KR950023648A - Polypeptides Showing Biological Activity - Google Patents

Polypeptides Showing Biological Activity Download PDF

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Publication number
KR950023648A
KR950023648A KR1019940000222A KR19940000222A KR950023648A KR 950023648 A KR950023648 A KR 950023648A KR 1019940000222 A KR1019940000222 A KR 1019940000222A KR 19940000222 A KR19940000222 A KR 19940000222A KR 950023648 A KR950023648 A KR 950023648A
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KR
South Korea
Prior art keywords
biological activity
polypeptide
short letter
amino acid
showing biological
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Application number
KR1019940000222A
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Korean (ko)
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KR100252624B1 (en
Inventor
이병재
박진모
Original Assignee
김영길
주식회사 녹십자
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Priority to KR1019940000222A priority Critical patent/KR100252624B1/en
Publication of KR950023648A publication Critical patent/KR950023648A/en
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Publication of KR100252624B1 publication Critical patent/KR100252624B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians

Abstract

하기식(I)로 나타내어지는 폴리펩티드는 생물학적 활성이 매우 높고 다양한 범위의 미생물에 대하여 생물학적 활성을 나타내며, 이와 동시에 인테내의 적혈구의 파괴를 일으키지 않고 세포내에서 분해될 경우에도 부작용이 적은 특성을 갖는 우수한 폴리펩티드로서, 질병치료제, 식품첨가제 등의 다양한 용도에 사용될 수 있는 폴리펩티드이다.The polypeptide represented by the following formula (I) has a very high biological activity and exhibits biological activity against a wide range of microorganisms, and at the same time has excellent properties with little side effects even when degraded in cells without causing destruction of red blood cells in the inte. As a polypeptide, it is a polypeptide which can be used for various uses, such as a disease therapeutic agent and a food additive.

[상기식(I)에서 단문자는 아미노산의 단문자 약어이며, X는 아미노산 중 N 또는 T인 것이 바람직하다.][In the above formula (I), a short letter is a short letter abbreviation of an amino acid, and X is preferably N or T among amino acids.]

Description

생물학적 활성을 나타내는 폴리펩티드Polypeptides Showing Biological Activity

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1(A)도는 겔 여과하여 분리한 단백질들의 컬럼 용출 분포를 나타내는 그래프이고,1 (A) is a graph showing the column elution distribution of the proteins separated by gel filtration,

제1(B)도는 본 발명의 생물학적 활성을 나타내는 물질의 전기영동 결과를 나타내는 사진이고,1 (B) is a photograph showing the results of electrophoresis of the material exhibiting the biological activity of the present invention,

제2(A)도는 HPLC하여 얻은 용출결과를 나타내는 그래프이고,Figure 2 (A) is a graph showing the elution results obtained by HPLC,

제2(B)도는 HPLC하여 얻은 분획들의 활성도를 스타피로코코스아우레우스를 대상으로 측정한 결과를 나타내는 사진이고,FIG. 2 (B) is a photograph showing the results of measuring the activity of the fractions obtained by HPLC with respect to Staphylococcus aureus,

제3(A)도는 본 발명의 생물학적 활성을 나타내는 물질을 투여하기 전의 아메바 프로테우스의 사진이고,FIG. 3 (A) is a photograph of Amoeba proteus before administration of a substance exhibiting the biological activity of the present invention,

제3(B)도는 본 발명의 생물학적 활성을 나타내는 물질을 투여한 후의 아메바 프로테우스의 사진이다.Figure 3 (B) is a photograph of Amoeba proteus after administration of a substance exhibiting the biological activity of the present invention.

Claims (2)

하기식(I)로 나타내어지는 폴리펩티드.Polypeptide represented by the following formula (I). [상기식(I)에서 단문자는 아미노산의 단문자 약어이며, X는 아미노산 중 N 또는 T인 것이 바람직하다.][In the above formula (I), a short letter is a short letter abbreviation of an amino acid, and X is preferably N or T among amino acids.] 제1항에 있어서, 상기한 X는 N 또는 T로 이루어진 군에서 선택되는 아미노산인 폴리펩티드.The polypeptide of claim 1, wherein X is an amino acid selected from the group consisting of N or T. 3. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940000222A 1994-01-07 1994-01-07 Polypeptide having biological activity KR100252624B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019940000222A KR100252624B1 (en) 1994-01-07 1994-01-07 Polypeptide having biological activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940000222A KR100252624B1 (en) 1994-01-07 1994-01-07 Polypeptide having biological activity

Publications (2)

Publication Number Publication Date
KR950023648A true KR950023648A (en) 1995-08-18
KR100252624B1 KR100252624B1 (en) 2000-05-01

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ID=19375389

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940000222A KR100252624B1 (en) 1994-01-07 1994-01-07 Polypeptide having biological activity

Country Status (1)

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KR (1) KR100252624B1 (en)

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Publication number Publication date
KR100252624B1 (en) 2000-05-01

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