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The method is for preparing a-L-aspartyl-L-phenylalanine methyl ester (aspartame, alpha-APM) with high yield. The method comprises the step to esterify L-phenyalanine using methanol with removing water by way of distillation, the step to couple the produced PM and N-formyl-L-aspartic acid anhydride, the step to deformylize the produced N-formyl-L-aspartyl-L-phenylalanine methyl ester, the step to crystallize the produced alpha-APM into L-aspartyl-L-phenylalanine methyl ester hydrochloride (alpha-APM HCl), the step to collect primary alpha-APM HCl and the step to produce secondary alpha-APM product by esterifying alpha-AP in filtrate. The method results in alpha-APM product with a high yield.
KR97009502A1992-08-271997-03-20PROCESS FOR PRODUCING Ñß-L-ASPARTYL-L- PHENYLALANINE METHLY ESTER
KR970009595B1
(en)