KR960033467A - Mucin secretion inhibitors - Google Patents

Mucin secretion inhibitors Download PDF

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Publication number
KR960033467A
KR960033467A KR1019950006828A KR19950006828A KR960033467A KR 960033467 A KR960033467 A KR 960033467A KR 1019950006828 A KR1019950006828 A KR 1019950006828A KR 19950006828 A KR19950006828 A KR 19950006828A KR 960033467 A KR960033467 A KR 960033467A
Authority
KR
South Korea
Prior art keywords
mucin
mucin secretion
mbp
epo
secretion inhibitors
Prior art date
Application number
KR1019950006828A
Other languages
Korean (ko)
Other versions
KR100288019B1 (en
Inventor
고광호
Original Assignee
권계홍
주식회사 녹십자
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 권계홍, 주식회사 녹십자 filed Critical 권계홍
Priority to KR1019950006828A priority Critical patent/KR100288019B1/en
Publication of KR960033467A publication Critical patent/KR960033467A/en
Application granted granted Critical
Publication of KR100288019B1 publication Critical patent/KR100288019B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

본 발명은 호산구 단백질인 EPO와 MBP를 유효성분으로 하여 고블렛 세포에서 생산되는 뮤신의 분비를 억제시키는 억제제에 관한 것이다. EPO와 MBP는 투여농도에 비례해서 뮤신의 방출을 억제했으며, 유효농도로 투여시에 세포독성을 나타내지 않았고 뮤신의 분비 억제에만 특이적으로 작용하는 체내 생성 단백질이다.The present invention relates to an inhibitor for inhibiting the secretion of mucin produced in goblet cells by using EPO and MBP as eosinophil proteins as active ingredients. EPO and MBP inhibited the release of mucin in proportion to dose, and did not show cytotoxicity when administered at the effective concentration, and are a body-producing protein that specifically acts only on inhibition of mucin secretion.

Description

뮤신분비 억제제Mucin secretion inhibitors

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

호산구 단백질을 유효성분으로 하는 뮤신 분비 억제제.Mucin secretion inhibitor using eosinophil protein as an active ingredient. 제1항에 있어서, 호산구 단백질이 EPO 및/또는 MBP인 것을 특징으로 하는 뮤신 분비 억제제.The mucin secretion inhibitor of claim 1, wherein the eosinophil protein is EPO and / or MBP. 제1항 또는 제2항에 있어서, 상기 호산구 단백질이 투여 용량에 비례하여 뮤신의 분비가 억제되는 것을 특징으로 하는 뮤신 분비 억제제.The mucin secretion inhibitor according to claim 1 or 2, wherein the eosinophil protein inhibits mucin secretion in proportion to the dose administered. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950006828A 1995-03-29 1995-03-29 Mucin secretion inhibitor KR100288019B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950006828A KR100288019B1 (en) 1995-03-29 1995-03-29 Mucin secretion inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950006828A KR100288019B1 (en) 1995-03-29 1995-03-29 Mucin secretion inhibitor

Publications (2)

Publication Number Publication Date
KR960033467A true KR960033467A (en) 1996-10-22
KR100288019B1 KR100288019B1 (en) 2001-05-02

Family

ID=37517357

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950006828A KR100288019B1 (en) 1995-03-29 1995-03-29 Mucin secretion inhibitor

Country Status (1)

Country Link
KR (1) KR100288019B1 (en)

Also Published As

Publication number Publication date
KR100288019B1 (en) 2001-05-02

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