KR960021016A - Acetaminophen formulations effectively conceal bitterness - Google Patents

Acetaminophen formulations effectively conceal bitterness Download PDF

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Publication number
KR960021016A
KR960021016A KR1019940034707A KR19940034707A KR960021016A KR 960021016 A KR960021016 A KR 960021016A KR 1019940034707 A KR1019940034707 A KR 1019940034707A KR 19940034707 A KR19940034707 A KR 19940034707A KR 960021016 A KR960021016 A KR 960021016A
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KR
South Korea
Prior art keywords
water
acetaminophen
bitter taste
sodium
acid
Prior art date
Application number
KR1019940034707A
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Korean (ko)
Inventor
유상현
류길수
남미순
Original Assignee
이웅열
주식회사 코오롱
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Application filed by 이웅열, 주식회사 코오롱 filed Critical 이웅열
Priority to KR1019940034707A priority Critical patent/KR960021016A/en
Publication of KR960021016A publication Critical patent/KR960021016A/en

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  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 쓴 맛이 효과적으로 은폐된 아세트아미노펜 제형에 관한 것으로, 아세트아미노펜 분말 또는 결정을 감미제, 교미제와 함께 각각 1∼9:1∼9:0.1∼5의 중량비로 물에 완전히 녹인 후 감압하에서 물을 제거하고 얻어진 고체를 볼밀을 사용하여 분쇄한 후 탑스프레이가 장착된 유동층 과립기에 주약물을 충진시키고 그것을 유동시키면서 유기용제, 물 또는 유기용제/물의 혼합용매에 용해, 분산시킨 수용성 또는/ 그리고 수불용성 물질을 녹인 용액을 코팅하여 제조된 쓴 맛이 은폐된 아세트아미노펜 제형을 제공한다.The present invention relates to an acetaminophen formulation in which a bitter taste is effectively concealed, wherein acetaminophen powder or crystals are completely dissolved in water at a weight ratio of 1-9: 1-9: 0.1-5 with sweetener and copulation agent, respectively, under reduced pressure. Water is removed and the obtained solid is pulverized using a ball mill and filled with the main drug in a fluidized bed granulator equipped with a top spray, and dissolved and dispersed in an organic solvent, water or a mixed solvent of water and an organic solvent / water while flowing it. A bitter concealed acetaminophen formulation prepared by coating a solution of a water insoluble substance is provided.

본 발명에 의한 아세트아미노펜 제형은 쓴 맛 은폐 효과가 우수하여 복용시의 불쾌감을 해소하며, 그 제형이 저작가능한 제제로 만들기에 적합하여 정제나 캡슐을 통으로 삼키기 어려운 어린이, 노인 등의 환자에 대한 투여에 편의성을 갖는다.Acetaminophen formulations according to the present invention have an excellent bitter taste concealment effect and relieve discomfort when taking them, and are suitable for making the formulations into chewable formulations, which are difficult to swallow via tablets or capsules for administration to children, the elderly, etc. To have convenience.

Description

쓴 맛이 효과적으로 은폐된 아세트아미노펜 제형Acetaminophen formulations effectively conceal bitterness

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (3)

아세트아미노펜의 쓴 맛을 은폐하기 위해 아세트아미노펜 분말 또는 결정을 감미제, 교미제와 함께 각각 1∼9:1∼9:0.1∼5의 중량비로 물에 완전히 녹인 후 감압하에서 물을 제거하고 얻어진 고체를 볼밀을 사용하여 입자의 크기가 최대 180㎛ 이하가 되도록 분쇄한 후, 탑스프레이가 장착된 유동층 과립기에 주약물을 충진시키고 유동시키면서, 쓴 맛 은폐용 수용성 및 수불용성 피복물질의 1종 이상을 유기용제, 물 또는 유기용제/물의 혼합용매에 용해, 분산시킨 용액을 코팅하여 제조한 쓴 맛이 은폐된 아세트아미노펜 제형.To conceal the bitter taste of acetaminophen, the acetaminophen powder or crystals are dissolved in water together with a sweetener and a copper in a weight ratio of 1-9: 1-9: 0.1-5, respectively, and then water is removed under reduced pressure. Using a ball mill, the particles are pulverized to a maximum size of 180 μm or less, and then one or more of the water-soluble and water-insoluble coating materials for concealing bitter taste are filled with the main drug in a fluidized bed granulator equipped with a top spray. A bitter concealed acetaminophen formulation prepared by coating a solution dissolved and dispersed in a solvent, water, or an organic solvent / water mixed solvent. 제1항에 있어서, 감미제가 아스파탐, 설탕, 글리실리진산삼나트륨, 글리실리산이나트륨, D-소르비톨, 스테비오사이드, D-키실로오스, 삭카린나트륨에서 선택된 감미제인 쓴 맛이 은폐된 아세트아미노펜 제형.The bitter taste concealed acetaminophen of claim 1, wherein the sweetener is a sweetener selected from aspartame, sugar, trisodium glycylisate, disodium glycylate, D-sorbitol, stevioside, D-xylose, sodium saccharin. Formulation. 제1항에 있어서, 교미제가 구연산, 구연산 나트륨, 글루크노델타락톤, 초산, DL-사과산, DL-사과산나트륨, 아디핀산, 젖산, 주석산, 주석산나트륨, 푸마르산, 푸마르산일나트륨, 호박산, 호박산나트륨에서 선택된 교미제인 쓴 맛이 은폐된 아세트아미노펜 제형.The method of claim 1, wherein the copulating agent is citric acid, sodium citrate, gluco no deltalactone, acetic acid, DL-peracid, DL-sodium peroxide, adipic acid, lactic acid, tartaric acid, sodium tartrate, fumaric acid, sodium fumarate, succinic acid, sodium succinate Acetaminophen formulation concealing bitter taste of the selected mating agent. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940034707A 1994-12-16 1994-12-16 Acetaminophen formulations effectively conceal bitterness KR960021016A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019940034707A KR960021016A (en) 1994-12-16 1994-12-16 Acetaminophen formulations effectively conceal bitterness

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940034707A KR960021016A (en) 1994-12-16 1994-12-16 Acetaminophen formulations effectively conceal bitterness

Publications (1)

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KR960021016A true KR960021016A (en) 1996-07-18

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KR1019940034707A KR960021016A (en) 1994-12-16 1994-12-16 Acetaminophen formulations effectively conceal bitterness

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