KR970707149A - Novel peptides and therapeutic agents (NOVEL PEPTIDE AND THERAPEUTIC AGENT) - Google Patents

Novel peptides and therapeutic agents (NOVEL PEPTIDE AND THERAPEUTIC AGENT)

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Publication number
KR970707149A
KR970707149A KR1019970702830A KR19970702830A KR970707149A KR 970707149 A KR970707149 A KR 970707149A KR 1019970702830 A KR1019970702830 A KR 1019970702830A KR 19970702830 A KR19970702830 A KR 19970702830A KR 970707149 A KR970707149 A KR 970707149A
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South Korea
Prior art keywords
formula
peptide
peptide represented
novel
agents
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KR1019970702830A
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Korean (ko)
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KR100351180B1 (en
Inventor
아키히코 후지와라
기요시 구리야마
요시코 아베
고지 이나가키
Original Assignee
니시자와 스스무
세키스이 가가쿠 고교 가부시키가이샤
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Priority claimed from JP26032494A external-priority patent/JP3148850B2/en
Priority claimed from JP26032694A external-priority patent/JP3148851B2/en
Priority claimed from JP04292795A external-priority patent/JP3148852B2/en
Application filed by 니시자와 스스무, 세키스이 가가쿠 고교 가부시키가이샤 filed Critical 니시자와 스스무
Priority claimed from PCT/JP1995/002187 external-priority patent/WO1996012732A1/en
Publication of KR970707149A publication Critical patent/KR970707149A/en
Application granted granted Critical
Publication of KR100351180B1 publication Critical patent/KR100351180B1/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 하기 화학식(Ⅰ)로 표시되는 신규의 펩티드에 관한 것이다. 본 발명은 신규의 펩티드는 알레르기성 및 비알레르기성 염증 억제 효과, 항균 효과, 항종양 효과 및 상처-치유 효과를 나타내며, 염증 억제제, 면역 억제제, 향균제, 항종양제, 상처 치유제, 항궤양제등으로 유용하다. 따라서, 본 발명은 또한 전술한 약리학적 효과를 가진 치료제를 제공한다.The present invention relates to a novel peptide represented by the following formula (I). The present invention relates to novel peptides which exhibit an allergic and non-allergic inflammation-inhibiting effect, an antimicrobial effect, an antitumor effect and a wound-healing effect and are useful as antiinflammatory agents, immunosuppressive agents, antibacterial agents, antitumor agents, wound healing agents, . Accordingly, the present invention also provides a therapeutic agent having the aforementioned pharmacological effect.

Description

신규의 펩티드 및 치료제(NOVEL PEPTIDE AND THERAPEUTIC AGENT)Novel peptides and therapeutic agents (NOVEL PEPTIDE AND THERAPEUTIC AGENT)

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (14)

하기 화학식(1)로 표시되는 신규 펩티드 :A novel peptide represented by the following formula (1): 제1항에 있어서, 액티노마이세스 에스. 노빌리스(Actinomyces S. mibilis)를 배양하여 얻는 배양배지, 배지의 건조 생성물 또는 배양된 박테리아로부터 유기용매를 사용하여 추출한 추출물을 다양한 칼럼 크로마토 그래피에 의해 정제하고, 목적 생성물을 함유하는 칼럼 크로마토그래피 분획을 재결정함으로써 수득되는 펩티드.The method according to claim 1, wherein the actinomycetes. The culture medium obtained by culturing Actinomyces S. mibilis, the dry product of the medium or the extract extracted from the cultured bacteria by using an organic solvent is purified by various column chromatography, and a column chromatography fraction containing the objective product ≪ / RTI > 제2항에 있어서, 액티노마이세스 에스. 노빌리스가 물리 및 화학 연구소(Institute of Physical and Chemical Research)에 기탁된 박테리아(JCM4274), 미국에서 기탁된 ATCC19252 또는 네덜란드에서 기탁된 CBS198. 65인 펩티드.3. The composition of claim 2, wherein the actinomycetes. Bacteria deposited in the Institute of Physical and Chemical Research (JCM 4274), ATCC 19252 deposited in the United States, or CBS 198 deposited in the Netherlands. 65 peptide. 제2항 또는 제3항에 있어서, 에스. 노빌리스의 배양 배지로부터의 추출물, 건조된 생성물 또는 그 박테리아는 황산암모늄으로 처리하고, 수득된 침전물을 용매로 추출한 것인 펩티드.4. The method according to claim 2 or 3, Wherein the extract, the dried product or the bacteria from the culture medium of Nobilis is treated with ammonium sulfate and the obtained precipitate is extracted with a solvent. 제2항 내지 제4항 중 어느 한 항에 있어서, 칼럼 크로마토그래피용 충전재가 옥타데실실란을 포함하는 펩티드.The peptide according to any one of claims 2 to 4, wherein the filler for column chromatography comprises octadecylsilane. 제1항에 따른 화학식(1)로 표시되는 펩티드를 함유하는 항생물질.An antibiotic substance containing a peptide represented by the formula (1) according to claim 1. 제1항에 따른 화학식(1)로 표시되는 펩티드를 함유하는 항균성 제제.An antimicrobial agent containing the peptide of formula (1) according to claim 1. 제1항에 따른 화학식(1)로 표시되는 펩티드를 함유하는 항종양 물질.An antitumor substance containing a peptide represented by the formula (1) according to claim 1. 제1항에 따른 화학식(1)로 표시되는 펩티드를 함유하는 항종양 제제.An antitumor preparation containing a peptide represented by formula (1) according to claim 1. 제1항에 따른 화학식(1)로 표시되는 펩티드를 함유하는 항염증성 물질.An anti-inflammatory substance containing a peptide represented by formula (1) according to claim 1. 제1항에 따른 화학식(1)로 표시되는 펩티드를 함유하는 항염증 제제.An anti-inflammatory agent containing a peptide represented by the formula (1) according to claim 1. 제1항에 따른 화학식(1)로 표시되는 펩티드를 함유하는 상처-치유 물질.A wound-healing substance comprising the peptide of formula (1) according to claim 1. 제1항에 따른 화학식(1)로 표시되는 펩티드를 함유하는 상처-치유용 제제.A wound-healing composition containing the peptide of formula (1) according to claim 1. 제1항에 따른 화학식(1)로 표시되는 펩티드를 함유하는 항궤양 제제.An anti-ulcer preparation containing a peptide represented by the formula (1) according to claim 1. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019970702830A 1994-10-25 1995-10-25 Novel peptides and therapeutic agents KR100351180B1 (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
JP26032494A JP3148850B2 (en) 1994-10-25 1994-10-25 New peptide
JP26032794 1994-10-25
JP26032694A JP3148851B2 (en) 1994-10-25 1994-10-25 New antitumor agent
JP94-260325 1994-10-25
JP94-260327 1994-10-25
JP94-260326 1994-10-25
JP26032594 1994-10-25
JP94-260324 1994-10-25
JP95-42927 1995-03-02
JP04292795A JP3148852B2 (en) 1994-10-25 1995-03-02 New anti-inflammatory agent
JP95-98605 1995-04-24
JP9860595 1995-04-24
PCT/JP1995/002187 WO1996012732A1 (en) 1994-10-25 1995-10-25 Novel peptide and therapeutic agent

Publications (2)

Publication Number Publication Date
KR970707149A true KR970707149A (en) 1997-12-01
KR100351180B1 KR100351180B1 (en) 2002-11-13

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KR102301151B1 (en) * 2020-02-04 2021-09-14 서울대학교산학협력단 Peptide compound, a preparing method thereof, and a use thereof

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