KR970074734A - Production method of? -Arylcarboxylic acid derivative having optical activity - Google Patents

Production method of? -Arylcarboxylic acid derivative having optical activity Download PDF

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Publication number
KR970074734A
KR970074734A KR1019960014401A KR19960014401A KR970074734A KR 970074734 A KR970074734 A KR 970074734A KR 1019960014401 A KR1019960014401 A KR 1019960014401A KR 19960014401 A KR19960014401 A KR 19960014401A KR 970074734 A KR970074734 A KR 970074734A
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South Korea
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group
optically active
acid derivative
arylcarboxylic acid
structural formula
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KR1019960014401A
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Korean (ko)
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KR100193367B1 (en
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김주인
조규일
김지숙
정원일
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이숭웅
삼성정밀화학 주식회사
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Abstract

본 발명은 광학활성을 갖는 α-아릴카르복시산 유도체의 제조방법에 관한 것으로서, 더욱 상세하게는 광학활성을 갖는 α-아릴시아노 유도체를 가수분해하여 시아노기를 카르복시기로 전환함에 있어 진한 염산과 아세트산이 거절 혼합비로 이루어져 있는 새로운 용매조건에서 반응을 수행하여 광학활성도를 그대로 유지하면서도 카르복시기를 생성시키는 방법에 관한 것이다.The present invention relates to a process for producing an optically active? -Arylcarboxylic acid derivative, and more particularly, to a process for the production of an optically active? -Arylcarboxylic acid derivative by hydrolysis of an optically active? -Arylcyano derivative to convert the cyano group into a carboxyl group. To a method for producing a carboxy group while maintaining the optical activity as it is.

Description

광학활성을 갖는 α-아릴카르복시산 유도체의 제조방법Production method of? -Arylcarboxylic acid derivative having optical activity

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (3)

다음 구조식(Ⅰ)로 표시되는 광학활성을 갖는 α-아릴시아노 유도체를 가수분해하여 다음 구조식(Ⅱ)로 표시되는 광학활성을 갖는 α-아릴카르복시산 유도체를 제조함에 있어서, 상기 가수분해 반응은 진한 염산과 아세트산이 1.6 : 1∼10 : 1 중량비로 혼합되어 있는 혼합용매 및 80∼110℃의 조건하에서 수행하는 것을 특징으로 하는 광학활성을 갖는 α-아릴카르복시산 유도체의 제조방법.In the production of an optically active? -Arylcarboxylic acid derivative represented by the following structural formula (II) by hydrolysis of an optically active? -Arylcyano derivative represented by the following structural formula (I), the hydrolysis reaction is carried out in a dark Characterized in that the reaction is carried out in a mixed solvent of hydrochloric acid and acetic acid in a weight ratio of 1.6: 1 to 10: 1 and at a temperature of 80 to 110 캜. 상기 식에서, Ar은 페닐기, 6-메톡시나프탈레닐기, 또는 치환된 페닐기(이때 치환기로는 니트로기, 할로겐, C1∼C5의 알킬아실기, 페닐기, 메톡시기, 페논기 또는 C1∼C5의 알킬기)이고; R은 C1∼C7의 선형 또는 비선형 알킬기 또는 알케닐기이다.Wherein, Ar is a phenyl, 6-methoxy-naphthyl Frontale group, or a substituted phenyl group (wherein the substituent is alkyl, acyl group, phenyl group, methoxy group of nitro, halogen, C 1 ~C 5, page nongi or C 1 ~ alkyl group of C 5), and; R is a C 1 -C 7 linear or non-linear alkyl or alkenyl group. 제1항에 있어서, 상기 구조식(Ⅰ)로 표시되는 광학활성을 갖는 α-아릴시아노 유도체는 Ar이 페닐기, 이소부틸페닐기 및 6-메톡시나프탈레닐기 중에서 선택된 것을 특징으로 하는 광학활성을 갖는 α-아릴카르복시산 유도체의 제조방법.The optically active? -Arylcyano derivative represented by the structural formula (I) according to claim 1, wherein Ar is a phenyl group, an isobutylphenyl group and a 6-methoxynaphthalenyl group. A process for producing an? -arylcarboxylic acid derivative. 제1항 또는 제2항에 있어서, 상기 구조식(Ⅰ)로 표시되는 α-아릴시아노 유도체는 R이 메틸기 및 에틸기 중에서 선택된 것을 특징으로 하는 광학활성을 갖는 α-아릴 카르복시산 유도체의 제조방법.The process for producing an optically active? -Arylcarboxylic acid derivative according to claim 1 or 2, wherein the? -Arylcyano derivative represented by the structural formula (I) is selected from the group consisting of methyl group and ethyl group. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019960014401A 1996-05-03 1996-05-03 Method for preparing alpha-arylcarboxylic acid derivative having optical activity KR100193367B1 (en)

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KR1019960014401A KR100193367B1 (en) 1996-05-03 1996-05-03 Method for preparing alpha-arylcarboxylic acid derivative having optical activity

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KR1019960014401A KR100193367B1 (en) 1996-05-03 1996-05-03 Method for preparing alpha-arylcarboxylic acid derivative having optical activity

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KR970074734A true KR970074734A (en) 1997-12-10
KR100193367B1 KR100193367B1 (en) 1999-06-15

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