audinių skysčių fotodinaminė diagnostika

Country Status (2)

Country Link
EP (1) EP2722059B1 (lt)
LT (1) LT6038B (lt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017129971A1 (de) * 2017-12-14 2019-06-19 Detlef Schikora Vorrichtung zur Registrierung und zur Zerstörung einzelner Tumorzellen, Tumorzellencluster und Mikrometastasen im Blutkreislauf

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19747172C2 (de) 1997-10-24 2000-04-13 Pulsion Verwaltungs Gmbh & Co Vorrichtung zur Feststellung eines Perikardergusses
DE19827417B4 (de) 1998-06-19 2004-10-28 Hahn, Rainer, Dr.Med.Dent. Material zur unterschiedlichen Modifizierung der optischen Eigenschaften unterschiedlicher Zellen
EP1203944B1 (de) * 2000-11-06 2006-03-01 Hofstetter, Alfons, Prof.Dr.med. Tumorzellenidentifizierungsverfahren
JP5034032B2 (ja) * 2004-09-29 2012-09-26 Ｓｂｉファーマ株式会社 腫瘍診断剤
US20070073364A1 (en) 2005-09-29 2007-03-29 Siemens Aktiengesellschaft Combined OCT catheter device and method for combined optical coherence tomography (OCT) diagnosis and photodynamic therapy (PDT)
EP2584356B9 (en) * 2010-06-21 2016-02-17 SBI Pharmaceuticals Co., Ltd. Method for detection of urothelial cancer
CA2827095C (en) 2011-02-16 2018-11-20 Sequana Medical Ag Apparatus and methods for treating intracorporeal fluid accumulation
LT5823B (lt) 2011-06-06 2012-04-25 Vilniaus Universiteto Onkologijos Institutas, , Intraarterinė fotodinaminė diagnostika
US9493810B2 (en) * 2012-06-07 2016-11-15 Pioma, Inc. 5-ALA for detection of brain tumors

Also Published As

Publication number Publication date
LT6038B (lt) 2014-06-25
EP2722059A2 (en) 2014-04-23
EP2722059B1 (en) 2017-05-17
EP2722059A3 (en) 2014-08-27

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Legal Events

Date Code Title Description
BB1A Patent application published

Effective date: 20140425

FG9A Patent granted

Effective date: 20140625

MM9A Lapsed patents

Effective date: 20181022