KR970021074A - Amine Compounds of Epi-Xanthatin and Methods for Making the Same - Google Patents

Amine Compounds of Epi-Xanthatin and Methods for Making the Same Download PDF

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Publication number
KR970021074A
KR970021074A KR1019950035587A KR19950035587A KR970021074A KR 970021074 A KR970021074 A KR 970021074A KR 1019950035587 A KR1019950035587 A KR 1019950035587A KR 19950035587 A KR19950035587 A KR 19950035587A KR 970021074 A KR970021074 A KR 970021074A
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KR
South Korea
Prior art keywords
same
epizantatin
dihydro
amine compounds
xanthatin
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Application number
KR1019950035587A
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Korean (ko)
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KR0180582B1 (en
Inventor
노재성
유시용
김성기
최영순
안종웅
이정옥
최상운
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강박광
재단법인 한국화학연구소
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Priority to KR1019950035587A priority Critical patent/KR0180582B1/en
Publication of KR970021074A publication Critical patent/KR970021074A/en
Application granted granted Critical
Publication of KR0180582B1 publication Critical patent/KR0180582B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 수용성이 우수하고 암세포의 성장 억제 효과를 나타내어 항암제로 사용 가능한 일반식(I)의 에피잔타틴의 아민 화합물, 이의 제조방법 및 이를 포함하는 항암제 조성물에 관한 것이다.The present invention relates to an amine compound of epixanthatin of general formula (I), which is excellent in water solubility and exhibits a growth inhibitory effect of cancer cells, which can be used as an anticancer agent, a method for preparing the same, and an anticancer composition comprising the same.

상기 식에서 X는 0, S, C-R 또는 N-R이고; R은 수소 원자 또는 저급 알킬기이고; n은 0 내지 2의 정수를 나타내며; 11번 탄소의 입체 화학은 R 또는 S이다.In which X is 0, S, C-R or N-R; R is a hydrogen atom or a lower alkyl group; n represents an integer of 0 to 2; The stereochemistry of carbon 11 is R or S.

Description

에피잔타틴(epi-Xanthatin)의 아민 화합물 및 이의 제조 방법Amine Compounds of Epi-Xanthatin and Methods for Making the Same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

하기 일반식 (I)의 에피잔타틴의 아민 화합물 :Amine compounds of epixanthatin of the general formula (I) 상기 식에서 X는 0, S, C-R또는 N-R이고; R은 수소 원자 또는 저급 알킬기이고; n은 0내지 2의 정수를 나타내며; 11번 탄소의 입체 화학은 R 또는 S이다.Wherein X is 0, S, C-R or N-R; R is a hydrogen atom or a lower alkyl group; n represents an integer of 0 to 2; The stereochemistry of carbon 11 is R or S. 제1항에 있어서, 13-(1-모르폴리닐)-11,13-디히드로-에피잔타틴; 13-(1-피페리디닐)-11,13-디히드로-에피잔타틴; 13-(1-피페라지닐)-11,13-디히드로-에피잔타틴; 또는 13-[1-(N′-메틸피페라지닐)]-11,13-디히드로-에피잔타틴인 것을 특징으로 하는 화합물.The compound of claim 1, further comprising 13- (1-morpholinyl) -11,13-dihydro-epizantatin; 13- (1-piperidinyl) -11,13-dihydro-epizantatin; 13- (1-piperazinyl) -11,13-dihydro-epizantatin; Or 13- [1- (N'-methylpiperazinyl)]-11,13-dihydro-epizantatin. 에피잔타틴을 2급 고리아민과 반응시켜 제1항에 따른 일반식 (I)의 에피잔타틴의 아민 화합물을 제조하는 방법.A process for producing an amine compound of epixanthatin of formula (I) according to claim 1 by reacting epixanthin with secondary cyclic amines. 제1항에 따른 일반식 (I)의 에피잔타틴의 아민 화합물 및 그의 염을 포함하는 항암제 조성물.An anticancer agent composition comprising an amine compound of epizantatin of formula (I) according to claim 1 and a salt thereof. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950035587A 1995-10-16 1995-10-16 Amine compounds of epi-xanthatin KR0180582B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950035587A KR0180582B1 (en) 1995-10-16 1995-10-16 Amine compounds of epi-xanthatin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950035587A KR0180582B1 (en) 1995-10-16 1995-10-16 Amine compounds of epi-xanthatin

Publications (2)

Publication Number Publication Date
KR970021074A true KR970021074A (en) 1997-05-28
KR0180582B1 KR0180582B1 (en) 1999-03-20

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KR1019950035587A KR0180582B1 (en) 1995-10-16 1995-10-16 Amine compounds of epi-xanthatin

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103193742B (en) * 2013-04-12 2014-08-13 南京中医药大学 Xanthatin derivative and medicine use thereof
KR102664925B1 (en) 2023-08-21 2024-05-10 민광표 Eco-friendly and functional edge manufacturing method

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