KR970032866A - Use of pyridoxatin as an inhibitor of type IV collagenase and inhibitor of tumor cell growth and preparation method thereof - Google Patents

Use of pyridoxatin as an inhibitor of type IV collagenase and inhibitor of tumor cell growth and preparation method thereof Download PDF

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Publication number
KR970032866A
KR970032866A KR1019950049648A KR19950049648A KR970032866A KR 970032866 A KR970032866 A KR 970032866A KR 1019950049648 A KR1019950049648 A KR 1019950049648A KR 19950049648 A KR19950049648 A KR 19950049648A KR 970032866 A KR970032866 A KR 970032866A
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South Korea
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inhibitor
type
compound
formula
collagenase
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KR1019950049648A
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Korean (ko)
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KR0185332B1 (en
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고영희
전효곤
이호재
이충환
정명철
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김은영
한국과학기술연구원
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Priority to KR1019950049648A priority Critical patent/KR0185332B1/en
Publication of KR970032866A publication Critical patent/KR970032866A/en
Priority to KR1019980037018A priority patent/KR100197749B1/en
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
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  • Wood Science & Technology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 토양에서 카우노피크니스 알바(Chaunopycnis alba) PT-262 균주(수탁번호 KCTC 0209 BP)를 분리하여 배양한 후 타이프IV 콜라게네이즈의 활성을 저해하는, 하기 구조식(I)의 화합물을 제조하고 동 화합물을 유효성분으로 하는 타이프IV 콜라게네이즈 활성 저해제 및 종양 세포 생육 저해제로서의 용동에 관한 것이다.The present invention provides a compound of formula (I) below, which inhibits the activity of type IV collagenase after isolating and culturing the chaunopycnis alba PT-262 strain (Accession No. KCTC 0209 BP) in soil. The present invention relates to a type IV collagenase activity inhibitor and a tumor cell growth inhibitor as an active ingredient.

Description

피리독사틴의 타이프IV 콜라게네이즈 저해제 및 종양세포 생육 저해제로서의 용도 및 그의 제조방법Use of pyridoxatin as an inhibitor of type IV collagenase and inhibitor of tumor cell growth and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

구조식(I)의 화합물(피리독사틴, pyridoxatin) 또는 이의 유도체를 유효성분으로 하는 타이프IV 콜라게네이즈 활성 저해제로서의 용도.Use as a type IV inhibitor of activity of type IV collagenase comprising a compound of formula (I) (pyridoxatin, pyridoxatin) or a derivative thereof as an active ingredient. 구조식(I)의 화합물 또는 이의 유도체를 유효성분으로 하는 종양 세포 생육저해제로서의 용도.Use as a tumor cell growth inhibitor comprising the compound of formula (I) or a derivative thereof as an active ingredient. 구조식(I)의 화합물 또는 이의 유도체를 유효성분으로 하는 류마티스성 관절염 및 치근막염의 치료제로서의 용도.Use as a therapeutic agent for rheumatoid arthritis and periodontitis with the compound of formula (I) or a derivative thereof as an active ingredient. 항전이 및 항종양 활성이 있는 구조식(I)의 화합물을 생산하는 카우피크니스 알바(Chaunopycnis alba) PT-262 균주(KCTC 0209 BP).Chaunopycnis alba PT-262 strain (KCTC 0209 BP), which produces a compound of formula (I) with anti-transition and anti-tumor activity. 카우노피크니스 알바(Chaunopycnis alba) PT-262 균주(KCTC 0209 BP)를 배양하여 배양물 또는 균사체로부터 하기 구조식(I)의 화합물을 분리하는 것을 특징으로 하는 구조식(I)의 화합물을 제조하는 방법.Method for preparing a compound of formula (I) characterized in that the cultivation of Kaunopycnis alba PT-262 strain (KCTC 0209 BP) to separate the compound of formula (I) from the culture or mycelium . ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950049648A 1995-12-14 1995-12-14 Type iv collagenase inhibitors of pyridoxatin KR0185332B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019950049648A KR0185332B1 (en) 1995-12-14 1995-12-14 Type iv collagenase inhibitors of pyridoxatin
KR1019980037018A KR100197749B1 (en) 1995-12-14 1998-09-08 Usage of pyridoxatin as an inhibitor of type 4 collagenase and inhibitor of tumor cell growth and preparing method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950049648A KR0185332B1 (en) 1995-12-14 1995-12-14 Type iv collagenase inhibitors of pyridoxatin

Publications (2)

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KR970032866A true KR970032866A (en) 1997-07-22
KR0185332B1 KR0185332B1 (en) 1999-05-01

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KR1019950049648A KR0185332B1 (en) 1995-12-14 1995-12-14 Type iv collagenase inhibitors of pyridoxatin
KR1019980037018A KR100197749B1 (en) 1995-12-14 1998-09-08 Usage of pyridoxatin as an inhibitor of type 4 collagenase and inhibitor of tumor cell growth and preparing method thereof

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Application Number Title Priority Date Filing Date
KR1019980037018A KR100197749B1 (en) 1995-12-14 1998-09-08 Usage of pyridoxatin as an inhibitor of type 4 collagenase and inhibitor of tumor cell growth and preparing method thereof

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KR0185332B1 (en) 1999-05-01
KR100197749B1 (en) 1999-06-15

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