KR970009595B1 - PROCESS FOR PRODUCING Ñß-L-ASPARTYL-L- PHENYLALANINE METHLY ESTER - Google Patents

PROCESS FOR PRODUCING Ñß-L-ASPARTYL-L- PHENYLALANINE METHLY ESTER

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Publication number
KR970009595B1
KR970009595B1 KR97009502A KR19970009502A KR970009595B1 KR 970009595 B1 KR970009595 B1 KR 970009595B1 KR 97009502 A KR97009502 A KR 97009502A KR 19970009502 A KR19970009502 A KR 19970009502A KR 970009595 B1 KR970009595 B1 KR 970009595B1
Authority
KR
South Korea
Prior art keywords
alpha
apm
aspartyl
produced
methyl ester
Prior art date
Application number
KR97009502A
Other languages
Korean (ko)
Inventor
Kyung-Suk Choe
Dae-Kwon Joo
Min-Soo Han
Ee-Nam Hwang
Hong-Kyu Choe
Original Assignee
Miwon Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR93016693A external-priority patent/KR970009594B1/en
Application filed by Miwon Co Ltd filed Critical Miwon Co Ltd
Application granted granted Critical
Publication of KR970009595B1 publication Critical patent/KR970009595B1/en

Links

Abstract

The method is for preparing a-L-aspartyl-L-phenylalanine methyl ester (aspartame, alpha-APM) with high yield. The method comprises the step to esterify L-phenyalanine using methanol with removing water by way of distillation, the step to couple the produced PM and N-formyl-L-aspartic acid anhydride, the step to deformylize the produced N-formyl-L-aspartyl-L-phenylalanine methyl ester, the step to crystallize the produced alpha-APM into L-aspartyl-L-phenylalanine methyl ester hydrochloride (alpha-APM HCl), the step to collect primary alpha-APM HCl and the step to produce secondary alpha-APM product by esterifying alpha-AP in filtrate. The method results in alpha-APM product with a high yield.
KR97009502A 1992-08-27 1997-03-20 PROCESS FOR PRODUCING Ñß-L-ASPARTYL-L- PHENYLALANINE METHLY ESTER KR970009595B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93596192A 1992-08-27 1992-08-27
KR93016693A KR970009594B1 (en) 1992-08-27 1993-08-26 PROCESS FOR PRODUCING Ñß- L - ASPARTYL - L - PHENYLALANINE METHYL ESTER

Publications (1)

Publication Number Publication Date
KR970009595B1 true KR970009595B1 (en) 1997-06-14

Family

ID=26629845

Family Applications (1)

Application Number Title Priority Date Filing Date
KR97009502A KR970009595B1 (en) 1992-08-27 1997-03-20 PROCESS FOR PRODUCING Ñß-L-ASPARTYL-L- PHENYLALANINE METHLY ESTER

Country Status (1)

Country Link
KR (1) KR970009595B1 (en)

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