KR970011073B1 - Capsule composition for control of diseases of adult people containing perilla japonica oil - Google Patents

Abstract

Capsule composition for inhibiting adult disease contains more than 90wt% of perilla oil, 0.1-0.2wt% of tocopherol, 1-5wt% of soybean phospholipid, 0.1-1.0wt% of garlic oil, 0.05-0.2wt% of b-carotene and 0.01-0.2wt% of vitamin C. Capsule composition has an effect on inhibiting fatness, resisting thrombi and lowering cholesterol.

Description

Capsule composition for inhibiting adult disease with perilla oil as main ingredient

The present invention relates to a capsule composition for inhibiting adult diseases, the main ingredient of perilla oil.

Circulatory disorders are due to genetic factors, mental stress, lack of exercise, obesity, and excessive sodium intake.However, the recent increase in national income caused by economic growth led to increased saturated fatty acid and cholesterol intake due to meat-oriented dietary patterns. It is emerging as a major cause. Increasing saturated fatty acid and cholesterol intake from animal sources not only increases plasma lipids and cholesterol levels, but also results in fat accumulation, hardening of tissues, and cholesterol accumulation in the smooth muscles of the arterial walls, as well as thromboxane A.₂Platelet coagulation due to this is an important factor. Reportedly, Greenland's Eskimos have significantly lower mortality from thrombosis and myocardial infarction due to eicosapentaenophosphate (EPA) and docosahexaenophosphate (DHA), which are abundant in their fish. Since then, much research has been conducted on the physiological function of highly unsaturated fatty acids. As a result, eicosapentaenoic acid acts competitively with arachidonic acid, resulting in thromboxane A₂ Thromboxane A while inhibiting biosynthesis₃Several articles have also been reported that biosynthesis results in antithrombotic effects and also lowers plasma lipids, triglycerides, low density lipoproteins, and LDL-cholesterol levels (Nestel et al. 1987, Hwang). et al. 1987, Puppione et al. 1987). On the other hand, ingestion of these highly unsaturated fatty acids is also a problem of promoting aging and causing various diseases, and fatty liver formation cannot be ruled out in the long term. In addition, since EPA purification is not easy from fish oil and the price of purified low purity EPA preparations or refined fish oil is not cheap, many people cannot use it.

Therefore, the present inventors have studied to solve the above problems, alpha-linolenic acid (α-linolenic acid) can be partially converted to eicosapentaenoic acid, docosahexaenoic acid in the body, eico Experiments confirmed that the production of malondialdehyde (Malondi-aldehyde) that causes damage to proteins or cell membranes in the body than intake of sapentanoenoic acid, docosahexaenophosphate was confirmed through experiments.

Although alpha-linolenic acid differs slightly depending on the sample to be analyzed, it contains about 80% in perilla oil containing about 80% polyunsaturated fatty acid, 10-14% monounsaturated fatty acid, and 7-10% saturated fatty acid. Although some Koreans have consumed perilla oil for the treatment of adult diseases, it is inconvenient to consume perilla oil due to its unique smell and taste, and hair loss, pigmentation and vitamin deficiency symptoms have been reported in some literatures. .

Accordingly, the present inventors have minimized these problems by using perilla oil as a main ingredient, preventing and treating geriatric diseases, smoothing the body's fat metabolism, and preparing a capsule-type preparation that is easy to carry and take.

The present invention is more than 90% by weight perilla oil, 0.1 to 0.2% by weight tocopherol, 0.1 to 0.5% by weight green tea extract, 1 to 5% by weight soybean phospholipid, 0.1 to 1.0% by weight garlic oil, 0.05 to 0.2% by weight beta carotene and vitamins It relates to a capsule composition for inhibiting adult disease containing C 0.01 to 0.2% by weight.

Hereinafter, the present invention will be described in detail. Perilla oil contains alpha-linolenic acid and has an unsaturation of 90% or more, so oxidation easily occurs at room temperature, and therefore, an antioxidant is required first. In the present invention, as an antioxidant, alpha-tocopherol and tea extracts showing antioxidant power in nature were used. Alpha-tocopherol is the best known antioxidant to date, which inhibits the formation of lipid peroxide in the body. As a result, it inhibits the aging and the cancer caused by lipid peroxide. In general, 0.4 to 0.6 mg per g of unsaturated fatty acid intake is required, and 0.10 to 0.20% was used in the present invention in consideration of absorption in the intestine and oxidation of alpha-tocopherol itself.

In addition, catechin (Catechin), a tannin component contained in the green tea extract, also exhibits anti-cancer and antioxidant activities, and lowers blood lipid and cholesterol levels in the body. Thus, the present invention provides about 0.1-0.5% green tea extract (Japan / Sampo Pharmaceutical, Sanfood oily) was added. The green tea extract formulation (Japan / Sanpo Pharmaceutical Sanfood, Oily) contains not only phenolic catechins but also some tocopherols and citric acid. When the 0.2% level is used, it shows sufficient antioxidant activity and many other physiological effects are expected. . Soybean phospholipid (60%) was added about 1 to 5% to promote the absorption of fat in the intestine, to dissolve lipids in the blood, and to reduce the formation of fatty liver, and to increase linoleic acid content with soybean phospholipid. In addition to the supply of essential fatty acids in the body can be expected to have a simultaneous effect of lowering blood cholesterol. In addition, beta carotene (β-carotene) (active 30% oil) was added 0.05 to 0.2% to inhibit lipid peroxide caused by oxidation of fatty acids and prevent cancer.

β-carotene structure

In addition, it has a function of preventing cancer, enhances immune function in the body, and garlic oil containing allicin (allicine), which is known to sterilize harmful bacteria, lowers blood pressure and has a thrombolytic effect, which is effective in preventing and treating adult diseases. Therefore, in the composition of the present invention, 0.1 to 1.0% garlic oil was added.

Considering the effects and the effects of each component, the representative components and ratios of the capsule composition according to the present invention is as follows, in the following examples, such a composition for preventing adult diseases was used.

In the composition for preventing adult diseases, vitamin C was added for the purpose of preventing scurvy and proper oxidation of fat.

The composition of the present invention described above was applied to the preparation, encapsulation and laboratory animals and described in detail based on examples.

Example 1

Pressurized perilla oil was removed by using an inhaler and Whatman filter paper to remove the gums present in the edible oil, followed by stirring at 60 ° C. while adding 0.2% green tea extract and soybean phospholipid.

Example 2

After confirming the homogeneous phase and reducing the temperature to 35 ° C. to 40 ° C., the alpha-tocopherol was stirred for 10 minutes, followed by addition of 0.1% of beta carotene, 0.5% of garlic extract (oil) and 0.05% of vitamin C powder. It stirred until it became a uniform phase, and manufactured the composition.

Example 3

20 female Sprague-Dawly females weighing about 100 g were divided into 4 groups of 5 rats, crude protein 20.0%, calcium 0.6%, phosphorus 0.4%, crude fat 3.0%, mineral 10.1%, and fiber. Basic solid feed containing 10.0% was free-adapted for one week.

Example 4

Group 2 of 4 groups continued to feed freely with solid feed, and the remaining two groups partially crushed the basic solid feed, and then mixed the basic solid feed, the composition of the present invention, and casein sodium at a ratio of 80%, 15%, and 5%, respectively. Free meals.

Example 5

At 4 weeks of the experiment, malondialdehyde was measured from the urine of 5 rats of the control and the control group, respectively, and the average of 57.65 and 56.93 µg / g (MDA / weight) of the control group showed no difference. It was confirmed through experiments that a large amount of peroxide (68.00㎍ / g) generated when ingesting fish oil was not produced.

Example 6

Plasma cholesterol was analyzed in 5 control and 5 composition added groups after 5 weeks of feeding. The cholesterol content was 66mg / 100ml in the control group, compared with 50mg / 100ml in the composition added group.

These results were lower than the blood cholesterol (55mg / 100ml) in rats fed only perilla oil, which is a synergistic effect of the hypocholesterolemic effect of catechin and garlic extract of green tea extract on unsaturated fatty acids of plant origin. Lose.

Example 7

In relation to antithrombosis, the bleeding time of rats was measured by the Hornstra method during the experiment 16. Hemostatic time was 119 seconds in the control group, but 138 seconds in the control group, indicating anti-blood coagulation. These results show a slight difference from the consumption of fish oil (169), but considering the risk of cerebral hemorrhage due to prolonged intake of fish oil, or hemostasis delay in an accident, it shows strongly the possibility of preventing thrombosis.

Example 8

At 16 weeks of experiment, liver and kidney tissues were confirmed to convert alpha-linolenic acid to EPA and DHA. After extracting total lipids of liver and kidney tissue, each phospholipid group was extracted and extracted by TLC analysis. The results are as follows.

Table 1 Fatty acid composition of hepatic phospholipids, phosphatidyl choline and phosphatidyl ethanolamine

In the case of liver tissue, eicosapentaenoic acid showed a trace amount in the control group, increased to 13.5% and 11.5% of the two phospholipid groups, respectively. ), Whereas the content of arachonindan was 23.6% and 20.1% of the two phospholipid groups, 6.2% and 5.7%, respectively, when the composition was added, and the possibility of inhibiting or blocking arachidonic acid production metabolism and preventing adult diseases. Could confirm. Docosahexaenophosphate also increased to 4.5% and 8.2% for the two phospholipid groups, respectively, and eventually showed conversion of alpha-linolenic acid to eicosapentaenoic acid and docosahexaenoic acid. The increased eicosapentaenoic acid and docosahexaenoic acid present present not only inhibit or block the arkidonic acid metabolism, but also act as a substrate for thromboxane A ₃ production, demonstrating the potential for inhibiting geriatric disease. Fatty acid composition of phospholipid Phosphatidyl choline and Phosphatidyl ethanolamine in renal tissue was analyzed at 16 weeks.

[Table 2 Fatty Acid Composition of Phospholipid Phosphatidyl Choline and Phosphatidyl Ethanolamine in Kidney Tissue]

The fatty acid composition of renal tissue phospholipids, like liver tissue, showed a tendency to increase linolenic acid, eicosapentaenoic acid and docosahexaenoic acid, while arachidonic acid tended to decrease, resulting in changes in eicosanoid production. And eventually showed the possibility of suppressing geriatric disease.

Example 9

In order to test the anti-obesity effect of the composition of the present invention, the body weight of 10 obese women between 63 and 70 kg was taken for 2 months while changing the daily dose as shown in Table 3. As shown in Table 3, there were 2 to 14% weight loss in 6 obese women and no change in the other 4 obese women.

TABLE 3 Influence on the weight of the composition of the present invention

This showed that the unsaturated fatty acid of plant origin inhibits triglyceride synthesis in the body and the composition of the present invention has an anti-obesity effect due to the synergy of vitamin C, citric acid and catechin.

Therefore, by properly ingesting the formulation of the present composition can not only prevent obesity, antithrombotic, lower cholesterol and treatment of cholesterol, but also reduce side effects due to lipid peroxide formation than EPA preparations made by refining fish oil. In addition, by properly supplying the essential fatty acids linolenic acid and linolenic acid, it is possible to inhibit the growth of the fatty acid deficiency such as skin coarse, and at the same time anti-cancer, antioxidant and anti-cancer of catechin, flavonoids and beta-carotene.

Claims (3)

Perilla oil 90% or more, 0.1 to 0.2% by weight of tocopherol, 0.1 to 0.5% by weight of green tea extract, 1 to 5% by weight of soybean phospholipid, 0.1 to 1.0% by weight of garlic oil, 0.05 to 0.2% by weight of beta carotene and 0.01 to 0.01% of vitamin C Obesity inhibitor capsule composition containing 0.2% by weight. Perilla oil 90% or more, 0.1 to 0.2% by weight of tocopherol, 0.1 to 0.5% by weight of green tea extract, 1 to 5% by weight of soybean phospholipid, 0.1 to 1.0% by weight of garlic oil, 0.05 to 0.2% by weight of beta carotene and 0.01 to 0.01% of vitamin C An antithrombotic capsule composition containing 0.2% by weight. Perilla oil 90% or more, 0.1 to 0.2% by weight of tocopherol, 0.1 to 0.5% by weight of green tea extract, 1 to 5% by weight of soybean phospholipid, 0.1 to 1.0% by weight of garlic oil, 0.05 to 0.2% by weight of beta carotene and 0.01 to 0.01% of vitamin C A cholesterol lowering capsule composition containing 0.2% by weight.