KR960022570A - 플라티늄(II) 착화합물과 히드록시프로필 β-사이클로덱스트린의 복합체 - Google Patents

플라티늄(II) 착화합물과 히드록시프로필 β-사이클로덱스트린의 복합체 Download PDF

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KR960022570A
KR960022570A KR1019940039816A KR19940039816A KR960022570A KR 960022570 A KR960022570 A KR 960022570A KR 1019940039816 A KR1019940039816 A KR 1019940039816A KR 19940039816 A KR19940039816 A KR 19940039816A KR 960022570 A KR960022570 A KR 960022570A
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South Korea
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complex
hydroxypropyl
platinum
cyclodextrin
structural formula
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KR1019940039816A
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KR100351707B1 (ko
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엄기안
정혜순
민동선
박병욱
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김준웅
주식회사 선경인더스트리
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 플라티늄(II) 착화합물과 히드록시프로필 β-사이클로덱스트린의 복합체에 관한 것으로서, 더욱 상세하게는 난용성 항암제인 플라티늄(II) 착화합물에 히드록시프로필 β-사이클로덱스트린을 포함시켜 이루어짐으로써 약물의 안정성 또는 용해도를 개선하고, 나아가 생체이용률을 증진시킨 플라티늄(II) 착화합물과 히드록시프로필 β-사이클로덱스트린의 복합체에 관한 것이다.

Description

플라티늄(II) 착화합물과 히드록시프로필 β-사이클로덱스트린의 복합체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 다음 구조식(A)로 표시되는 신규 플라티늄(II) 착화합물에 다음 구조식(B)로 표시되는 히드록시프로필 β-사이클로덱스트린을 포접시켜 이루어진 것을 특징으로 하는 플라티늄(II) 착화합물과 히드록시프로필 β-사이클로덱스트린의 복합체.
    상기 식에서, R1및 R2는 각각 같거나 다른 것으로서, 수소원자 또는 C1~C4의 저급알킬기이거나 이들의 고리화 화합물을 나타내고, R은이며 이때 n은 0,1,2.3‥‥‥ 이다.
  2. 제1항에 있어서, 상기 플라티늄(II) 착화합물과 히드록시프로필 β-사이클로덱스트린은 1:1.5~3몰비로 포접하는 것을 특징으로 하는 플라티늄(II) 착화합물과 히드록시프로필 β-사이클로덱스트린의 복합체.
  3. 제1항의 플라티늄(II) 착화합물과 히드록시프로필 β-사이클로덱스트린의 복합체을 함유하는 주사제.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019940039816A 1994-12-30 1994-12-30 플라티늄(II)착화합물과히드록시프로필β-사이클로덱스트린의복합체 KR100351707B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019940039816A KR100351707B1 (ko) 1994-12-30 1994-12-30 플라티늄(II)착화합물과히드록시프로필β-사이클로덱스트린의복합체

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940039816A KR100351707B1 (ko) 1994-12-30 1994-12-30 플라티늄(II)착화합물과히드록시프로필β-사이클로덱스트린의복합체

Publications (2)

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KR960022570A true KR960022570A (ko) 1996-07-18
KR100351707B1 KR100351707B1 (ko) 2002-11-02

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KR1019940039816A KR100351707B1 (ko) 1994-12-30 1994-12-30 플라티늄(II)착화합물과히드록시프로필β-사이클로덱스트린의복합체

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Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL76889A0 (en) * 1984-11-02 1986-02-28 Johnson Matthey Plc Solubilised platinum compound,method for the production thereof and pharmaceutical compositions containing the same
KR950014120B1 (ko) * 1992-10-06 1995-11-21 삼성전자주식회사 반도체 패키지의 제조방법
KR940010296A (ko) * 1992-10-24 1994-05-24 김주용 온도 급냉이 가능한 가스 전도식 히팅 장치
US5362860A (en) * 1993-02-01 1994-11-08 Warner-Lambert Company Neutral stabilization complex for CI-979 HCl, a cognition activator

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