KR950014075A - 5-aminopyrazole derivatives and preparation method thereof - Google Patents

5-aminopyrazole derivatives and preparation method thereof Download PDF

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Publication number
KR950014075A
KR950014075A KR1019930024912A KR930024912A KR950014075A KR 950014075 A KR950014075 A KR 950014075A KR 1019930024912 A KR1019930024912 A KR 1019930024912A KR 930024912 A KR930024912 A KR 930024912A KR 950014075 A KR950014075 A KR 950014075A
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South Korea
Prior art keywords
methyl
hydrogen atom
ethyl
aminopyrazole
aminopyrazole derivatives
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KR1019930024912A
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Korean (ko)
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KR970001474B1 (en
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김용환
박치현
전원배
조희준
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권석명
동양화학공업 주식회사
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Priority to KR1019930024912A priority Critical patent/KR970001474B1/en
Publication of KR950014075A publication Critical patent/KR950014075A/en
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Publication of KR970001474B1 publication Critical patent/KR970001474B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

본 발명은 다음식과 같이 히드라진을 시아노아크릴레이트와 친핵축합반응시켜 벼에 약해가 없으면 제초효과가 뛰어난 5-아미노피라졸 유도체만을 선택적으로 제조하도록 하였으며, 이때 합성 용매로 물을 사용하여 별도의 용매종류 공정없이 직접추출, 농축공정으로 진행할 수 있도록 한 5-아미노피라졸 유도체만을 선택적으로 제조하는 방법에 관한 것이다.In the present invention, nucleocondensation reaction of hydrazine with cyanoacrylate is used to selectively prepare only 5-aminopyrazole derivatives having excellent herbicidal effect without damaging rice. The present invention relates to a method for selectively preparing only 5-aminopyrazole derivatives which can be directly extracted and concentrated without any kind of process.

상기 식에서, R1은 수소원자, 메틸, 에틸 또는 페닐기를 나타내고, R2는 수소원자, 메틸 또는 에틸기를 나타낸다.In the above formula, R 1 represents a hydrogen atom, methyl, ethyl or phenyl group, and R 2 represents a hydrogen atom, methyl or ethyl group.

Description

5-아미노피라졸 유도체 및 이 유도체의 제조방법5-aminopyrazole derivatives and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

다음식(I)로 표시되는 5-아미노피라졸유도체의 제조방법Manufacturing method of 5-aminopyrazole derivative represented by the following formula (I) 상기 식에서, R1은 수소원자, 메틸, 에틸 또는 페닐기를 나타내고, R2는 수소원자, 메틸 또는 에틸기를 나타낸다.In the above formula, R 1 represents a hydrogen atom, methyl, ethyl or phenyl group, and R 2 represents a hydrogen atom, methyl or ethyl group. 합성용매로 물을 사용하고 촉매로 모노메틸아민, 모노에틸아민, 디메틸아민, 디에틸아민, 트리메틸아민, 트리에틸아민 등의 유기염기와 수산화나트륨, 수산화칼륨, 수산화암모늄, 탄산나트륨, 탄산칼륨, 탄산암모늄 등의 무기염기를 사용하여 시아노아크 릴레이트와 히드라진을 친핵축합반응시키므로서 다음 일반식(I)의 5-아미노피라졸 유도체 화합물만을 선택적으로 제조하는 것을 특징으로 하는 5-아미노피라졸 유도체의 제조방법.Water is used as a synthetic solvent, and organic bases such as monomethylamine, monoethylamine, dimethylamine, diethylamine, trimethylamine, and triethylamine as catalysts, sodium hydroxide, potassium hydroxide, ammonium hydroxide, sodium carbonate, potassium carbonate, and carbonic acid. 5-aminopyrazole derivatives, characterized in that only 5-aminopyrazole derivative compounds of the following general formula (I) Manufacturing method. 상기 식에서, Rl은 수소원자, 메틸, 에틸 또는 페닐기를 나타내고, R2는 수소원자, 메틸 또는 에틸기를 나타낸다.In the above formula, R 1 represents a hydrogen atom, methyl, ethyl or phenyl group, and R 2 represents a hydrogen atom, methyl or ethyl group. 제2항에 있어서, 촉매량을 시아노아크릴레이트 대비 0.1당량에서 3.0당량 사용하는 것을 특징으로 하는 5-아미노 피라졸 유도체의 제조방법.The method for preparing 5-amino pyrazole derivatives according to claim 2, wherein the catalytic amount is used in an amount of 0.1 equivalents to 3.0 equivalents of cyanoacrylate. 제2항에 있어서, 톨루엔, 디메틸설폭시드, n-부탄올, 에탄올 또는 아세토니트릴을 합성용매로 사용하는 것을 특징으로 하는 5-아미노피라졸유도체의 제조방법.The process for producing 5-aminopyrazole derivatives according to claim 2, wherein toluene, dimethyl sulfoxide, n-butanol, ethanol or acetonitrile are used as a synthetic solvent. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019930024912A 1993-11-22 1993-11-22 Process of preparation of 5-aminopyrazole derivatives KR970001474B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019930024912A KR970001474B1 (en) 1993-11-22 1993-11-22 Process of preparation of 5-aminopyrazole derivatives

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Application Number Priority Date Filing Date Title
KR1019930024912A KR970001474B1 (en) 1993-11-22 1993-11-22 Process of preparation of 5-aminopyrazole derivatives

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KR950014075A true KR950014075A (en) 1995-06-15
KR970001474B1 KR970001474B1 (en) 1997-02-06

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100459938B1 (en) * 2001-10-16 2004-12-03 한국화학연구원 Fluorine-substituted heterocyclic compounds as intermediate for synthesis of agrochemical and medicinal antagonist and method for preparing thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100459938B1 (en) * 2001-10-16 2004-12-03 한국화학연구원 Fluorine-substituted heterocyclic compounds as intermediate for synthesis of agrochemical and medicinal antagonist and method for preparing thereof

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Publication number Publication date
KR970001474B1 (en) 1997-02-06

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