KR950028783A - Peptides with Human Immune Regulation Against Hepatitis C Virus - Google Patents

Peptides with Human Immune Regulation Against Hepatitis C Virus Download PDF

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Publication number
KR950028783A
KR950028783A KR1019940007819A KR19940007819A KR950028783A KR 950028783 A KR950028783 A KR 950028783A KR 1019940007819 A KR1019940007819 A KR 1019940007819A KR 19940007819 A KR19940007819 A KR 19940007819A KR 950028783 A KR950028783 A KR 950028783A
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KR
South Korea
Prior art keywords
virus
hepatitis
peptides
present
ctl
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KR1019940007819A
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Korean (ko)
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KR0137153B1 (en
Inventor
황유경
김태연
조성유
정흥석
박송용
문홍모
윤창노
윤정혁
Original Assignee
허영섭
재단법인 목암생명공학연구소
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Priority to KR1019940007819A priority Critical patent/KR0137153B1/en
Publication of KR950028783A publication Critical patent/KR950028783A/en
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Publication of KR0137153B1 publication Critical patent/KR0137153B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24233—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory

Abstract

본 발명은 C형 간염 바이러스에 대한 인체의 면역성 조절기능을 가지는 신규한 일련의 펩타이드군에 관한 것이다. 좀 더 구체적으로, 본 발명은 C형 간염 바이러스 단백질 항원중 간염 바이러스에 대한 세포독성 T-임파구(Cytotoxic T lymphocytes, CTL)를 유도하거나, 그 바이러스에 대해 면역 관용(immunological tolerance)을 유도하는 항원의 특정 부위(epitope)에 해당하는 펩타이드의 아미노산서열에 관한 것이다. 본 발명의 C7, C8, C14, C22 및 C24 등 5종의 신규한 펩타이드는 인체내에 존재하는 C형 간염바이러스 항원을 인지하는 CTL을 활성화시키며, 그 CTL에 의해 다시 인지될 수 있는 펩타이드로서, 간염바이러스 관련 질환의 예방과 치료에 사용될 수 있을 것이다.The present invention relates to a novel series of peptides having an immune regulatory function of the human body against hepatitis C virus. More specifically, the present invention provides a method for preparing cytotoxic T lymphocytes (CTL) against hepatitis virus, or for inducing immune tolerance against the virus. It relates to an amino acid sequence of a peptide corresponding to a specific epitope. Five novel peptides, such as C7, C8, C14, C22, and C24, of the present invention activate CTLs that recognize hepatitis C virus antigens present in the human body, and can be recognizable by the CTLs. It may be used for the prevention and treatment of virus-related diseases.

Description

C형 간염 바이러스에 대한 인체면역 조절기능을 가진 펩타이드Peptides with Human Immune Regulation Against Hepatitis C Virus

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1(A), 1(B), 및 1(C)도는 T2세포의 표면에 발현되는 MHC Class I분자의 변화를 형광강도로 나타내는 그래프이다, 제2도는 CTL에 의한 T2세포의 살해능을 나타내는 그래프이다.1 (A), 1 (B), and 1 (C) are graphs showing the change in MHC Class I molecules expressed on the surface of T2 cells by fluorescence intensity. FIG. 2 shows the killing ability of T2 cells by CTL. It is a graph.

Claims (6)

세포독성 T임파구(CTL)에 의해 인지되어 바이러스에 의해 세포살해능을 나타내는 C형 간염 바이러스 펩타이드.Hepatitis C virus peptide recognized by cytotoxic T lymphocytes (CTL) and exhibiting cytotoxicity by a virus. S M V G N W A K VS M V G N W A K V (상기에서, 아미노산 서열은 IUPAE의 명명법에 따라 기재하였다.)(In the above, the amino acid sequence is described according to the nomenclature of IUPAE.) 세포독성 T임파구(CTL)에 의해 인지되어 바이러스에 의해 세포살해능을 나타내는 C형 간염 바이러스 펩타이드.Hepatitis C virus peptide recognized by cytotoxic T lymphocytes (CTL) and exhibiting cytotoxicity by a virus. C L V D Y P Y R LC L V D Y P Y R L (상기에서, 아미노산 서열은 IUPAE의 명명법에 따라 기재하였다.)(In the above, the amino acid sequence is described according to the nomenclature of IUPAE.) 세포독성 T임파구(CTL)에 의해 인지되어 바이러스에 의해 세포살해능을 나타내는 C형 간염 바이러스 펩타이드.Hepatitis C virus peptide recognized by cytotoxic T lymphocytes (CTL) and exhibiting cytotoxicity by a virus. R L V P G A A Y A VR L V P G A A Y A V (상기에서, 아미노산 서열은 IUPAE의 명명법에 따라 기재하였다.)(In the above, the amino acid sequence is described according to the nomenclature of IUPAE.) 세포독성 T임파구(CTL)에 의해 인지되어 바이러스에 의해 세포살해능을 나타내는 C형 간염 바이러스 펩타이드.Hepatitis C virus peptide recognized by cytotoxic T lymphocytes (CTL) and exhibiting cytotoxicity by a virus. I L A G Y G A G VI L A G Y G A G V (상기에서, 아미노산 서열은 IUPAE의 명명법에 따라 기재하였다.)(In the above, the amino acid sequence is described according to the nomenclature of IUPAE.) 세포독성 T임파구(CTL)에 의해 인지되어 바이러스에 의해 세포살해능을 나타내는 C형 간염 바이러스 펩타이드.Hepatitis C virus peptide recognized by cytotoxic T lymphocytes (CTL) and exhibiting cytotoxicity by a virus. R L I V F P D L G VR L I V F P D L G V (상기에서, 아미노산 서열은 IUPAE의 명명법에 따라 기재하였다.)(In the above, the amino acid sequence is described according to the nomenclature of IUPAE.) 제1항 내지 제5항중의 어느 한항의 펩타이드를 이용하여 C형 간염 바이러스에 대한 특이성을 가진 세포독성 T임파구(CTL)를 유도하는 방법.A method of inducing cytotoxic T lymphocytes (CTL) having specificity for hepatitis C virus using the peptide of any one of claims 1 to 5. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940007819A 1994-04-14 1994-04-14 Peptide controlling immune response against hcv KR0137153B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019940007819A KR0137153B1 (en) 1994-04-14 1994-04-14 Peptide controlling immune response against hcv

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940007819A KR0137153B1 (en) 1994-04-14 1994-04-14 Peptide controlling immune response against hcv

Publications (2)

Publication Number Publication Date
KR950028783A true KR950028783A (en) 1995-11-22
KR0137153B1 KR0137153B1 (en) 1998-04-25

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