KR960702457A - 4-P-fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation, and their use in the treatment of psychosis and schizophrenia (4-P-FLUOROBENZOYL-1-PIPERIDINYL-PROPOXY -CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS AND SCHIZOPHRENIA - Google Patents

4-P-fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation, and their use in the treatment of psychosis and schizophrenia (4-P-FLUOROBENZOYL-1-PIPERIDINYL-PROPOXY -CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS AND SCHIZOPHRENIA

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Publication number
KR960702457A
KR960702457A KR1019950705162A KR19950705162A KR960702457A KR 960702457 A KR960702457 A KR 960702457A KR 1019950705162 A KR1019950705162 A KR 1019950705162A KR 19950705162 A KR19950705162 A KR 19950705162A KR 960702457 A KR960702457 A KR 960702457A
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KR
South Korea
Prior art keywords
chromen
fluorobenzoyl
piperidinyl
propoxy
schizophrenia
Prior art date
Application number
KR1019950705162A
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Korean (ko)
Other versions
KR0182088B1 (en
Inventor
라파엘 포겟
조르디 보로스
오레리오 사크리스탄
조세에이 오티즈
Original Assignee
라파엘 포겟
페레르 인터내쇼날, 에스.에이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 라파엘 포겟, 페레르 인터내쇼날, 에스.에이. filed Critical 라파엘 포겟
Priority claimed from PCT/EP1995/001008 external-priority patent/WO1995025733A1/en
Publication of KR960702457A publication Critical patent/KR960702457A/en
Application granted granted Critical
Publication of KR0182088B1 publication Critical patent/KR0182088B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은, 일반식(I):The present invention, general formula (I):

(상기 식에서, R1및 R2수소, 탄소원자 1 내지 4개를 가진 알킬, 할로겐, 트리풀루오로메틸, 선택적으로 치환된 페닐 또는 히드록시메틸임)의 신규 크로멘 화합물, 및 그의 약학적으로 허용되는 염에 관한 것이다.Novel chromene compounds, wherein R 1 and R 2 hydrogen, alkyl having 1 to 4 carbon atoms, halogen, trifluomethyl, optionally substituted phenyl or hydroxymethyl, and pharmaceuticals thereof It relates to the salts allowed.

이들 화합물은 정신병 및 정신분열증의 치료에 유용하다.These compounds are useful for the treatment of psychosis and schizophrenia.

Description

4-p-플루오로벤조일-1-피페리디닐-프로폭시-크로멘-4-온 유도체, 그의 제조, 및 그의 정신병 및 정신분열증 치료에의 이용(4-P-FLUOROBENZOYL-1-PIPERIDINYL-PROPOXY-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS AND SCHIZOPHRENIA)4-p-fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation, and their use in the treatment of psychosis and schizophrenia (4-P-FLUOROBENZOYL-1-PIPERIDINYL-PROPOXY -CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF PSYCHOSIS AND SCHIZOPHRENIA

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (6)

다음식 (I)의 크로멘 화합물 및 그의 약학적으로 허용되는 염Chromium compound of formula (I) and pharmaceutically acceptable salts thereof (상기 식에서, R1및 R2는, 수소, 탄소원자 1 내지 4개를 가진 알킬, 할로겐, 트리플루오로메틸, 선택적으로 치환된 페닐 또는 히드록시메틸이다.Wherein R 1 and R 2 are hydrogen, alkyl having 1 to 4 carbon atoms, halogen, trifluoromethyl, optionally substituted phenyl or hydroxymethyl. 제1항에 있어서, 7-[3-(4-p-플루오로벤조일-1-피페리디닐)프로폭시]-크로멘-4-온; 7-[3-(4-P-플루오로벤조일-1-피페리리닐)프로폭시]-3-메틸-크로멘-4-온; 3-히드록시메틸-7-[3-(4-p-플루오로벤조일-1-피페리디닐)프로폭시]크로멘-4-온 및 그의 약학적으로 허용되는 부가염인 화합물.The compound of claim 1, further comprising 7- [3- (4-p-fluorobenzoyl-1-piperidinyl) propoxy] -chromen-4-one; 7- [3- (4-P-fluorobenzoyl-1-piperidinyl) propoxy] -3-methyl-chromen-4-one; 3-hydroxymethyl-7- [3- (4-p-fluorobenzoyl-1-piperidinyl) propoxy] chromen-4-one and its pharmaceutically acceptable addition salts. 제1항 또는 제2항에 있어서, 정신병 및 정신분열증의 치료에 사용되는 식(I)의 크로멘 화합물.The chrome compound of formula (I) according to claim 1 or 2, which is used for the treatment of psychosis and schizophrenia. 제1항 또는 제2항에 의한 적어도 한 화합물을 함유하고, 선택적으로는 약학적으로 허용되는 단체 및/또는 보조제와 조합된 약학 조성물.A pharmaceutical composition containing at least one compound according to claim 1 or 2, optionally in combination with a pharmaceutically acceptable body and / or adjuvant. 포유 동물에 제1항 또는 제2항에 의한 적어도 한 화합물의 유효량을 투여량하는 것으로 되어 있는 정신병 및 정신분열증의 치료 방법.A method of treating psychosis and schizophrenia, wherein the mammal is administered an effective amount of at least one compound according to claim 1. 식(Ⅱ):Formula (II): 의 4-(p-플루오로벤조일)피페피딘을, 식(Ⅲ):4- (p-fluorobenzoyl) pipepidine of formula (III): (이 식에서 X는 염소, 브롤 또는 요오드이고, R1및 R2는 제1항에서의 정의와 같음)의 7-(3-할로프로폭시)크로멘-4-온으로 알킬화시키고, 소망에 따라서는 유리염기형의 식(I)의 화합물을 그의 산부가염으로 변환시키는 것으로 되어 있는 제1항 또는 제2항의 크로멘 화합물의 제조 방법.Alkylated with 7- (3-halopropoxy) chromen-4-one, wherein X is chlorine, bromine or iodine, and R 1 and R 2 are as defined in claim 1, and if desired The process for producing the chromate compound of claim 1 or 2, wherein the compound of formula (I) of free base type is converted into its acid addition salt. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950705162A 1994-03-18 1995-03-17 4-p-fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and their use in the treatment KR0182088B1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
ES09400581A ES2101620B1 (en) 1994-03-18 1994-03-18 NEW COMPOUND DERIVED FROM CHROMENE.
ES9400581 1994-03-18
ES09401437A ES2101635B1 (en) 1994-03-18 1994-07-01 NEW CHROME-DERIVED COMPOUND
ES9401437 1994-07-01
ES09500163A ES2101644B1 (en) 1994-03-18 1995-01-30 NEW CHROME-DERIVED COMPOUND
ES9500163 1995-01-30
PCT/EP1995/001008 WO1995025733A1 (en) 1994-03-18 1995-03-17 4-p-fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis and schizophrenia

Publications (2)

Publication Number Publication Date
KR960702457A true KR960702457A (en) 1996-04-27
KR0182088B1 KR0182088B1 (en) 1999-05-01

Family

ID=8285614

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950705162A KR0182088B1 (en) 1994-03-18 1995-03-17 4-p-fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and their use in the treatment

Country Status (3)

Country Link
KR (1) KR0182088B1 (en)
ES (3) ES2101620B1 (en)
ZA (1) ZA951962B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2154176B1 (en) * 1998-09-21 2001-10-16 Ferrer Int NEW PROCEDURE FOR OBTAINING 3- (HYDROXIMETHYL) CROMEN-4-ONAS.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3117389A1 (en) * 1981-05-02 1982-11-18 Boehringer Mannheim Gmbh, 6800 Mannheim BENZOPYRANYLETHER, METHOD FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4678787A (en) * 1985-01-30 1987-07-07 Warner-Lambert Company 4H-1-benzopyran-4-ones and their sulfur containing analogs
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
US5278174A (en) * 1990-06-04 1994-01-11 Scios Nova, Inc. Sigma binding site agents
EP0558245A1 (en) * 1992-02-25 1993-09-01 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors

Also Published As

Publication number Publication date
ES2101644A1 (en) 1997-07-01
ZA951962B (en) 1996-03-12
ES2101635A1 (en) 1997-07-01
KR0182088B1 (en) 1999-05-01
ES2101635B1 (en) 1998-04-01
ES2101620A1 (en) 1997-07-01
ES2101644B1 (en) 1998-04-01
ES2101620B1 (en) 1998-04-01

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