KR960705825A - 6-Oxo-nucleosides useful as immunosuppressants - Google Patents

6-Oxo-nucleosides useful as immunosuppressants

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Publication number
KR960705825A
KR960705825A KR1019960702453A KR19960702453A KR960705825A KR 960705825 A KR960705825 A KR 960705825A KR 1019960702453 A KR1019960702453 A KR 1019960702453A KR 19960702453 A KR19960702453 A KR 19960702453A KR 960705825 A KR960705825 A KR 960705825A
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South Korea
Prior art keywords
compound
hydrogen
guanosine
trans
formula
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KR1019960702453A
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Korean (ko)
Inventor
알. 보르쉐르뎅 데이비드
케이. 에드워즈 3세 칼
엘. 마골린 알렉세이
할라지 세르게
에장스피예 안네
Original Assignee
게리 디. 스트리트
메렐 파마슈티칼즈 인코포레이티드
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Publication of KR960705825A publication Critical patent/KR960705825A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Abstract

본 발명은 면역억제제로서 유용한 신규의 6-옥소-뉴클레오시드 및 이의 제조방법에 관한 것이다.The present invention relates to novel 6-oxo-nucleosides useful as immunosuppressive agents and methods for their preparation.

Description

면역억제제로서 유용한 6-옥소-뉴클레오시드(6-Oxo-nucleosides useful as immunosuppressants)6-Oxo-nucleosides useful as immunosuppressants

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (28)

하기 일반식(I)의 화합물 또는 약학적으로 허용되는 이의 염.A compound of formula (I) or a pharmaceutically acceptable salt thereof. 상기 식에서, X는 OH, N3,NH2, NHR, N(R)2, CN, CH2NH2, CONH2,CO2H, CH2OH, SH 또는 SR이고, R은 C1-C4알킬 또는 수소이며, Z는 수소 또는 NH2이고, n은 1 또는 2이다.Wherein X is OH, N 3 , NH 2 , NHR, N (R) 2 , CN, CH 2 NH 2 , CONH 2 , CO 2 H, CH 2 OH, SH or SR, R is C 1 -C 4 alkyl or hydrogen, Z is hydrogen or NH 2 and n is 1 or 2. 하기 일반식(Ⅱ)의 화합물 또는 약제학적으로 허용되는 이의 염.A compound of formula (II) or a pharmaceutically acceptable salt thereof. 상기 식에서, X1및 X2는 각각 독립적으로 수소 또는 OH이다.Wherein X 1 and X 2 are each independently hydrogen or OH. 제1항에 있어서, n이 1인 화합물.The compound of claim 1, wherein n is 1. 제3항에 있어서, Z가 수소인 화합물.The compound of claim 3, wherein Z is hydrogen. 제4항에 있어서, X가 N3인 화합물.The compound of claim 4, wherein X is N 3 . 제1항에 있어서, (1R,3R)-(트랜스)-1-(6-하이드록시-푸린-9-일)-3-아지도사이클로펜탄인 화합물.The compound of claim 1, which is (1R, 3R)-(trans) -1- (6-hydroxy-purin-9-yl) -3-azidocyclopentane. 제1항에 있어서, (1R,3R)-(트랜스)-9-(3-하이드록시사이클로펜틸)구아노신인 화합물.The compound of claim 1, which is (1R, 3R)-(trans) -9- (3-hydroxycyclopentyl) guanosine. 제1항에 있어서, (±)-(트랜스)-9-(3-하이드록시사이클로펜틸)구아노신인 화합물.The compound of claim 1, which is (±)-(trans) -9- (3-hydroxycyclopentyl) guanosine. 제1항에 있어서, (±)-(시스)-9-(3-하이드록시사이클로펜틸)구아노신인 화합물.The compound of claim 1, which is (±)-(cis) -9- (3-hydroxycyclopentyl) guanosine. 제1항에 있어서, (±)-(시스)-9-(3-하이드록시사이클로헥실)구아노신인 화합물.The compound of claim 1, which is (±)-(cis) -9- (3-hydroxycyclohexyl) guanosine. 제1항에 있어서, (±)-(트랜스)-9-(3-하이드록시사이클로헥실)구아노신인 화합물.The compound of claim 1, which is (±)-(trans) -9- (3-hydroxycyclohexyl) guanosine. 제2항에 있어서, (±)-(트랜스)-9-〔3-하이드록시사이클로펜틸)메틸〕구아노신인 화합물.The compound according to claim 2, which is (±)-(trans) -9- [3-hydroxycyclopentyl) methyl] guanosine. 제2항에 있어서, (±)-(시스,트랜스)-9-〔3,4-디하이드록시사이클로펜틸)메틸〕구아노신인 화합물.The compound of claim 2, which is (±)-(cis, trans) -9- [3,4-dihydroxycyclopentyl) methyl] guanosine. 제2항에 있어서, (±)-(트랜스,트랜스)-9-〔3,4-디하이드록시사이클로펜틸)메틸〕구아노신인 화합물.The compound according to claim 2, which is (±)-(trans, trans) -9- [3,4-dihydroxycyclopentyl) methyl] guanosine. 하기 일반식(Ⅳ)의 화합물을 적절한 AMP 데아미나제와 반응시킴을 포함하는, 하기 일반식(Ⅲ)의 화합물의 제조방법.A process for preparing a compound of formula (III) comprising reacting a compound of formula (IV) with an appropriate AMP deaminase. 상기 식에서, X는 OH, N3, NH2, NHR, N(R)2, CN, CH2NH2, CONH2, CO2H, CH2OH, SH 또는 SR이고, R은 C1-C4알킬 또는 수소이며, Z는 수소 또는 NH2이고, Q는 NH2, 할로겐 또는 OR1이며, R1은 C1-C4알킬이다.Wherein X is OH, N 3 , NH 2 , NHR, N (R) 2 , CN, CH 2 NH 2 , CONH 2 , CO 2 H, CH 2 OH, SH or SR, R is C 1 -C 4 is alkyl or hydrogen, Z is hydrogen or NH 2 , Q is NH 2 , halogen or OR 1 , and R 1 is C 1 -C 4 alkyl. 제15항에 있어서, Z가 수소인 방법.The method of claim 15, wherein Z is hydrogen. 제16항에 있어서, X가 N3인 방법.The method of claim 16, wherein X is N 3 . 면역 억제를 필요로 하는 환자에게 일반식(1) 또는 일반식(2)으로부터 선택된 화합물 또는 약제학적으로 허용되는 이들의 염을 면역 억제 유효량으로 투여함을 포함하는 당해 환자의 면역억제 방법.A method for immunosuppression of a patient comprising administering to a patient in need of immunosuppression a compound selected from Formula (1) or Formula (2) or a pharmaceutically acceptable salt thereof in an immunosuppressive effective amount. 상기 식에서, X는 OH, N3, NH2, NHR, N(R)2, CN, CH2NH2, CONH2, CO2H, CH2OH, SH 또는 SR이고, R은 C1-C4알킬 또는 수소이며, Z는 수소 또는 NH2이고, n은 1 또는 2이며, X1및 X2는 각각 독립적으로 수소 또는 OH이다.Wherein X is OH, N 3 , NH 2 , NHR, N (R) 2 , CN, CH 2 NH 2 , CONH 2 , CO 2 H, CH 2 OH, SH or SR, R is C 1 -C 4 is alkyl or hydrogen, Z is hydrogen or NH 2 , n is 1 or 2, and X 1 and X 2 are each independently hydrogen or OH. 적응성 면역 억제를 필요로 하는 환자에게 일반식(1) 또는 일반식(2)으부터 선택된 화합물 또는 약제학적으로 허용되는 이의 염을 면역 억제 유효량으로 투여함을 포함하는, 당해 환자의 적용성 면역 억제 방법.Applicable immunosuppression in a patient in need thereof, comprising administering to the patient in need of adaptive immunosuppression a compound selected from formula (1) or formula (2) or a pharmaceutically acceptable salt thereof in an immunosuppressive effective amount Way. 상기 식에서, X는 OH, N3, NH2, NHR, N(R)2, CN, CH2NH2, CONH2, CO2H, CH2OH, SH 또는 SR이고, R은 C1-C4알킬 또는 수소이며, Z는 수소 또는 NH2이고, n은 1 또는 2이며, X1및 X2는 각각 독립적으로 수소 또는 OH이다.Wherein X is OH, N 3 , NH 2 , NHR, N (R) 2 , CN, CH 2 NH 2 , CONH 2 , CO 2 H, CH 2 OH, SH or SR, R is C 1 -C 4 is alkyl or hydrogen, Z is hydrogen or NH 2 , n is 1 or 2, and X 1 and X 2 are each independently hydrogen or OH. 제19항에 있어서, 화합물이 (1R,3R)-(트랜스)-9-(3-하이드록시사이클로펜틸)구아노신인 방법.The method of claim 19, wherein the compound is (1R, 3R)-(trans) -9- (3-hydroxycyclopentyl) guanosine. 제19항에 있어서, 환자가 동종이식편 거부 반응에 대한 치료를 필요로 하는 방법.The method of claim 19, wherein the patient requires treatment for allograft rejection. 제19항에 있어서, 환자가 자가면역 질환에 대한 치료를 필요로 하는 방법.The method of claim 19, wherein the patient requires treatment for autoimmune disease. 제22항에 있어서, 자가면역 질환이 인슐린 의존성 당뇨병인 방법.The method of claim 22, wherein the autoimmune disease is insulin dependent diabetes. 제22항에 있어서, 자가면역 질환이 다발성 경화증인 방법.The method of claim 22, wherein the autoimmune disease is multiple sclerosis. 제22항에 있어서, 자가면역 질환이 류마티스성 관절염인 방법.The method of claim 22, wherein the autoimmune disease is rheumatoid arthritis. 제22항에 있어서, 자가면역 질환이 근무력증(myesthenia gravis)인 방법.The method of claim 22, wherein the autoimmune disease is myesthenia gravis. 제22항에 있어서, 자가면역 질환이 전신 루프스 홍반인 방법.The method of claim 22, wherein the autoimmune disease is systemic lupus erythema. 제22항에 있어서, 자가면역 질환이 패혈증성 쇽 증후군인 방법.The method of claim 22, wherein the autoimmune disease is sepsis shock syndrome. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019960702453A 1993-11-12 1994-10-13 6-Oxo-nucleosides useful as immunosuppressants KR960705825A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15108893A 1993-11-12 1993-11-12
US08/151,088 1993-11-12
PCT/US1994/011778 WO1995013277A1 (en) 1993-11-12 1994-10-13 6-oxo-nucleosides useful as immunosuppressants

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KR960705825A true KR960705825A (en) 1996-11-08

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EP (1) EP0728134A1 (en)
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KR (1) KR960705825A (en)
CN (1) CN1137274A (en)
AU (1) AU677732B2 (en)
CA (1) CA2175897A1 (en)
FI (1) FI962010A (en)
HU (1) HUT74989A (en)
IL (1) IL111544A0 (en)
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AU717160B2 (en) * 1994-06-22 2000-03-16 Shire Canada Inc. Novel substituted purinyl derivatives with immunomodulating activity
US6110923A (en) * 1994-06-22 2000-08-29 Biochem Pharma Inc. Method for treating cancer using novel substituted purinyl derivatives with immunomodulating activity
US6859652B2 (en) 2000-08-02 2005-02-22 Mobile Satellite Ventures, Lp Integrated or autonomous system and method of satellite-terrestrial frequency reuse using signal attenuation and/or blockage, dynamic assignment of frequencies and/or hysteresis
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection

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IN164556B (en) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
YU47791B (en) * 1988-01-20 1996-01-09 Regents Of The University Of Minnesota PROCEDURE FOR OBTAINING DIDEOXYCHIDROCAR-BOCYCLIC NUCLEOSIDES
AU647822B2 (en) * 1990-09-14 1994-03-31 Marion Merrell Dow Inc. Novel carbocyclic adenosine analogs useful as immunosuppressants

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FI962010A (en) 1996-07-10
JPH09509397A (en) 1997-09-22
AU677732B2 (en) 1997-05-01
NO961901D0 (en) 1996-05-10
EP0728134A1 (en) 1996-08-28
ZA948591B (en) 1995-06-23
CA2175897A1 (en) 1995-05-18
CN1137274A (en) 1996-12-04
WO1995013277A1 (en) 1995-05-18
FI962010A0 (en) 1996-05-10
HU9601262D0 (en) 1996-07-29
HUT74989A (en) 1997-03-28
IL111544A0 (en) 1995-01-24
AU8120794A (en) 1995-05-29
NO961901L (en) 1996-07-11

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