KR970000247A - Diagnostic reagents and diagnostic kits for prenatal intrauterine infection and perinatal diagnosis - Google Patents

Diagnostic reagents and diagnostic kits for prenatal intrauterine infection and perinatal diagnosis Download PDF

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Publication number
KR970000247A
KR970000247A KR1019950018727A KR19950018727A KR970000247A KR 970000247 A KR970000247 A KR 970000247A KR 1019950018727 A KR1019950018727 A KR 1019950018727A KR 19950018727 A KR19950018727 A KR 19950018727A KR 970000247 A KR970000247 A KR 970000247A
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South Korea
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diagnostic reagent
amniotic fluid
diagnostic
concentration
prenatal
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KR1019950018727A
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Korean (ko)
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윤보현
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윤보현
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Priority to KR1019950018727A priority Critical patent/KR970000247A/en
Publication of KR970000247A publication Critical patent/KR970000247A/en

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Abstract

본 발명은 산모의 양수나 질분비물 또는 태아혈액중의 인터루킨-6 농도를 측정하여 산전 자궁내 감염과 주산기이환을 진단하는 IL-6의 새로운 용도에 관한 것이다.The present invention relates to a novel use of IL-6 for diagnosing prenatal uterine infections and perinatal disease by measuring the level of interleukin-6 in maternal amniotic fluid, vaginal discharge or fetal blood.

또한, 본 발명은 산모의 양수나 질분비물 또는 태아혈액중의 인터루킨-6 농도를 측정하여 산전 자궁내 감염과 주산기 이환을 진단하는 진단시약 및 진단키트에 관한 것이다.The present invention also relates to a diagnostic reagent and diagnostic kit for diagnosing prenatal uterine infection and perinatal disease by measuring the level of interleukin-6 in the mother's amniotic fluid, vaginal discharge or fetal blood.

Description

산전 자궁내 감염과 주산기 이환진단을 위한 진단시약 및 진단키트Diagnostic reagents and diagnostic kits for prenatal intrauterine infection and perinatal diagnosis

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

제1도는 인터루킨-6 농도에 따른 조직학적 자궁내 감염의 발생도1 is the incidence of histological intrauterine infection according to interleukin-6 concentration.

Claims (9)

산모의 양수나 질분비물 또는 태아의 혈액중의 IL-6의 농도를 측정함에 의하여 산전 자궁내 간염 및 주산기 이환을 진단하는 방법.A method for diagnosing prenatal uterine hepatitis and perinatal disease by measuring the concentration of IL-6 in the mother's amniotic fluid, vaginal discharge or fetal blood. 제1항에 있어서, 주산기 이환이 뇌성마비, 신생아 패혈중, 신생아 호흡부전, 패렴, 기관지 폐이형성증, 뇌실내출혈, 괴사성 장염 또는 미숙아 망막증인 것을 특징으로 하는 진단방법.The diagnostic method according to claim 1, wherein the perinatal disease is cerebral palsy, neonatal sepsis, neonatal respiratory failure, pneumonia, bronchial pulmonary dysplasia, intraventricular hemorrhage, necrotizing enteritis or prematurity retinopathy. 산모의 양수나 질분비물 또는 태아의 혈액중의 IL-6의 농도를 측정함에 의하여 산전 자궁내 감염 및 주산기 이환을 진단하는 진단시약.A diagnostic reagent that diagnoses prenatal uterine infections and perinatal disease by measuring the concentration of IL-6 in the mother's amniotic fluid, vaginal discharge or fetal blood. 제3항에 있어서, 진단시약은 IL-6의 항체를 하나 또는 그 이상 함유하는 것을 특징으로 하는 진단시약.The diagnostic reagent according to claim 3, wherein the diagnostic reagent contains one or more antibodies of IL-6. 제4항에 있어서, 항체는 IL-6의 단일클론성 항체이거나 다클론성 항체인 것을 특징으로 하는 진단시약.The diagnostic reagent according to claim 4, wherein the antibody is a monoclonal antibody or a polyclonal antibody of IL-6. 제3항에 있어서, 산모의 양수나 질분비물 또는 태아의 혈액중의 IL-6의 농도가 50pg/ml~100mg/ml이상이면 산전 자궁내 감염 및 주산기 이환임을 진단하는 것을 특징으로 하는 진단시약.4. A diagnostic reagent according to claim 3, wherein if the concentration of IL-6 in the mother's amniotic fluid, vaginal discharge or fetal blood is 50 pg / ml-100 mg / ml or more, the diagnosis reagent is diagnosed as prenatal uterine infection and perinatal disease. . 제6항에 있어서, 양수내 IL-6의 농도가 5~20mg/ml 이상이면 자궁내 감염임을 진단하는 것을 특징으로 하는 진단시약.The diagnostic reagent according to claim 6, wherein the amniotic fluid is diagnosed as an intrauterine infection if the concentration of IL-6 in the amniotic fluid is 5-20 mg / ml or more. 제7항에 있어서, 양수내 IL-6의 농도가 17mg/ml 이상이면 자궁내 감염임을 진단하는 것을 특징으로 하는 진단시약.The diagnostic reagent according to claim 7, wherein the amniotic fluid is diagnosed as an intrauterine infection if the concentration of IL-6 in the amniotic fluid is 17 mg / ml or more. 제3항 내지 제8항중 어느 한 항의 진단시약을 포함하는 진단시약키트.A diagnostic reagent kit comprising the diagnostic reagent according to any one of claims 3 to 8. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950018727A 1995-06-30 1995-06-30 Diagnostic reagents and diagnostic kits for prenatal intrauterine infection and perinatal diagnosis KR970000247A (en)

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KR1019950018727A KR970000247A (en) 1995-06-30 1995-06-30 Diagnostic reagents and diagnostic kits for prenatal intrauterine infection and perinatal diagnosis

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101142434B1 (en) * 2011-09-08 2012-05-08 (주)오비메드 Method for noninvasive prediction or diagnosis of inflammation and infection in amniotic fluid of patients with premature rupture of membranes
KR101390611B1 (en) * 2012-03-22 2014-04-29 가톨릭대학교 산학협력단 Use of Lin-28 as a diagnostic marker for cerebral palsy
KR20170069460A (en) * 2015-12-11 2017-06-21 대동공업주식회사 Hydraulic circuit for working machine lifting and floating

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101142434B1 (en) * 2011-09-08 2012-05-08 (주)오비메드 Method for noninvasive prediction or diagnosis of inflammation and infection in amniotic fluid of patients with premature rupture of membranes
US8859216B2 (en) 2011-09-08 2014-10-14 Snu R&Db Foundation Method for noninvasive prediction or diagnosis of inflammation and infection in amniotic fluid of patients with premature rupture of membranes
KR101390611B1 (en) * 2012-03-22 2014-04-29 가톨릭대학교 산학협력단 Use of Lin-28 as a diagnostic marker for cerebral palsy
KR20170069460A (en) * 2015-12-11 2017-06-21 대동공업주식회사 Hydraulic circuit for working machine lifting and floating

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