KR970061910A - A novel ginseng saponin, a process for producing the same, and an antitumor agent comprising the same as an active ingredient - Google Patents

A novel ginseng saponin, a process for producing the same, and an antitumor agent comprising the same as an active ingredient Download PDF

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Publication number
KR970061910A
KR970061910A KR1019960004879A KR19960004879A KR970061910A KR 970061910 A KR970061910 A KR 970061910A KR 1019960004879 A KR1019960004879 A KR 1019960004879A KR 19960004879 A KR19960004879 A KR 19960004879A KR 970061910 A KR970061910 A KR 970061910A
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South Korea
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same
formula
compound
active ingredient
novel
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KR1019960004879A
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Korean (ko)
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KR0169536B1 (en
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박만기
이승기
박정일
김종문
이광열
한상범
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박만기
손경식
제일제당 주식회사
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Priority to KR1019960004879A priority Critical patent/KR0169536B1/en
Priority to PCT/KR1996/000123 priority patent/WO1997031933A1/en
Priority to AU65334/96A priority patent/AU6533496A/en
Publication of KR970061910A publication Critical patent/KR970061910A/en
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Publication of KR0169536B1 publication Critical patent/KR0169536B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 강력한 항암효과를 나타내는 신규한 인삼 사포닌인 하기 구조식(Ⅰ) 및 (Ⅱ)의 화합물에 관한 것이다.The present invention relates to a compound of the following structural formulas (I) and (II), which is a novel ginseng saponin exhibiting a strong anticancer effect.

(Ⅰ)(I)

(Ⅱ)(II)

상기 화합물(Ⅰ) 및 (Ⅱ)는 신규한 화합물로 인삼속 식물을 110 내지 180℃의 고온에서 0.5내지 20시간 동안 가열함으로써 생성되거나, 각각 공지의 인삼사포닌인 진세노사이드 Rg및 △20(22)-진세노사이드 Rg3를 아세틸화시켜 합성할 수 있다본 발명은 또한 이들 화합물(Ⅰ) 및 (Ⅱ)를 활성성분으로서 함유하는 항종양제 조성물에 관한 것이다.The compounds (I) and (II) are novel compounds which are produced by heating a plant of the genus Ginseng at a high temperature of 110 to 180 캜 for 0.5 to 20 hours, or a ginsenoside Rg and? 20 ) - Gene present invention can be synthesized by acetylation of ginsenosides Rg 3 also relates to anti-tumor compositions containing these compounds (ⅰ) and (ⅱ) as an active ingredient.

Description

신규한 인삼 사포닌, 그의 제조 방법 및 이를 유효 성분으로 하는 항종양제A novel ginseng saponin, a process for producing the same, and an antitumor agent comprising the same as an active ingredient

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (7)

하기 구조식(Ⅰ)로 표시되는 신규한 인삼 사포닌 화합물:A novel ginseng saponin compound represented by the following structural formula (I): (Ⅰ)(I) 하기 구조식(Ⅱ)로 표시되는 신규한 인삼 사포닌 화합물:A novel ginseng saponin compound represented by the following structural formula (II): (Ⅱ)(II) 하기 구조식(Ⅲ)의 진세노사이드 Rg3를 아세틸화시켜 구조식(Ⅰ)의 화합물을 제조하는 방법.A process for the preparation of a compound of formula (I) by acetylating ginsenoside Rg 3 of structure (III) (Ⅰ)(I) (Ⅱ)(II) 하기 구조식(Ⅳ)의 △20(22)-진세노사이드 Rg3를 아세틸화시켜 구조식(Ⅱ)의 화합물을 제조하는 방법:Method for preparing a compound of formula (II) by acetylating? 20 (22) -ginsenoside Rg 3 of formula (IV) (Ⅱ)(II) (Ⅳ)(IV) 파낙스속 식물의 물 또는 저급알콜에 의한 추출물을 110 내지 180℃의 온도에서 0.5 내지 20시간 동안 가열 처리하고, 수득된 가공인삼을 물, 유기용매 또는 이들의 혼합물로 추출한 후에 추출물을 비극성 유기용매로 추출하고, 수충을 분리하여 극성 유기용매로 추출하고, 이 추출물을 크로마트그라피하여 화합물(Ⅰ) 및 (Ⅱ)를 함유하는 분획을 수득하고, 이 분획을 물 및 저급알콜의 혼합 용매로부터 결정화시킴을 특징으로 하여 구조식(I) 또는 (Ⅱ)의 화합물을 제조하는 방법.Treating the extract of Panax ginseng with water or a lower alcohol at a temperature of 110 to 180 ° C for 0.5 to 20 hours, extracting the obtained processed ginseng with water, an organic solvent or a mixture thereof, and then adding the extract to a nonpolar organic solvent And extracted with a polar organic solvent. The extract is chromatographed to obtain a fraction containing the compounds (I) and (II), and this fraction is crystallized from a mixed solvent of water and a lower alcohol (I) or (II). ≪ / RTI > 구조식(Ⅰ) 또는 (Ⅱ)의 화합물 또는 이들의 화합물을 유효성분으로 함유하는 항종양에 조성물.An antitumor composition comprising a compound of formula (I) or (II) or a compound thereof as an active ingredient. 제6항에 있어서, 추가로 약제학적으로 허용되는 담체를 사용하여 약제학적 단위제형으로 제형화시킨 항종양제 조성물.7. An antitumor agent composition according to claim 6, further formulated into a pharmaceutical unit dosage form using a pharmaceutically acceptable carrier. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019960004879A 1996-02-27 1996-02-27 Novel ginseng saponins, process for preparation thereof and anti-tumor agents containing the same as an active ingredient KR0169536B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1019960004879A KR0169536B1 (en) 1996-02-27 1996-02-27 Novel ginseng saponins, process for preparation thereof and anti-tumor agents containing the same as an active ingredient
PCT/KR1996/000123 WO1997031933A1 (en) 1996-02-27 1996-07-29 Novel ginseng saponin compounds, process for preparation thereof and anti-tumor agent comprising the same as an active component
AU65334/96A AU6533496A (en) 1996-02-27 1996-07-29 Novel ginseng saponin compounds, process for preparation thereof and anti-tumor agent comprising the same as an active component

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Application Number Priority Date Filing Date Title
KR1019960004879A KR0169536B1 (en) 1996-02-27 1996-02-27 Novel ginseng saponins, process for preparation thereof and anti-tumor agents containing the same as an active ingredient

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KR970061910A true KR970061910A (en) 1997-09-12
KR0169536B1 KR0169536B1 (en) 1999-01-15

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AU (1) AU6533496A (en)
WO (1) WO1997031933A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100746799B1 (en) * 2003-06-19 2007-08-23 최용석 A preparation method of new saponin solution

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1131237C (en) 1997-09-26 2003-12-17 中国人民解放军军事医学科学院放射医学研究所 Usage of steroi saponin for preventing and curing senile dementia and new steroid saponin
GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
US6888014B2 (en) * 2001-07-24 2005-05-03 Panagin Pharmaceuticals Inc. Dammarane sapogenins, their use as anti-cancer agents, and a process for producing same
US6949523B2 (en) 2001-07-24 2005-09-27 Panagin Pharmaceuticals, Inc. Aglycon dammarane sapogenins, their use as anti-cancer agents, and a process for producing same
WO2003086438A1 (en) * 2002-04-08 2003-10-23 Ginseng Science Inc. Extract of processed panax genus plant, the preparation method thereof, and compositions containing the same
AU2003201777A1 (en) * 2002-04-08 2003-10-27 Ginseng Science Inc. Novel use of the extract of processed panax genus plant and saponin compound isolated therefrom
KR100485936B1 (en) * 2002-10-23 2005-04-27 주식회사 바이오사포젠 Anticarcinogenic constituents of ginsenoside Rh2 and Rg3
WO2005075449A1 (en) * 2004-02-03 2005-08-18 Yale University Compounds and methods to increase anti-p-glycoprotein activity of baicalein by alkylation on the a ring
CN103316119B (en) * 2013-05-17 2014-08-06 胡庆华 Traditional Chinese medicine for treating leukemia
CN105777838A (en) * 2014-12-17 2016-07-20 富力 20(R)-ginsenoside Rg3 derivatives, and preparation method and application thereof
CN105753923B (en) * 2014-12-17 2017-09-29 富力 The 20 many acyl derivatives of (R) ginseng sapoglycoside Rg 3, preparation and its application

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DE4001895A1 (en) * 1990-01-23 1991-07-25 Harrier Gmbh PRODUCTION OF PARTICULAR STEROID GLYCOSIDES

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100746799B1 (en) * 2003-06-19 2007-08-23 최용석 A preparation method of new saponin solution

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AU6533496A (en) 1997-09-16
KR0169536B1 (en) 1999-01-15

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