KR960021039A - Pharmaceutical composition for improving liver function and treating hepatitis, containing extracts of the materiaceae - Google Patents

Pharmaceutical composition for improving liver function and treating hepatitis, containing extracts of the materiaceae Download PDF

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Publication number
KR960021039A
KR960021039A KR1019940035685A KR19940035685A KR960021039A KR 960021039 A KR960021039 A KR 960021039A KR 1019940035685 A KR1019940035685 A KR 1019940035685A KR 19940035685 A KR19940035685 A KR 19940035685A KR 960021039 A KR960021039 A KR 960021039A
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South Korea
Prior art keywords
water
molecular weight
liver function
pharmaceutical composition
treating hepatitis
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KR1019940035685A
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Korean (ko)
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KR100328467B1 (en
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한영복
김정룡
경홍기
김춘원
김종배
홍은경
최희숙
이치호
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한영복
김순배
태림제약 주식회사
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Priority to KR1019940035685A priority Critical patent/KR100328467B1/en
Publication of KR960021039A publication Critical patent/KR960021039A/en
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Publication of KR100328467B1 publication Critical patent/KR100328467B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/84—Valerianaceae (Valerian family), e.g. valerian
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 마타리과(Valerianaceae) 식물의 총추출물 또는 그의 수용성 저분자량 분획을 함유함을 특징으로 하는 간기능 개선 및 간염 치료용 의약 조성물에 관한 것이다. 본 발명에 따르는 마타리과 식물의 총추출물 또는 그의 수용성 저분자량 분획은 약물의존성이 매우 낮고 부작용이 거의 없으며, 숙주의 면역기능 부전을 회복시키고 간염치료와 손상된 간세포의 재생 및 간장 보호기능을 가지고 있다.The present invention relates to a pharmaceutical composition for improving liver function and treating hepatitis, which comprises a total extract of a Valerianaceae plant or a water-soluble low molecular weight fraction thereof. The total extract of the cultivars of the present invention or its water-soluble low molecular weight fraction has very low drug dependence and almost no side effects, restores immune dysfunction of the host, has hepatitis treatment and regeneration of damaged hepatocytes and hepatoprotective function.

Description

마타리과 식물의 추출물을 함유하는 간기능 개선 및 간염 치료용 의약 조성물Pharmaceutical composition for improving liver function and treating hepatitis, containing extracts of the materiaceae

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (7)

마타리과(Vdedmaceae) 식물의 총추출물 또는 그의 수용성 저분자량 분획을 유효성분으로 함유함을 특징으로 하는 간기능 개선 및 간염치료용 의약 조성물.A pharmaceutical composition for improving liver function and treating hepatitis, characterized by containing a total extract of the plant of the Materiaceae (Vdedmaceae) or a water-soluble low molecular weight fraction thereof as an active ingredient. 제1항에 있어서, 마타리과 식물의 총추출물이 물에 의한 추출물임을 특징으로 하는 간기능 개선 및 간염 치료용 의약 조성물.The pharmaceutical composition for improving liver function and treating hepatitis according to claim 1, wherein the total extract of the plant is a water extract. 제1항에 있어서, 마타리과 식물의 추출물중의 수용성 저분자량 분획을 유효성분으로 함유함을 특징으로 하는 간기능 개선 및 간염 치료용 의약 조성물.2. The pharmaceutical composition for improving liver function and treating hepatitis according to claim 1, which comprises a water-soluble low molecular weight fraction in the extract of Matariaceae as an active ingredient. 제3항에 있어서, 수용성 저분자량 분획이 분자량 50000미만의 저분자량 다당류임을 특징으로 하는 간기능 개선 및 간염 치료용 의약 조성물.The pharmaceutical composition for improving liver function and treating hepatitis according to claim 3, wherein the water-soluble low molecular weight fraction is a low molecular weight polysaccharide having a molecular weight of less than 50000. 제1항에 있어서, 추가로 다른 면역중간제 또는 간기능 개선제를 함유함을 특징으로 하는 간기능 개선 및 간염 치료용 의약 조성물.The pharmaceutical composition for improving liver function and treating hepatitis according to claim 1, which further contains other immune intermediates or liver function improving agents. 마타리과 식물을 물로 추출하고, 수추출물을 여과하여 여액을 증기압(121℃/15파운드/in a2)에 포화시켜 단백질을 응고시켜 침전으로 석출시킨 후에 원심분리 하여 제거하고, 용매로 처리하여 섬유질, 수지 및 용매-가용성 불순물을 제거하고, 수층을 정제한 후에 동결건조시킴을 특징으로 하는 마타리과 식물의 충추출물을 제조하는 방법.Matariaceae is extracted with water, the water extract is filtered and the filtrate is saturated with vapor pressure (121 ℃ / 15 pounds / in a 2 ), the protein is coagulated, precipitated by precipitation, centrifuged to remove, treated with a solvent, fibrous, A method for preparing packed extracts of materiaceae, characterized in that the resin and solvent-soluble impurities are removed and the aqueous layer is purified and lyophilized. 마타리과 식물을 물로 추출하고, 수추출물을 여과하여 여액을 증기압(121℃/15파운드/in a2)에 포화시켜 단백질을 응고시켜 침전으로 석출시킨 후에 원심분리 하여 제거하고, 용매로 처리하여 섬유질, 수지 및 용매-가용성 불순물을 제거하고, 수충을 정제한 후에, 계속해서 수충에 에탄올을 가하여 여과하고, 여액을 중화시키고 한외여과하여 여과된 분자량 50000미만의 분획을 회수하여 동결건조시킴을 특징으로 하여 마타리과 식물의 추출몰의 수용성 저분자량 분획을 제조하는 방법.Matariaceae is extracted with water, the water extract is filtered and the filtrate is saturated with vapor pressure (121 ℃ / 15 pounds / in a 2 ), the protein is coagulated, precipitated by precipitation, centrifuged to remove, treated with a solvent, fibrous, After removing the resin and the solvent-soluble impurities, purifying the water larvae, the ethanol was subsequently added to the water filtration, the filtrate was neutralized, and ultrafiltration was performed to recover the fractions of the molecular weight less than 50000 and freeze-dried. A method for producing a water soluble low molecular weight fraction of the extract moles of materiaceae. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940035685A 1994-12-21 1994-12-21 Composition for improving liver function and treating hepatitis containing extract of valerianaceae KR100328467B1 (en)

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KR1019940035685A KR100328467B1 (en) 1994-12-21 1994-12-21 Composition for improving liver function and treating hepatitis containing extract of valerianaceae

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KR1019940035685A KR100328467B1 (en) 1994-12-21 1994-12-21 Composition for improving liver function and treating hepatitis containing extract of valerianaceae

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KR960021039A true KR960021039A (en) 1996-07-18
KR100328467B1 KR100328467B1 (en) 2002-06-28

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001082941A1 (en) * 2000-05-02 2001-11-08 Medvill Co., Ltd. Composition for treatment of b-type hepatitis and liver cirrhosis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001082941A1 (en) * 2000-05-02 2001-11-08 Medvill Co., Ltd. Composition for treatment of b-type hepatitis and liver cirrhosis
KR100389131B1 (en) * 2000-05-02 2003-06-25 (주) 메드빌 Composition for B type Hepatitis and Cirrhosis of Liver Comprising Phellodendron amurense Rupr. cortex and Patrinia scabiosaefolia FISCH. Extract

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