KR950028772A - Indomethacin external preparation and its manufacturing method - Google Patents
Indomethacin external preparation and its manufacturing method Download PDFInfo
- Publication number
- KR950028772A KR950028772A KR1019940009330A KR19940009330A KR950028772A KR 950028772 A KR950028772 A KR 950028772A KR 1019940009330 A KR1019940009330 A KR 1019940009330A KR 19940009330 A KR19940009330 A KR 19940009330A KR 950028772 A KR950028772 A KR 950028772A
- Authority
- KR
- South Korea
- Prior art keywords
- indomethacin
- poloxamer
- lower alcohols
- purified water
- tocopherol acetate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
본 발명은 활성성분으로서 인도메타신을 함유하는 새로운 인도메타신 외용제제 및 그 제조방법에 관한 것으로, 겔화기제로서 폴록사머 유도체를 함유하여 피부의 자극을 최소화하며, 약물의 피부 투과율을 높인 새로운 인도메타신 겔제제를 제공한다.The present invention relates to a new indomethacin external preparation containing indomethacin as an active ingredient and a method for preparing the same, and a new indomethac which contains poloxamer derivatives as a gelling agent to minimize skin irritation and increases skin permeability of drugs. Provide a sour gel formulation.
본 발명은 또한 인도메타신과 폴록사머 유도체를 가열, 용융시키고, 따로 저급알코올류에 용해가능한 성분을 용해시켜 상기 용융액에 가하고, 여기에 수용성 물질을 녹인 정제수 또는 완충액을 추가로 가하여 인도메타신겔제제를 제조하는 방법을 제공한다.The present invention also heats and melts indomethacin and poloxamer derivatives, and separately dissolves soluble components in lower alcohols, adds to the melt, and further adds purified water or a buffer in which water-soluble substances are added to indomethacin gel formulation. It provides a method of manufacturing.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
제1도는 PH에 따른 본 발명의 겔제제의 피부 투과율을 나타내는 그래프이다.1 is a graph showing the skin permeability of the gel preparation of the present invention according to PH.
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940009330A KR0142900B1 (en) | 1994-04-29 | 1994-04-29 | Indomethacin external preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940009330A KR0142900B1 (en) | 1994-04-29 | 1994-04-29 | Indomethacin external preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
KR950028772A true KR950028772A (en) | 1995-11-22 |
KR0142900B1 KR0142900B1 (en) | 1998-07-15 |
Family
ID=19382136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019940009330A KR0142900B1 (en) | 1994-04-29 | 1994-04-29 | Indomethacin external preparation |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR0142900B1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112294750A (en) * | 2020-10-29 | 2021-02-02 | 广东药科大学 | Indometacin micelle composite microneedle and preparation method thereof |
-
1994
- 1994-04-29 KR KR1019940009330A patent/KR0142900B1/en not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112294750A (en) * | 2020-10-29 | 2021-02-02 | 广东药科大学 | Indometacin micelle composite microneedle and preparation method thereof |
CN112294750B (en) * | 2020-10-29 | 2023-06-20 | 广东药科大学 | Indometate Xin Jiaoshu composite microneedle and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
KR0142900B1 (en) | 1998-07-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY24210A1 (en) | STICK-FREE, CLEAR OR TRANSLUCENT GEL OR ANTI-TRANSPIRANT BAR COMPOSITION AND METHOD OF MANUFACTURING | |
KR970703132A (en) | METHOD FOR STABILIZING DUOCARMYCIN DERIVATIVES | |
ES2118677T3 (en) | A COMPOSITION THAT INCLUDES A DISSOLVED ACTIVE AGENT IN A GLASS TRAINING VEHICLE AND A PROCEDURE FOR PREPARATION. | |
DE60045153D1 (en) | PREPARATIONS FOR PERCUTANEOUS ABSORPTION | |
NZ295211A (en) | Topical aqueous gel containing a water-soluble cellulose derivative, propylene glycol & drug(s) for haemorrhoids | |
BR9702362A (en) | New stable liquid formulas based on paracetamol and its preparation. | |
DE69927963D1 (en) | GELABLE PHARMACEUTICAL COMPOSITIONS | |
BR9906735A (en) | Aqueous liquid pharmaceutical composition | |
BR0107646A (en) | Osmotic device inside an osmotic device | |
DE69940769D1 (en) | ORAL LIQUID COMPOSITIONS | |
ATE77050T1 (en) | EMULSION OF GEL PARTICLES AND COMPOSITION CONTAINING THEM. | |
DE59108530D1 (en) | Antimicrobial agents and substituted 2-cyclohexan-1-yl-amine derivatives and their preparation | |
CA1309025C (en) | Topical preparation containing ofloxacin | |
MX173607B (en) | CRYSTALLINE ANTIPERSPIRANT AND METHOD FOR ITS PREPARATION | |
GEP20002069B (en) | Taxoid Based Pharmaceutical Compositions and Method for its Production | |
ES2112567T3 (en) | PROCEDURES AND COMPOSITIONS FOR ADMINISTERING FRAGRANCES. | |
PT994727E (en) | Process for Solubilizing Pharmaceutically Active Ingredients in Water and Other Aqueous Vehicles | |
DK0801559T3 (en) | Process for the preparation of oral dosage forms containing a beta-lactam antibiotic | |
AU2001278708A1 (en) | Adenosine derivatives and use thereof | |
TR200100896T2 (en) | Substituted propanol derivatives, methods of manufacture, drugs containing compositions, their use | |
KR950028772A (en) | Indomethacin external preparation and its manufacturing method | |
JPH0536412B2 (en) | ||
DK0647129T3 (en) | Preparation for topical use | |
KR920703060A (en) | Pharmaceutical Formulations | |
ES2138226T3 (en) | DERIVATIVES OF THE IMIDAZO ACID (1,2-A) INDENO (1,2-E) PIRAZINA-2-CARBOXILICO, ITS PREPARATION AND THE MEDICINES CONTAINING THEM. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20030326 Year of fee payment: 6 |
|
LAPS | Lapse due to unpaid annual fee |