KR950702437A - A DRUG DELIVERY DEVICE AND A METHOD OF MAKING SUCH DEVICE - Google Patents

A DRUG DELIVERY DEVICE AND A METHOD OF MAKING SUCH DEVICE Download PDF

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KR950702437A
KR950702437A KR1019950700048A KR19950700048A KR950702437A KR 950702437 A KR950702437 A KR 950702437A KR 1019950700048 A KR1019950700048 A KR 1019950700048A KR 19950700048 A KR19950700048 A KR 19950700048A KR 950702437 A KR950702437 A KR 950702437A
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South Korea
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polymer
delivery device
matrix
crosslinking agent
drug delivery
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KR1019950700048A
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Korean (ko)
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헬러 브론스테드
라르스 호브가드
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클레이스 윌헬름선
아스트라 에이 비이
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Publication of KR950702437A publication Critical patent/KR950702437A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명의 약제 전달 장치는 폴리머 매트릭스와 해당 매트릭스에 포함되어 있거나 둘러싸여져 있는 약제로 이루어져 있되 상기 폴리머 매트릭스는 덱스트라나아제 분해성 폴리머와 상기 폴리머 사슬간에 공유 결합의 망상 구조 결합을 제공하게 되는 가교제로 이루어진 가교된 히드로겔 매트릭스이다. 상기 장치는 약제를 결장까지 전달하기에 적합하다. 상기 장치를 제조하는 방법은 a) 덱스트라나아제 분해성 폴리머를 용매에 용해시키는 단계; b) 상기 용액과 공유 결합되게 폴리머를 가교시킬 수 있는 가교제로 첨가하는 단계; c) 상기 가교제를 덱스트라나아제 분해성 폴리머와 반응시켜 가교된 히드로겔 매트릭스를 제공하고, 상기 폴리머와 가교제간에 반응이 완료되기 전 또는 후에 상기 용액에 약제를 부가하는 단계로 이루어진다.The drug delivery device of the present invention comprises a polymer matrix and a drug contained in or enclosed in the matrix, wherein the polymer matrix is a crosslinking agent that provides a covalent bond between the dextranase degradable polymer and the polymer chain. Crosslinked hydrogel matrix. The device is suitable for delivering medication to the colon. The method of making the device comprises a) dissolving the dextranase degradable polymer in a solvent; b) adding a crosslinking agent capable of crosslinking the polymer covalently with the solution; c) reacting the crosslinker with a dextranase degradable polymer to provide a crosslinked hydrogel matrix and adding a medicament to the solution before or after the reaction between the polymer and the crosslinker is complete.

Description

약제 전달 장치 및 이의 제조 방법(A DRUG DELIVERY DEVICE AND A METHOD OF MAKING SUCH DEVICE)A DRUG DELIVERY DEVICE AND A METHOD OF MAKING SUCH DEVICE

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 DMSO의 함량에 따른 본 발명의 장치의 평윤 평형도를 나타낸 그래프,1 is a graph showing the equilibrium equilibrium of the device of the present invention according to the content of DMSO,

제2도는 가교제의 함량에 따른 본 발명의 장치의 팽윤 평형도,2 shows the swelling equilibrium of the device of the present invention according to the content of

제3도는 덱스트란의 분자량에 따른 본 발명의 장치의 팽윤 평형도를 나타낸 그래프,3 is a graph showing the swelling balance of the device of the present invention according to the molecular weight of dextran,

제4도는 시간에 따른 본 발명의 장치의 결장과 위에서의 분해를 보여주는 그래프이다,4 is a graph showing decomposition of the colon and stomach of the device of the invention over time,

제5도는 본 발명에 따른 장치로 부터 히드로코오티조운(hydrocortisone)의 방출 프로필을 나타낸 그래프이다.5 is a graph showing the release profile of hydrocortisone from the device according to the invention.

Claims (12)

폴리머 매트릭스와, 해당 매트릭스에 함유되어 있거나 해당 폴리머 매트릭스에 의해 둘러 싸여진 약제로 이루어진 약제 전달 장치에 있어서, 상기 폴리머 매트릭스는 덱스트라나아제 분해성 폴리머와 폴리머 사슬간에 공유 결합의 망상 구조 결합을 제공하는 가교제로 이루어진 가교된 히드로겔 매트릭스인 것을 특징으로 하는 약제 전달 장치.In a drug delivery device comprising a polymer matrix and a drug contained in or surrounded by the polymer matrix, the polymer matrix provides a crosslinking agent that provides a covalent bond between the dextranase degradable polymer and the polymer chain. Pharmaceutical delivery device, characterized in that the cross-linked hydrogel matrix consisting of. 제1항에 있어서, 상기 덱스트라나아제 분해성 폴리머는 덱스트란인 것을 특징으로 하는 약제 전달 장치.The device of claim 1, wherein the dextranase degradable polymer is dextran. 제1항에 있어서, 상기 덱스트란은 황산, 알콕시, 산화 또는 에스테르화 된 것을 특징으로 하는 약제 전달 장치.The device of claim 1, wherein the dextran is sulfuric acid, alkoxy, oxidized or esterified. 제1 내지 3항 중 어느 하나의 항에 있어서, 상기 덱스트란 분해성 폴리머는 분자량이 10,000와 2,000,000g/몰 사이, 바람직하기로는 40,000과 2,000,000g/몰 사이, 특히 바람직하기로는 70,000과 500,000g/몰 사이인 것을 특징으로 하는 약제 전달 장치.4. The dextran degradable polymer of claim 1, wherein the dextran degradable polymer has a molecular weight between 10,000 and 2,000,000 g / mol, preferably between 40,000 and 2,000,000 g / mol, particularly preferably 70,000 and 500,000 g / mol Pharmaceutical delivery device, characterized in that between. 제1 내지 4항 중 어느 하나의 항에 있어서, 상기 가교제는 우레탄 결합 형성제인 것을 특징으로 하는 약제 전달 장치.The drug delivery device according to any one of claims 1 to 4, wherein the crosslinking agent is a urethane bond former. 제5항에 있어서, 상기 우레탄 결합 형성제는 헥사메틸렌디이소시아네이트 또는 1,4-페닐렌디이소시아네이트인 것을 특징으로 하는 약제 전달 장치.6. The drug delivery device according to claim 5, wherein the urethane bond former is hexamethylene diisocyanate or 1,4-phenylenedi isocyanate. 제1 내지 6항 중 어느 하나의 항에 있어서, 상기 가교제는 히드로겔에 모노머 단위가 0.05 내지 25몰%로 포함되어 있는 것을 특징으로 하는 약제 전달 장치.The drug delivery device according to any one of claims 1 to 6, wherein the crosslinking agent contains 0.05 to 25 mol% of monomer units in the hydrogel. 제1 내지 7항 중 어느 하나의 항에 있어서, 상기 약제는 상기 히드로겔 매트릭스에 균일하게 분산되어 있는 것을 특징으로 하는 약제 전달 장치.The drug delivery device according to any one of claims 1 to 7, wherein the drug is uniformly dispersed in the hydrogel matrix. 제1 내지 7항 중 어느 하나의 항에 있어서, 상기 약제는 상기 매트릭스로 둘러 싸여 있는 것을 특징으로 하는 약제 전달 장치.8. A drug delivery device according to any one of claims 1 to 7, wherein the drug is surrounded by the matrix. a) 덱스트라나아제 분해성 폴리머를 용매에 용해시키는 단계; b) 상기 용액과 공유 결합되게 폴리머를 가교시킬 수 있는 가교제로 첨가하는 단계; c) 상기가교제를 덱스트라나아제 분해성 폴리머와 반응시켜 가교된 히드로겔 매트릭스를 제공하고, 상기 폴리머와 가교제간에 반응이 완료되기 전 또는 후에 상기 용액에 약제를 부가하는 단계로 이루어지는 것을 특징으로 하는 상기 제1 내지 9항에 따른 약제 전달 장치의 제조 방법.a) dissolving the dextranase degradable polymer in a solvent; b) adding a crosslinking agent capable of crosslinking the polymer covalently with the solution; c) reacting the crosslinking agent with a dextranase degradable polymer to provide a crosslinked hydrogel matrix, and adding a medicament to the solution before or after the reaction between the polymer and the crosslinking agent is completed. A method for producing a drug delivery device according to claim 1. 제10항에 있어서, 상기 약제는 가교 반응이 완료되기 전에 상기 폴리머와 가교제에 의해 둘러 싸여지면, 그 다음에 가교 반응이 완료되도록 함을 특징으로 하는 약제 전달 장치의 제조 방법.The method of claim 10, wherein the drug is surrounded by the polymer and the crosslinking agent before the crosslinking reaction is completed, and then the crosslinking reaction is completed. 제10항에 있어서, 상기 약제는 용액 또는 액체 형태로 가교된 히드로겔에 부가하여 미리 건조된 히드로겔이 약제에 흡수되도록 하는 것을 특징으로 하는 약제 전달 장치의 제조방법.The method of claim 10, wherein the medicament is added to the cross-linked hydrogel in solution or liquid form to allow the pre-dried hydrogel to be absorbed by the medicament. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950700048A 1992-07-07 1993-07-06 A DRUG DELIVERY DEVICE AND A METHOD OF MAKING SUCH DEVICE KR950702437A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK92895A DK89592D0 (en) 1992-07-07 1992-07-07 PHARMACEUTICAL DELIVERY ESTABLISHMENT AND PROCEDURES FOR PREPARING THEREOF
DK0895/92 1992-07-07
PCT/DK1993/000227 WO1994001136A1 (en) 1992-07-07 1993-07-06 A drug delivery device and a method of making such device

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KR950702437A true KR950702437A (en) 1995-07-29

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JP (1) JPH07508735A (en)
KR (1) KR950702437A (en)
AU (1) AU671651B2 (en)
BR (1) BR9306700A (en)
CA (1) CA2139747A1 (en)
CZ (1) CZ3895A3 (en)
DK (1) DK89592D0 (en)
FI (1) FI950065A (en)
HU (1) HUT75665A (en)
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PL (1) PL172724B1 (en)
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US5783214A (en) * 1994-06-13 1998-07-21 Buford Biomedical, Inc. Bio-erodible matrix for the controlled release of medicinals
PT910412E (en) 1996-07-01 2003-09-30 Univ Utrecht HYDROLOGICAL HYDROGEES FOR CONTROLLED LIBERATION
EA006402B1 (en) 1999-12-23 2005-12-29 Пфайзер Продактс Инк. Combination of drug and cellulosic polymer, enhancing concentration, method of drug administering and aqueous solution thereof
JP2013523748A (en) * 2010-03-29 2013-06-17 サーモディクス，インコーポレイテッド Drug delivery formulation for injection
CA2858161C (en) * 2011-12-05 2020-03-10 Incept, Llc Medical organogel processes and compositions

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US2550750A (en) * 1947-09-22 1951-05-01 Arthur C Abelt Differential for automobiles
US4024073A (en) * 1972-01-08 1977-05-17 Toray Industries, Inc. Hydrogel and production thereof
IT1131833B (en) * 1980-06-20 1986-06-25 Crinos Industria Farmaco EXCIPIENTS FOR SPERMICIDE SUBSTANCES
JPS5997346A (en) * 1982-11-24 1984-06-05 Komatsu Ltd Differential device of car
SE9002339L (en) * 1990-07-04 1992-01-05 Kabi Pharmacia Ab THERAPEUTIC COMPOSITION AND PROCEDURE FOR ITS PREPARATION

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HU9500042D0 (en) 1995-03-28
FI950065A0 (en) 1995-01-05
HUT75665A (en) 1997-05-28
CA2139747A1 (en) 1994-01-20
RU2139093C1 (en) 1999-10-10
DK89592D0 (en) 1992-07-07
PL307050A1 (en) 1995-05-02
WO1994001136A1 (en) 1994-01-20
BR9306700A (en) 1998-12-08
EP0648129A1 (en) 1995-04-19
SK1795A3 (en) 1995-09-13
CZ3895A3 (en) 1995-09-13
NZ253678A (en) 1996-07-26
FI950065A (en) 1995-03-02
AU671651B2 (en) 1996-09-05
AU4417893A (en) 1994-01-31
JPH07508735A (en) 1995-09-28
PL172724B1 (en) 1997-11-28

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