KR970042583A - Alpha cyclotextrin derivatives useful for optical isomer separation - Google Patents

Alpha cyclotextrin derivatives useful for optical isomer separation Download PDF

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Publication number
KR970042583A
KR970042583A KR1019950056715A KR19950056715A KR970042583A KR 970042583 A KR970042583 A KR 970042583A KR 1019950056715 A KR1019950056715 A KR 1019950056715A KR 19950056715 A KR19950056715 A KR 19950056715A KR 970042583 A KR970042583 A KR 970042583A
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KR
South Korea
Prior art keywords
optical isomer
cyclotextrin
alpha
stationary phase
isomer separation
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KR1019950056715A
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Korean (ko)
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KR100217863B1 (en
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김병억
우순형
Original Assignee
김종진
포항종합제철 주식회사
신창식
재단법인 산업과학기술연구소
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Priority to KR1019950056715A priority Critical patent/KR100217863B1/en
Publication of KR970042583A publication Critical patent/KR970042583A/en
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3833—Chiral chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/29—Chiral phases

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

본 발명은-시클로 덱스트린 유도체에 관한 것이며, 보다 상세하게는 광학 이성질체 분리에 유용한-시클로 덱스트린 유도체 및 그 이용에 관한 것으로,The present invention -Cyclodextrin derivatives, and more particularly useful for optical isomer separation To a cyclodextrin derivative and its use,

6번 위치의 탄소에 실란기가 도입된 하기 식(Ⅰ)을 갖는 새로운-CD 유도체가 제공되며 이는 종래 CGC 컬럼에 고정상으로 사용되는 물질과 혼합하여 라세미 광학활성 물질의 분리에 고정상으로 사용된다.A new compound having the following formula (Ⅰ) in which a silane group is introduced into the carbon at position 6 A -CD derivative is provided, which is mixed with materials conventionally used in the CGC column as a stationary phase and used as a stationary phase for the separation of racemic optically active materials.

Description

광학 이성질체 분리에 유용한 알파 시클로텍스트린 유도체Alpha cyclotextrin derivatives useful for optical isomer separation

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 본 발명에 의한-CD 유도체를 이용하여 고리형 알코올 광학 이성질체를 분리한 기체 크로마토그램.1 is according to the present invention Gas chromatogram of cyclic alcohol optical isomers separated using a -CD derivative.

제2도는 본 발명에 의한-CD 유도체를 이용하여 이차 알코올 이성질체를 분리한 기체 크로마토그램.2 is according to the present invention Gas chromatogram of secondary alcohol isomers separated using a -CD derivative.

제3도는 본 발명에 의한-CD 유도체를 이용하여 니트로기 및 페닐기가 포함된 알코올 및 디올 광학 이성질체를 분리한 크로마토그램.3 is according to the present invention -Chromatogram separating alcohol and diol optical isomers containing nitro group and phenyl group using CD derivative.

제4도는 본 발명에 의한-CD 유도체를 이용하여 할로겐화 알칸 광학 이성질체를 분리한 기체 크로마토그램.4 is according to the present invention Gas chromatogram of halogenated alkane optical isomers separated using a -CD derivative.

Claims (4)

하기 구조식(Ⅰ)을 갖는 광학 이성질체분리에 고정상으로 유용한 6-tert-부틸디메틸실릴-2, 3-디에틸--시클로 덱스트린 화합물.6-tert-butyldimethylsilyl-2, 3-diethyl- useful as a stationary phase for optical isomer separation having the structural formula (I) Cyclodextrin compounds. 정지상과 혼합물을 접촉시켜 광학이성질체를 분리하는 기체크로마토그래피 분리 방법에 있어서, 상기 정지상으로 청구범위 제1항의 식(Ⅰ)의 시클로덱스트린 유도체를 사용함을 특징으로 하는 방법.A gas chromatography separation method for separating an optical isomer by contacting a stationary phase with a mixture, wherein the stationary phase uses a cyclodextrin derivative of formula (I) of claim 1. 제2항에 있어서, 상기 광학 이성질체는 알코올 화합물임을 특징으로 하는 방법.The method of claim 2, wherein the optical isomer is an alcohol compound. 제3항에 있어서, 상기 알코올은 2-헥산올, 3-헥산올, 3-헵탄올, 3-니트로-2-부탄올로 구성되는 그룹에서 선택됨을 특징으로 하는 방법.The method of claim 3 wherein the alcohol is selected from the group consisting of 2-hexanol, 3-hexanol, 3-heptanol, 3-nitro-2-butanol.
KR1019950056715A 1995-12-26 1995-12-26 Alpha cyclodextrin derivative which is useful for separation of isomer KR100217863B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950056715A KR100217863B1 (en) 1995-12-26 1995-12-26 Alpha cyclodextrin derivative which is useful for separation of isomer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950056715A KR100217863B1 (en) 1995-12-26 1995-12-26 Alpha cyclodextrin derivative which is useful for separation of isomer

Publications (2)

Publication Number Publication Date
KR970042583A true KR970042583A (en) 1997-07-24
KR100217863B1 KR100217863B1 (en) 1999-10-01

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