KR970001494B1 - Chemical substances for sterilizing and rinsing contact lenses containing n-tetradecyl tri(amino ethyl) - Google Patents

Abstract

New sterilizing, preservative and detergent composition for contact lens is composed of 0.01wt.% of tetradecyl tri(aminoethyl)glycine= HCL, 0.2-0.5 wt.% of sodium chloride, 0.5 wt.% of boric acid, and distilled water. For an example, 3g of common salt is melted in 1L distilled water to give saline water, which is mixed with 0.0001 wt.% of tetradecyl tri(aminoethyl)glycine= HCL and 0.5 wt.% of boric acid. The composition is harmless to a human being and shows a good bactericidal activity.

Description

Bactericidal, Preservative and Cleanser Compositions for Contact Lenses Containing N-tetradecyl Tri (aminoethyl) glycineHCI

The present invention relates to a bactericidal, preservative and cleaning composition for contact lenses containing N-tetradecyl tri (aminoethyl) glycine-HCI.

According to the present invention, when a solution containing N-tetradecyl tri (aminoethyl) glycine-HCI is used as a disinfectant, preservative or cleaning agent for contact lenses, the effect is very excellent and convenient to use, and the surface of the lens is smooth after use. It relates to a new composition that provides comfort to the wearer.

In general, lens contamination problems are more frequent with soft lenses than with hard lenses. A hydrophilic soft lens is a protein from a finger while a lens, such as mucin or albumin, or lipids, enzymes, etc. in tears adhere to the network of synthetic resin lenses. This is because fat is easily attached.

In addition, minerals such as calcium ions in tears bind to the surface or inside of the lens by secondary bonding with proteins, qualities, and the like, which are primarily attached to the lens, thereby facilitating adhesion of the contaminants to the surface or inside of the lens. If contaminants adhere to the surface of the lens and then penetrate into the inside of the lens polymer's network structure, the wearer will have strong toxicity and irritation to the eye.

Conventional treatment methods for removing such contaminants include chemical treatment and heat treatment. However, the heat treatment method has a disadvantage in that such contaminants are attached to the surface of the lens and repeatedly deform the lens, thereby degrading the visual sensitivity or costly. In addition, in some cases, it promotes the growth of mold and bacteria to harm the lens wearer.

Reagents used in chemical treatment methods include benzyl konium chloride, thimerosal, chlorohexamine, hydrogen peroxide, and the like. Of these reagents, however, benzyl-konium chloride is not used because it invades the cornea, and thimerosal is a relatively low toxicity, weak antibacterial and antifungal bactericidal agent with low antibacterial activity and high concentration. Pseudomonnasaeruginosa can kill, but is less effective for Staphliococcus aureus, and if contact lenses are used in thimerosal solution for 24 hours at a concentration lower than the bacterial concentration, the cornea is damaged. appear. In addition, chlorohexanine is not only less active but also toxic to the cells, which is harmful to the eye.

The most commonly used reagent for the sterilization of contact lenses is hydrogen peroxide (H ₂ O ₂ ), which has good sterilizing power, but the hydrogen peroxide remains in the equatorial eye, causing irritation to the eyes and ending the harm. , Neutralize with iodine, potassium iodide, etc. In this case, incidental problems occur.

Therefore, there is an urgent need for the development of contact lens sterilizers and cleaners that can satisfy two conditions, which are harmless to the human body and should be excellent in sterilization.

The present inventors conducted extensive research to improve the disadvantages of the conventional methods for disinfecting contact lenses. As a result, the solution for contact lenses using dodecyl di (aminoethyl) glycine / HCI registered in Korean Patent No. 052204. Has been prepared, used, and reported. Dodecyl di (aminoethyl) glycine-HCI is widely used in food and industrial hygiene, and has been proved to have good bactericidal properties against many pathogens and molds.

Based on dodecyl di (aminoethyl) glycineHCl, which exhibits excellent bactericidal power and stable effect under any conditions, the present invention does not specifically induce the interaction of contact lens with tetradecyl tri (aminoethyl) glycineHCl. Was used to invent the sterilization, preservation and cleaning composition of contact lenses.

An object of the present invention is to provide a sterilization, preservation and cleaning composition for a contact lens containing tetradecyl tri (aminoethyl) glycine-HCI.

It is also an object of the present invention to provide a method for sterilizing, preserving and cleaning a contact lens characterized in that the tetradecyl tri (aminoethyl) glycine-HCI is brought into contact with the contact lens.

Hereinafter, the present invention will be described in detail.

The molecular structure of tetradecyl tri (aminoethyl) glycine-HCI is as follows.

Tetradecyl tri (aminoethyl) glycine-HCl exhibits excellent sterilizing power under environmental conditions, water quality conditions, or adverse conditions in which various foreign substances are mixed.

As shown in the molecular structure, when used as a disinfecting solution for contact lenses by the tetradecan moiety and triamine groups, the disinfecting solution is better than the disinfecting power seen in dodecyl di (aminoethyl) glycine / HCl. When used as, it appeared to be better than the bactericidal power seen in dodecyl di (aminoethyl) glycine-HCl and was found to be very stable to contact lenses in structure.

Tetradecyl tri (aminoethyl) glycine-HCl is a potent surfactant with potent bactericidal activity against a wide range of pathogens, regardless of pH, even under environmental conditions, water quality, or any adverse conditions in which various foreign substances are mixed. Ethyl) glycine-HCl was used for the disinfection of contact lenses, which is not found in any conventional literature.

The present invention provides the use of ketradecyl tri (aminoethyl) glycine-HCl for sterilization, preservation and washing of contact lenses.

The detergent composition for a contact lens according to the present invention contains 0.005 to 1.0 wt% of tetradecyl tri (aminoethyl) glycine-HCl together with an ordinary contact lens solution, for example, saline or distilled water, together with an osmotic pressure regulator and a pH regulator. It is solution.

The sterilization, preservation and cleaning composition of the contact lens containing tetradecyl tri (aminoethyl) glycine CH1 according to the present invention has the following advantages over the conventional solution for disinfecting contact lenses.

1) The solution for contact lenses of the present invention is non-irritating and non-irritating, and even if worn immediately after disinfecting the contact lens, the disinfectant does not react at all with the lens, so there is no abnormality in the tissue of the eye.

2) It has strong sterilizing ability against pathogens under any adverse conditions, so it can be completely sterilized when sterilizing contact lenses.

3) Unlike conventional disinfectants, it is possible to completely sterilize even when using a very small amount.

4) Conventional contact lens disinfectants, when protein is present, pass through the network between the network of the soft lens or bind with the protein, the precipitation phenomenon appears to be ineffective, but the solution for the contact lens of the present invention is a protein It is not affected by any and there is no decrease in efficacy.

5) Most of the conventional fungicides are prolonged use, and many bacteria are resistant to the disinfectant, forming a human bacterium. In such cases, extremely dangerous phenomena can occur due to bacterial reactivation. However, the solution for contact lenses of the present invention does not generate bacterial resistance even after repeated disinfection of the lens.

6) When disinfecting the lens with the solution for the contact lens of the present invention, due to the characteristics of the positive surface activity, a thin film is formed on the contact lens and the sterilization effect lasts for a very long time.

7) Since the solution for the contact lens of the present invention does not affect the physical properties of the contact lens at all, no deformation such as transparency, torsion, or discoloration occurs.

8) When disinfecting a contact lens with the solution for a contact lens of the present invention, no abnormality occurs in the degree of curvature and size of the lens.

Therefore, the sterilization, preservation and cleaning composition of the contact lens containing tetradecyl tri (aminoethyl) glycine-HCl according to the present invention exhibits high sterilizing power even when using extremely small amounts, and can simultaneously satisfy two requirements of non-toxicity of human body. It is a solution for contact lenses having excellent characteristics that cannot be found in the prior art.

In general, as described above, people who wear the lens have serious problems due to contaminants and pathogens attached to the lens.

The formation of such attachments is closely related to the condition of the individual wearer.

The solution of the present invention has been proved that the molecular structure is composed of a structure suitable for the contact lens, non-irritating, non-toxic, excellent disinfection effect, there is no phenomenon associated with penetrating into the matrix of the contact lens combined.

Hereinafter, a solution containing tetradecyl tri (aminoethyl) glycine-HCl of the present invention will be described in more detail based on the following examples.

Example 1

Preparation of Sterilizing Solution for Contact Lenses

3 g of saline was added to 1 liter of distilled water to dissolve 0.3% of saline solution. Then, tetradecyl tri (aminoethyl) glycine / HCl was added to 0.005 wt%, and borax was added in an appropriate amount to adjust the pH of the contact lens sterilization solution. To prepare a solution that can be used as.

Example 2

Preparation of cleaning and storage solution for contact lenses

5 g of saline was added to 1 liter of distilled water to dissolve 0.5% of saline solution. Then, 0.0001 wt% of tetradecyl tri (aminoethyl) glycine / HCl was added thereto, followed by adding an appropriate amount to wash and store the contact lens. To prepare a solution that can be used as.

Experimental Example 1

Toxicity Test

The solution of Example 1 is continuously dropped one or two drops daily into the eyes of ten people. If any symptoms or irritation were reported immediately, the results were continuously checked. Tests at 12-14 hours, 7 days, 2 weeks, 6 weeks, and 5 months showed no eye irritation and no damage to tissues.

Experimental Example 2

Toxicity Test

Tetradecyl tri (aminoethyl) glycine-HCl20% was bred for three weeks with 5 g / kg of the test rabbit tomorrow, but no injuries occurred.

This test shows that 300g of tetradecyl tri (aminoethyl) glycine / HCl 0.005wt% in an adult human body (60kg body weight) is not irritating to the human eye, as well as damage to tissues. It is proved that I do not wear it.

Experimental Example 3

Stimulation test

It is weaker than 1/10 to 1/50 of the irritation phenomenon when the aqueous tetradecyl tri (aminoethyl) glycine-HCl solution is instilled in rabbit eyes and aqueous solution of benzalkonium chloride.

Experimental Example 4

Sterilization test under protein coexistence

Experimental Example 5

Sterilization Test

The nutrient medium is inoculated with Staphylococcus aureus ATCC 6633, Pseudomonas aeruginosa ATCC 29260 and E. coli, respectively, and incubated at 35 ° C for 24 hours. The medium is then exposed to teteddecyl tri (aminoethyl) glycine-HCl as shown in the table below to test bactericidal power. The result is as follows.

Experimental Example 6

Sterilization Test

Prepare the nutrient medium in a sterile test tube. And the bacteria shown in the following table is added dropwise to the solution of Example 2. The bacteria-containing solution was contacted by 1 loop after 2 minutes, 3 minutes, and 15 minutes in the nutrient batch, followed by incubation at 360 ° C. ± 1 ° C. for 24 hours, and then observed sterilizing power. The results are shown in the table below.

As can be seen from Experimental Examples 2 to 4, tetradecyl tri (aminoethyl) glycine-HCl of the present invention shows excellent bactericidal power and stability against almost all bacteria under any conditions.

Experimental Example 7

Effect of Tetradecyl Tri (aminoethyl) glycineHCl on Contact Lenses

Ten lenses were immersed in tetradecyl tri (aminoethyl) glycine-HCl stock solution and 10% solution, respectively, and left for 12 hours, 24 hours, 2 days and 3 days, and then contact lenses were observed. The results are shown in the table below.

As can be seen from the above results, when the contact lens is immersed in the tetradecyl tri (aminoethyl) glycine-HCl solution of the present invention, the transparency of the contact lens is unchanged, and there is no abnormality in discoloration, torsion, flexure and size. There was no.

Therefore, the sterilization, preservation and cleaning composition of the tetradecyl tri (aminoethyl) glycine-HCl of the present invention is harmless to the human body and shows excellent sterilizing power, and in particular, it is not chemically bonded to the contact lens. Due to its advantages, it is a useful contact lens solution having excellent effects that did not appear in conventional contact lens disinfection solutions.

Claims (6)

A sterilization, preservation and cleaning composition for contact lenses containing tetradecyl tri (aminoethyl) glycineHCl. The sterilization, preservation and cleaning composition of a contact range according to claim 1, which contains 0.00005 to 1.0 wt% of tetradecyl tri (aminoethyl) glycineHCl. The sterilizing, preserving and cleaning composition for a contact lens according to claim 1, which is composed of tetradecyl tri (aminoethyl) glycine-HCl and sodium chloride, boric acid, borax, and distilled water. The sterilizing, preserving and cleaning composition for a contact lens according to claim 1 or 3, wherein the tetradecyl tri (aminoethyl) glycine HCl 0.01wt%, sodium chloride 0.2-0.5wt%, boric acid 0.5wt% and the remainder are distilled water. . A method using tetradecyl tri (aminoethyl) glycine-HCl as a disinfecting, preserving and cleaning agent for contact lenses. A method of using a composition containing tetradecyl tri (aminoethyl) glycineHCl as an eyepiece.