KR960703913A - Method of Preparing N, N'-Dibenzybispidine - Google Patents

Method of Preparing N, N'-Dibenzybispidine

Info

Publication number
KR960703913A
KR960703913A KR1019960700211A KR19960700211A KR960703913A KR 960703913 A KR960703913 A KR 960703913A KR 1019960700211 A KR1019960700211 A KR 1019960700211A KR 19960700211 A KR19960700211 A KR 19960700211A KR 960703913 A KR960703913 A KR 960703913A
Authority
KR
South Korea
Prior art keywords
followed
dibenzylbispidon
solvent
benzylpiperidone
benzylamine
Prior art date
Application number
KR1019960700211A
Other languages
Korean (ko)
Inventor
볼프강 비이르귀쯔
마르코 티에스
Original Assignee
귄터 스타인호프·베른하르트 라이싱거
바스프 악티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 귄터 스타인호프·베른하르트 라이싱거, 바스프 악티엔게젤샤프트 filed Critical 귄터 스타인호프·베른하르트 라이싱거
Publication of KR960703913A publication Critical patent/KR960703913A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Abstract

본 발명은 N-벤질피페리돈을 벤질아민과 반응시킨 후 환원시키는 것으로 이루어지는 개선된 N,N′-디벤질비스피딘의 제조방법에 관한 것이다.The present invention is directed to a process for the preparation of an improved N, N'-dibenzylbispidine which consists of reacting N-benzylpiperidone with benzylamine followed by reduction.

Description

N,N′-디벤질비스피딘의 제조 방법(Method of Preparing N,N′-Dibenzylbispidine)Method of Preparing N, N′-Dibenzylbispidine

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

50~100℃에서 먼저 벤질아민, 아세트산, 용매, 및 벤질피페리돈의 일부를 도입하고, 이어서 나머지 벤질 피페리돈, 및 포르말린의 일부를 첨가한 후, 나머지 포르말린을 첨가하여 50~100℃에서 용매 중에서 아세트산 존재하에 N-벤질피페리돈을 모르말린 및 벤질아민과 반응시키고, 반응 혼합물을 환류 온도로 가열하고, 이와 같이 하여 생성된 N,N′-디벤질비스피돈의 아세테이트를 얻고, 증류에 의해 메탄올을 제거한 후 추출에 의해 부산물로부터 정제하고, 이어서 N,N′-디벤질비스피돈을 유리 및 단리시킨 후, N,N′-디벤질비스피돈을 80~200℃에서 용매 중에서 히드라진과 반응시키고, 산 및 알칼리로 처리한 후, N,N′-디벤질비스피딘을 톨루엔으로 추출하는 것을 포함하는 N,N′-디벤질비스피돈의 제조 방법.A portion of benzylamine, acetic acid, solvent, and benzylpiperidone are first introduced at 50-100 ° C., followed by the addition of the remaining benzyl piperidone, and a portion of formalin, followed by the addition of the remaining formalin in solvent at 50-100 ° C. Reacting N-benzylpiperidone with mormalin and benzylamine in the presence of acetic acid, heating the reaction mixture to reflux temperature, thereby obtaining an acetate of the resulting N, N'-dibenzylbispidon, and distilling Methanol was removed and purified from the by-products by extraction, followed by freeing and isolating N, N'-dibenzylbispidon, and then N, N'-dibenzylbispidon with hydrazine in a solvent at 80-200 ° C. A method for producing N, N'-dibenzylbispidone, which comprises reacting, treating with acid and alkali, and then extracting N, N'-dibenzylbispidine with toluene. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019960700211A 1993-07-17 1994-06-28 Method of Preparing N, N'-Dibenzybispidine KR960703913A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4324086A DE4324086A1 (en) 1993-07-17 1993-07-17 Process for the preparation of N, N`-dibenzylbispidine
DEP4324086.0 1993-07-17
PCT/EP1994/002101 WO1995002599A1 (en) 1993-07-17 1994-06-28 Method of preparing n,n'-dibenzylbispidine

Publications (1)

Publication Number Publication Date
KR960703913A true KR960703913A (en) 1996-08-31

Family

ID=6493125

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960700211A KR960703913A (en) 1993-07-17 1994-06-28 Method of Preparing N, N'-Dibenzybispidine

Country Status (11)

Country Link
EP (1) EP0710238A1 (en)
JP (1) JPH09500119A (en)
KR (1) KR960703913A (en)
AU (1) AU7073394A (en)
CA (1) CA2167406A1 (en)
CZ (1) CZ5296A3 (en)
DE (1) DE4324086A1 (en)
HU (1) HU9503859D0 (en)
MX (1) MX9405030A (en)
PL (1) PL312609A1 (en)
WO (1) WO1995002599A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115626925A (en) * 2022-12-08 2023-01-20 山东汇海医药化工有限公司 Synthesis method of bispidine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2428792A1 (en) * 1974-06-14 1976-01-02 Knoll Ag NEW ANTIARRHYTHMICS

Also Published As

Publication number Publication date
PL312609A1 (en) 1996-04-29
HU9503859D0 (en) 1996-02-28
MX9405030A (en) 1995-01-31
JPH09500119A (en) 1997-01-07
WO1995002599A1 (en) 1995-01-26
EP0710238A1 (en) 1996-05-08
CA2167406A1 (en) 1995-01-26
CZ5296A3 (en) 1996-04-17
DE4324086A1 (en) 1995-01-19
AU7073394A (en) 1995-02-13

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