KR950011440A - Method for preparing azole derivatives - Google Patents

Method for preparing azole derivatives Download PDF

Info

Publication number
KR950011440A
KR950011440A KR1019930022051A KR930022051A KR950011440A KR 950011440 A KR950011440 A KR 950011440A KR 1019930022051 A KR1019930022051 A KR 1019930022051A KR 930022051 A KR930022051 A KR 930022051A KR 950011440 A KR950011440 A KR 950011440A
Authority
KR
South Korea
Prior art keywords
formula
hydrogen
halogen
compound
following formula
Prior art date
Application number
KR1019930022051A
Other languages
Korean (ko)
Inventor
김기성
김덕규
김문성
윤영구
조종환
Original Assignee
유충식
동아제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 유충식, 동아제약 주식회사 filed Critical 유충식
Priority to KR1019930022051A priority Critical patent/KR950011440A/en
Publication of KR950011440A publication Critical patent/KR950011440A/en

Links

Landscapes

  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

본 발명은 다음 구조식(III)의 화합물을 다음 구조식(IV)의 카파(I) 화합물 촉매로 하여, 금속 염기 존재하, 구조식(II)의 화합물과 유기용매 내에서 반응시킴을 특징으로 하는 다음 구조식(I)로 표시되는 화합물 및 이의 약학적으로 허용되는 산부가염을 제조하는 방법에 관한 것이다.The present invention is characterized by reacting a compound of formula (III) with a kappa (I) compound catalyst of formula (IV) in the presence of a metal base in a organic solvent with a compound of formula (II) A method for producing a compound represented by (I) and a pharmaceutically acceptable acid addition salt thereof.

상기식에서, R은 수소 또는 Cl-C4의 저급알킬이나 아릴알킬이고, A는 탄소 또는 질소이고, Y는 수소, 리튬, 소디움, 칼륨 또는 할로겐이고, X는 수소, 염소, 브롬 또는 요오드이고, M은 할로겐 또는 산소이다.Wherein R is hydrogen or lower alkyl or arylalkyl of C 1 -C 4 , A is carbon or nitrogen, Y is hydrogen, lithium, sodium, potassium or halogen, X is hydrogen, chlorine, bromine or iodine , M is halogen or oxygen.

Description

아졸 유도체의 제조방법Method for preparing azole derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

다음 구조식(III)의 화학물을 다음 구조식(IV)의 카파(I) 화합물을 촉매로 하여, 금속 염기 존재하, 구조식(II)의 화합물과 유기용매 내에서 반응시킴을 특징으로 하는 다음 구조식(I)로 표시되는 화합물 및 이의 약학적으로 허용되는 산부가염의 제조방법.The chemical formula of the following formula (III) is reacted in the organic solvent with the compound of the formula (II) in the presence of a metal base using a kappa (I) compound of the following formula (IV) as a catalyst A method for producing a compound represented by I) and a pharmaceutically acceptable acid addition salt thereof. 상기식에서, R은 수소 또는 C1-C4의 저급알킬이나 아릴알킬이고, A는 탄소 또는 질소이고, Y는 수소, 리튬, 소디움, 칼륨 또는 할로겐이고, X는 수소, 염소, 브롬 또는 요오드이고, M은 할로겐 또는 산소이다.Wherein R is hydrogen or lower alkyl or arylalkyl of C 1 -C 4 , A is carbon or nitrogen, Y is hydrogen, lithium, sodium, potassium or halogen, X is hydrogen, chlorine, bromine or iodine , M is halogen or oxygen. 제1항에 있어서, 촉매로서 1가의 카파할라이드 또는 카파옥사이드를 사용함을 특징으로 하는 방법.The process according to claim 1, wherein monovalent kappahalide or kappa oxide is used as a catalyst. 제1항에서, 구조식(III)의 제조에 있어서, 다음 구조식(VII)의 페닐이소시아네이트 할로겐 유도체를 이용하는 것을 특징으로 하는 방법.2. Process according to claim 1, characterized in that for the preparation of formula (III), a phenyl isocyanate halogen derivative of the following formula (VII) is used. 식중, X는 할로겐 원소를 나타낸다.In the formula, X represents a halogen element. 제1항에서, 금속염기로 소디움하이드라이드 또는 포타슘 t-부톡사이드를 이용하는 것을 특징으로 하는 방법.The method of claim 1, wherein sodium hydride or potassium t-butoxide is used as the metal base. 제1항에서, 불활성 유기용매하 90-130℃에서 반응시킴을 특징으로 하는 방법.The method of claim 1 wherein the reaction is carried out at 90-130 ° C. under an inert organic solvent. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019930022051A 1993-10-22 1993-10-22 Method for preparing azole derivatives KR950011440A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019930022051A KR950011440A (en) 1993-10-22 1993-10-22 Method for preparing azole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019930022051A KR950011440A (en) 1993-10-22 1993-10-22 Method for preparing azole derivatives

Publications (1)

Publication Number Publication Date
KR950011440A true KR950011440A (en) 1995-05-15

Family

ID=66824971

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930022051A KR950011440A (en) 1993-10-22 1993-10-22 Method for preparing azole derivatives

Country Status (1)

Country Link
KR (1) KR950011440A (en)

Similar Documents

Publication Publication Date Title
KR850003393A (en) Method for preparing 1-benzyl-aminoalkyl-pyrrolidinone
KR880000433A (en) Method for preparing imidazopyridine and intermediate compound
KR850005440A (en) Method for producing a bactericide containing thiazole and oligoether groups
KR840006977A (en) Process for preparing substituted phenylsulfonyloxybenzimidazole carbamate
ES8606381A1 (en) Novel 2'-deoxy-5-substituted uridine derivatives, processes for preparing the same and antitumor agent containing the same.
KR840001134A (en) Method of preparing (thio-) urea
KR860008144A (en) Method for preparing 1,3-dialkyl-2-imidazolidinone
KR950011440A (en) Method for preparing azole derivatives
ES485593A1 (en) Process for producing phenoxycarboxylic acid derivative
KR840007228A (en) Method for preparing triazole derivative
US4417048A (en) N-alkylation of organonitrogen compounds
KR920004397A (en) Method for preparing 1-oxa-3,8-diaza-4-oxospyro [4,5] decane compound.
KR870008892A (en) 2-[(2-pyridyl) methylsulfinyl] thieno imidazole and its related compounds as anti-ulcer agents
CA1138455A (en) 4-(3-iodopropargyloxy) pyrimidine derivatives and process for their production
GB1506021A (en) Process for the preparation of 5-triazolo(3,4-b)-benzothiazoles
Tanaka et al. N-Acyl-1-chloro-2, 2, 2-trifluoroethylamine as a 2, 2, 2-Trifluoroethylamine-Building Block.
KR920002535A (en) Method for preparing 2-aryl-5- (trifluoromethyl) pyrrole compound and 1,1,1-trifluoro-2-propene compound and method for preparing same
KR890700587A (en) Method for preparing compound of anti-ulcer action
KR830008993A (en) Method for preparing mercaptoacyl-carnitine
JPS5519221A (en) Production of fixed crown
KR850007058A (en) Process for preparing prostaglandin intermediate
JPS5622765A (en) Novel method of preparing pindolol
KR830009030A (en) Method for preparing phenoxy pyridyl methyl ester
CN115650919A (en) Method for preparing fipronil from trichloromethyl sulfinyl chloride
NZ500733A (en) Reduction of aromatic halogenides by LiBH4 in the presence of oxygen

Legal Events

Date Code Title Description
WITN Withdrawal due to no request for examination