KR960000212A - Oral Drug Delivery System Using Hydrophobic Polymer Matrix Containing Hydrophilic Polymer - Google Patents

Oral Drug Delivery System Using Hydrophobic Polymer Matrix Containing Hydrophilic Polymer Download PDF

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Publication number
KR960000212A
KR960000212A KR1019940015569A KR19940015569A KR960000212A KR 960000212 A KR960000212 A KR 960000212A KR 1019940015569 A KR1019940015569 A KR 1019940015569A KR 19940015569 A KR19940015569 A KR 19940015569A KR 960000212 A KR960000212 A KR 960000212A
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KR
South Korea
Prior art keywords
drug delivery
delivery system
oral drug
hydrophobic polymer
water
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Application number
KR1019940015569A
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Korean (ko)
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KR0136211B1 (en
Inventor
이해방
오승열
정희원
조선행
Original Assignee
강박광
재단법인 한국화학연구소
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Priority to KR1019940015569A priority Critical patent/KR0136211B1/en
Publication of KR960000212A publication Critical patent/KR960000212A/en
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Publication of KR0136211B1 publication Critical patent/KR0136211B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Abstract

친수성 약물 및, 수용성 고분자 물질 및 친수성 당류입자중에서 선택된 하나 또는 그 이상을 포함한 소수성 고분자 용액으로 제조된 매트릭스를 사용하는 것을 특징으로 하는 경구용 약물 전달체계는 약물의 방출 속도를 조절하기가 용이하여 적정 시간동안 약물의 농도를 치료영역 내에 존재하게 한다.An oral drug delivery system using a matrix made of a hydrophilic drug and a hydrophobic polymer solution containing one or more selected from water-soluble polymers and hydrophilic sugar particles is easy to control the release rate of the drug. The concentration of drug is allowed to exist in the treatment area over time.

Description

친수성 고분자 물질을 함유하는 소수성 고분자 매트릭스를 이용한 경구용 약물 전달 체계Oral Drug Delivery System Using Hydrophobic Polymer Matrix Containing Hydrophilic Polymer

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

제1도는 5-불화우라실 200㎎및 알긴산나트륨 각각 200및 500㎎을 함유한 매트릭스로부터의 5-불화우라실의 방출 프로파일이며,FIG. 1 is the release profile of 5-uraura fluoride from a matrix containing 200 mg 5-urafluoride and 200 mg 500 mg sodium alginate, respectively.

제2도는 5-불화우라실 400㎎및 700㎎을 함유한 매트릭스로부터의 5-불화우라실의 방출 프로파일이다.FIG. 2 is the release profile of 5-urauryl fluoride from a matrix containing 400 mg and 700 mg of 5-urauryl fluoride.

Claims (5)

친수성 약물 및, 수용성 고분자 물질 및 친수성 당류입자중에서 선택된 하나 또는 그 이상을 포함한 소수성 고분자 용액으로 제조된 매트릭스를 사용하는 것을 특징으로 하는 경구용 약물 전달체계.An oral drug delivery system using a matrix made of a hydrophilic drug and a hydrophobic polymer solution containing one or more selected from water-soluble polymers and hydrophilic sugar particles. 제1항에 있어서, 상기한 수용성 고분자물질은 알긴산나트륨,폴리에틸렌글라이콜, 폴리프로필렌글라이콜 메틸셀룰로오스, 카르복시메틸셀룰로오즈, 폴리아크릴산, 폴리비닐아크릴산, 폴리비닐알콜로 이루어지는 군에서 선택되어지는 것을 특징으로 하는 경구용 약물 전달체계.The method of claim 1, wherein the water-soluble high molecular material is selected from the group consisting of sodium alginate, polyethylene glycol, polypropylene glycol methyl cellulose, carboxymethyl cellulose, polyacrylic acid, polyvinyl acrylic acid, polyvinyl alcohol Oral drug delivery system characterized by. 제1항에 있어서, 상기 매트릭스는 0.5 내지 3.0mm의 두께를 지님을 특징으로 하는 경구용 약물 전달체계.The oral drug delivery system according to claim 1, wherein the matrix has a thickness of 0.5 to 3.0 mm. 제1항에 있어서, 상기한 수용성 당류로는 락토오스, 갈락토오스, 슈크로즈, 프럭토오스, 말토오스, 전분으로 이루어진 군에서 선택되어지는 것을 특징으로 하는 경구용 약물 전달체계.The oral drug delivery system of claim 1, wherein the water-soluble sugars are selected from the group consisting of lactose, galactose, sucrose, fructose, maltose, and starch. 제1항에 있어서, 상기한 소수성 고분자로는 폴리우레탄, 폴리에틸렌, 폴리프로필렌, 폴리비닐클록라이드, 폴리카보네이트, 에틸렌비닐아세테이트, 폴리비닐에스터로 이루어지는 군에서 선택되어지는 것을 특징으로 하는 경구용 약물 전달체계.According to claim 1, wherein the hydrophobic polymer is oral drug delivery, characterized in that selected from the group consisting of polyurethane, polyethylene, polypropylene, polyvinyl chloride, polycarbonate, ethylene vinyl acetate, polyvinyl ester system. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940015569A 1994-06-30 1994-06-30 Oral drug delivery system using lipophilic polymer matrix containing hydrophilic polymer KR0136211B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019940015569A KR0136211B1 (en) 1994-06-30 1994-06-30 Oral drug delivery system using lipophilic polymer matrix containing hydrophilic polymer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940015569A KR0136211B1 (en) 1994-06-30 1994-06-30 Oral drug delivery system using lipophilic polymer matrix containing hydrophilic polymer

Publications (2)

Publication Number Publication Date
KR960000212A true KR960000212A (en) 1996-01-25
KR0136211B1 KR0136211B1 (en) 1998-04-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940015569A KR0136211B1 (en) 1994-06-30 1994-06-30 Oral drug delivery system using lipophilic polymer matrix containing hydrophilic polymer

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KR (1) KR0136211B1 (en)

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KR0136211B1 (en) 1998-04-25

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