KR960010627A - Novel Carbamate Compounds Containing Pyridyl Groups - Google Patents

Novel Carbamate Compounds Containing Pyridyl Groups Download PDF

Info

Publication number
KR960010627A
KR960010627A KR1019940023912A KR19940023912A KR960010627A KR 960010627 A KR960010627 A KR 960010627A KR 1019940023912 A KR1019940023912 A KR 1019940023912A KR 19940023912 A KR19940023912 A KR 19940023912A KR 960010627 A KR960010627 A KR 960010627A
Authority
KR
South Korea
Prior art keywords
pyridyl
carbamate
propanediol
single carbamate
extracted
Prior art date
Application number
KR1019940023912A
Other languages
Korean (ko)
Other versions
KR0139717B1 (en
Inventor
최용문
한동일
김형철
Original Assignee
조규향
주식회사 유 공
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1019940023912A priority Critical patent/KR0139717B1/en
Application filed by 조규향, 주식회사 유 공 filed Critical 조규향
Priority to PCT/KR1995/000125 priority patent/WO1996009284A1/en
Priority to CA002176968A priority patent/CA2176968A1/en
Priority to EP95931455A priority patent/EP0730576A1/en
Priority to US08/612,903 priority patent/US5849772A/en
Priority to DE69509745T priority patent/DE69509745T2/en
Priority to EP95931454A priority patent/EP0730575B1/en
Priority to ES95931454T priority patent/ES2134491T3/en
Priority to CN95190934A priority patent/CN1071315C/en
Priority to JP8510765A priority patent/JP2809884B2/en
Priority to JP8510764A priority patent/JP2809883B2/en
Priority to CN95190935A priority patent/CN1135751A/en
Priority to CA002176960A priority patent/CA2176960C/en
Priority to PCT/KR1995/000124 priority patent/WO1996009283A1/en
Publication of KR960010627A publication Critical patent/KR960010627A/en
Application granted granted Critical
Publication of KR0139717B1 publication Critical patent/KR0139717B1/en
Priority to CN001374621A priority patent/CN1216858C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

본 발명은 피리딜기를 포함하는 신규한 단일 카바메이트 화합물에 관한 것으로서, 좀더 상세하게는 (R)-2-(2-피리딜)-1,3-프로판디올 단일 카바메이트와 (S)-2-(2-피리딜)-1,3-프로판디올 단일 카바메이트의 2종에 관한 것이다.The present invention relates to a novel single carbamate compound comprising a pyridyl group, and more particularly to (R) -2- (2-pyridyl) -1,3-propanediol single carbamate and (S) -2 -(2-pyridyl) -1,3-propanediol single carbamate.

본 발명에 따른 광학이성질체는 중추신경계 질병, 예를 들어 신경성 근육통, 간질 뇌졸증의 치료 및 예방에 유용하다.The optical isomers according to the invention are useful for the treatment and prevention of diseases of the central nervous system, for example neuromuscular pain, epileptic stroke.

Description

피리딜기를 포함하는 신규한 카바메이트 화합물Novel Carbamate Compounds Containing Pyridyl Groups

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (10)

하기식(Ⅰ)로 표시되는 (R)-2-(2-피리딜)-1,3-프로판디올 단일 카바메이트(R) -2- (2-pyridyl) -1,3-propanediol single carbamate represented by the following formula (I) 하기식(Ⅱ)로 표시되는 (S)-2-(2-피리딜)-1,3-프로판디올 단일 카바메이트(S) -2- (2-pyridyl) -1,3-propanediol single carbamate represented by the following formula (II) 하기 식(Ⅲ)의 (R)-3-아세톡시-2-(2-피리딜) 프로판올 카바메이트를 완충용액하에서 효소를 촉매로서 반응시켜, 하기식(Ⅰ)로 표시되는 (R)-2-(2-피리딜)-1,3-프로판디올 단일 카바메이트를 빠른 시간내에 높은 광학적 순도로 제조하는 것을 특징으로 하는 (R)-2-(2-피리딜)-1,3-프로판디올 단일 카바메이트의 제조방법.(R) -3-acetoxy-2- (2-pyridyl) propanol carbamate of the formula (III) is reacted with an enzyme as a catalyst in a buffer solution, and is represented by the following formula (I): (R) -2- (2-pyridyl) -1,3-propanediol characterized in that a single carbamate is prepared in high optical purity in a short time Process for the preparation of a single carbamate. 제3항에 있어서, 상기 효소가 돼지의 췌장에서 추출한 슈도모나스 리파제(PSL), 칸디다 리파제(CCL) 또는 돼지의 간에서 추출한 에스테라제(PEL)인 것을 특징으로 하는 방법.4. The method of claim 3, wherein the enzyme is Pseudomonas lipase (PSL), Candida lipase (CCL) extracted from pig pancreas, or esterase (PEL) extracted from pig liver. 제3항에 있어서, 상기 반응의 온도는 0℃∼35℃로 유지됨을 특징으로 하는 방법.The method of claim 3, wherein the temperature of the reaction is maintained at 0 ℃ to 35 ℃. 제3항에 있어서, 상기 사용된 완충용액의 pH가 6∼9로 유지됨을 특징으로 하는 방법.4. The method according to claim 3, wherein the pH of the used buffer solution is maintained at 6-9. 하기식(Ⅳ)의 (S)-3-아세톡시-2-(2-피리딜) 프로판올 카바메이트를 완충용액하에서 효소를 촉매로서 반응시켜, 하기식(Ⅱ)로 표시되는 (S)-2-(2-피리딜)-1,3-프로판디올 단일 카바메이트를 빠른 시간내에 높은 광학적 순도로 제조하는 것을 특징으로 하는 (S)-2-(2-피리딜)-1,3-프로판디올 단일 카바메이트의 제조방법.(S) -2 represented by the following formula (II) by reacting (S) -3-acetoxy-2- (2-pyridyl) propanol carbamate of formula (IV) as a catalyst with a catalyst (S) -2- (2-pyridyl) -1,3-propanediol, characterized in that a single carbamate is prepared in high optical purity in a short time Process for the preparation of a single carbamate. 제7항에 있어서, 상기 효소가 돼지의 췌장에서 추출한 슈도모나스 리파제(PSL), 칸디다 리파제(CCL) 또는 돼지의 간에서 추출한 에스테라제(PEL)인 것을 특징으로 하는 방법.8. The method according to claim 7, wherein the enzyme is Pseudomonas lipase (PSL), Candida lipase (CCL) extracted from pig pancreas or esterase (PEL) extracted from pig liver. 제7항에 있어서, 상기 반응의 온도는 0℃∼35℃로 유지됨을 특징으로 하는 방법.The method of claim 7, wherein the temperature of the reaction is maintained at 0 ℃ to 35 ℃. 제7항에 있어서, 상기 사용된 완충용액의 pH가 6∼9로 유지됨을 특징으로 하는 방법.8. The method of claim 7, wherein the pH of the used buffer is maintained at 6-9. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940023912A 1994-09-22 1994-09-22 Carbamic compound KR0139717B1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
KR1019940023912A KR0139717B1 (en) 1994-09-22 1994-09-22 Carbamic compound
JP8510764A JP2809883B2 (en) 1994-09-22 1995-09-21 Novel carbamate compound and method for producing the same
EP95931455A EP0730576A1 (en) 1994-09-22 1995-09-21 Novel carbamate compounds and processes for preparing the same
US08/612,903 US5849772A (en) 1994-09-22 1995-09-21 Carbamate compounds and processes for preparing the same
DE69509745T DE69509745T2 (en) 1994-09-22 1995-09-21 NEW CARBAMATE COMPOUNDS AND METHOD FOR THEIR PRODUCTION
EP95931454A EP0730575B1 (en) 1994-09-22 1995-09-21 Novel carbamate compounds and processes for preparing the same
PCT/KR1995/000125 WO1996009284A1 (en) 1994-09-22 1995-09-21 Novel carbamate compounds and processes for preparing the same
CN95190934A CN1071315C (en) 1994-09-22 1995-09-21 Novel carbamate compounds and processes for preparing the same
JP8510765A JP2809884B2 (en) 1994-09-22 1995-09-21 Novel carbamate compound and method for producing the same
CA002176968A CA2176968A1 (en) 1994-09-22 1995-09-21 Novel carbamate compounds and processes for preparing the same
CN95190935A CN1135751A (en) 1994-09-22 1995-09-21 Novel carbamate compounds and processes for preparing the same
CA002176960A CA2176960C (en) 1994-09-22 1995-09-21 Novel carbamate compounds and processes for preparing the same
PCT/KR1995/000124 WO1996009283A1 (en) 1994-09-22 1995-09-21 Novel carbamate compounds and processes for preparing the same
ES95931454T ES2134491T3 (en) 1994-09-22 1995-09-21 NEW CARBAMATE COMPOUNDS AND PROCEDURES FOR ITS PREPARATION.
CN001374621A CN1216858C (en) 1994-09-22 2000-12-20 Carbamate compound and its prep.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940023912A KR0139717B1 (en) 1994-09-22 1994-09-22 Carbamic compound

Publications (2)

Publication Number Publication Date
KR960010627A true KR960010627A (en) 1996-04-20
KR0139717B1 KR0139717B1 (en) 1998-06-01

Family

ID=19393281

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940023912A KR0139717B1 (en) 1994-09-22 1994-09-22 Carbamic compound

Country Status (1)

Country Link
KR (1) KR0139717B1 (en)

Also Published As

Publication number Publication date
KR0139717B1 (en) 1998-06-01

Similar Documents

Publication Publication Date Title
DE69333675T2 (en) Enzymatic methods for the separation of enantiomeric mixtures of compounds useful as intermediates for the preparation of taxanes
EP0475255A2 (en) Process for the preparation of optically pure (S)-alpha-[(tert-butylsulfonyl)methyl]hydro cinnamic acid
DE69023934D1 (en) Substance PF 1022, process for its preparation and anthelmintic composition containing this substance.
KR910009622A (en) Enzymatic cleavage method of endo-bicyclo [2.2.1] heptan-2-ol and prepared optically active compound
KR910004198A (en) Oligonucleotide Sequences of Anti-Messenger RNA Opposite Alpha TNF, Methods of Making the Same, Uses as Pharmaceuticals, and Pharmaceutical Compositions
KR970707102A (en) 2-[(2-alkoxy-6-trifluoromethylpyrimidin-4-yl) oxymethylene] phenylacetic acid derivative, preparation method, intermediate and use thereof (2-[(2-Alkoxy-6-Trifluoromethyl Pyrimidine-4 -yl) -Oxymethylene] Phenyl-Acetic Acid Derivatives, Processes and Intermediate Products for Their Production and Their Use)
KR960010627A (en) Novel Carbamate Compounds Containing Pyridyl Groups
DE3768603D1 (en) FLUORED VITAMIN-D3 COMBINED BODIES AND METHOD FOR THE PRODUCTION THEREOF.
KR960029322A (en) Novel carbamate compounds containing thiocarbamoyl groups and preparation methods thereof
KR920701469A (en) Process for preparing antibacterial compounds and intermediates thereof
ATE248144T1 (en) METHOD FOR PRODUCING N-(D-ALPHA-METHYL-BETA-MERCAPTOPROPIONYL)-L-PROLINE AND INTERMEDIATES THEREOF
EP0289804A3 (en) Process for preparing optically active mercapto compound
CA2244917A1 (en) Method of producing optically active amines
KR930012741A (en) Method for preparing 4-hydroxymethyltetrahydropyran
KR890003955A (en) Enzymatic Preparation of Optically Active Phosphorus-Containing Functional Acetic Acid Derivatives
KR960029463A (en) Optical cleavage method of (R, S) -1,2-phenylethanediol using enzyme
KR900000481A (en) Enzymatic separation of optical isomers of racemic ester derivatives of 3-mercapto-2-alkyl-propionic acid
KR960010615A (en) Monocarbamate Compound Derived from 2-phenyl-1,3-propanediol
KR960010626A (en) Novel carbamate compounds derived from 2- (2-pyridyl) propanediol
DE19505672A1 (en) Process for the enzymatic acylation of alcohols with alkoxy vinyl acetates by transesterification
ATE77412T1 (en) PROCESS FOR THE ENZYMATIC RESOLUTION OF RACEMIC 2-AMINO-1-ALKANOLS.
EP0709464B1 (en) Process for the enzymatic separation of enantiomers of racemic 2-oxotricyclo-2,2,1,03,5-heptan-7-carboxylic acids and esters thereof
DE730028T1 (en) Novel cholesterol oxidase
JPS6012992A (en) Production of optically active carboxylic acid
DE69818133T2 (en) Production of an optically active sphingoid compound

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20110211

Year of fee payment: 14

LAPS Lapse due to unpaid annual fee