KR970042485A - Novel method for preparing 2,6-dinitroaniline derivatives - Google Patents

Novel method for preparing 2,6-dinitroaniline derivatives Download PDF

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Publication number
KR970042485A
KR970042485A KR1019950072364A KR19950072364A KR970042485A KR 970042485 A KR970042485 A KR 970042485A KR 1019950072364 A KR1019950072364 A KR 1019950072364A KR 19950072364 A KR19950072364 A KR 19950072364A KR 970042485 A KR970042485 A KR 970042485A
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South Korea
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unsubstituted
structural formula
preparing
dinitroaniline
substituted
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KR1019950072364A
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Korean (ko)
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왕한철
장길상
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김용구
주식회사 한화
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Priority to KR1019950072364A priority Critical patent/KR970042485A/en
Publication of KR970042485A publication Critical patent/KR970042485A/en

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Abstract

본 발명은 다음 구조식(Ⅰ)로 표시되는 2, 6-디니트로 아닐린 유도체의 신규한 제조방법에 관한 것이다.The present invention relates to a novel process for preparing 2, 6-dinitroaniline derivatives represented by the following structural formula (I).

(Ⅰ) (Ⅰ)

상기 식(Ⅰ)에서 R1및 R2는 수소, 치환 또는 비치환된 C1내지 C4의 알킬기 또는 트리플로로 메틸기로써 서로 같거나 다르며, Y와 Z는 수소, 할로겐, 치환 또는 비치환된 C1내지 C4의 알킬기 또는 비치환된, C1내지 C4의 알켄기 또는 트리플로로 메틸기로써 서로 같거나 다르다. 상기 구조식(Ⅰ)로 표시되는 화합물은 제초제 및 살균제 등의 농약 및 의약 중간체로 사용되는 물질로써, 본 발명의 제조방법에 따르면 페산 발생량이 감소되며, 고수율과 고순도로 제조할 수 있는 장점이 있다.In Formula (I), R 1 and R 2 are the same as or different from each other as hydrogen, a substituted or unsubstituted C 1 to C 4 alkyl group, or a trifluoro methyl group, and Y and Z are hydrogen, halogen, substituted or unsubstituted. C 1 to C 4 alkyl groups or unsubstituted C 1 to C 4 alkenes or trifluoro methyl groups are the same as or different from each other. Compound represented by the formula (I) is a material used as a pesticide and pharmaceutical intermediates, such as herbicides and fungicides, according to the production method of the present invention has the advantage of reducing the amount of acid produced, can be produced in high yield and high purity .

Description

2, 6-디니트로아닐린 유도체의 신규한 제조방법Novel preparation of 2, 6-dinitroaniline derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

다음 구조식(Ⅱ)로 표시되는 N-알킬화 아민과 다음 구조식(Ⅲ)으로 표시되는 디클로로에탄 반응 용매의 혼합물에 진한 질산과 디클로로에탄의 혼합물을 적가하여 반응시킨 후, 중화하여 감압하에서 반응용매를 제거한 후, 염산과 에탄올로 처리하여 결정화시키는 것을 특징으로 하는 다음 구조식(Ⅰ)로 표시되는 2, 6-디니트로 아닐린 유도체의 신규한 제조방법.To the mixture of N-alkylated amine represented by the following structural formula (II) and the dichloroethane reaction solvent represented by the following structural formula (III) was added dropwise to react with a mixture of concentrated nitric acid and dichloroethane, followed by neutralization to remove the reaction solvent under reduced pressure. Thereafter, a novel method for producing 2, 6-dinitroaniline derivatives represented by the following structural formula (I) characterized by crystallization by treatment with hydrochloric acid and ethanol. 상기 식(Ⅰ)과 (Ⅱ)에서 R1및 R2는 수소, 치환 또는 비치환된 C1내지 C4의 알킬기 또는 트리플로로 메틸기로써 서로 같거나 다르며, Y와 Z는 수소, 할로겐, 치환 또는 비치환된 C1내지 C4의 알킬기 또는 비치환된 C1내지 C4의 알켄기 또는 트리플로로 메틸기로써 서로 같거나 다르다.In Formulas (I) and (II), R 1 and R 2 are the same as or different from each other as hydrogen, a substituted or unsubstituted C 1 to C 4 alkyl group, or a trilomethyl group, and Y and Z are hydrogen, halogen, substituted Or an unsubstituted C 1 to C 4 alkyl group or an unsubstituted C 1 to C 4 alkene group or a trifluoro methyl group. 제 1항에 있어서, 상기 질산은 상기 구조식(Ⅱ)로 표시되는 N-알킬화 아민에 대해 몰비로 2.0~4.0배 사용하는 것을 특징으로 하는 2,6-디니트로 아닐린 유도체의 제조방법.The method for preparing a 2,6-dinitroaniline derivative according to claim 1, wherein the nitric acid is used in a molar ratio of 2.0 to 4.0 times with respect to the N-alkylated amine represented by the structural formula (II). 제 1항에 있어서, 상기 반응 온도가 50~100℃인 것을 특징으로 하는 2,6-디니트로 아닐린 유도체의 제조방법.The method for producing a 2,6-dinitroaniline derivative according to claim 1, wherein the reaction temperature is 50 to 100 ° C. 제 1항에 있어서, 상기 반응 용매를 N-알킬화 아민에 대해 중량비로 3~10배 사용하는 것을 특징으로 하는 2,6-디니트로 아닐린 유도체의 제조방법.The method for preparing a 2,6-dinitroaniline derivative according to claim 1, wherein the reaction solvent is used 3 to 10 times by weight relative to the N-alkylated amine.
KR1019950072364A 1995-12-27 1995-12-27 Novel method for preparing 2,6-dinitroaniline derivatives KR970042485A (en)

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KR1019950072364A KR970042485A (en) 1995-12-27 1995-12-27 Novel method for preparing 2,6-dinitroaniline derivatives

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Application Number Priority Date Filing Date Title
KR1019950072364A KR970042485A (en) 1995-12-27 1995-12-27 Novel method for preparing 2,6-dinitroaniline derivatives

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KR970042485A true KR970042485A (en) 1997-07-24

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