KR970021065A - Chemical method - Google Patents

Chemical method Download PDF

Info

Publication number
KR970021065A
KR970021065A KR1019950036118A KR19950036118A KR970021065A KR 970021065 A KR970021065 A KR 970021065A KR 1019950036118 A KR1019950036118 A KR 1019950036118A KR 19950036118 A KR19950036118 A KR 19950036118A KR 970021065 A KR970021065 A KR 970021065A
Authority
KR
South Korea
Prior art keywords
phosgene
dihydroxypyrimidine
suitable base
base
mixture
Prior art date
Application number
KR1019950036118A
Other languages
Korean (ko)
Other versions
KR100411400B1 (en
Inventor
찰스 보우던 마틴
마틴 브라운 스테펀
데이비드 존스 존
Original Assignee
비자야 쿠마리 말리페디
제네카 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 비자야 쿠마리 말리페디, 제네카 리미티드 filed Critical 비자야 쿠마리 말리페디
Priority to KR1019950036118A priority Critical patent/KR100411400B1/en
Publication of KR970021065A publication Critical patent/KR970021065A/en
Application granted granted Critical
Publication of KR100411400B1 publication Critical patent/KR100411400B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

본 발명은 적당한 염기 및 임의로 용매의 존재하에 4,6-디하이드록시피리미딘을 포스겐으로 처리시키는 것으로 구성되는 4,6-디클로로피리미딘의 제조방법에 관한다.The present invention relates to a process for the preparation of 4,6-dichloropyrimidine consisting of treating 4,6-dihydroxypyrimidine with phosgene in the presence of a suitable base and optionally a solvent.

Description

화학적 방법Chemical method

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (8)

적당한 염기의 존재하에 4,6-디하이드록시피리미딘을 포스겐으로 처리시키는 것으로 구성되는 4,6-디클로로피리미딘 제조방법.A process for preparing 4,6-dichloropyrimidine, comprising treating 4,6-dihydroxypyrimidine with phosgene in the presence of a suitable base. 제1항에 있어서, 염기 : 포스겐 몰비가 1 : 10-10 : 1의 범위내인 방법.The method of claim 1 wherein the base: phosgene molar ratio is in the range of 1: 10-10: 1. 제1항 또는 제2항에 있어서, 상기 방법을 용매 또는 용매 혼합물내에서 수행시키는 방법.The process according to claim 1 or 2, wherein the process is carried out in a solvent or solvent mixture. 제1항, 제2항 또는 제3항에 있어서, 염기가 식 R1R2R3N(식중, R1,R2및 R3는 독립적으로 C1-10알킬, 아릴, 헤테로아릴 또는 아릴(C1-4)알킬임)의 4차 아민이거나 또는 C1-10알킬로 임의 치환된 복소환식 아민인 방법.A compound according to claim 1, 2 or 3, wherein the base is of the formula R 1 R 2 R 3 N wherein R 1 , R 2 and R 3 are independently C 1-10 alkyl, aryl, heteroaryl or aryl (C 1-4 ) alkyl) or a heterocyclic amine optionally substituted with C 1-10 alkyl. 제1항, 제2항, 제3항 또는 제4항에 있어서, 포스겐을 4,6-디하이드록시피리미딘 및 적당한 염기의 혼합물에 가하는 방법.The process according to claim 1, 2, 3 or 4, wherein the phosgene is added to a mixture of 4,6-dihydroxypyrimidine and a suitable base. 제1항, 제2항, 제3항, 제4항 또는 제5항에 있어서, 상기 방법이 4,6-디하이드록시피리미딘 및 염소화된 용매내 적당한 염기의 혼합물에 포스겐을 가하는 것으로 구성되고, 4,6-디하이드록시피리미딘 : 적당한 염기 : 포스겐의 몰비가 1 : (0.8-2.5) : (2.5-3.6)의 범위내인 방법.The process according to claim 1, 2, 3, 4 or 5, wherein the process consists in adding phosgene to a mixture of 4,6-dihydroxypyrimidine and a suitable base in a chlorinated solvent and , 4,6-dihydroxypyrimidine: a suitable base: phosgene molar ratio in the range of 1: (0.8-2.5): (2.5-3.6). 제1항, 제2항, 제3항, 제4항 또는 제5항에 있어서, 상기 방법이 4,6-디하이드록시피리미딘 및 니트릴 용매내 적당한 염기의 혼합물에 포스겐을 가하는 것으로 구성되고, 4,6-디하이드록시피리미딘 : 적당한 염기 : 포스겐의 몰비가 1 : (0. 1-2.4) : (4-9)의 범위내인 방법.The process according to claim 1, 2, 3, 4 or 5, wherein the process consists in adding phosgene to a mixture of 4,6-dihydroxypyrimidine and a suitable base in a nitrile solvent, The molar ratio of 4,6-dihydroxypyrimidine: suitable base: phosgene is in the range of 1: (0. 1-2.4): (4-9). 전기한 항들 중 어느 한 항에 있어서, 염기가 디메틸아닐린 또는 디이소프로필에틸아민인 방법.The method of claim 1, wherein the base is dimethylaniline or diisopropylethylamine. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950036118A 1995-10-19 1995-10-19 Chemical method KR100411400B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950036118A KR100411400B1 (en) 1995-10-19 1995-10-19 Chemical method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950036118A KR100411400B1 (en) 1995-10-19 1995-10-19 Chemical method

Publications (2)

Publication Number Publication Date
KR970021065A true KR970021065A (en) 1997-05-28
KR100411400B1 KR100411400B1 (en) 2004-03-30

Family

ID=49516034

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950036118A KR100411400B1 (en) 1995-10-19 1995-10-19 Chemical method

Country Status (1)

Country Link
KR (1) KR100411400B1 (en)

Also Published As

Publication number Publication date
KR100411400B1 (en) 2004-03-30

Similar Documents

Publication Publication Date Title
RU96122489A (en) METHOD FOR PRODUCING 4,6-Dichloropyrimidine
DE69405864T2 (en) Process for the production of quaternary diesters
KR900004700A (en) Arylenediamine substituted pyrimidine
KR960041254A (en) Synergistic stabilizer mixture
DE69534576D1 (en) Process for the preparation of 4,6-dichloropyrimidines
MY104952A (en) Explosive composition.
KR850003719A (en) Improvements to Cyanopyrazole Herbicides
KR910016695A (en) 4- (aminomethyl) piperidine derivatives, methods for their preparation and use in therapy
KR920701120A (en) Substituted bicycloheptanedione derivatives
KR850000442A (en) Method for preparing 7-piperidino-1,2,3,5-tetrahydro imidazo [2,1-b] quinazolin-2-one
KR830004210A (en) 2-amino-3-benzoyl-phenylacetamide and cyclic homologues
KR970021065A (en) Chemical method
KR910004626A (en) Substituted thienopyranone, preparation method thereof and use for eradication of parasites
KR870002113A (en) Method of Making Herbicides
KR870007908A (en) Manufacturing method of indene compound
DE3864354D1 (en) POLYFUNCTIONAL AETHYLENIC MONOMERS.
KR890009951A (en) Si.Si'-Diorganyl-N-alkyl-tetrachloro-disilazane and preparation method thereof
KR870007136A (en) Method for preparing 2,4-diamino-6-halo alkylpyrimidine
KR970704707A (en) Synthesis of 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thione (Process for preparing 5-Aryl- 4-Triazole-3-Thiones)
ES8706189A1 (en) 4-Substituted benzothiazol-2-ylazo-N-c8-14-alkykl-N-(2'-cyanoethyl)anilines optionally having a 3-C1-4-alkyl group
TH28990B (en) Pharmacologically active mixtures of pyrexol as a protein kinase inhibitor.
TH11180EX (en) Various carbamic acid derivatives, and their production and use
KR840002396A (en) Preparation of substituted cyclopropylmethoxy anhydride urea herbicides
KR930007944A (en) Sulfonyl urea herbicides and preparation method thereof
KR930010012A (en) Method for preparing 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20121122

Year of fee payment: 10

FPAY Annual fee payment

Payment date: 20131115

Year of fee payment: 11

LAPS Lapse due to unpaid annual fee