KR970020082A - Biodegradable shielding membrane for periodontal tissue regeneration and its manufacturing method - Google Patents

Biodegradable shielding membrane for periodontal tissue regeneration and its manufacturing method Download PDF

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KR970020082A
KR970020082A KR1019950035025A KR19950035025A KR970020082A KR 970020082 A KR970020082 A KR 970020082A KR 1019950035025 A KR1019950035025 A KR 1019950035025A KR 19950035025 A KR19950035025 A KR 19950035025A KR 970020082 A KR970020082 A KR 970020082A
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South Korea
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polymer
solvent
drug
membrane
tissue regeneration
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KR1019950035025A
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Korean (ko)
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KR0180585B1 (en
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배철민
정종평
이승진
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김상응
주식회사 삼양사
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Priority to KR1019950035025A priority Critical patent/KR0180585B1/en
Priority to CA002219995A priority patent/CA2219995C/en
Priority to PCT/KR1996/000063 priority patent/WO1996034634A1/en
Priority to CNB961936703A priority patent/CN1136922C/en
Priority to JP53319096A priority patent/JP3676374B2/en
Priority to DE69625822T priority patent/DE69625822T2/en
Priority to EP96912319A priority patent/EP0857072B1/en
Publication of KR970020082A publication Critical patent/KR970020082A/en
Priority to US08/765,021 priority patent/US5948020A/en
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Publication of KR0180585B1 publication Critical patent/KR0180585B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

본 발명은 손상된 치조골의 재생을 유도하기 위한 약물을 함유하는 생분해성 차폐막 및 이를 제조하는 방법에 관한 것으로, 본 발명에 따라 폴리글리콜산 기본 망상에 약물을 함유한 생분해성 고분자 용액을 도포하여 제조된 다공성 차폐막은, 망사에 고분자를 피복하여 정교하게 다공성 미세구조를 형성함으로써 차폐막이 삽입되는 부위 조직들의 생장을 보다 용이하게 조절할 수 있으며, 약물을 함유하는 차폐막이 분해됨에 따라 이들 약물이 조절 방출되어 치료효과를 증대시킬 수 있으므로 치조골 재생 치료에 유용하게 사용될 수 있다.The present invention relates to a biodegradable shielding membrane containing a drug for inducing regeneration of damaged alveolar bone and a method for producing the same, prepared by applying a biodegradable polymer solution containing a drug on a polyglycolic acid based network according to the present invention. Porous shielding membranes, by coating a polymer on the mesh to form finely porous microstructures, can more easily control the growth of the tissues in which the shielding membranes are inserted, and these drugs are controlled and released as the drug-containing shielding membrane is decomposed. It can be useful for the treatment of alveolar bone regeneration as it can increase the effect.

Description

치주조직 재생용 생분해성 차폐막 및 그의 제조방법Biodegradable shielding membrane for periodontal tissue regeneration and its manufacturing method

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1A도 및 제1B도는 각각 본 발명에 따라 제조된 차폐막의 표면 및 단면의 주사전자현미경 사진이고,1A and 1B are scanning electron micrographs of the surface and cross section of the shielding film prepared according to the present invention, respectively.

제2A도 및 제2도는 본 발명의 차폐막에 있어서, 혼합 용매의 비율에 따른 염산 미노사이클린과 소 혈청 알부민의 투과랑을 각각 나타낸 것이며,2A and 2A show the permeation channels of minocycline hydrochloride and bovine serum albumin, respectively, according to the proportion of the mixed solvent in the shielding membrane of the present invention.

제3도는 본 발명의 차폐막으로부터 플루비프로펜과 테트라사이클린의 방출량을 약물 함유량에 나타낸 것이고,3 shows the amount of release of flubiprofen and tetracycline from the shielding membrane of the present invention in terms of drug content,

제4A, 4B도 및 제4C도는 본 발명의 차폐막에 있어서, 고분자의 분자량에 따른 무게 변화, 분자량 변화 및 고유 점도 변화를 각각 나타낸 것이다.4A, 4B and 4C show the weight change, molecular weight change and intrinsic viscosity change according to the molecular weight of the polymer in the shielding film of the present invention, respectively.

Claims (12)

폴리글리콜산 망사에 약물을 함유한 생분해성 고분자가 도포된 치주조직 재생 유도용 차폐막.A membrane for inducing periodontal tissue regeneration coated with a biodegradable polymer containing a drug in a polyglycolic acid mesh. 제1항에 있어서, 상기 생분해성 고분자가 분자랑 5만 내지 38만 범위의 락트산의 단일중합체, 락트산과 글리콜산의 공중합체 또는 이들의 혼합물인 것을 특징으로 하는 차폐막.The shielding membrane of claim 1, wherein the biodegradable polymer is a homopolymer of lactic acid in the range of 50,000 to 380,000 molecules, a copolymer of lactic acid and glycolic acid, or a mixture thereof. 제1항에 있어서, 상기 약물이 플루비프로펜, 이부프로펜, 인도메타신, 나프록센, 메페남산, 테트라사이클린, 미노사이클린, 옥시테트라사이클린, 메트로니다졸, 혈소판유래 중식인자, 인슐린 유사 성장인자, 상피성장인자 및 종양 중식인자로 이루어진 그룹중에서 선택된 적어도 하나인 것을 특징으로 하는 차폐막.The method of claim 1, wherein the drug is flubiprofen, ibuprofen, indomethacin, naproxen, mephenamic acid, tetracycline, minocycline, oxytetracycline, metronidazole, platelet-derived Chinese factor, insulin-like growth factor, epidermal growth factor and At least one member selected from the group consisting of tumor Chinese factors. 폴리글리콜산 섬유로 망사를 제작하고, 약물을 포함하는 생분해성 고분자 용액을 상기 망상의 양면에 도포하는 것을 특징으로 하는, 치주조직 재생 유도용 차폐막의 제조방법A method for producing a periodontal tissue regeneration inducing membrane, characterized in that the mesh is made of polyglycolic acid fibers and a biodegradable polymer solution containing a drug is applied to both sides of the network. 제4항에 있어서, 상기 고분자 용액이, 용매, 용매의 5 내지 15%(w/v)의 고분자, 상기 고분자의 5 내지 20%(w/w)의 약물, 상기 고분자의 10 내지 30%(w/v)의 가소제, 상기 고분자의 10 내지 20%(w/w)의 친수성 물질 및 상기 고분자의 5 내지 15%(w/w)의 계면활성제를 포함하는 용액인 것을 특징으로 하는 방법.The method of claim 4, wherein the polymer solution is a solvent, 5 to 15% (w / v) of the polymer, 5 to 20% (w / w) of the polymer, 10 to 30% of the polymer ( w / v) plasticizer, 10-20% (w / w) hydrophilic material of the polymer and 5-15% (w / w) surfactant of the polymer. 제5항에 있어서, 상기 용매가 아세트산에틸, 디옥산 및 클로로포름으로 이루어진 그룹중에서 선택된 적어도 하나와 염화메틸렌의 혼합용매인 것을 특징으로 하는 방법.The method of claim 5, wherein the solvent is a mixed solvent of methylene chloride and at least one selected from the group consisting of ethyl acetate, dioxane and chloroform. 제6항에 있어서, 상기 용매가 염화메틸렌과 아세트산에틸의 1 : 1 내지 30 : 1의 혼합용매인 것을 특징으로 하는 방법.7. The method according to claim 6, wherein the solvent is a mixed solvent of 1: 1 to 30: 1 of methylene chloride and ethyl acetate. 제4항에 있어서, 상기 차폐막을 비용매 수조 또는 비용매의 증기가 포화되 수조에 침지시킨 후 건조하여 처리하는 것을 특징으로 하는 방법.The method according to claim 4, wherein the shielding membrane is treated by drying the non-solvent tank or the non-solvent vapor after saturation in the bath. 제8항에 있어서 상기 비용매가 증류수, 메탄올 또는 아세트산에틸인 것을 특징으로 하는 방법.The method according to claim 8, wherein the nonsolvent is distilled water, methanol or ethyl acetate. 제5항에 있어서, 상기 가소제가 디에틸프탈레이트, 폴리에틸렌글리콜, 글리세린 또는 이들의 혼합물인 것을 특징으로 하는 방법.The method of claim 5 wherein the plasticizer is diethylphthalate, polyethylene glycol, glycerin or mixtures thereof. 제5항에 있어서, 상기 친수성 물질이 하이드록시프로필메틸셀룰로즈, 하이드록시프로필셀룰로즈, 염화나트륨, 글리세린, 키토산, 알기네이트 또는 이들의 혼합물인 것을 특징으로 하는 방법.6. The method of claim 5 wherein the hydrophilic material is hydroxypropylmethylcellulose, hydroxypropylcellulose, sodium chloride, glycerin, chitosan, alginate or mixtures thereof. 제5항에 있어서, 상기 계면활성제가 플루로닉인 것을 특징으로 하는 방법.6. The method of claim 5 wherein said surfactant is pluronic. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950035025A 1995-05-01 1995-10-12 Biodegradability shielding film for alveolar organ KR0180585B1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
KR1019950035025A KR0180585B1 (en) 1995-10-12 1995-10-12 Biodegradability shielding film for alveolar organ
CA002219995A CA2219995C (en) 1995-05-01 1996-05-01 Implantable bioresorbable membrane and method for the preparation thereof
PCT/KR1996/000063 WO1996034634A1 (en) 1995-05-01 1996-05-01 Implantable bioresorbable membrane and method for the preparation thereof
CNB961936703A CN1136922C (en) 1995-05-01 1996-05-01 Implantable bioresorbable membrane and method for the preparation thereof
JP53319096A JP3676374B2 (en) 1995-05-01 1996-05-01 Biodegradable shielding film for transplantation and production method
DE69625822T DE69625822T2 (en) 1995-05-01 1996-05-01 IMPLANTABLE, BIORESORBABLE MEMBRANE AND METHOD FOR THE PRODUCTION THEREOF
EP96912319A EP0857072B1 (en) 1995-05-01 1996-05-01 Implantable bioresorbable membrane and method for the preparation thereof
US08/765,021 US5948020A (en) 1995-05-01 1997-12-26 Implantable bioresorbable membrane and method for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950035025A KR0180585B1 (en) 1995-10-12 1995-10-12 Biodegradability shielding film for alveolar organ

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KR970020082A true KR970020082A (en) 1997-05-28
KR0180585B1 KR0180585B1 (en) 1999-03-20

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100336701B1 (en) * 1999-07-26 2002-05-13 오석송 A teethridege tissue recovery membrane, and a process of preparing the same
KR100341243B1 (en) * 1999-06-07 2002-06-21 이승진 Moldable drug releasing barrier membranes and their fabrication method
KR100464930B1 (en) * 2001-06-30 2005-01-05 이승진 Barrier membrance for guided tissue regeneration and the preparation thereof
KR100803287B1 (en) * 2005-02-28 2008-02-13 재단법인서울대학교산학협력재단 Method for Manufacturing a Barrrier Membrane for Guided Tissue Regeneration Having an Efficient Durability and the Barrier Membrane Using the Method
WO2012081944A2 (en) * 2010-12-16 2012-06-21 Republic Of Korea(Management : Rural Development Administration) Dental membrane and method of manufacturing the same

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100341243B1 (en) * 1999-06-07 2002-06-21 이승진 Moldable drug releasing barrier membranes and their fabrication method
KR100336701B1 (en) * 1999-07-26 2002-05-13 오석송 A teethridege tissue recovery membrane, and a process of preparing the same
KR100464930B1 (en) * 2001-06-30 2005-01-05 이승진 Barrier membrance for guided tissue regeneration and the preparation thereof
KR100803287B1 (en) * 2005-02-28 2008-02-13 재단법인서울대학교산학협력재단 Method for Manufacturing a Barrrier Membrane for Guided Tissue Regeneration Having an Efficient Durability and the Barrier Membrane Using the Method
WO2012081944A2 (en) * 2010-12-16 2012-06-21 Republic Of Korea(Management : Rural Development Administration) Dental membrane and method of manufacturing the same
WO2012081944A3 (en) * 2010-12-16 2012-10-11 Republic Of Korea(Management : Rural Development Administration) Dental membrane and method of manufacturing the same

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