KR970703363A - Cyclic Depsipeptide (CYCLODEPSIPEPTIDE) - Google Patents

Cyclic Depsipeptide (CYCLODEPSIPEPTIDE) Download PDF

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Publication number
KR970703363A
KR970703363A KR1019960706672A KR19960706672A KR970703363A KR 970703363 A KR970703363 A KR 970703363A KR 1019960706672 A KR1019960706672 A KR 1019960706672A KR 19960706672 A KR19960706672 A KR 19960706672A KR 970703363 A KR970703363 A KR 970703363A
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KR
South Korea
Prior art keywords
cyclic depsipeptide
pharmacologically acceptable
acceptable salt
cyclic
depsipeptide
Prior art date
Application number
KR1019960706672A
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Korean (ko)
Inventor
디에떼르 헤르만
한스-게오르그 오피쯔
하랄드 질츠
알프레드 메르뗀스
시게루 히라모또
유끼오 사이또
시게오 하따나까
아끼꼬 신가이
Original Assignee
포우쿠에 하버트, 베버 만프레트
뵈링거 만하임 게엠베하
마사다 오사무
니신 세이훈 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from DE4418690A external-priority patent/DE4418690A1/en
Application filed by 포우쿠에 하버트, 베버 만프레트, 뵈링거 만하임 게엠베하, 마사다 오사무, 니신 세이훈 가부시끼가이샤 filed Critical 포우쿠에 하버트, 베버 만프레트
Priority claimed from PCT/JP1995/001003 external-priority patent/WO1995032990A1/en
Publication of KR970703363A publication Critical patent/KR970703363A/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

하기 화학식(I)의 환상 뎁시펩티드 또는 이의 약리학적으로 허용가능한 염.Cyclic depsipeptide of formula (I) or a pharmacologically acceptable salt thereof.

(식중, n은 정수 5-15이다).(Wherein n is an integer of 5-15).

이는 바실러스 속의 환상 뎁시펩티드-생산 세균을 배양하여 생산하며, 고지혈증 치료, 지질분비 억제제, 및 아폴리포단백질 B 생산 억제제로 유용하다.It is produced by culturing cyclic depsipeptide-producing bacteria of the genus Bacillus and is useful as a treatment for hyperlipidemia, lipid secretion inhibitors, and inhibitors of apolypoprotein B production.

Description

환상 뎁시펩티드(CYCLODEPSIPEPTIDE)Cyclic Depsipeptide (CYCLODEPSIPEPTIDE)

[도면의 간단한 설명][Brief Description of Drawings]

제2도는 본 발명의 환상 뎁시펩티드(화합물 1)의 적외선 흡수 스펙트럼을 나타낸다.2 shows the infrared absorption spectrum of the cyclic depsipeptide (Compound 1) of the present invention.

제3도는 본 발명의 환상 뎁시펩티드(화합물 1)의1H 핵자기공명스펙트럼을 나타낸다.3 shows the 1 H nuclear magnetic resonance spectrum of the cyclic depsipeptide (Compound 1) of the present invention.

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (8)

하기 화학식(I)의 환상 뎁시펩티드 및 이의 약리학적으로 허용가능한 염:Cyclic depsipeptides of formula (I) and pharmacologically acceptable salts thereof: (식중, n은 정수 5-15이다).(Wherein n is an integer of 5-15). n은 정수 6-12인 제1항의 환상 뎁시펩티드 및 이의 약리학적으로 허용가능한 염.n is the integer 6-12 cyclic depsipeptide of claim 1 and its pharmacologically acceptable salts. n은 7,8,9 또는 10인 제1항의 환상 뎁시펩티드 및 이의 약리학적으로 허용가능한 염.The cyclic depsipeptide of claim 1, wherein n is 7,8,9 or 10 and a pharmacologically acceptable salt thereof. 바실러스 속에 속하고 제1항의 환상 뎁시펩티드를 생산할 수 있는 미생물을 배양하고, 생산된 환상 뎁시펩티드를 배양액으로부터 회수하는 것을 특징으로 하는 환상 뎁시펩티드의 제조 방법.A method for producing a cyclic depsipeptide, comprising culturing a microorganism belonging to Bacillus and capable of producing the cyclic depsipeptide of claim 1, and recovering the produced cyclic depsipeptide from the culture solution. 제1항 내지 제3항 중 어느 한 항의 환상 뎁시펩티드 또는 이의 약리학적으로 허용가능한 염을 함유하는 제약학적 조성물.A pharmaceutical composition comprising the cyclic depsipeptide of any one of claims 1 to 3 or a pharmacologically acceptable salt thereof. 제1항 내지 제3항 중 어느 한 항의 환상 뎁시펩티드 또는 이의 약리학적으로 허용가능한 염을 함유하는 고지혈증 치료제.A therapeutic agent for hyperlipidemia containing the cyclic depsipeptide of any one of claims 1 to 3 or a pharmacologically acceptable salt thereof. 제1항 내지 제3항 중 어느 한 항의 환상 뎁시펩티드 또는 이의 약리학적으로 허용가능한 염을 함유하는 지질분비 억제제.A lipid secretion inhibitor comprising the cyclic depsipeptide of any one of claims 1 to 3 or a pharmacologically acceptable salt thereof. 제1항 내지 제3항 중 어느 한 항의 환상 뎁시펩티드 또는 이의 약리학적으로 허용가능한 염을 함유하는 아폴리포단백질 B의 생산 억제제.Inhibitor of production of apolypolyprotein B containing the cyclic depsipeptide of any one of claims 1 to 3 or a pharmacologically acceptable salt thereof. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019960706672A 1994-05-26 1995-05-25 Cyclic Depsipeptide (CYCLODEPSIPEPTIDE) KR970703363A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP11302394 1994-05-26
JP94-113023 1994-05-26
DEP4418690.8 1994-05-28
DE4418690A DE4418690A1 (en) 1994-05-28 1994-05-28 Nucleoside 5'-mono-phosphate ester(s) of glyceryl di:ether derivs.
PCT/JP1995/001003 WO1995032990A1 (en) 1994-05-26 1995-05-25 Cyclodepsipeptide

Publications (1)

Publication Number Publication Date
KR970703363A true KR970703363A (en) 1997-07-03

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KR1019960706672A KR970703363A (en) 1994-05-26 1995-05-25 Cyclic Depsipeptide (CYCLODEPSIPEPTIDE)

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KR (1) KR970703363A (en)

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