KR970027132A - Anticoagulant sulfonated block copolymers and medical supplies made therefrom - Google Patents

Anticoagulant sulfonated block copolymers and medical supplies made therefrom Download PDF

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Publication number
KR970027132A
KR970027132A KR1019950039578A KR19950039578A KR970027132A KR 970027132 A KR970027132 A KR 970027132A KR 1019950039578 A KR1019950039578 A KR 1019950039578A KR 19950039578 A KR19950039578 A KR 19950039578A KR 970027132 A KR970027132 A KR 970027132A
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South Korea
Prior art keywords
polymer
block copolymer
anticoagulant
sulfonated block
sulfonated
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KR1019950039578A
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Korean (ko)
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KR0175975B1 (en
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김영하
박기동
한동근
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김은영
한국과학기술연구원
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Priority to KR1019950039578A priority Critical patent/KR0175975B1/en
Publication of KR970027132A publication Critical patent/KR970027132A/en
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Publication of KR0175975B1 publication Critical patent/KR0175975B1/en

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

본 발명은 항응혈성을 갖는 술폰산화 블록 공중합체, 이의 제조 방법 및 이로부터 제조되는 의료 용품에 관한 것이다. 보다 구체적으로는, 본 발명은 친수성인 술폰산화 폴리에틸렌옥시드[poly(ethylene oxide), PEO]와 소수성 고분자와의 블록 공중합체, 이의 제조 방법 및 이의 용도에 관한 것이다. 본 발명의 술폰산화블록 공중합체는 헤파린(heparin)과 같은 항응혈 활성을 가지므로 의료용 재료로서 이용될 수 있다.FIELD OF THE INVENTION The present invention relates to sulfonated block copolymers having anticoagulant, methods for their preparation and medical articles produced therefrom. More specifically, the present invention relates to a block copolymer of hydrophilic sulfonated polyethylene oxide (poly (ethylene oxide), PEO) with a hydrophobic polymer, a preparation method thereof, and a use thereof. Since the sulfonated block copolymer of the present invention has anticoagulant activity such as heparin, it can be used as a medical material.

Description

항응혈성 술폰산화 블록 공중합체 및 이로부터 제조된 의료 용품Anticoagulant sulfonated block copolymers and medical supplies made therefrom

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (5)

하기 일반식(1) 또는 (2)로 나타내는, 친수성의 술폰산화 폴리에틸렌옥시드와 소수성 고분자로 구성되어 있는 항응혈성 술폰산화 블록 공중합체.The anticoagulant sulfonated block copolymer comprised from hydrophilic sulfonated polyethylene oxide and a hydrophobic polymer represented by following General formula (1) or (2). X-(CH2)ℓ-AmB (1)X- (CH 2 ) l -A m B (1) X-(CH2)ℓ-AmBAm-(CH2)ℓ-Y (2)X- (CH 2 ) l -A m BA m- (CH 2 ) l -Y (2) 상기 각 식 중, A는 폴리에틸렌옥시드(PEO)의반복 단위이고, B는 소수성 고분자이며, X는 술폰산기이고, Y는 술폰산기 또는 히드록실기이며, ℓ은 0 내지 3의 수이고, m은 1 내지 150의 수이다.In each formula, A is a polyethylene oxide (PEO) It is a repeating unit, B is a hydrophobic polymer, X is a sulfonic acid group, Y is a sulfonic acid group or a hydroxyl group, L is a number of 0-3, m is a number of 1-150. 제1항에 있어서, 상기 소수성 고분자(B)가 분자량 150~3,000인 알킬 에스테르, 알킬 에테르 또는 프로필렌옥시드인 술폰산화 블록 공중합체.The sulfonated block copolymer according to claim 1, wherein the hydrophobic polymer (B) is an alkyl ester, alkyl ether or propylene oxide having a molecular weight of 150 to 3,000. 폴리에틸렌옥시드 유도체를 알킬 술톤 또는 중아황산나트륨과 반응시키는 것을 특징으로 하는 항응혈성 술폰산화 블록 공중합체의 제조 방법.A method for producing an anticoagulant sulfonated block copolymer, wherein the polyethylene oxide derivative is reacted with alkyl sultone or sodium bisulfite. 제1항 기재의 블록 공중합체를 고분자 기질 상에 코팅시키거나, 기질과 혼합하여 압출, 사출 또는 압축 성형시켜 제조한 것을 특징으로 하는 의료 용품.A medical article characterized in that the block copolymer of claim 1 is prepared by coating on a polymer substrate or by mixing with the substrate and extruding, injection or compression molding. 제4항에 있어서, 상기 고분자 기질이 수용성 고분자 및 히드로겔이 아닌 고분자로서 올레핀계, 스티렌계, 염화비닐계, 아크릴계 고분자 또는 그의 공중합체, 또는 아미드계, 에스테르계, 카보네이트계 또는 에폭시계 고분자인 의료 용품.The polymer according to claim 4, wherein the polymer substrate is a water-soluble polymer and a non-hydrogel polymer, which is an olefin-based, styrene-based, vinyl chloride-based, acrylic-based polymer or copolymer thereof, or an amide-based, ester-based, carbonate-based or epoxy-based polymer. Medical supplies. ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is to be disclosed based on the initial application.
KR1019950039578A 1995-11-03 1995-11-03 Block-copolymers with sulfonic acid for anti-coagulation and medical articles produced therefrom KR0175975B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950039578A KR0175975B1 (en) 1995-11-03 1995-11-03 Block-copolymers with sulfonic acid for anti-coagulation and medical articles produced therefrom

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950039578A KR0175975B1 (en) 1995-11-03 1995-11-03 Block-copolymers with sulfonic acid for anti-coagulation and medical articles produced therefrom

Publications (2)

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KR970027132A true KR970027132A (en) 1997-06-24
KR0175975B1 KR0175975B1 (en) 1999-05-15

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KR1019950039578A KR0175975B1 (en) 1995-11-03 1995-11-03 Block-copolymers with sulfonic acid for anti-coagulation and medical articles produced therefrom

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100789730B1 (en) * 2006-05-30 2008-01-02 재단법인 산재의료관리원 Acrylic ionic high molecule electric potential actuator material

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100378109B1 (en) * 2000-10-24 2003-03-29 주식회사 메디프렉스 Hydrophobic multicomponant heparin conjugates, a preparing method and a use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100789730B1 (en) * 2006-05-30 2008-01-02 재단법인 산재의료관리원 Acrylic ionic high molecule electric potential actuator material

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