KR960000276A - Pseudo mobile phase chromatography - Google Patents

Pseudo mobile phase chromatography Download PDF

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KR960000276A
KR960000276A KR1019940013824A KR19940013824A KR960000276A KR 960000276 A KR960000276 A KR 960000276A KR 1019940013824 A KR1019940013824 A KR 1019940013824A KR 19940013824 A KR19940013824 A KR 19940013824A KR 960000276 A KR960000276 A KR 960000276A
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column
columns
inlet
outlet
mobile phase
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KR1019940013824A
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Korean (ko)
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KR0174289B1 (en
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히로까즈 이께다
마사까즈 네가와
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원본미기재
다이셀 가가꾸 고오교 가부시끼가이샤
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/1828—Simulated moving beds characterized by process features
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Sustainable Development (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 의사(擬似) 이동상 크로마토분리법(simulated moving bed chromatographic proces)에 관한 것으로서, 용리유체로서 초임계 유체를 사용하므로써 분리 효율 및 운전 효율을 현저히 개량하고 크로마토분리 공정후의 농축단계를 생략할 수 있다.The present invention relates to simulated moving bed chromatographic proces, which can significantly improve separation efficiency and operation efficiency by using supercritical fluid as an eluting fluid and omit the concentration step after the chromatographic separation process. .

Description

의사(擬似) 이동상 크로마토분리법Pseudo mobile phase chromatography

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

제1도는 본 발명에 의한 의사 이동상 크로마토분리법을 나타내는 개략 설명도이다.1 is a schematic explanatory diagram showing a pseudo mobile phase chromatographic separation method according to the present invention.

제2도는 12개의 단위컬럼을 갖는 의사 이동상을 이용하는, 본 발명에 따른 의사 이동상 크로마토분리법을 나타내는 개략 설명도이다.2 is a schematic explanatory diagram showing a pseudo mobile phase chromatographic separation method according to the present invention using a pseudo mobile phase having 12 unit columns.

Claims (5)

고체 흡착제가 충전되어 있고 도입구 및 배출구가 설치된 복수개의 컬럼을 말단이 없는 형태로 일련으로 연결하여 순환유로(循環流路)를 형성하고; 이 순환유로내에서 용리액인 초임계 유체를 강제 순환시키기 위해 제1단위컬럼의 도입구(제1도입구)를 통해 제일 단위 컬럼내에 도입시키며; 상기 유체로 하여금 상기 컬럼 및 순차적으로 연결된 수개의 컬럼내에 흡착되어 있는 물질을 탈착하도록 하고; 이들 컬럼에 흡착되어 있다가 그로부터 탈착된 물질을 풍부하게 포함하고 있는 용액을 이들 컬럼중 최종 컬럼의 배출구(제1배출구)를 통해 배출시키며; 분리하고자 하는 복수개의 물질을 함유하고 있는 원료 용액을 그 다음의 컬럼에 그 컬럼의 도입구(제2도입구)를 통해 도입하여 목적 물질이 상기 컬럼 및 순차적으로 연결된 수개의 컬럼내의 흡착제에 흡착되도록 하고; 이들 컬럼에 흡착되지 않은 라피네이트를 이들 컬럼중 최종 컬럼의 배출구(제2배출구)를 통해 배출시키며; 잔류 용액과 초임계 유체를 순차적인 수개의 단위 컬럼에 차례대로 통과시키고; 이 순환유로내를 순환하는 유체의 흐름방향에 따라 상기 제1도입구, 제1배출구, 제2도입구 및 제2배출구를 소정 간격으로 순차적으로 이동시키므로써 흡착성 물질과 비흡착성 물질을 분리하는 것을 특징으로 하는 복수 물질의 혼합물을 분리하기 위한 의사(擬似) 이동상 크로마토분리법(simulated moving bed chromatographic proces).Connecting a plurality of columns filled with a solid adsorbent and provided with an inlet and an outlet in series without end to form a circulation flow path; Introducing into the first unit column through the inlet (first inlet) of the first unit column to forcibly circulate the supercritical fluid that is the eluent in the circulation passage; Allow the fluid to desorb material adsorbed within the column and several columns connected in series; The solution adsorbed on these columns and abundantly desorbed therefrom is discharged through the outlet (first outlet) of the final column in these columns; A raw material solution containing a plurality of substances to be separated is introduced into the next column through the inlet (second inlet) of the column so that the target substance is adsorbed to the adsorbent in the column and several columns connected sequentially. and; The raffinate not adsorbed to these columns is discharged through the outlet (second outlet) of the final column of these columns; Passing the residual solution and the supercritical fluid sequentially through several sequential unit columns; By separating the adsorbent material and the non-adsorbent material by sequentially moving the first inlet, the first outlet, the second inlet and the second outlet in a predetermined interval according to the flow direction of the fluid circulating in the circulation passage. Simulated moving bed chromatographic proces for separating a mixture of plural substances characterized by the above-mentioned. 제1항에 있어서, 고체 흡착제가 광학이성체 분리용 필러임을 특징으로 하는 의사 이동상 크로마토분리법.The pseudo mobile phase chromatographic separation method according to claim 1, wherein the solid adsorbent is a filler for separating optical isomers. 제1항에 있어서, 고체 흡착제가 셀룰로오스 에스테르 유도체 입자, 셀룰로오스 카르바민산염 유도체의 입자 또는 담체에 지지된 이들 입자임을 특징으로 하는 의사 이동상 크로마토분리법.2. The pseudo mobile phase chromatographic separation method according to claim 1, wherein the solid adsorbent is cellulose ester derivative particles, particles of cellulose carbamate derivatives or these particles supported on a carrier. 제1항에 있어서, 상기 분리하고자 하는 물질 혼합물이 광학이성체의 혼합물, 디아스테레오머의 혼합물 또는 구조이성체의 혼합물임을 특징으로 하는 의사 이동상 크로마토분리법.The pseudo mobile phase chromatographic separation method according to claim 1, wherein the substance mixture to be separated is a mixture of optical isomers, a mixture of diastereomers or a mixture of structural isomers. 제1항에 있어서, 총 컬럼의 각 1/4씩이 탈착단계, 정제단계, 흡착단계 및 용리액 회수단계에 배치되어 있음을 특징으로 하는 의사 이동상 크로마토분리법.2. The pseudo mobile phase chromatographic separation method according to claim 1, wherein each quarter of the total column is disposed in a desorption step, a purification step, an adsorption step, and an eluent recovery step. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940013824A 1994-06-18 1994-06-18 Simulated moving bed chromatography KR0174289B1 (en)

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KR100741750B1 (en) * 2005-12-26 2007-07-23 삼성토탈 주식회사 Simulated moving bed adsorptive separation process with irregular switching time of rotary valve
KR100926150B1 (en) * 2007-10-19 2009-11-10 인하대학교 산학협력단 Chromatographic Method of Using Three-Zone Simulated Moving Bed Process Comprising Partial Recycle

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