KR970073606A - 항 인체 인터루킨-6 항체 및 이를 이용한 인체 인터루킨-6의 검정 - Google Patents

항 인체 인터루킨-6 항체 및 이를 이용한 인체 인터루킨-6의 검정 Download PDF

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KR970073606A
KR970073606A KR1019960018323A KR19960018323A KR970073606A KR 970073606 A KR970073606 A KR 970073606A KR 1019960018323 A KR1019960018323 A KR 1019960018323A KR 19960018323 A KR19960018323 A KR 19960018323A KR 970073606 A KR970073606 A KR 970073606A
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human interleukin
interleukin
composition
monoclonal antibody
antibody
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KR1019960018323A
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KR100210512B1 (ko
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최인표
마정재
강형식
남경수
변광호
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박원훈
한국과학기술연구원
한승수
제일약품 주식회사
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Priority to KR1019960018323A priority Critical patent/KR100210512B1/ko
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
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  • Hematology (AREA)
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Abstract

본 발명은 인체 인터루킨-6(human interleukin-6)을 특이적으로 인식하는 단일클론 항체(monoclonal antibody) 및 다클론 항체(polyclonal antibody)에 관한 것으로, 이를 이용하여 세포배양액, 혈액 또는 체액 중 인체 인터루킨-6을 검색함으로써 류마티스 관절염, 다발성 골수종, 심장 점액종, 간경변, 조산 등 인체 인터루킨-6 관련 질병의 예방, 진단 및 치료에 활용할 수 있다.

Description

항 인체 인터루킨-6항체 및 이를 이용한 인체 인터루킨-6의 검정
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 인체 인터루킨-6을 특이적으로 인식하는 단일클론 항체 YB3.
  2. 제1항의 단일클론 항체 YB3를 생산하는 하이브리도마 세포주 YB3(KCTC 0242BP).
  3. 제1항의 단일클론 항체를 포함하는, 세포 배양액, 혈액 또는 체액 중 인체 인터루킨-6의 측정용 시약.
  4. 제1항의 단일클론 항체를 포함하는 인터루킨-6 관련 질병의 진단 및 치료용 조성물.
  5. 제4항에 있어서, 상기 질병이 류마티스 관절염, 다발성 골수종, 심장 점액종, 간 경변 또는 조산인 것을 특징으로 하는 조성물.
  6. 인체 인터루킨-6을 특징으로 인식하는 다클론 항체를 포함하는, 세포 배양액, 혈액 또는 체액 중 인체 인터루킨-6의 측정용 시약.
  7. 인체 인터루킨-6을 특이적으로 인식하는 다클론 항체를 포함하는, 인터루킨-6 관련 질병의 진단 및 치료용 조성물.
  8. 제7항에 있어서, 상기 질병이 류마티스 관절염, 다발성 골수종, 심장 점액종, 간경변 또는 조산인 것을 특징으로 하는 조성물.
  9. 인터루킨-6을 생산하는 세포주 B9-G7(KCTC 0243BP).
    ※ 참고사항：최초출원 내용에 의하여 공개하는 것임.
KR1019960018323A 1996-05-28 1996-05-28 항 인체 인터루킨-6 항체 및 이를 이용한 인체 인터루킨-6의검정 KR100210512B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019960018323A KR100210512B1 (ko) 1996-05-28 1996-05-28 항 인체 인터루킨-6 항체 및 이를 이용한 인체 인터루킨-6의검정

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960018323A KR100210512B1 (ko) 1996-05-28 1996-05-28 항 인체 인터루킨-6 항체 및 이를 이용한 인체 인터루킨-6의검정

Publications (2)

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KR970073606A true KR970073606A (ko) 1997-12-10
KR100210512B1 KR100210512B1 (ko) 1999-07-15

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KR101559975B1 (ko) 2015-04-17 2015-10-14 이화여자대학교 산학협력단 32주 미만의 조산 위험성을 예측하기 위한 마커 il-7 및 이의 이용

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