KR950013506A - Ibuprofen Liquid - Google Patents
Ibuprofen Liquid Download PDFInfo
- Publication number
- KR950013506A KR950013506A KR1019930023940A KR930023940A KR950013506A KR 950013506 A KR950013506 A KR 950013506A KR 1019930023940 A KR1019930023940 A KR 1019930023940A KR 930023940 A KR930023940 A KR 930023940A KR 950013506 A KR950013506 A KR 950013506A
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- KR
- South Korea
- Prior art keywords
- sodium
- calcium
- potassium
- phosphate
- citrate
- Prior art date
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
본 발명은 알칼리성 첨가제를 사용하여 쓴 맛을 제거한 이부프로펜 액제에 관한 것으로, 종래의 수산화알루미늄으로 쓴 맛을 제거한 현탁액제의 제조후 안정성이 적어 보관중 침전이 발생하기 쉬울 뿐만 아니라 제조공정이 복잡하고 복용이 불편한 단점을 극복하였는 바, 약물로서 이부프로펜을 함유하고, 알칼리성 첨가물로는 예를 들면, 탄산수소나트륨, 탄산이수소나트륨, 탄산마그네슘, 탄산알루미늄, 탄산칼슘, 인산수소나트륨, 인산나트륨, 인산알루미늄, 인산칼슘, 인산칼륨, 수산화나트륨, 수산화칼륨, 수산화마그네슘, 스테아린산칼륨, 스테아린산칼슘, 스테아린산마그네슘, 시트르산알루미늄, 시트르산칼슘, 시트르산나트륨, 시트르산칼륨과 같은 무기 알칼리성 첨가제, 또는 α-사이클로덱스트린, β-사이클로덱스트린,-사이클로덱스트린, 사이클로덱스트린 유도체, 리진, 히스티딘, 수크로스 지방산에스테르, 글루코스아민과 같은 유기 단분자, 또는 메타그릴산과 메타크릴산메틸에스테르의 공중합체, 셀룰로스아세테이트프탈레이트, 히드록시프로필메틸셀룰로스프탈레이트, 폴리비닐아세테이트프탈레이트, 카르복시메틸에틸셀룰로스, 히드록시프로필메틸셀루로스아세테이트숙시네이트, 폴리아크릴산유도체, 알진산 등의 나트륨염, 칼슘염, 칼륨염 그리고 디메틸아미노에틸 메타크릴레이트와 메타크릴산메틸에스테르의 공중합체, 폴리비닐피롤리돈 유도체 등에서 선택되는 1종 이상을 함유하며, 여기에 감미제, 향료, 색소, 방부제, 향산화제, 안정화제를 포함하는 통상의 보조제를 첨가하여 쓴 맛이 없고 보관안정성이 뛰어난 새로운 이부프로펜 액제를 제공한다.The present invention relates to an ibuprofen liquid solution from which a bitter taste is removed using an alkaline additive, and is less stable after preparation of a suspension which has been removed from the bitter taste of conventional aluminum hydroxide, so that precipitation does not easily occur during storage, and the manufacturing process is complicated and dosed. Overcoming this uncomfortable disadvantage, it contains ibuprofen as a drug, and as the alkaline additive, for example, sodium bicarbonate, sodium bicarbonate, magnesium carbonate, aluminum carbonate, calcium carbonate, sodium hydrogen phosphate, sodium phosphate, aluminum phosphate , Inorganic alkaline additives such as calcium phosphate, potassium phosphate, sodium hydroxide, potassium hydroxide, magnesium hydroxide, potassium stearate, calcium stearate, magnesium stearate, aluminum citrate, calcium citrate, sodium citrate, potassium citrate, or α-cyclodextrin, β- Cyclodextrin, Cyclodextrins, cyclodextrin derivatives, lysine, histidine, sucrose fatty acid esters, organic monomolecules such as glucoseamine, or copolymers of methacrylic acid and methacrylic acid methyl esters, cellulose acetate phthalate, hydroxypropylmethylcellulose phthalate, poly Sodium salts such as vinyl acetate phthalate, carboxymethyl ethyl cellulose, hydroxypropyl methyl cellulose acetate succinate, polyacrylic acid derivatives, alginic acid, calcium salts, potassium salts and dimethylaminoethyl methacrylate and methacrylic acid methyl ester It contains at least one member selected from copolymers, polyvinylpyrrolidone derivatives, and the like, and it has no bitter taste and excellent storage stability by adding ordinary supplements including sweeteners, flavorings, pigments, preservatives, oxidizing agents and stabilizers. Provide a new ibuprofen solution.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019930023940A KR950013506A (en) | 1993-11-11 | 1993-11-11 | Ibuprofen Liquid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019930023940A KR950013506A (en) | 1993-11-11 | 1993-11-11 | Ibuprofen Liquid |
Publications (1)
Publication Number | Publication Date |
---|---|
KR950013506A true KR950013506A (en) | 1995-06-15 |
Family
ID=66825394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019930023940A KR950013506A (en) | 1993-11-11 | 1993-11-11 | Ibuprofen Liquid |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR950013506A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100788449B1 (en) * | 2005-11-08 | 2008-01-02 | 주식회사 일신케미칼 | Manufacturing method of dexibuprofen particle for suspension and dexibuprofen suspension |
WO2023043207A1 (en) * | 2021-09-15 | 2023-03-23 | 구주제약주식회사 | Pharmaceutical composition with improved stability comprising propionic acid-based drug and stabilizer |
-
1993
- 1993-11-11 KR KR1019930023940A patent/KR950013506A/en not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100788449B1 (en) * | 2005-11-08 | 2008-01-02 | 주식회사 일신케미칼 | Manufacturing method of dexibuprofen particle for suspension and dexibuprofen suspension |
WO2023043207A1 (en) * | 2021-09-15 | 2023-03-23 | 구주제약주식회사 | Pharmaceutical composition with improved stability comprising propionic acid-based drug and stabilizer |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |