KR970032848A - Alginate ultrafine particles and preparation method thereof - Google Patents

Alginate ultrafine particles and preparation method thereof Download PDF

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Publication number
KR970032848A
KR970032848A KR1019950050632A KR19950050632A KR970032848A KR 970032848 A KR970032848 A KR 970032848A KR 1019950050632 A KR1019950050632 A KR 1019950050632A KR 19950050632 A KR19950050632 A KR 19950050632A KR 970032848 A KR970032848 A KR 970032848A
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South Korea
Prior art keywords
alginate
ultrafine particles
emulsion
added
solution
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KR1019950050632A
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Korean (ko)
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KR0164462B1 (en
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정서영
권익찬
김용희
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김은영
한국과학기술연구원
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Priority to KR1019950050632A priority Critical patent/KR0164462B1/en
Publication of KR970032848A publication Critical patent/KR970032848A/en
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Publication of KR0164462B1 publication Critical patent/KR0164462B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

본 발명은 알긴산염으로 이루어진, 입자 직경이 나노미터 내지 수 마이크로미터인 알긴산염 초미세구립자 및 그의 제조방법을 제공한다. 본 발명의 알긴산염 초미세구립자의 제조방법은 알긴산염 수용액을 계면활성제가 첨가된 유기용매에 분산, 교반시켜 에멀젼을 만든 다음, 칼슘 용액을 이 에멀젼에 첨가하여 겔화하고, 탈수 용매를 가해 탈수시키고 경화시키는 것으로 이루어진다. 본 발명의 알긴산염 초미세구립자는 비경구 투여에 의한 약물의 표적 지향, 펩타이드 약물의 경구 흡수, 또는 경구용 백신 개발등 폭넓게 응용될 수 있다.The present invention provides alginate ultrafine particles having a particle diameter of from nanometers to several micrometers, and al processes for preparing alginate. In the method for preparing alginate ultrafine particles of the present invention, an aqueous alginate solution is dispersed and stirred in an organic solvent to which a surfactant is added to make an emulsion, and then calcium solution is added to the emulsion to gel, and dehydrated by adding a dehydrating solvent. It consists of curing. The alginate ultrafine particles of the present invention can be widely applied to target orientation of drugs by parenteral administration, oral absorption of peptide drugs, or development of oral vaccines.

Description

알긴산염 초미세구립자 및 그의 제조방법Alginate ultrafine particles and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (10)

알긴산염으로 이루어진, 입자 직경이 나노미터 내지 수 마이크로미터인 알긴산염 초미세구립자.Alginate ultrafine particles having a particle diameter of nanometers to several micrometers. 알긴산염 수용액을 계면활성제가 첨가된 유기 용매에 분산, 교반시켜 에멀젼을 만든 다음, 칼슘 용액을 이 에멀젼에 첨가하여 겔화하고, 탈수 용매를 가해 탈수시키고 경화시키는 것으로 이루어진 제1항의 알긴산염 초미세구립자의 제조방법.The aqueous alginate solution is dispersed and stirred in an organic solvent to which the surfactant is added to form an emulsion, and then the calcium solution is added to the emulsion to gel, and the dehydrating solvent is added to dehydrate and cure the alginate ultrafine granules. Method of manufacturing 제2항에 있어서, 알긴산염 수용액의 알긴산염 농도가 0.1~9중량%인 제조방법.The production method according to claim 2, wherein the alginate concentration of the alginate aqueous solution is 0.1 to 9% by weight. 제2항에 있어서, 계면활성제가 폴리옥시메틸렌계 또는 스판계인 제조방법.The production method according to claim 2, wherein the surfactant is polyoxymethylene or span based. 제2 또는 4항에 있어서, 계면활성제의 농도가 유기 용매의 1~10중량%인 제조방법.The production method according to claim 2 or 4, wherein the concentration of the surfactant is 1 to 10% by weight of the organic solvent. 제2항에 있어서, 칼슘 용액의 유기 용매가 헥산올, 헵탄올, 또는 옥탄올 중에서 선택되는 제조방법.The method of claim 2, wherein the organic solvent of the calcium solution is selected from hexanol, heptanol, or octanol. 제2 또는 6항에 있어서, 칼슘 용액의 칼슘농도가 0.1~5중량%인 제조방법.The method according to claim 2 or 6, wherein the calcium concentration of the calcium solution is 0.1 to 5% by weight. 재2항에 있어서, 탈수 용매가 메탄올, 애탄올 이소프로판을 또는 아세톤 중에서 선택되는 제조방법.The process according to claim 2, wherein the dehydrating solvent is selected from methanol, ethanol isopropane or acetone. 제2항에 있어서, 에멀젼을 만드는데 초음파 장치, 호모지나이저 또는 마이크로플루이다이저를 사용하는 제조방법.The method of claim 2, wherein an ultrasonic device, homogenizer, or microfluidizer is used to make the emulsion. 저분자 약물, 펩타이드 약물, 백신 제제, 또는 유전자를 제1항의 초미세구립자에 함유시킨 비경구 투여 또는 경구 투여용 약물제제.A pharmaceutical preparation for parenteral or oral administration containing a small molecule drug, a peptide drug, a vaccine preparation, or a gene in the ultrafine particles of claim 1. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950050632A 1995-12-15 1995-12-15 Preparation process for micro capsules of alginate KR0164462B1 (en)

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Application Number Priority Date Filing Date Title
KR1019950050632A KR0164462B1 (en) 1995-12-15 1995-12-15 Preparation process for micro capsules of alginate

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Application Number Priority Date Filing Date Title
KR1019950050632A KR0164462B1 (en) 1995-12-15 1995-12-15 Preparation process for micro capsules of alginate

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KR970032848A true KR970032848A (en) 1997-07-22
KR0164462B1 KR0164462B1 (en) 1999-01-15

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100919508B1 (en) * 2007-08-14 2009-09-28 강원대학교산학협력단 Alginate particle containing calcium carbonate in matrix and the method for production of the said alginate particle

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020028547A (en) * 2000-10-10 2002-04-17 우재영 Composition of enteric-coated granules of oral typhoid vaccine and process for preparing the same
KR100690318B1 (en) * 2004-09-25 2007-03-09 경북대학교 산학협력단 Process for preparing nano-hydrogel of hydrophilic polymer
KR100730321B1 (en) * 2005-09-30 2007-06-19 한국콜마 주식회사 A cosmetic composition of 2 agent and gel patch type for skin lifting, method for manufacturing and using the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100919508B1 (en) * 2007-08-14 2009-09-28 강원대학교산학협력단 Alginate particle containing calcium carbonate in matrix and the method for production of the said alginate particle

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