KR970032866A - Use of pyridoxatin as an inhibitor of type IV collagenase and inhibitor of tumor cell growth and preparation method thereof - Google Patents
Use of pyridoxatin as an inhibitor of type IV collagenase and inhibitor of tumor cell growth and preparation method thereof Download PDFInfo
- Publication number
- KR970032866A KR970032866A KR1019950049648A KR19950049648A KR970032866A KR 970032866 A KR970032866 A KR 970032866A KR 1019950049648 A KR1019950049648 A KR 1019950049648A KR 19950049648 A KR19950049648 A KR 19950049648A KR 970032866 A KR970032866 A KR 970032866A
- Authority
- KR
- South Korea
- Prior art keywords
- inhibitor
- type
- compound
- formula
- collagenase
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
본 발명은 토양에서 카우노피크니스 알바(Chaunopycnis alba) PT-262 균주(수탁번호 KCTC 0209 BP)를 분리하여 배양한 후 타이프IV 콜라게네이즈의 활성을 저해하는, 하기 구조식(I)의 화합물을 제조하고 동 화합물을 유효성분으로 하는 타이프IV 콜라게네이즈 활성 저해제 및 종양 세포 생육 저해제로서의 용동에 관한 것이다.The present invention provides a compound of formula (I) below, which inhibits the activity of type IV collagenase after isolating and culturing the chaunopycnis alba PT-262 strain (Accession No. KCTC 0209 BP) in soil. The present invention relates to a type IV collagenase activity inhibitor and a tumor cell growth inhibitor as an active ingredient.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
Claims (5)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019950049648A KR0185332B1 (en) | 1995-12-14 | 1995-12-14 | Type iv collagenase inhibitors of pyridoxatin |
KR1019980037018A KR100197749B1 (en) | 1995-12-14 | 1998-09-08 | Usage of pyridoxatin as an inhibitor of type 4 collagenase and inhibitor of tumor cell growth and preparing method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019950049648A KR0185332B1 (en) | 1995-12-14 | 1995-12-14 | Type iv collagenase inhibitors of pyridoxatin |
Publications (2)
Publication Number | Publication Date |
---|---|
KR970032866A true KR970032866A (en) | 1997-07-22 |
KR0185332B1 KR0185332B1 (en) | 1999-05-01 |
Family
ID=19439918
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950049648A KR0185332B1 (en) | 1995-12-14 | 1995-12-14 | Type iv collagenase inhibitors of pyridoxatin |
KR1019980037018A KR100197749B1 (en) | 1995-12-14 | 1998-09-08 | Usage of pyridoxatin as an inhibitor of type 4 collagenase and inhibitor of tumor cell growth and preparing method thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019980037018A KR100197749B1 (en) | 1995-12-14 | 1998-09-08 | Usage of pyridoxatin as an inhibitor of type 4 collagenase and inhibitor of tumor cell growth and preparing method thereof |
Country Status (1)
Country | Link |
---|---|
KR (2) | KR0185332B1 (en) |
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1995
- 1995-12-14 KR KR1019950049648A patent/KR0185332B1/en not_active IP Right Cessation
-
1998
- 1998-09-08 KR KR1019980037018A patent/KR100197749B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR0185332B1 (en) | 1999-05-01 |
KR100197749B1 (en) | 1999-06-15 |
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