KR950023419A - Biomaterial Fixing Lumburokinase and Manufacturing Method Thereof - Google Patents

Biomaterial Fixing Lumburokinase and Manufacturing Method Thereof Download PDF

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KR950023419A
KR950023419A KR1019940001599A KR19940001599A KR950023419A KR 950023419 A KR950023419 A KR 950023419A KR 1019940001599 A KR1019940001599 A KR 1019940001599A KR 19940001599 A KR19940001599 A KR 19940001599A KR 950023419 A KR950023419 A KR 950023419A
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biomaterial
crosslinking agent
producing
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lumpurokinase
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KR1019940001599A
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KR970004591B1 (en
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유규하
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민병구
박선양
이민화
이시 이 요우 이찌
주식회사 메디슨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A61L27/165—Rubbers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

폴리우레탄과 같은 고분자 기재에 말레익 안하이드라드 메틸비닐 에테르 공중합체와 같은 가교제를 결합시키고 여기에 룸부로키나제를 결합시켜 만들어진 룸부로키나제가 고정된 생체재료는 헐전분해능이 우수하고, 피브리노겐 흡착 및 혈소판 점착을 억제한 능력이 우수하여 고도의 혈액적합성을 요구하는 순환계 인공장기용 생체재료로서 적합하다.A biomaterial fixed with a lumpurokinase made by combining a crosslinking agent such as a maleic anhydride methylvinyl ether copolymer with a polymer base such as polyurethane and a lumpurokinase thereto is excellent in the hydrolysis ability, adsorption of fibrinogen and It is excellent as an ability to suppress platelet adhesion and is suitable as a biomaterial for circulatory artificial organs that requires high blood compatibility.

Description

룸부로키나제를 고정한 생체재료 및 그 제조방법Biomaterial Fixing Lumburokinase and Manufacturing Method Thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 본 발명이 일실시예인 생체재료의 섬유소분해 합성도를 나타내는 사진이고,Figure 1 is a photograph showing the degree of fibrinolysis of the biomaterial of an embodiment of the present invention,

제2도는 본 발명의 일실시예인 생체재료의 단백질분해 활성도를 나타내는 그래프이고,Figure 2 is a graph showing the proteolytic activity of the biomaterial of an embodiment of the present invention,

제3도는 본 발명의 일실시예인 생체재료의 혈장단백질 분해 활성도를 나타내는 사진이고,3 is a photograph showing the plasma protein degradation activity of the biomaterial of an embodiment of the present invention,

제4도는 본 발명의 일실시예인 생체재료에 피브리노젠의 흡착량을 나타내는 사진이고,4 is a photograph showing the adsorption amount of fibrinogen to a biomaterial, which is an embodiment of the present invention,

제5도는 본 발명의 일실시예인 생체재료에 혈소판의 점착을 나타내는 사진이다.5 is a photograph showing adhesion of platelets to a biomaterial, which is an embodiment of the present invention.

Claims (14)

고분자 기재; 상기 고분자 기재표면에 결합된 가교제; 상기 가교제에 결합된 룸부로키나제; 롤 포함하는 체재료.A polymer substrate; A crosslinking agent bonded to the polymer substrate surface; Rumbaurokinase bound to the crosslinker; Sieve material containing roll. 제1항에 있어서, 상기한 고분자는 천연 고무, 합성고무, 실리콘 수지, 셀룰로오즈, 엘라스토머, 폴리우레탄, 하이드로젤, 폴리비닐클로라이드, 폴리에틸렌, 폴리테트라플루오로에틸렌, 폴리에스터, 나일론으로 이루어진 .에서 선택되는 생체재료.The method of claim 1, wherein the polymer is selected from natural rubber, synthetic rubber, silicone resin, cellulose, elastomer, polyurethane, hydrogel, polyvinyl chloride, polyethylene, polytetrafluoroethylene, polyester, and nylon. Biomaterials. 제1항에 있어서, 상기한 가교제는 말레익 안하이드라이드 메틸비닐에테르공중합체, 헥사에틸렌디이소시아네이트, 톨루엔디이소시아네이트, 디페닐메탄디이소시아네이트로 이루어진 군에서 선택되는 하나 이상의 것인 생체재료.The biomaterial according to claim 1, wherein the crosslinking agent is at least one selected from the group consisting of maleic anhydride methylvinyl ether copolymer, hexaethylene diisocyanate, toluene diisocyanate, diphenylmethane diisocyanate. 제1항에 있어서, 상기한 룸부로키나제는 F-I-0, F-1-1, F-I-2, F-II, F-III-1, F-III-2로 이루어진 군에서 선택되는 하나 이상의 것인 생체재료.The method of claim 1, wherein the lumpurokinase is at least one selected from the group consisting of FI-0, F-1-1, FI-2, F-II, F-III-1, F-III-2 Biomaterials. 제1항에 있어서, 상기간 생체재료의 최적 pH는 pH 6.5∼10.5인 생체재료.The biomaterial of claim 1, wherein the optimal pH of the liver biomaterial is pH 6.5-10.5. 제1항에 있어서, 상기한 생체재료의 최적 온도는 30∼70℃인 생체재료.The biomaterial according to claim 1, wherein the optimum temperature of the biomaterial is 30 to 70 ° C. 고분자 기재의 표면에 가교제를 도포결합하고; 상기 기재 표면의 가교제에 룸부로키나제를 도포결합하는; 공정들로 이루어진 룸부로키나제를 고정한 생체재료의 제조방법.Applying a crosslinking agent to the surface of the polymer substrate; Coating and attaching rumbaurokinase to a crosslinking agent on the surface of the substrate; A method for producing a biomaterial fixed with lumpurokinase consisting of steps. 제7항에 있어서, 상기한 고분자는 천연 고무, 합성고무, 실리콘수지, 셀룰로오즈, 엘라스토머, 폴리우레탄, 하이드로겔, 폴리비닐클로라이드, 폴리에틸렌, 폴리테트라플루오로에틸렌, 폴리에스타 나일론으로 이루어진 군에서 선택되는 룸부로키나제를 고정한 생체재료의 제조방법.The method of claim 7, wherein the polymer is selected from the group consisting of natural rubber, synthetic rubber, silicone resin, cellulose, elastomer, polyurethane, hydrogel, polyvinyl chloride, polyethylene, polytetrafluoroethylene, and polyester nylon. A method for producing a biomaterial to which rumurokinase is fixed. 제7항에 있어서, 상기한 가교제는 말레익 안하이드라이드 메틸비닐에테르 공중합체, 헥사메틸렌디이소시아네이트, 톨루엔디이소시아네이트, 디페닐메탄디이소시아네이트로 이루어진 군에서 선택되는 하나 이상의 것인 룸부로키나제를 고정한 생체재료의 제조방법.8. The method of claim 7, wherein the crosslinking agent is at least one selected from the group consisting of maleic anhydride methyl vinyl ether copolymer, hexamethylene diisocyanate, toluene diisocyanate, diphenylmethane diisocyanate, Method of producing biomaterials. 제7항에 있어서, 상기한 가교제는 테트라히드로푸란, 아세톤, 디메틸아세트아미드, 디메티포름아미드로 이루어진 군에서 선택되는 하나 또는 그 이상의 혼합용매에 용해시킨 가교제 용액인 룸부로키나제를 고정한 생체재료의 제조방법.8. The biomaterial according to claim 7, wherein the crosslinking agent is a crosslinking agent solution dissolved in one or more mixed solvents selected from the group consisting of tetrahydrofuran, acetone, dimethylacetamide and dimethicamide. Manufacturing method. 제7항에 있어서, 상기한 가교제와 용매의 혼합비는 용매:가교제=1:0.001∼0.1W/V인 룸부로키나제를 고정한 생체재료의 제조방법.The method for producing a biomaterial according to claim 7, wherein the mixing ratio of the crosslinking agent and the solvent is solvent: crosslinking agent = 1: 0.001-0.1 W / V. 제7항에 있어서, 상기한 룸부로키나제는 F-I-0, F-I-1, F-I-2, F-II, F-III-1, F-III-2로 이루어진 군에서 선택되는 하나 이상의 것인 룸부로키나제를 고정한 생체재료의 제조방법.The room of claim 7, wherein the lumpurokinase is at least one selected from the group consisting of FI-0, FI-1, FI-2, F-II, F-III-1, and F-III-2. A method for producing a biomaterial having immobilized burokinase. 제7항에 있어서, 상기한 룸부로키나제의 도포결합은 2∼24시간 실시하는 룸부로키나제를 고정한 생체재료의 제조방법.8. The method of producing a biomaterial according to claim 7, wherein the application of the lumburokinase is performed for 2 to 24 hours. 제7항에 있어서, 상기한 룸부로키나제의 도포결합은 4∼37℃에서 실시하는 룸부로키나제를 고정한 생체재료의 제조방법.8. The method for producing a biomaterial according to claim 7, wherein the application of the lumburokinase is performed at 4 to 37 占 폚. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940001599A 1994-01-28 1994-01-28 Tissue material for living body KR970004591B1 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100491700B1 (en) * 2002-03-22 2005-05-27 주식회사 뉴하트바이오 Method for immobilization of antithrombotic proteins on polytetrafluoroethylene surface by plasma treatment

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100491700B1 (en) * 2002-03-22 2005-05-27 주식회사 뉴하트바이오 Method for immobilization of antithrombotic proteins on polytetrafluoroethylene surface by plasma treatment

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