KR970065517A - A novel method for producing melatonin - Google Patents

A novel method for producing melatonin Download PDF

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Publication number
KR970065517A
KR970065517A KR1019960005730A KR19960005730A KR970065517A KR 970065517 A KR970065517 A KR 970065517A KR 1019960005730 A KR1019960005730 A KR 1019960005730A KR 19960005730 A KR19960005730 A KR 19960005730A KR 970065517 A KR970065517 A KR 970065517A
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KR
South Korea
Prior art keywords
compound
formula
following structural
structural formula
solvent
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KR1019960005730A
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Korean (ko)
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KR0177901B1 (en
Inventor
장혜경
Original Assignee
성재갑
주식회사 Lg 화학
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Priority to KR1019960005730A priority Critical patent/KR0177901B1/en
Publication of KR970065517A publication Critical patent/KR970065517A/en
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Publication of KR0177901B1 publication Critical patent/KR0177901B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/22—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

본 발명은 인돌아민계 호르몬인 하기 구조식(Ⅰ)의 멜라토닌의 신규한 제조방법 및 그를 유효성분으로 함유하는 불면증 치료, 골다공증 예방 및 암 치료용 약제학적으로 허용되는 조성물에 관한 것이다.The present invention relates to a novel process for producing melatonin of the following structural formula (I), which is an indolamine-type hormone, and a pharmaceutically acceptable composition for the treatment of insomnia, osteoporosis and cancer, comprising the same as an active ingredient.

Description

멜라토닌의 신규한 제조방법A novel method for producing melatonin

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (5)

하기 구조식(Ⅳ)의 화합물을 동시에 환원 반응과 아세틸화 반응시킴을 특징으로 하여, 하기 구조식(Ⅰ)의 멜라토닌 화합물을 제조하는 방법.A method for producing a melatonin compound of the following structural formula (I), characterized by simultaneous reduction and acetylation of a compound of the following structural formula (IV). 제1항에 있어서, 용매의 존재하에서 나트륨 보로하이드라이드, 코발터스 클로라이드와 무수초산을 동시에 사용하여 반응시킴을 특징으로 하는 방법.The method according to claim 1, wherein sodium borohydride, co-valeral chloride and anhydrous acetic acid are simultaneously used in the presence of a solvent. 제1항에 있어서, 용매의 존재하에서 동시에 촉매하 수소부가 반응과 무수초산을 이용한 아세틸화 반응시킴을 특징으로 하는 방법.The method according to claim 1, wherein the hydrogenation reaction under the catalyst and the acetylation reaction with anhydrous acetic acid are simultaneously carried out in the presence of a solvent. 제1항에 있어서, 구조식(Ⅳ)의 화합물이 4-메톡시페닐하이드라진 염산염과 3-시아노프로피온알데히드디에틸아세탈을 반응시킴으로써 제조된 화합물임을 특징으로 하는 방법.The process according to claim 1, wherein the compound of formula (IV) is a compound prepared by reacting 4-methoxyphenylhydrazine hydrochloride with 3-cyanopropionaldehyde diethyl acetal. 약제학적으로 허용되는 담체와 함께 유효성분으로서 제1항에 정의된 구조식(Ⅰ)의 화합물을 함유하는 불면증 치료, 골다공증 예방 및 암 치료용 조성물.A composition for treating insomnia, prevention of osteoporosis and treating cancer, which comprises a compound of formula (I) as defined in claim 1 together with a pharmaceutically acceptable carrier. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019960005730A 1996-03-05 1996-03-05 The new process for preparation of melatonin KR0177901B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019960005730A KR0177901B1 (en) 1996-03-05 1996-03-05 The new process for preparation of melatonin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960005730A KR0177901B1 (en) 1996-03-05 1996-03-05 The new process for preparation of melatonin

Publications (2)

Publication Number Publication Date
KR970065517A true KR970065517A (en) 1997-10-13
KR0177901B1 KR0177901B1 (en) 1999-03-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960005730A KR0177901B1 (en) 1996-03-05 1996-03-05 The new process for preparation of melatonin

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Publication number Publication date
KR0177901B1 (en) 1999-03-20

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