KR970009819A - Solid dialysis solvent and method for manufacturing the same - Google Patents

Solid dialysis solvent and method for manufacturing the same Download PDF

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Publication number
KR970009819A
KR970009819A KR1019960015192A KR19960015192A KR970009819A KR 970009819 A KR970009819 A KR 970009819A KR 1019960015192 A KR1019960015192 A KR 1019960015192A KR 19960015192 A KR19960015192 A KR 19960015192A KR 970009819 A KR970009819 A KR 970009819A
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chloride
sodium
solid dialysis
calcium chloride
dialysis solvent
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KR100398299B1 (en
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가즈히꼬 다마가와
히데유끼 아오야마
미사오 모또끼
슈지 다까하시
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도미따 스미히로
도미따 세이야꾸 가부시끼가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A61M1/1666—Apparatus for preparing dialysates by dissolving solids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • External Artificial Organs (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은, 염화나트륨 및 염화칼륨으로 이루어지는 군으로부터 선택되는 적어도 1종을 주성분으로서 포함하는 핵층과, 아세트산나트륨과 염화칼슘의 바능에 의해 생성된 복염, 다른 전해질 조성물 및 pH 조정제 및 임의 성분으로서의 포도당을 포함하는 복염층의 2층 구조를 갖는 고형 투석용제; 염화나트륨 및 염화칼륨으로 이루어지는 군으로부터 선택되는 적어도 1종을 주성분으로서 포함하는 핵층과, 아세트산 나트륨과 염화칼슘의 반응에 의해 생성된 복염, 다른 전해질 조성물 및 pH 조정제를 포함하는 복염층과, 포도당을 포함하는 외층과의 3층 구조를 갖는 고형 투석용제 및 이들의 제조법을 제공한다.The present invention relates to a method for producing an aqueous solution containing a core layer containing at least one member selected from the group consisting of sodium chloride and potassium chloride as a main component, a complex salt formed by the action of sodium acetate and calcium chloride, another electrolyte composition and pH adjusting agent, A solid dialysis solvent having a two-layer structure of double salt layer; A core layer containing at least one member selected from the group consisting of sodium chloride and potassium chloride as a main component, a double salt layer comprising a double salt formed by the reaction of sodium acetate and calcium chloride, another electrolyte composition and a pH adjuster, And a method of producing the same.

Description

고형 투석용제 및 그의 제조 방법Solid dialysis solvent and method for manufacturing the same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

제 1 도는 제 1발명의 제제의 구조를 나타내는 모식도,FIG. 1 is a schematic view showing the structure of the preparation of the first invention,

제 2 도는 제 1발명의 제제의 구조를 나타내는 모식도,FIG. 2 is a schematic view showing the structure of the preparation of the first invention,

제 3 도는 제 1발명의 제제의 구조를 나타내는 모식도,FIG. 3 is a schematic view showing the structure of the preparation of the first invention,

제 4 도는 실시예 1에서 얻어진 고형 투석용제의 광학 현미경상,4 shows the optical microscope image of the solid dialysis solvent obtained in Example 1,

제 5 도는 실시예 1에서 얻어진 고형 투석용제의 전자 현미경상.5 is an electron microscope image of the solid dialysis solvent obtained in Example 1. Fig.

Claims (15)

염화나트륨, 염화칼륨, 염화칼슘, 염화마그네슘 및 아세트산나트륨으로 이루어지는 전해질 조성물과 pH 조정제를 포함하는 고형 투석용제에 있어서, 염화나트륨 및 염화칼륨으로 이루어지는 군으로부터 선택되는 적어도 1종을 주성분으로서 포함하는 핵층과, 아세트산나트륨과 염화칼슘의 반응에 의해 생성된 복염, 다른 전해질 조성물 및 pH 조정제를 포함하는 복염층의 구조를 갖는 것이 특징인 고형 투석용제.A solid dialysis solvent comprising an electrolyte composition comprising sodium chloride, potassium chloride, calcium chloride, magnesium chloride and sodium acetate, and a pH adjuster, wherein the core layer comprises at least one selected from the group consisting of sodium chloride and potassium chloride as a main component, Salt structure comprising a salt of a salt produced by the reaction of calcium chloride, another electrolyte composition and a pH adjuster. 제 1항에 있어서, 상기 복염층에 포도당을 더 포함하는 것인 고형 투석용제.The solid dialysis solvent according to claim 1, further comprising glucose in the double salt layer. 제 1항 또는 2항에 있어서, 상기 핵층의 평균 입경이 150 내지 2,000㎛, 바람직하게는 250 내지 1,000㎛인 것인 고형 투석용제.The solid dialysis solvent according to claim 1 or 2, wherein the average particle diameter of the core layer is 150 to 2,000 mu m, preferably 250 to 1,000 mu m. 제 1항 내지 3항 중 어느 하나의 항에 있어서, 상기 pH 조정제가 아세트산인 것인 고형 투석용제.The solid dialysis solvent according to any one of claims 1 to 3, wherein the pH adjusting agent is acetic acid. 제 1항 내지 4항 중 어느 하나의 항에 있어서, 아세트산나트륨과 염화칼슘의 반응에 의해 생성된 복염이, X선 회절에 있어서, 2Θ=약 6.8°내지 7.0°(X선:Cuλ(Kα1)=1.5405Å)에서 특정한 피크를 갖는 것인 고형 투석용제.The method according to any one of claims 1 to 4, wherein the double salt produced by the reaction of sodium acetate and calcium chloride has an X-ray diffraction peak at 2? = About 6.8 to 7.0 (X-ray: Cu? (K? 1 ) = 1.5405A). ≪ / RTI > 제 1항 내지 5항 중 어느 하나의 항에 기재된 고형 투석용제와 탄산수소나트륨의 2제로 이루어지는 중탄산 투석용제.A bicarbonate dialysis solution comprising the solid dialysis solvent according to any one of claims 1 to 5 and a two-component sodium hydrogen carbonate solution. 염화나트륨, 염화칼륨, 염화칼슘, 염화마그네슘 및 아세트산나트륨으로 이루어지는 전해질 조성물과 pH 조정제 및 포도당을 포함하는 고형 투석용제에 있어서, 염화나트륨 및 염화칼륨으로 이루어지는 군으로부터 선택되는 적어도 1종을 주성분으로서 포함하는 핵층과, 아세트산나트륨과 염화칼슘의 반응에 의해 생성된 복염, 다른 전해질 조성물 및 pH 조정제를 포함하는 복염층과, 포도당을 포함하는 외층과의 3층 구조를 갖는 것이 특징인 고형 투석용제.A solid dialysis solvent comprising an electrolyte composition comprising sodium chloride, potassium chloride, calcium chloride, magnesium chloride and sodium acetate, a pH adjuster and glucose, characterized in that it comprises a core layer containing at least one member selected from the group consisting of sodium chloride and potassium chloride as a main component, Layer structure of a double salt layer formed by the reaction of sodium and calcium chloride, a double salt layer containing another electrolyte composition and a pH adjusting agent, and an outer layer containing glucose. 제 7항에 있어서, 상기 핵층의 평균 입경이 150 내지 2,000㎛, 바람직하게는 250 내지 1,000㎛인 것인 고형 투석용제.The solid dialysis solvent according to claim 7, wherein the average particle size of the core layer is 150 to 2,000 mu m, preferably 250 to 1,000 mu m. 제 7항 또는 8항에 있어서, 상기 pH 조정제가 아세트산인 것인 고형 투석용제.The solid dialysis solvent according to claim 7 or 8, wherein the pH adjusting agent is acetic acid. 제 7항 내지 9항 중 어느 하나의 항에 있어서, 아세트산나트륨과 염화칼슘의 반응에 의해 생성된 복염이, X선 회절에 있어서, 2Θ=약 6.8°내지 7.0°(X선:Cuλ(Kα1)=1.5405Å)에서 특정한 피크를 갖는 것인 고형 투석용제.The method according to any one of claims 7 to 9, wherein the double salt produced by the reaction of sodium acetate and calcium chloride has an X-ray diffraction peak at 2? = About 6.8 to 7.0 (X-ray: Cu? (K? 1 ) = 1.5405A). ≪ / RTI > 제 7항 내지 10항 중 어느 하나의 항에 기재된 고형 투석용제와 탄산수소나트륨의 2제로 이루어지는 중탄산 투석용제.A bicarbonate dialysis solution comprising the solid dialysis solvent according to any one of claims 7 to 10 and a bicarbonate of sodium hydrogencarbonate. 염화나트륨, 염화칼륨, 염화마그네슘 및 아세트산나트륨의 혼합물에 물을 가하고, 내온 50 내지 100℃정도의 가온 하에 염화칼슘을 가하며, 염화칼슘을 가했을 때 혼합물 중의 물의 함량이 염화칼슘 중량의 20 내지 300중량% 정도인 혼합 조립 공정, 정립, 건조 및 pH 조정제를 가하여 혼합하는 각 공정을 포함하는 것이 특징인, 염화나트륨 및 염화칼륨으로 이루어지는 군으로부터 선택되는 적어도 1종을 주성분으로서 포함하는 핵층과, 아세트산나트륨과 염화칼슘의 반응에 의해 생성된 복염, 다른 전해질 조성물 및 pH 조정제를 포함하는 복염층의 2층 구조를 갖는 고형 투석용제의 제조 방법.Wherein water is added to a mixture of sodium chloride, potassium chloride, magnesium chloride and sodium acetate, calcium chloride is added at a temperature of about 50 to 100 DEG C and the content of water in the mixture is about 20 to 300 wt% And a step of mixing the aqueous solution of sodium chloride with a solution of sodium chloride and calcium chloride, and a step of mixing, adding, adding, processing, sizing, drying and a pH adjusting agent. Layer structure of a double salt layer comprising a polyphosphoric acid salt, a polyphosphoric acid salt, a polyphosphoric acid salt, a polyphosphoric acid salt, a polyphosphoric acid salt and a polyphosphoric acid salt. 염화나트륨, 염화칼륨, 염화마그네슘 및 아세트산나트륨 및 포도당의 혼합물에 물을 가하고, 내온 50 내지 80℃정도의 가온 하에 염화칼슘을 가하며, 염화칼슘을 가했을 때 혼합물 중의 물의 함량이 염화칼슘 중량의 20 내지 100중량% 정도인 혼합 조립 공정, 염화칼슘 첨가 후 pH 조정제를 가하여 혼합하는 공정, 정립 공정 및 건조 공정을 포함하는 것이 특징인, 염화나트륨 및 염화칼륨으로 이루어지는 군으로부터 선택되는 적어도 1종을 주성분으로서 포함하는 핵층과, 아세트산나트륨과 염화칼슘의 반응에 의해 생성된 복염, 다른 전해질 조성물 및 pH 조정제를 포함하는 복염층의 2층 구조를 갖는 고형 투석용제의 제조 방법.Water is added to a mixture of sodium chloride, potassium chloride, magnesium chloride and sodium acetate and glucose and the calcium chloride is added under heating at an internal temperature of 50 to 80 DEG C and the content of water in the mixture is about 20 to 100 wt% A core layer containing as a main component at least one member selected from the group consisting of sodium chloride and potassium chloride, which comprises a mixing and granulating step, a step of mixing and adding calcium chloride after adding a pH adjusting agent, a sizing step and a drying step, A method for producing a solid dialysis solvent having a two-layer structure of a double salt layer formed by a reaction of calcium chloride, another electrolyte composition, and a double salt layer comprising a pH adjusting agent. 염화나트륨, 염화칼륨, 염화마그네슘 및 아세트산나트륨의 혼합물에 물을 가하고, 내온 50 내지 100℃정도의 가온 하에 염화칼슘을 가하며, 염화칼슘을 가했을 때의 혼합물 중 물의 함량이 염화칼슘 20 내지 300중량% 정도인 혼합 조립 공정에 의해 얻은 pH 조정제를 첨가하지 않은 2층 구조의 고형 투석용제를 내온 30 내지 80℃ 정도, 바람직하게는 40 내지 60℃ 정도, 더욱 바람직하게는 40 내지 50℃ 정도의 가온 하에 포도당을 가하여 혼합하고, 이 고형 투석용제와 포도당 총중량의 0.5 내지 5.0중량% 정도의 물이 존재 하에 혼합 조립하는 공정, 이 조립물에 아세트산을 첨가하여 혼합하는 공정 및 건조 공정을 포함하는 것이 특징인, 염화나트륨 및 염화칼륨으로 이루어지는 군으로부터 선택되는 적어도 1종을 주성분으로서 포함하는 핵층과, 아세트산나트륨과 염화칼슘의 반응에 의해 생성된 복염, 다른 전해질 조성물 및 pH 조정제를 포함하는 복염층과, 포도당을 포함하는 외층과의 3층 구조를 갖는 고형 투석용제의 제조 방법.Wherein water is added to a mixture of sodium chloride, potassium chloride, magnesium chloride and sodium acetate, calcium chloride is added under a temperature of about 50 to 100 DEG C, and the content of water in the mixture when calcium chloride is added is about 20 to 300 wt% Layered solid dialysis solution to which no pH adjusting agent is added is mixed with glucose at an internal temperature of 30 to 80 캜, preferably about 40 to 60 캜, and more preferably about 40 to 50 캜, , A step of mixing and granulating the solid dialysis solvent in the presence of water in an amount of about 0.5 to 5.0% by weight of the total weight of glucose, a step of adding acetic acid to the granulated product and mixing, and a step of drying, A core layer containing at least one member selected from the group consisting of sodium acetate, Layer structure of a double salt layer formed by the reaction of calcium chloride, a double salt layer containing another electrolyte composition and a pH adjusting agent, and an outer layer containing glucose. 제 1항, 2항 또는 7항에 기재된 고형 투석용제를, 규소 산화물을 포함하여 투습도(40℃, 90% RH)가 2.0g/㎠·24hr 이하인 포재에 포장하여 되는 포장 고형 투석용제.A packaged solid dialysis solvent packed with a solid dialysis solvent according to any one of claims 1, 2, or 7, wherein the solid dialysis solvent is packed in a package containing silicon oxide and having a moisture permeability (40 캜, 90% RH) of 2.0 g / cm 2 24 hours or less. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019960015192A 1995-08-02 1996-05-09 Solid dialysis solvent and method for manufacturing the same KR100398299B1 (en)

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JP95-197648 1995-08-02
JP7197648A JP2987488B2 (en) 1995-08-02 1995-08-02 Solid dialysis agent and method for producing the same

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KR100398299B1 KR100398299B1 (en) 2003-12-31

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